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Zaxial (Calcitriol)
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Zaxial

Zaxial is the active form of vitamin D, normally made in the kidney. It is also known as 1,25-dihydroxycholecalciferol. It is a hormone which binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes.

Other names for this medication:
Actical, Admax, Alcee, Alfacalcirol, Apcical, Arcium, Biocal, Biocitral, Bonestat, Bonetuf, Calasto, Calbec, Calcibest, Calcikind, Calcitriol, Calday, Caldikind, Calosto, Calotec, Calsure, Caltive, Caltop, Carcal, Coecoral, Dmcal, Estovon, Ikmag, Koncal, Minroset, Netxod, Novadee, Nutribone, Osteobel, Ostonex, Refirm, Riecal, Rockbon, Romical, Septriol

Similar Products:
Benemid, Rocaltrol, Diamox, Indocin, Floxin, Nexium

Also known as: Calcitriol

Description

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are available in the foods that you eat. Vitamin D is necessary for strong bones and teeth.

Lack of vitamin D may lead to a condition called rickets, especially in children, in which bones and teeth are weak. In adults it may cause a condition called osteomalacia, in which calcium is lost from bones so that they become weak. Your doctor may treat these problems by prescribing vitamin D for you. Vitamin D is also sometimes used to treat other diseases in which calcium is not used properly by the body.

Ergocalciferol is the form of vitamin D used in vitamin supplements.

Some conditions may increase your need for vitamin D. These include:

Alcoholism Intestine diseases Kidney disease Liver disease Overactivity of the parathyroid glands with kidney failure Pancreas disease Surgical removal of stomach

In addition, individuals and breast-fed infants who lack exposure to sunlight, as well as dark-skinned individuals, may be more likely to have a vitamin D deficiency. Increased need for vitamin D should be determined by your health care professional.

Alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are forms of vitamin D used to treat hypocalcemia (not enough calcium in the blood). Alfacalcidol, calcifediol, and calcitriol are also used to treat certain types of bone disease that may occur with kidney disease in patients who are undergoing kidney dialysis.

Claims that vitamin D is effective for treatment of arthritis and prevention of nearsightedness or nerve problems have not been proven. Some psoriasis patients may benefit from vitamin D supplements; however, controlled studies have not been performed.

Injectable vitamin D is given by or under the supervision of a health care professional. Some strengths of ergocalciferol and all strengths of alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are available only with your doctor's prescription. Other strengths of ergocalciferol are available without a prescription. However, it may be a good idea to check with your health care professional before taking vitamin D on your own. Taking large amounts over long periods may cause serious unwanted effects.

Dosage

Generic Zaxial is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Zaxial suddenly.

Overdose

If you overdose Generic Zaxial and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Zaxial are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Zaxial if you are allergic to Generic Zaxial components. Do not take Generic Zaxial if you are pregnant, planning to become pregnant, or are breast-feeding. It is not known if this medication appears in breast milk. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Be careful with Generic Zaxial if you have heart disease, kidney disease or kidney stones, coronary artery disease (hardening of the arteries). Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. It can be dangerous to stop Generic Zaxial taking suddenly.

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Porphyrin photodynamic therapy in an experimental retinoblastoma model. As late as 24 weeks post-transplantation, the RDEB grafts remain human, are not significantly replaced by mouse cells, and retain the RDEB disease phenotype. Treatment of noncomminuted zygoma fractures with percutaneous reduction and rigid external devices. Routine pre-operative investigations (including liver function and renal function tests) were within the normal limit, serological investigation for rheumatoid arthritis was negative. STEROID EFFECTS ON PERMEABILITY OF RAT THYMIC LYMPHOCYTES TO ALPHA-AMINOISOBUTYRATE. Although few cases of hemophagocytic syndrome have been reported in HIV positive patient, it could represent an underestimated cause of pancytopenia. Clinical information may play little role in the diagnosis of CI. Aggregation of zero-valent nanoparticles in groundwater is influenced by several physical phenomena.

