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Viagra

Viagra is used to treat men who have erectile dysfunction (also called sexual impotence). Sildenafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. The penis is one of the areas where this enzyme works. Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. When a man is sexually stimulated, his body's normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, sildenafil helps to maintain an erection after the penis is stroked. Without physical action to the penis, such as that occurring during sexual intercourse, sildenafil will not work to cause an erection.

Other names for this medication:
Caverta, Intagra, Kamagra, Penegra, Revatio, Silagra, Sildenafil, Sildenafila, Sildenafilo, Sildenafilum, Sildigra, Suhagra, Veega, Zenegra

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Also known as: Sildenafil

Description

Viagra is an anti-impotence drug which enables men to achieve and sustain an erection. The active ingredient of Viagra is Sildenafil Citrate (PDE-5 inhibitor). In response to sexual arousal, Sildenafil Citrate stimulates the release of nitric oxide (NO) in the corpus cavernosum. Nitric oxide activates the lyase enzyme which is followed by increasing levels of cyclic guanosine monophosphate (cGMP). This cyclic nucleotide relaxes smooth muscles in blood vessels of the corpus cavernosum, increasing blood flow and thus inducing an erection. Along with the treatment of erectile disorders, Viagra effectively prolongs sexual performance, preventing premature ejaculation (PE). Sildenafil Citrate is also used in the treatment of PAH (pulmonary arterial hypertension). Viagra is also known as Aphrodil, Caverta, Kamagra, Suhagra, Edegra, Erasmo, Penegra, Revatio, Supra, Silagra, Zwagra. Viagra does not protect you or your partner from sexually transmitted diseases (including HIV) or from pregnancy.

Dosage

Take Viagra exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Viagra is usually taken only when needed, 30 minutes to 1 hour before sexual activity. You may take it up to 4 hours before sexual activity. Do not take Viagra more than once per day.

Viagra can help you have an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. Follow your doctor's instructions.

During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect of Viagra.

Overdose

In studies with healthy volunteers of single doses up to 800 mg, adverse reactions were similar to those seen at lower doses but incidence rates and severities were increased.

In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and it is not eliminated in the urine.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Viagra are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Below are the cases in which Viagra is contraindicated in men:

Sildenafil is contraindicated in case the patient is consuming medicines classified under nitrates, organic nitrites and nitric oxide donors. Examples of such medicines include sodium Nitroprusside, amyl nitrite and glyceryl trinitrate.

Sildenafil should not be consumed in cases where sexual activity is prohibited by doctors due to medical conditions affecting the cardiovascular health. Sildenafil will increase the blood flow in this case and as a result heart will exert that may lead to severe complications.

In case of severe hepatic and renal impairment - if an individual with erectile dysfunction suffers from severely affected liver and kidney disorders consumes the sildenafil, there are chances that liver will not be able to process the drug into the bloodstream and kidneys may not excrete the drug as in the normal healthy individual. As a result there can be damage to liver as well as kidneys and lack of excretion will increase side-effects and complications.

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Analog Method for Radiographic Assessment of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva. We focus our study on the dependence of such magnetic properties on the geometrical parameters of the complexes (asymmetry of the ligands and the out-of-plane shift of the Fe(II) cation with respect to the three equatorial nitrogen atoms) and the influence of the basicity of the N ligands. Anatomic demonstration of axon collaterals of the periaqueductal gray formation and the ventrobasal thalamic nuclei of both sides. We tested cerebrospinal fluid (CSF) hypocretin-1 (orexin-A) levels in 10 CH patients during an active cluster period. A dual task paradigm was used to compare the performance level of a probe reaction time (RT) in sitting (simple task) and during standing or walking on a treadmill (dual task conditions). Other angiographic based techniques potentially useful in research include the semi-quantification of collateral circulation, thrombolysis in myocardial infarction (TIMI) frame count, and TIMI blush score. The preservation and degradation of filamentous bacteria and biomolecules within iron oxide deposits at Rio Tinto, Spain. Tissue samples were collected at 8, 15, 30, and 60 days PW for biochemical and microscopic analysis.

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Investigating transmission of Mycobacterium bovis in the United Kingdom in 2005 to 2008. Studies of carbohydrate metabolism after hemodialysis and hemofiltration in uremic patients. Two cases of smallpox in Hanover (1967 and 1972): clinical features, epidemiology, and laboratory diagnosis. Subjective alertness was reduced by oxazepam (P less than 0.01) and atenolol (P less than 0.05), while propranolol (40 mg) reduced anxiety (P less than 0.01) and propranolol (80 mg) impaired ability to concentrate (P less than 0.05). Secretory proteins undergo a stringent quality control process in the endoplasmic reticulum (ER). An adjustable laryngeal implant made of titanium has been developed for the treatment of unilateral vocal fold paralysis. Historical perspectives and current highlights on lithium treatment in manic-depressive illness.

