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Tofranil

This medication is used to treat depression. It works by restoring the balance of certain natural substances (neurotransmitters such as norepinephrine) in the brain. For bed-wetting, this medication may work by blocking the effect of a certain natural substance (acetylcholine) on the bladder.

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Also known as: Imipramine

Description

Imipramine is used to treat depression. It belongs to a group of medicines known as tricyclic antidepressants (TCA). These medicines are thought to work by increasing the activity of a chemical called serotonin in the brain.

Imipramine tablets are also used to treat enuresis (bedwetting) in children.

This medicine is available only with your doctor's prescription.

Dosage

Take Generic Tofranil orally. Take Generic Tofranil with or without food. For adults The usual starting dose is 75 mg a day. The maximum daily dose is 200 mg. For children Total daily dosages for children should not exceed 2.5 mg for each 2.2 pounds of the child's weight. Doses usually begin at 25 mg per day. This amount should be taken an hour before bedtime. If needed, this dose may be increased after 1 week to 50 mg (ages 6 through 11) or 75 mg (ages 12 and up), taken in one dose at bedtime or divided into 2 doses, 1 taken at mid-afternoon and 1 at bedtime. Aged people The usual dosage should start with 25 to 50 mg per day. The dose may be increased as necessary, but effective dosages usually do not exceed 100 mg a day. If you want to achieve most effective results do not stop taking Generic Tofranil suddenly.

Overdose

If you overdose Generic Tofranil and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Tofranil overdosage: agitation, bluish skin, convulsions, difficulty breathing, dilated pupils, drowsiness, heart failure, high fever, involuntary writhing or jerky movements, irregular or rapid heartbeat, lack of coordination, low blood pressure, overactive reflexes, restlessness, rigid muscles, shock, stupor, sweating, vomiting.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Tofranil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Tofranil if you are allergic to Generic Tofranil components. Be very careful with Generic Tofranil if you are pregnant, planning to become pregnant, or are breast-feeding. Do not take Generic Tofranil if you are recovering from a recent heart attack or take MAO inhibitors, such as the antidepressants Nardil and Parnate. Be very careful with Generic Tofranil if you have diabetes, hypoglycemia, a history of mental disorders. Be very careful with Generic Tofranil if you are taking albuterol (Proventil, Ventolin), antidepressants that act on serotonin, including Prozac, Paxil and Zoloft, antipsychotic drugs such as Mellaril and chlorpromazine, barbiturates such as Nembutal and Seconal, blood pressure medications such as Catapres, Carbamazepine (Tegretol), cimetidine (Tagamet), decongestants such as Sudafed, drugs that control spasms, such as Cogentin, Epinephrine (EpiPen), Flecainide (Tambocor), Guanethidine, Methylphenidate (Ritalin), Norepinephrine, other antidepressants such as Elavil and Pamelor, Phenytoin (Dilantin), Propafenone (Rythmol), Quinidine, thyroid medications such as Synthroid, tranquilizers and sleep aids such as Halcion, Xanax, and Valium. Avoid alcohol. Do not participate in any activities that require full alertness if you are unsure about your ability. Try to stay out of the sun as much as possible. It can be dangerous to stop Generic Tofranil taking suddenly.

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Deficiency of the vestibular spine in atrioventricular septal defects in human fetuses with down syndrome. simplex (parasites of fish and mammals), Contracaecum osculatum, C. Sudden cardiac death resulting from acute coronary artery aneurysm occlusion: successful resuscitation and treatment of an adolescent boy with previously unrecognized Kawasaki disease. Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice. An otherwise healthy 85-year-old woman presented with purulent multifocal subcutaneous nodules on the dorsal side of the right forearm and hand. A prosthetic fistula after aortic surgery is a rare but potentially fatal complication. Anterior mitral valve aneurysm perforation secondary to aortic valve endocarditis detected by Doppler colour flow mapping.

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Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy. Moreover, the temperature dependence of the current in the range of 300 to 380 K indicates thermally activated hysteretic behaviors. Inhibition by classic protonable amine and quaternary reversible inhibitors (ethopropazine, donepezil, tacrine, edrophonium, BW284c51, propidium) shows that DjChE is far less sensitive to these inhibitors than human AChE, suggesting discrete differences in active center and peripheral site recognition and structures. An elective single autograft with high-dose melphalan: single-center study of 451 patients. Supraglottal jet variability was investigated in a scaled-up flow facility incorporating driven vocal fold models with and without wall rotation.

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Linker histones: conformational changes and the role in the structural organization of chromatin. The statement includes the following specific suggestions: 1) that the UN promote the democratization of communications with a gender focus, 2) that women be assured access to new communications technologies that empower their communicational capacity, 3) that steps be taken to ensure that media content projects a positive and nondiscriminatory image of women, and 4) that guidelines be drawn up to promote labor equality between the genders and a greater presence of women in decision-making positions in the media. In children with learning difficulties the possibility of underlying sleep problems should be excluded. Localization of chitin in the cell wall of Candida albicans by means of wheat germ agglutinin. The authors note that following a period of rapid urbanization focusing on the primary urban centers, government policies since the 1970s have attempted, with considerable success, to divert migration to a number of other urban centers, including the ports of Inchon and Pusan. Aberrant infiltration and functions of macrophages are commonly found in oral squamous cell carcinoma (OSCC).