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Do Implantable Cardioverter Defibrillators Reduce Mortality in Patients With Chronic Kidney Disease at All Stages?. Electronic search of literature was conducted (2000-2016) on PubMed, Web of Science, and Scopus databases. The polarization of this cell orients its mitotic spindle in addition to inducing endodermal fate in one daughter cell. Divergent Population Genetic Structure of the Endangered Helianthemum (Cistaceae) and Its Implication to Conservation in Northwestern China. Additional data are available at http://cassandra.bio.uniroma1.it/mr-results-casp.html. Stroke, especially in the vertebrobasilar territory, is more likely to occur in patients with GCA who experience recent ophthalmic ischemic symptoms and who exhibit low inflammatory variables. The structure is hollow-spherical, composed of a total of 24 globins as a dimer of dodecamer.

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This complex, that was initially described as a co-factor for nuclear receptors, has recently been associated with the control of cell growth. We aimed to compare survival outcomes between patients diagnosed as T1HG after initial transurethral resection of the bladder tumor (TUR-BT) and patients who presented with lower stage and/or grade but progressed to T1HG at the time of tumor recurrence. One such splice variant, extradomain-B (ED-B) FN, is normally absent in normal adult tissues and is proposed to be a marker of tumoral angiogenesis. The midline location was identified in both the upper and lower lips to be the most variable. Identification of Pseudomonas aeruginosa-induced genes in human mast cells using suppression subtractive hybridization: up-regulation of IL-8 and CCL4 production. Since nucleated erythrocytes are common in fetal blood but rarely found in the peripheral circulation of adults, the method has potential application for the determination of fetal sex from analysis of flow-sorted nucleated erythrocytes present in the maternal circulation during pregnancy. Summary of the 22nd United States-Japan Joint Cholera Conference. Topics covered include project versus programmatic support, the indirect cost game, accountability, federal regulations, and the bureaucratic syndrome. We also mapped the receptive field dimensions of the crossed isthmotectal axons. Human Rights and the Political Economy of Universal Health Care: Designing Equitable Financing.

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In addition to the classical K-nearestneighbor and r-neighborhood methods for graph construction, l1-graph and its variants are emerging methods for finding the neighboring samples of a center datum, where the corresponding ingoing edge weights are simultaneously derived by the sparse reconstruction coefficients of the remaining samples. The histogenesis, diagnosis and prognosis of this tumor are discussed briefly. Facial color varies depending on emotional state, and emotions are often described in relation to facial color. The survey asked about needs, attitudes, and practices related to civil legal issues, including medical-legal partnerships. Comparison of these and GenBank sequences identified 2 new genotypes in the United Kingdom. After certain typical skin lesions had developed after two months, the diagnosis cutaneous polyarteritis could be made. In this study we aimed to determine the effects of heterosexually acquired HIV on small-intestinal function in native Africans, among whom there is a high prevalence of tropical enteropathy. Prioritizing individual genetic variants after kernel machine testing using variable selection. A total of 1455 participants completed a random-digit dial telephone survey that assessed hepatitis A immunization status of 3- to 17.9-year-old children from May 1 to June 24, 2003. Much has been learned about the molecular pathogenesis of infection by Neisseria gonorrhoeae, but immunity from natural infection does not protect against reinfection with the same strain, and the goal of a protective vaccine remains elusive.

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Attention deficit hyperactivity disorder (ADHD) is a highly prevalent childhood psychiatric disorder characterized by impaired attention, excessive motor activity, and impulsivity. At anterior electrodes, GBA showed a complementary pattern, being maximal when stimuli were oriented horizontally. Pathological tumour response was evaluated using Mandard regression grades. Breast augmentation with subglandular versus subpectoral implants may differentially impact the early detection of breast cancer and treatment recommendations. Vikasol administration stimulated biotransformation of amidopyrine and benzoic acid, the low doses of vikasol (3 mg/kg) being more effective as compared to the high doses (30 mg/kg). Wistar rats were exposed to mild water immersion and restraint stress (WRS) for 3.5 h and then sacrificed at 0, 2, 4, 6, 12 and 24 h after the termination of WRS. The aim of this study is to explore the association of dietary patterns with depression, perceived stress, and self-esteem among postmenopausal Chinese women.

