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Primacal (Calcitriol)

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Primacal is used to treat and prevent low levels of calcium and bone disease in patients whose kidneys or parathyroid glands are not working normally. It is also used to treat secondary hyperparathyroidism (a condition in which the body produces too much parathyroid hormone and metabolic bone disease in people with kidney disease.

Other names for this medication:
Admax, Alfacal, Alfacalcirol, Aristrol, Calbovic, Calcigra, Calcikind, Calcitriol, Calday, Caldikind, Caldix, Calotec, Caltop, Calzem, Carcal, Cholical, Coecoral, Qpcal, Refirm, Rolsical, Septriol, Solbiocal, Sorvate, Statbone, Vezocal, Vitalpha

Similar Products:
Rebetol, Inderal, Trandate, Arcoxia, Zetia, Zanaflex, Lamictal, Reminyl, Mircette, Glyburide

Also known as: Calcitriol


Generic Primacal is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Primacal are intestine and bone. Generic Primacal receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Primacal may also act on the kidney and the parathyroid glands. Generic Primacal is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Primacal has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Primacal, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Primacal in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Primacal produces other independent beneficial effects. Primacal is also known as Calcitriol. Generic Primacal treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Primacal is Calcitriol. Brand name of Generic Primacal is Primacal.


Generic Primacal is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Primacal suddenly.


If you overdose Generic Primacal and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Primacal are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Immunolocalization and quantitation of transforming growth factor alpha in hydatidiform mole. This eliminates the need for thin layer chromatography for the separation of dimethylacetals and esterified fatty acids. Nevertheless, considerable evidence indicates that RT effects extend beyond the mere elimination of the more radiosensitive fraction of cancer cells present within a tumor at the time of radiation exposure. The fraction of time without chest compressions increased during transport of out-of-hospital cardiac arrest patients. Caregivers value interactive interventions that are tailored to their unique needs and the illness context. Mycotoxins, which may contaminate peanut and peanut products, are responsible for many diseases to humans.

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Operative access must be planned with regard to level and type of lesion, and prevention of postoperative complications. Our study is the largest to investigate the diagnostic performance of BCR. To examine characteristics of individuals who show a rapid and sustained response to cognitive-behavioral therapy (CBT) for bulimia nervosa (BN). No abnormality was detected in central nervous, cardiovascular, respiratory, genitourinary, or gastrointestinal systems. ON THE EPIDEMIOLOGY AND BACTERIAL EXAMINATION OF FOOD POISONING CAUSED BY HALOPHILIC BACTERIA IN TOKYO DURING 1961. For the PR model, the DRM attained significantly lower overall median parameter error values and lower residuals in the vast majority of tests. When the spinal cord and the notochord explants were co-cultured in collagen gel, growing Contactin-positive spinal axons were repelled by notochord-derived repulsive activity. In osteoarthritic joint disease, expression of bFGF and MMP-13 in chondrocytes and their release into the synovial fluid are significantly increased. A broad range of conditions led to readmission, with the majority representing minor complications. Gallstone-associated pancreatitis continues to have a mortality rate that approaches 10 percent.

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Health care providers should perform more careful monitoring of adherence in patients with the factors identified by this study. Translation initiation factor eIF4B interacts with a picornavirus internal ribosome entry site in both 48S and 80S initiation complexes independently of initiator AUG location. In a 13-month period in 2009/2010, all patients with a serum sodium level less than or equal to 130 mmol/L (the hyponatremia group) in a cohort of hospitalized older patients were studied and compared to a normonatremic control group of patients who were matched for age, sex, and diagnosis group. Various procedures and perspectives that are associated with action research are outlined. This article reviews the historical development of the medical consultant. In the initial stage, the lesion is seen as a small purple or violaceous papule, 2--3 mm in diameter.

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Results of the present study seem to suggest that for the anterior temporal and suprahyoid muscles there is no specific body position that could be relevant to initiate and/or to perpetuate a craniomandibular dysfunction. NUCLEAR VOLUME OF THE ADRENAL CORTEX AND 17-HYDROXYCORTICOSTEROID EXCRETION IN URINE IN GUINEA PIGS AFTER A SINGLE ACTH ADMINISTRATION. New endoscope channels were exposed to 8 days of repeated rounds of biofilm formation using ATS2015 containing Enterococcus faecalis and Pseudomonas aeruginosa, rinsing, fixation with glutaraldehyde, and rinsing. In addition, Wnt1 may play a critical role in regulating the intratumoral MMP-7 expression. Questions about transfusion safety and shortage have led to extensive research on alternatives to blood transfusion, ranging from non-pharmacological to pharmacological solutions. Host organism defense by a peptide-polysaccharide extracted from the fungus Sporothrix schenckii. This increase is markedly enhanced at nicotinic acid levels of 1000 and 2000 micrograms ml-1 following stimulation with exogenous arachidonic acid (p less than 0.01). The pattern of occupation within smoking categories remains basically unchanged, and, in fact, becomes more pronounced among males.