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Both sets of cells grew at similar rates, exhibited comparable extensions of life spans, and had equivalent levels of early transcripts. Surface chemistry of topographically patterned grooved samples with ridges of 150 nm width, adsorbed with self-assembled monolayers (SAMs) of alkanethiols on gold, have been characterized by near edge X-ray absorption fine structure (NEXAFS) spectroscopy. Toxicologic analysis confirmed isolated cocaine use in each patient. The other group received neoadjuvant chemotherapy using Cisplatin and Etoposide along with Wobe Mugos E which is a proteolytic enzyme preparation. As an example, profiling of miRNAs in four prostate cancer cell lines has revealed that a set of miRNAs were differentially expressed between androgen-dependent and androgen-independent metastatic prostate cancer cells. Upper respiratory tract infections in children--why do parents seek medical consultation?. In some species, such as rabbits and guinea pigs, it is also followed by testicular lesions, mediated by in situ immune complexes and/or delayed hypersensitivity reactions. Respondents were 113 individuals who had graduated from a private dental school from 1986 to 1997.

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Nonetheless, further studies of Expert Patient Illness Narratives are needed in order to improve its benefits as a teaching and learning methodology. All scans were reconstructed and calculated based on the European Association of Nuclear Medicine/EANM Research Ltd guidelines. Evaluating STORM skills training for managing people at risk of suicide. There is also evidence that the platelet response is stable over time, but there are few studies that have assessed consistency of platelet function over months and years. Lifetime migration to the major cities of the United States, Asia, and Africa. In regard to arthroscopic treatment of popliteal cysts, we explored the refuted pathology for popliteal cysts proposed by others. Both impaired heart rate recovery (HRR) and low fitness are associated with higher mortality risk. Furthermore, they rated angry faces as significantly less likely to produce positive emotional outcomes than the other face categories. Quantification of mitral regurgitation orifice area by 3-dimensional echocardiography: comparison with effective regurgitant orifice area by PISA method and proximal regurgitant jet diameter. The initial white cell counts in patients with acute myocardial infarction (AMI) may reflect the stage of AMI evolution, and may also be related to the efficacy of thrombolytic agents in recanalizing occluded epicardial arteries.

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To review case histories of patients in whom fibrosis played a significant role in the pathogenesis of their disease, and to determine whether intravenous gammaglobulin (IVIg) contributed to the regression of their fibrotic condition. The objective of this study is to explore how social media users in the Arab world share sensitive health information through Facebook. Hiatal hernia was present in a significantly larger number of the patients with reflux at radiography than in those without reflux. To this end, we developed an extension for the SQUAD software, allowing semi-quantitative analysis of network states. Exercise, nutrition and you: an off-campus course for grades 2-12. The production of IP10 from RCR-transduced cells could be maintained for at least three months in culture.

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In Patient 2, the diagnosis of occult orbital varix was initially considered but an orbital exploration and a biopsy specimen showed no vascular anomaly. Pneumatic displacement of submacular hemorrhage appears to be a safe and effective technique to treat the condition. Alpha-albumin, a CNS specific protein, identical to GFA protein and specific glial cells, has been found in the human pineal gland using histoimmunological and quantitative methods. Simple far-field emission polarization microscopy reveals that the emission transition dipole of CdSe colloidal quantum dots (QDs) is twofold degenerate at room temperature. The process of preparing of CDs modified electrodes would, consequently, open new avenues for new electrochemical sensors and, therefore, widen their use in biomedical and drug analysis. This result supports the notion that Le(b) present on human gastric epithelial cells is capable of being a receptor for H. The specimens were formalin-fixed, paraffin-embedded and stained with hematoxylin and eosin. Lead-Free Perovskite Nanowire Array Photodetectors with Drastically Improved Stability in Nanoengineering Templates.

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Three hypothetical patient vignettes, involving the admission of a patient to a nursing home, to day care, and to an outreaching nursing home care project, were constructed and presented in the questionnaire. Intravascular lymphoma mimicking a Vogt-Koyanagi-Harada disease. The result must be confirmed in additional studies, and pathophysiological examinations must be performed. Stimulation of spinal serotonergic receptors facilitates seminal emission and suppresses penile erectile reflexes. The development of ambient stable organic n-channel semiconductor molecules for thin-film transistors has experienced a tremendous impetus in the last decade to close the gap in performance in comparison to that of their p-channel counterparts.