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Developing dashboards to measure and manage inpatient pharmacy costs. Knowledge of such neovascular mediastinal pseudotumours may prevent the use of invasive investigations such as direct puncture or thoracotomy. These results indicate that GH plays a pivotal role in the regulation of PsChe activity in vitro, and that under the conditions used in this study, E2 does not influence the ability of hepatocytes in culture to express this enzyme. He was admitted to our hospital with symptoms of weakness of limbs, high fever, and alteration of consciousness. To evaluate the prevalence of anxiety, depression and kinesiophobia and their association with the symptoms of low back pain. Cox proportional hazards modeling and Kaplan-Meier analysis were performed to evaluate variables independently associated with overall survival. Pathogenic reactions also were found when the hrp secretion mutants were co-infiltrated into bean leaves with a non-lesion-forming gacS mutant of B728a.

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Mitochondrial and microsomal hepatic palmitoyl-CoA hydrolase activities were inhibited by the three drugs in a concentration-dependent fashion. Decoding Crucial LncRNAs Implicated in Neurogenesis and Neurological Disorders. First, it formulates a novel state-space representation for the joint dynamic stiffness modeled by a parallel-cascade structure with a concise parameter set that provides a direct link between the state-space representation matrices and the parallel-cascade parameters. Bowel function, clinical assessment, anal endosonography and manometry performed at a mean of 140 days after delivery. The prediction of perturbations can be performed easily by using a presented result which enables the efficient computation of the required iterative formulas. Large cohorts will be necessary to confirm the predictive value of 7 T MRI in the preoperative evaluation of TLE patients. It is also demonstrated that the mechanism for generating these frequencies between the two arrays is different from that of a master-slave interaction, a synchronization effect, or that of subharmonic and ultraharmonic solutions generated by forced systems. Levels of memory, learning, and visuomotor speed were higher after DS injuries, but improvement was less. Complex processes involving gene expression and epigenetic regulation are considered to perpetuate across generations. In Y-STR (short tandem repeat) analysis tests on 668 habitants of Jeju Island, the largest island in the Korean peninsula located apart from the mainland, a deletion at DYS448 was found in 10 samples.

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The other 3 foals have had normal epiglottic function for 2-4 years. It is one of the common causes of admission to the paediatric ward. A 12-year-old boy was treated conservatively for a grade II splenic laceration. This difference implies the presence of organically complexed Pt species in the estuarine waters. Moreover, GA-specific short-term T-cell lines, either exogenously labeled or genetically marked, adoptively transferred by the intraperitoneal route to colitis-induced mice, localized in the inner layers of the colon and secreted in situ the regulatory cytokine TGF-beta. Western blot analysis was performed to detect the MDR-1 level in these cell lines. Moreover, HupA treatment significantly blocked the upregulation of the LIP level and other aberrant iron metabolism changes induced by iron overload. The three groups of audiograms with different degrees of hearing loss allowed investigations of the influence of age, sex, vestibular disturbance and vascular disease. Such cross-talk among systems is dependent upon feedback loops working to maintain homeostatic equilibrium. As errors during the obviously existing process of chromosome counting are one if not the major origin of germline/somatic aneuploidy the here presented hypotheses should further elaborated and experimentally tested.

