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Sintedix (Amoxicillin)
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Sintedix

Sintedix is a penicillin-like (beta-lactam) antibiotic. It belongs to the most widely-used group of antibiotics available. Sintedix is usually the drug of choice within the class because it is better absorbed, following oral administration, than other beta-lactam antibiotics.

Other names for this medication:
Acimox, Alfamox, Almodan, Aloxyn, Amoclen, Amoksicilin, Amopen, Amoram, Amoxi, Amoxicilina, Amoxicillin, Amoxicillinum, Amoxiline, Amoxisol, Amoxivet, Amoxypen, Amurol, Bimoxan, Bristamox, Cipmox, Clamoxyl, Flemoxin, Flemoxon, Galenamox, Gimalxina, Hidramox, Hydramox, Larotid, Lupimox, Moxicillin, Novamoxin, Ospamox, Penamox, Penimox, Polymox, Raylina, Reloxyl, Robamox, Servamox, Sintedix, Solciclina, Stacillin, Sumox, Tolodina, Utimox, Velamox, Wymox, Zimox

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Also known as: Amoxicillin

Description

Amoxicillin is used to treat bacterial infections in many different parts of the body. It is also used with other medicines (e.g., clarithromycin, lansoprazole) to treat H. pylori infection and duodenal ulcers.

Amoxicillin belongs to the group of medicines known as penicillin antibiotics. It works by killing the bacteria and preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Dosage

Adults: 500 mg PO every 12 hours or 250 mg PO every 8 hours for mild/moderate infections and 875 mg PO every 12 hours or 500 mg PO every 8 hours for severe infections.

Infants 6 months and older, Children, and Adolescents: 80 to 90 mg/kg/day PO in divided doses every 12 hours is recommended by the American Academy of Pediatrics (AAP) as first-line therapy. Do not exceed 500 mg/dose if given every 8 hours or 875 mg/dose if given every 12 hours. AAP recommends a 10-day course for any child with severe disease and for all patients less than 2 years of age, regardless of severity. For children 2 to 5 years with mild to moderate disease, a 7-day course is acceptable. For children 6 years and older with mild to moderate disease, a 5- to 7-day course is acceptable. The FDA-approved dosage is 20 mg/kg/day PO in divided doses every 8 hours (Max: 250 mg/dose) or 25 mg/kg/day PO in divided doses every 12 hours (Max: 500 mg/dose) for mild to moderate infections and 40 mg/kg/day PO in divided doses every 8 hours (Max: 500 mg/dose) or 45 mg/kg/day PO in divided doses every 12 hours (Max: 875 mg/dose) for severe infections.

Infants 4 to 5 months: 80 to 90 mg/kg/day PO given in divided doses every 12 hours for 10 days was recommended by experts as first-line therapy in previous guidelines ; however, this age group is not addressed in the most current guidelines by the American Academy of Pediatrics (AAP). The FDA-approved dosage is 20 mg/kg/day PO in divided doses every 8 hours or 25 mg/kg/day PO in divided doses every 12 hours for mild to moderate infections and 40 mg/kg/day PO in divided doses every 8 hours or 45 mg/kg/day PO in divided doses every 12 hours for severe infections.

Infants 3 months and younger: 30 mg/kg/day PO given in divided doses every 12 hours is the general FDA-approved dosing. Young infants are less capable of responding to infection, and the clinical manifestations of infection can be subtle. Because of the increased risk for complications of an undiagnosed systemic infection, every young infant presenting with a fever should be carefully evaluated.

Overdose

In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures as required. If the overdosage is very recent and there is no contraindication, an attempt at emesis or other means of removal of drug from the stomach may be performed. A prospective study of 51 pediatric patients at a poison-control center suggested that overdosages of less than 250 mg/kg of Sintedix are not associated with significant clinical symptoms and do not require gastric emptying.

Interstitial nephritis resulting in oliguric renal failure has been reported in a small number of patients after overdosage with Sintedix.

Crystalluria, in some cases leading to renal failure, has also been reported after Sintedix overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis should be maintained to reduce the risk of Sintedix crystalluria.

Renal impairment appears to be reversible with cessation of drug administration. High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of Sintedix. Sintedix may be removed from circulation by hemodialysis.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

You may store the oral liquid in the refrigerator. Throw away any unused medicine after 14 days. Do not freeze.

Detailed Amoxil dosage information

Side effects

The most common side effects associated with Sintedix are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Penicillins have been used in the elderly and have not been shown to cause different side effects or problems in older people than they do in younger adults.

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