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Over the course of the next few days the patient developed progressive neurologic signs and symptoms including lethargy, tonic deviation of his eyes to the left, asymmetic pupils, and right-sided decerebrate posturing elicited by painful stimuli. Human papillomavirus (HPV) is the main risk factor for developing cervical cancer. On the basis of encouraging preliminary results, we conducted a randomized, controlled trial to determine whether minocycline reduces the risk of conversion from a first demyelinating event (also known as a clinically isolated syndrome) to multiple sclerosis. It has been suggested that fibrosis is an inflammatory process, and cytokines such as tumor necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta have been shown to play key roles in the pathogenesis of fibrotic lung disease. Cells of the AT individuals showed an elevated damage induction and a reduced repair capacity compared to patients with average tissue reactions. Chemotherapy may be offered to stage II patients only in select instances, yet a definitive indication is still unavailable. Strengthening exercise integrated rTMS has positive effects on motor function recovery in subacute stroke patients. Presence of Toxoplasma gondii DNA, serologic test results, clinical findings, treatment, and outcome. We used a cleavable crosslinking reagent dithiobis(succinimidyl propionate) to covalently link the monoclonal antibody with its antigenic determinant in the membrane of intact cells. It has been shown that oxidation products of CA, rather than CA themselves, are responsible for such adaptation to a new equilibrium.

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There were no significant changes in NFR and VAS while resting without chewing. The ureter is reimplanted after creation of an anti-reflux system with a submucosal tunnel between the mucosa and the detrusor. Immunotherapy Expands and Maintains the Function of High-Affinity Tumor-Infiltrating CD8 T Cells In Situ. Association with cell-binding ability and superoxide anion production. It was extrapolated that occupational therapy practitioners were at risk for occupational musculoskeletal injuries. Both the timing and the pathway of internalization followed by the erbB-2/p185 appear totally similar to those described for the EGFR. Automotive restraint systems suitable for use with low birth weight infants were crash tested using a small infant dummy developed for the study. Sf-1 polyps were treated at a restrictive temperature of 27 degrees C for varying lengths of time, their tissues were macerated, and the resultant dissociated cells were examined for evidence of phagocytosis after Feulgen staining. We aim to elucidate misophonia, a condition in which particular sounds elicit disproportionally strong aversive reactions. Eighty-six percent of the patients studied were atopic and 46 percent of asthmatic patients had a history of other associated allergic conditions (allergic rhinitis, atopic dermatitis).

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To assess beam damage at the angstrom scale, we followed the intensity of P3HT and PCBM diffraction rings as a function of accumulated electron dose by acquiring dose series and varying the electron dose rate, sample preparation, and the temperature during acquisition. In addition to empathetic and supportive talks with the patient and the positive reinforcement of an active behaviour pattern, basic psychotherapeutic treatment of depression also focuses on the prescription of an appropriate antidepressant. The 15 subjects enrolled in this uncontrolled study were diagnostically categorized and treated with 150 units of BTX-A. Regulation of macroautophagy in amiodarone-induced pulmonary fibrosis. Mapping of ornithine aminotransferase gene sequences to mouse chromosomes 7, X, and 3. Stapling ability was evaluated by the staple formation on the resected bronchial stump. These findings show for the first time that CDKN1C expression is reduced in BWS patients with AI and suggest that CDKN1C haploinsufficiency contributes to the BWS phenotype in patients with mosaic paternal isodisomies of chromosome 11. Translation rates of isolated liver mitochondria under conditions of hepatic mitochondrial proliferation. Doppler sonography and renal graft vessel thromboses after OKT3 treatment. Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer-related death, and new prognostic biomarkers are urgently needed.

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The 26S proteasome degrades polyubiquitylated substrates by recognizing them through stoichiometrically bound ubiquitin receptors, but substrates are also delivered by reversibly bound shuttles. Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing. Associations between high FSH and pregnancies with Down syndrome and chromosomally abnormal spontaneous abortions have also been reported. In this study, we have evaluated whether the humoral alloimmune response involved in chronic rejection is elicited within the graft. Cardiovascular disease risk factors explain much of the relationship between prediabetes and the development of chronic kidney disease.

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Symptoms, signs and neuroradiological findings of 15 cases with atlanto-axial dislocation (AAD) due to rheumatoid arthritis are presented. A histological study on degenerative changes in cervical IVDs and EPs was conducted. al demonstrated that a population based approach to identify and test women at high risk for cervical C trachomatis infection effectively reduced risk of PID. Determinants of a successful problem list to support the implementation of the problem-oriented medical record according to recent literature. The SEP alone were a poor indicator of cerebral function in these unanaesthetized rats, because they were markedly influenced by changes in activity and arousal of the animals.