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A case of hepatic coma in the 2d trimester of pregnancy with a favorable outcome for the mother and fetus. Scaling-up experiments indicated the flask-scale results could be reproduced at 40 g of substrate in 5-L fermenter. Here we show that Maf1 is a common component of multiple signaling pathways in S. SCSA results suggested different critical points in sperm maturation (spermatozoa with loose chromatin to more condensed chromatin) among species: from corpus to cauda in ram and from caput to corpus in deer and dog. Ethanol also had an enhancing effect on the motor patterns of a protractor muscle which moves the cephalopharyngeal skeleton relative to the body. Vaginal pH effects caused by OCs and various copper and inert IUDs. To evaluate the reliability and validity of a portable instrument for measuring macular pigment optical density. Prevention of arterial thrombotic diseases has high priority in developed countries.

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Hemodynamic effects of nicotinic acid infusion in normotensive and hypertensive subjects. Psychotherapy, symptom outcomes, and role functioning over one year among patients with bipolar disorder. A dominant negative mutant of Rac, but not dominant negative mutants of RhoA or Cdc42, blocked MIP-1alpha-induced lamellipodia formation. These results may reflect the active synthesis of H and ABO antigens in normal hematopoietic peripheral blood progenitor cells. It plays crucial roles in principal cell fate decisions and regulates cell differentiation, development, proliferation, apoptosis, and inflammation. Mechanism of Protein Kinase R Inhibition by Human Cytomegalovirus pTRS1. Social networks and alcohol use among older adults: a comparison with middle-aged adults. DTBNpP also provided effective catalysts for amination reactions of aryl chlorides at elevated temperatures. In this review we focus on signalling molecules that regulate this altered metabolic paradigm in a cancer cell with emphasis on small molecule mediated intervention for attenuation of growth and progression of tumor. Engineered spin-orbit coupling (SOC) in cold-atom systems can enable the study of new synthetic materials and complex condensed matter phenomena.

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Alumina-fluorapatite composite coating deposited by atmospheric plasma spraying: An agent of cohesion between bone and prostheses. A predicted cation transporter protein, BPSS1228, is involved in intracellular behaviour of Burkholderia pseudomallei in a human lung epithelial cell line (A549). Fetal brain grafts induce recovery of learning deficits and connectivity in rats with gustatory neocortex lesion. Defining episodes of diarrhoea: results from a three-country study in Sub-Saharan Africa. There were 22 male and 63 female patients with an average age of 13.9 years at the time of surgery. In addition to this systemic inflammatory process, sepsis and septic shocks cause a profound decrease in the peripheral vasomotor tone leading to a great decrease in the peripheral resistance. CXCR4 is involved in CD133-induced EMT in non-small cell lung cancer. A simple epidemiological model was used to compare the distributions of two different taxa of ectoparasitic insects, sucking lice (Insecta: Siphonaptera) and fleas (Insecta: Anoplura), on the same rodent host, Rattus norvegicus Berkenhout (Rodentia: Muridae), in Yunnan Province, China. These cells occurred along the entire mediolateral extent of lamina I and seemed to have a prevalent projection to the contralateral caudal ventrolateral periaqueductal gray. The Effects of Stability and Presentation Order of Rewards on Justice Evaluations.

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Depression is a disorder that can have particularly deleterious effects on individuals from racial/ethnic minority and low-income backgrounds. This study described a simple synthetic methodology for preparing biomembrane mimicking monolithic column. A genetic association between human leucocytic antigen-linked hemochromatosis and idiopathic refractory sideroblastic anemia has been suggested that may predispose some patients with idiopathic refractory sideroblastic anemia to develop gross iron overload. Immunotherapies using antibodies that potently inhibit HCV infection have the potential to control or even prevent graft reinfection. The RA twin cDNA was labeled with cy5 fluorescent dye, and the cDNA of the healthy co-twin was labeled with cy3.

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Forty nonagenarians (90-97) were randomly assigned to an intervention or control group (16 women and 4 men per group). Identification of trypanosomatid PEX19: functional characterization reveals impact on cell growth and glycosome size and number. The maximum serum activity in samples of patients with acute pancreatitis was 126 U/l. The B-cell activating factor (BAFF) is a member of tumour necrosis factor (TNF) superfamily that specifically regulates B lymphocyte proliferation and survival. Accelerated partial breast irradiation: a dosimetric comparison of three different techniques. Both Herpes simplex (DNA) and indapamide bnf dose Parainfluenza viruses (RNA) were used for the determination of antiviral activity of the P.

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Spatial and temporal analysis of miRNA accumulation by in situ analyses is the prerequisite of understanding the precise biological functions of miRNAs. Small sample sizes severely limited calculation of estimates of ectopic pregnancy. Developing a modern endoscopy unit demands the institution of a quality assurance programme, continuous training and monitoring of service delivery. In the presence of catalytic amount of copper salt, an efficient and flexible synthetic method towards the synthesis of a structurally new type of spirocyclic lactams was developed. Dense core vesicles resemble active-zone transport vesicles and are diminished following synaptogenesis in mature hippocampal slices. This study was designed to investigate in the Sardinian population the frequency distribution of four of the most common variants accounting for TPMT deficiency and to conduct comparative analyses with other populations in order to obtain insights into the main factors that have shaped diversity at the TPMT locus in Sardinia.

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