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AIH arises in a genetically predisposed host, when yet unknown triggers - such an encounter with a pathogen - lead to a T cell-mediated immune response targeting liver autoantigens. Outcomes after percutaneous coronary interventions in diabetic patients are shadowed by the increased rate of recurrence compared with nondiabetic patients. The findings emphasize that the combined localization of dopamine-beta-hydroxylase and neuropeptide Y or the presence of tyrosine hydroxylase is not exclusively a marker for peripheral adrenergic neurons. Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis. Identifying genes preferentially expressed in undifferentiated embryonic stem cells. In addition, the polymorphic nature of the data sets requires a more standardized method for integration and exploration. Erythrocytes and alcohol: hemorheologic manifestations of alcoholism. In the anatomical phase, 4 genicular nerves (superior medial, superior lateral, inferior medial and inferior lateral) were blocked with 4ml of local anaesthetic with iodinated contrast and methylene blue in each (16ml in total). In 30 dogs, left ventricular and pleural pressures were measured with micromanometers, and left ventricular volume was assessed with global ultrasonic crystals. Ultrasonographic findings included hyperechoic renal cortices, loss of corticomedullary junction definition, dilated pelves and irregularly shaped small kidneys.

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Vitamin E had a minor beneficial effect on tardive dyskinesia ratings in a selected group of patients who had had tardive dyskinesia for 5 years or less. When they considered individuals, people tempered or domesticated the more mechanistic explanations about racialized physical appearance, ancestry and genetics that were apparent at the collective level. An Actinomycete, strain K-128, which was isolated from soil, formed a transfer product when the strain was cultured in a medium containing both stevioside and curdlan. We have defined unique molecular signatures for each of the eight cells in the posterior-most two rows of the neural plate - rows I and II. If the difference in ability to reverse LVH, between ACE inhibitors and beta-blockers/diuretics would correspond to a difference in prognosis, then the outcome of antihypertensive therapy might be expected to improve. The demethylenation was also sensitive to catalase and was stimulated by the addition of ferric ion and EDTA to the microsomal incubation mixture. A NEW MATHEMATICAL FORMULA FOR CHEMICAL ANALYSIS IN A TWO PHASE SYSTEM. The observed differences are probably an effect of the different living mode of the compared fish. These data were further confirmed by Western blot and immunoprecipitation of parasites extracts with an antiserum raised against a recombinant clone expressing part of the Ag332.

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It has potential for improvement via addition of clinical markers, such as coeliac serology and faecal calprotectin. Effective Alternating Direction Optimization Methods for Sparsity-Constrained Blind Image Deblurring. Administrators need to enhance their policies such as event debriefing or shifting workloads to support nurses caring for dying patients. Continuous monitoring of HIV, risk behaviors, and use of prevention and treatment is needed to evaluate prevention efforts and monitor HIV transmission risk. Electrophysiological signatures of atypical intrinsic brain connectivity networks in autism. To increase tumor-to-nontumor localization ratios of injected radiolabeled antibodies (Abs), several interrelated methods were used. Surgical revision of an incarceration of the iris can be safely performed by means of gonioscopy. 37 residents and 21 staff surgeons of a military orthopaedic residency program were asked to voluntarily complete an anonymous electronic survey. Use of an oral phosphodiesterase-4 inhibitor (apremilast) for the treatment of chronic, severe atopic dermatitis: a case report.

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SERUM LACTIC DEHYDROGENASE, LEUCINE AMINOPEPTIDASE AND 5-NUCLEOTIDASE ACTIVITIES: OBSERVATION IN PATIENTS WITH CARCINOMA OF THE PANCREAS AND HEPATOBILIARY DISEASE. Telmisartan combined with leflunomide, not clopidogrel, is safe and effective for decreasing proteinuria in certain IgAN patients. Role of histamine H1 receptor antagonists (antihistaminics) in therapy of bronchial asthma. The effects of bee venom melittin on the order and dynamics of dimyristoylphosphatidylcholine unilamellar and multilamellar vesicles at a protein-to-lipid molar ratio of 1:60 have been investigated by employing the techniques of nanosecond emission anisotropy with 1,6-diphenyl-1,3,5-hexatriene as the fluorescent probe, enhancement by polar groups of the weakly allowed 0-0 vibronic transition in the fluorescence spectrum of pyrene, and Raman spectroscopy. We therefore cultured DRG neurons in the presence of GDNF, and looked at the expression of substance P and of the capsaicin receptor, VR1, two nociceptive properties already known to be NGF regulated. Core and periphery concentrations of short-chain fatty acids in luminal contents of the rat colon.