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The elements of both short- and long-term policies concerning urbanization are outlined. The aim of the Telehealth for Emergency-Community Continuity of Care Connectivity via Home Telemonitoring (TEC4Home) study is to generate evidence through a programmatic evaluation and a clinical trial to determine how home telemonitoring may improve care and increase patient safety during the transition of care and determine how it is best implemented to support patients with heart failure within this context. CTLA-4-Ig and CD28-Ig are both agonist ligands of B7 coreceptor molecules on mouse dendritic cells (DCs), yet they bias the downstream response in opposite directions, and CTLA-4-Ig promotes tolerance, whereas CD28-Ig favors the onset of immunity. Understanding surface receptor clustering and redistribution processes at the cell-matrix contact zone requires detailed knowledge of the spatial integration of these molecules in the architecture of this complex interface. Ranibizumab is an antibody fragment approved for the treatment of wet AMD. In this work, we used a Universal ProbeLibrary (UPL)-based design to detect-in a rapid, sensitive, specific, and reproducible way-the small nucleolar RNA (snoRNA) GlsR17 and its derived miRNA (miR2) of Giardia lamblia using a stem-loop RT-qPCR approach. Factor XI deficiency has been associated with bleeding diathesis mostly secondary to trauma and post-operatively depending on the severity of deficiency. Population distribution and structure of economic regions in the German Democratic Republic: changes, 1964-1974. OCTN2 was not expressed in B-cells, notwithstanding that the metabolism of long-chain fatty acids, which are transported into the mitochondria with the help of carnitine, was expected for fatty acid-stimulated insulin secretion.

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Ribosomes isolated from zoospore nuclear caps in low salt buffer failed to support polyuridylic acid-dependent phenylalanine incorporation. Guanidine-based peptide moduretic generic nucleic acid (GPNA) monomers and oligomers containing all four natural (adenine (A), cytosine (C), guanine (G), and thymine (T)) and two unnatural (2-thiouracil (sU) and 2,6-diaminopurine (D)) nucleobases have been synthesized. Low levels of aERD2 were detected in both young and fully mature leaves when compared with roots. Porphyrins produce uniquely ephemeral animal colouration: a possible signal of virginity. The effects on complement component 3 of dietary variation of protein, fat and vitamin E during growth of young mice. AM showed a potent dose-dependent inhibiting effect on angiotensin II (AngII) induced-proliferation and a stimulatory effect on proliferation of quiescent cells. Literature reviews reveal few documented cases of brain injury following neuroleptic malignant syndrome.

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Thrombelastography and platelet function analysis in routine cardiac surgery demonstrate high negative predictive values for postoperative bleeding, which supports early identification and targeted treatment of surgical bleeding by distinguishing it from a significant coagulopathy. Partial k-space sampling with zero filling used with phase-contrast flow measurements: in vivo and in vitro validation. We used a site-specific crosslinking approach to study the membrane integration of the polytopic protein opsin at the endoplasmic reticulum. The present studies, and those by others, showed that a brief is zofran safe while breastfeeding dose of X-rays prior to a second exposure to a sub-lethal dose might induce a tolerance to radiation. There were few positive bacteria cultures from the tubings in the circle system, regardless of fresh gas flow. Serodiagnosis of the role of opportunistic bacteria in cases of burn wound sepsis. Immunohistochemically, fibrothecoma-like stromal cells were positive for cytochrome P-450 aromatase, which catalyzes the conversion from androgen to estrogen, and negative for c-Jun protein, which has recently reported to attenuate estrogen biosynthesis by directly down-regulating transcription of the aromatase gene. It is also difficult to compare these data with the anti-IgG prevalence in the general population because age and sex are not matched in most studies. Here we describe a workflow to identify potential gene targets in aberrated genes or pathways and their corresponding drugs. The gonads of exposed fish showed no evidence of sex reversal or intersex.

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Fucoidan, a sulfated polysaccharide extracted from brown seaweed, has anticoagulant and antithrombotic activities. All these morphological evidences showed that further regression of the castrated guinea pig seminal vesicles can be achieved by cyproterone acetate treatment. Caries-related microbiological findings in a group of teenagers and their parents. NMR studies on the solution structure of a deletion mutant of the transcarboxylase biotin carrier subunit. Perhydrocarbyl ReVII complexes: comparison of molecular and surface complexes. Compared with other closely related herpesviruses, EBV has developed much more elaborate and sophisticated strategies for subverting host immune system, which may account for its high prevalence in immune competent hosts. Overall physician satisfaction with anatomic pathology and 10 selected aspects of the laboratory service (professional interaction, diagnostic accuracy, pathologist responsiveness to problems, pathologist accessibility for frozen section, tumor board presentations, courtesy of secretarial and technical staff, communication of relevant information, teaching conferences and courses, notification of significant abnormal results, and timeliness of reporting). Sexual practices, risk perception and knowledge of sexually transmitted disease risk among lesbian and bisexual women. To conduct a systematic review of published trials to compare outcomes and toxic effects between cisplatin-etoposide and carboplatin-paclitaxel in patients with non-small-cell lung cancer receiving thoracic radiation. The study assessed the effects of all sexually active women of reproductive age in the US using each method for periods of 1, 2, 3, 4, or 5 years.

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