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Zetia

Zetia is a cholesterol absorption inhibitor used to lower total cholesterol, LDL-C, Apo-B, and non-HDL-C in primary hyperlipidemia and familial cholesterolemia. Zetia is indicated to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with primary hyperlipidemia, alone or in combination with an HMG-CoA reductase inhibitor (statin).

Other names for this medication:
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Also known as: Ezetimibe

Description

Zetia (ezetimibe) reduces the level of total cholesterol and LDL (bad) cholesterol in the blood.

Zetia is used to treat high cholesterol in people who cannot control their cholesterol levels by diet and exercise alone.

Zetia works to reduce the amount of cholesterol your body absorbs. You should stay on a cholesterol-lowering diet while taking this medicine.

Zetia is sometimes given together with other cholesterol-lowering medications.

Dosage

Usual Adult Dose of Zetia for Hyperlipidemia:

10 mg orally once a day Uses: -For use as monotherapy or in combination with an HMG-CoA reductase inhibitor (statin) as an adjunct to diet to reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and non-high-density lipoprotein cholesterol (non-HDL-C) in patients with primary (heterozygous familial and non-familial) hyperlipidemia -For use as combination therapy with fenofibrate as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with mixed hyperlipidemia -As an adjunct to diet to reduce elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia -For use as combination therapy with atorvastatin or simvastatin to reduce elevated total-C and LDL-C levels in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable

Usual Adult Dose of Zetia for Homozygous Familial Hypercholesterolemia:

10 mg orally once a day Uses: -For use as monotherapy or in combination with an HMG-CoA reductase inhibitor (statin) as an adjunct to diet to reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and non-high-density lipoprotein cholesterol (non-HDL-C) in patients with primary (heterozygous familial and non-familial) hyperlipidemia -For use as combination therapy with fenofibrate as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with mixed hyperlipidemia -As an adjunct to diet to reduce elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia -For use as combination therapy with atorvastatin or simvastatin to reduce elevated total-C and LDL-C levels in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable

Usual Adult Dose of Zetia for Sitosterolemia:

10 mg orally once a day Uses: -For use as monotherapy or in combination with an HMG-CoA reductase inhibitor (statin) as an adjunct to diet to reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and non-high-density lipoprotein cholesterol (non-HDL-C) in patients with primary (heterozygous familial and non-familial) hyperlipidemia -For use as combination therapy with fenofibrate as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with mixed hyperlipidemia -As an adjunct to diet to reduce elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia -For use as combination therapy with atorvastatin or simvastatin to reduce elevated total-C and LDL-C levels in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable

Usual Pediatric Dose for Hyperlipidemia:

10 years or older: 10 mg orally once a day Uses: -For use as monotherapy or in combination with a statin as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with primary (heterozygous familial and non-familial) hyperlipidemia -For use as combination therapy with a fenofibrate as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with mixed hyperlipidemia -As an adjunct to diet to reduce elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia -For use as combination therapy with atorvastatin or simvastatin for the reduction of elevated total-C and LDL-C in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable

Usual Pediatric Dose for Homozygous Familial Hypercholesterolemia:

10 years or older: 10 mg orally once a day Uses: -For use as monotherapy or in combination with a statin as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with primary (heterozygous familial and non-familial) hyperlipidemia -For use as combination therapy with a fenofibrate as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with mixed hyperlipidemia -As an adjunct to diet to reduce elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia -For use as combination therapy with atorvastatin or simvastatin for the reduction of elevated total-C and LDL-C in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable

Usual Pediatric Dose for Sitosterolemia:

10 years or older: 10 mg orally once a day Uses: -For use as monotherapy or in combination with a statin as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with primary (heterozygous familial and non-familial) hyperlipidemia -For use as combination therapy with a fenofibrate as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with mixed hyperlipidemia -As an adjunct to diet to reduce elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia -For use as combination therapy with atorvastatin or simvastatin for the reduction of elevated total-C and LDL-C in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable

Detailed Zetia dosage information

Overdose

If you overdose Generic Zetia and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Zetia are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Zetia if you are allergic to ezetimibe, or if you have:

moderate to severe liver disease.