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Relapsing thrombotic microangiopathy and intravenous sustained-release oxycodone. Item response theory methods were used to assess differential item functioning (DIF) in the quality of life (measured by the EORTC QLQ-C30) of cancer patients across four ethnic groups (Caucasian, Filipino, Hawaiian, and Japanese). All 7 responders experienced an increase of VAS self-ratings of hunger in contrast to what has been observed in normal subjects who show a decrease in hunger after amphetamine. We conducted a randomized controlled trial to compare the effect of flapless (FLS) or flap-involving (F) immediate placement and provisionalization of single-tooth implants in the aesthetic zone. The results from this technique were excellent and without major complications. As the serological test of streptococcal infection, the measurement of anti-exotoxin antibodies such as ASO is widely practiced.

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In PAD patients, circulating B2M is elevated and correlates with the severity of disease independent of other risk factors. A research sample of 138 older residents was recruited from eight nursing homes located in southern Taiwan. Factors linked to the development of pleuro-pulmonary metastases in breast cancer. We tested this notion by assessing interoceptive accuracy (IA) in FM patients and matched healthy controls. He was mechanically ventilated for 12 hours and survived without serious side effects. Despite previously reported barriers, effective fall risk screenings may be performed in hearing clinic settings with measures often readily accessible to audiologists. The occurrence of rheumatic disorders in patients treated by long-term haemodialysis (HD) has been emphasized for several years.

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Genetic influences on hormonal markers of chronic hypothalamic-pituitary-adrenal function in human hair. Viability of cells was assessed by the method of eosin dye exclusion upon 2 hour incubation at 37 degrees C. After BPD, fasting serum glucose concentration fell within normal values in all but two of the operated subjects and remained in the physiological range in all but six up until 10 years. Modulatory effects of FMRF-NH2 on outward currents and oscillatory activity in heart interneurons of the medicinal leech. The presence of bona fide RNA G4s in cells has long been a matter of debate.

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The magnetoresistance effect in a conducting molecular crystal consisting of dicyano(phthalocyaninato)manganese(iii). Neural activity was related with eye tracking to the words, which were scanned without restrictions on the eye movements. Quantification of Total and 2-LTR (Long terminal repeat) HIV DNA, HIV RNA and Herpesvirus DNA in PBMCs. This article describes a batch culture technique for biofilm and planktonic cell metal susceptibility testing using the MBEC assay. All SF-36 mental and physical health subscale scores were how much pepcid 10 mg can i take worse in patients with panic disorder than in the general population. There is a global call for formulations, which are better suited for children of different age categories and in a variety of settings. aerophilum NDP kinase sequence contains two unique segments not present in other NDP kinases, comprising residues 66-100 and 156-165. To analyse the psychometric properties of the Top Down Motor Milestone Test (TDMMT), an internationally used instrument in the planning and evaluation of movement-oriented interventions.

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In these cultures we looked for new markers coming from the irradiated transforming arava medication DNA. Higher concentrations of gefitinib (1-2 microM), on the other hand, significantly decreased EGFRvIII phosphotyrosine load, EGFRvIII-mediated proliferation and anchorage-independent growth. Adolescent Social Defeat Induced Alterations in Social Behavior and Cognitive Flexibility in Adult Mice: Effects of Developmental Stage and Social Condition. The data were intended to guide recent efforts by the Government of Cambodia to reduce the number of children living in residential care institutions and increase the number of children growing up in supportive family environments. High frequency rTMS did not affect the activation in the swallowing sensorimotor cortices of elderly people. Due to life-span prolongation combined with the increased rate of diabetes, a growing population of patients is afflicted with neuropathic foot deformities.

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