Zetia is not approved for use by anyone younger than 10 years old.

You should not use Zetia with a "statin" cholesterol medicine (Zocor, Lipitor, Crestor, and others) if:

you have active liver disease; you are pregnant; or you are breastfeeding a baby.

Statin cholesterol medications can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

To make sure Zetia is safe for you, tell your doctor if you have:

liver disease; kidney disease; or unexplained muscle pain or weakness.

Tell your doctor if you are pregnant or breastfeeding.

Use effective birth control to prevent pregnancy while you are using Zetia with a statin medicine. Tell your doctor if you plan to become pregnant.

Do not breastfeed if you take Zetia with a statin medicine.

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Neopterin has recently gained growing importance as an immunological marker in psychiatric disorders. For that purpose, we analyzed the first year experience of a unit for the control of nosocomial infection (NI) created in our hospital. CM enhancement on CT did not show any harmful effect on stroke severity or outcome. Cytokines are important mediators of the pathogenesis of lung fibrosis. Although some of the problems encountered were specific to the MIQUEST software, many, including considering appropriate ranges for age and biochemical test results and paying careful attention to the reliability of drug and diagnosis coding, are relevant whenever data are extracted from the EPR for any purpose. Pregnancy outcome after liver transplantation: a single-center experience of 71 pregnancies in 45 recipients. Malformations of the craniofacial region are reviewed with respect to evolutionary, embryonic, genetic, and clinical perspectives under the following headings: How Old Is Our Head?, Head Organization Genes, Genetics of Craniofacial Anomalies, Craniofacial Derivatives, Anencephaly, Cephalocele, Holoprosencephaly, Craniosynostosis, Hypertelorism, Branchial Arch Anomalies, and Orofacial Clefting. A wide spectrum of abnormalities can affect the throwing shoulder. Additionally, applications with GA3 elicited synthesis of L lopressor dosage strengths -proline in berries, and mono- and sesquiterpenes in all the tissues.

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Development of a novel multiplex type-specific quantitative real-time PCR for detection and differentiation of infections with human papillomavirus types HPV2, HPV27, and HPV57. Prospective studies that elucidate the conditions under which individual physicians do and do not screen, as well as future efforts to educate physicians about the most effective brief intervention approaches, seem warranted. We aimed to bring the strengths of these new approaches together with our proposed two-stage imputation for family data. Ultrasound assessment of the effect of parity on postpartum uterine involution. Women recruited from a hereditary cancer registry provided ratings of distress associated with different aspects of high-risk status and can i drink alcohol while on neurontin genetic testing and completed measures of general psychological distress, emotional and social health, and role functioning. The remaining vacancies exhibit two distinct types of puckering.

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The effect of pyridoxine deficiency on aortic elastin biosynthesis. Socio-economic determinants of age differences between spouses in Bangladesh. cDNA microarray analysis of the differential gene expression in the neuropathic pain and electroacupuncture treatment models. However, immunohistochemical analysis of paraffin-embedded porcine tissues showed reactivity on blood vessel plasma, and indicates recognition of a plasma protein. After collection of additional data, the profiles may be refined. The SPS rats were administered by AF (at doses of 3.5, 7 and 14.0mg/kg, i.g.) after induction of SPS from days 2-13. Some issues concerning the determination of an optimum population for Czechoslovakia are discussed, and their implications for the development of appropriate population policies are considered.

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He also evaluates to what extent demographic conditions in the region in the eighteenth and nineteenth centuries (relatively severe mortality and high levels of migration in some areas) affected the accuracy of the estimates. On polyacrylamide gel electrophoresis, the C3AF isolate contains a high m.w. carotovora strains spontaneously assemble at the self-assembly centers (or crystallization centers), which have a diameter of 26-65 nm and contain a dense proteinaceous material. The null hypothesis was that no difference between celecoxib and ibuprofen exists. Phase-sensitive tomography of the joint spectral amplitude of photon pair sources. Access to the maxilla was gained through a small mucosa incision in the vestibule to create a visualization port to the maxillary sinus through a bur hole.

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Three patients developed complications following dermabrasion with a new potent skin refrigerant mixture. Thymidine uptake experiments verified that Immolina did not affect the viability and growth rate of THP-1 cells. Although these findings warrant further research on causality, the associations between folate, tHcy and semen quality emphasize the importance of preconception counselling in male subfertility. These hybrid nanoparticles could be a promising fluorescent probe for bioimaging. The evolution of UCPs is of general interest in the search for the origin of mammalian UCP1-mediated nonshivering thermogenesis. Dissociation between activation of the hypothalamo-hypophyseal antidiuretic system and the type of diuresis during acute intracranial hypertension. Association of smoking with other lifestyle factors and mental health status of Japanese factory workers. However, potential pathogenic autoreactive lymphocytes are normally present in the periphery of all individuals.

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Inotropic response to digoxin and dopamine in patients with severe sepsis, cardiac failure, and systemic hypoperfusion. These effects can have a large impact on the biological availability, mobilization, and transport of macro- and micronutrients, toxic metal ions, and xenobiotic organic cations in pig slurry-amended soils. Monthly admission rates in total and by age group for all patients, patients admitted with acute conditions and with acute conditions at vasotec normal dosage internal medicine departments. Before surgery, he had experienced vertigo when turning even slightly in bed. Analyses included analysis of covariance and hierarchical multiple linear regression. Contrary to some previous reports, inducible NO synthase was actively synthesized by macrophages of the protected hamsters with concomitant high levels of NO production. Response of normal children to the treadmill exercise test using the Bruce protocol. This regulatory function is mediated via the release of vasoactive cytokines called adipokines. Each microwave oven had its unique characteristic operating frequencies, which were also affected by the location and shape of the load.

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A case of chronic recurrent infiltrative eosinophilic lung disease. The primary end points of the study were: (a) clinical and pathological response, (b) downstaging and conversion to operable disease, and (c) recurrence-free survival (RFS) and overall survival (OS). The ratio of donor and recipient height, as well as the ratio of predicted TLC in donors and recipients, were calculated in 80 patients after bilateral lung transplantation. The SENIC study has convincingly demonstrated that for the four most important hospital-associated infections in the U.S., active ongoing intense surveillance based on daily patient chart and/or Kardex reviews in itself reduces the infection rate. The authors noted radiopacities around the right TMJ space on a panoramic radiograph. The aim of this study was to examine the time course of upregulation of growth factors and correlate this with the macrophage and myofibroblast interstitial infiltrate. Minimal stimulation appears to be an effective protocol in cases of unexplained infertility undergoing intrauterine insemination.

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Upon phylogenetic analysis, lemur DRB genes were clustered by themselves and separated from the other primate DRB genes (simians and non-Malagasy prosimians). Data compression increases the number of images that can be stored on magnetic disks or tape and reduces the time required for transmission of images between stations. Our findings enrich the knowledge of miR-376a in ovarian cancer formation and progression, providing a possibility of using miR-376a as a diagnostic and prognostic biomarker for ovarian cancer. Fifty percent of eyes had an increase in the accommodation amplitude of at least 0.5 diopters immediately after application of the WSs. Thirteen women viewed a set of nine 2-min amusing, sad, or neutral film clips two times. Human rhinoviruses (HRVs) are a major trigger of asthma exacerbations, with the bronchial epithelium being the major site of HRV infection and replication. For the latter a single class of pathways leads to the native state again through a two-state process. During a 9-month follow-up, no further tachycardia episodes were detected by the device.

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