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Galectin-3 triggered sustained extracellular signal-regulated kinase (ERK) phosphorylation that induced apoptosis. The lowest detection limit of NO analysis was found to be 0.05 micro/M. Experience has shown that these cells comprise the tissue bed inflammatory infiltrate in Lyme disease affecting the joint synovia, myocardium, and skin. Reports emerging about these relatives of the traditional chlamydial pathogens are matched by the continued identification of novel Chlamydia-related bacteria in the phylum Chlamydiae, providing evidence that many may be pathogenic to humans or animals and pose a zoonotic or vector-borne risk. Well-developed flexor and extensor muscles were found in mysticetes and basal odontocetes (i.e., physeterids, kogiids, and ziphiids), whereas later diverging odontocetes (i.e., monodontids, phocoenids, and delphinids) lack or reduce these muscles. Their thermogenic activity is due to the presence of a mitochondrial uncoupling protein (UCP). We used three venous blood samples of 100 mL and an alternating current device. It has been known for some years that specific language impairment (SLI), an unexpected failure to acquire age-appropriate language skills, is highly heritable.

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Adoption of the recommended terminology will improve outcome comparisons between institutions performing the different procedures. Robotic TECAB allows the routine harvesting and use of the RIMA graft in a safe and reproducible manner. At therapeutic concentrations (200-1500 ng/mL), CsA induced changes in the frequency and amplitude of the beating activity of cardiomyocytes 15 min after application. The unique genomic landscape surrounding the EPSPS gene in glyphosate resistant Amaranthus palmeri: a repetitive path to resistance. An integral part of this technique is the use of a new device called the Breast Implant Planning Device.

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Cloning and sequence analysis of the muramidase-2 gene from Enterococcus hirae. In Experiment 1, three kinds of incongruous words were formed by altering the first, second or both syllables of the congruous disyllabic terminal words in high constraint spoken sentences. Clinical efficacy of the pneumatic dilation was evaluated on the basis of a symptom score defined prior to, and 2 months after the procedure. There are few documented cases in the literature of retinal hamartomas (astrocytomas) with aggressive progression in the context of this disease. Analysis of gene expression and whole-genome features of 64 human epidermal growth factor 2 (HER2)-positive breast tumors supports the idea that their intrinsic heterogeneity actually reflects their cell of origin, suggesting that HER2 amplification is an embedded event in the natural history of these tumors. Introduction of a high copy number 2 mu-URA3-LEU2d plasmid with GAL1p-PRC1 fusion in a vpl1 strain resulted in a 200-fold increase of secreted CPY (about 40 mg/l) as compared to a vpl1 mutant carrying a single copy of the wild-type PRC1 gene. A DBU-catalyzed aerobic oxidative Robinson annulation adalat 10 mg kapseln of 2-isocyanochalcones with active methylene ketones was developed for the expedient synthesis of phenanthridines in high to excellent yields. Evidence in normal human cerebral white matter suggests an underlying vulnerability of the premature infant to free radical injury resulting from a developmental mismatch of antioxidant enzymes (AOE) and subsequent imbalance in oxidant metabolism. Interposed cartilage as a precaution against extrusions of ceramic ossicular replacement implants.

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For this purpose, we used a BM/Hitachi System 704 model and reagents for automated analysis of serum enzymes from Boehringer Mannheim. Intra- and Interlaboratory Agreement in Assessing the In Vitro Activity of Micafungin against Common and Rare Candida Species with the EUCAST, CLSI, and Etest Methods. Association of Early Amniotomy After Foley Balloon Catheter Ripening and Duration of Nulliparous Labor Induction. The damaged melanocytes developed vacuolation, and the melanin granules were gathered into autophagosomes or had disappeared. Samples of squamous epithelium from the uvula of 15 nonsmoking patients without past or present squamous cell carcinoma were used as normal controls. Isolation, crystallization, and preliminary x-ray study of a Fab fragment of monoclonal antibody against human interleukin-2 and its complex with antigenic peptide. Secondary hyperparathyroidism contributes to extraskeletal calcification and is associated with all-cause and cardiovascular mortality.

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Cytologically the pseudocyst fluid was aseptic in all patients and had low numbers of inflammatory cells in 5 of 6 patients. Repression occurs in a dosage-dependent manner within 24-96 hours after exposure to DMSO. Disintegrins have been shown to have many therapeutic implications for the treatment of strokes, heart attacks, and cancer. The boy presented with a 6-week history of progressive tiredness and weakness and a short history of respiratory depression. Estimation accuracy and the impact of between- and within-level sample sizes as well as different prior specifications on parameter recovery were investigated in a Monte Carlo simulation study.

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The typology developed in two previous surveys of illicit heroin products is applicable to many of the samples studied in this work, although significant changes have occurred in the chemical profile of illicit heroin products from certain geographical regions. Pulmonary fibrosis and lung remodelling, characteristic of EIPH, are important because these lesions may enhance the severity of bleeding during exercise. Changes of expression of peritoneal macrophages Fc and C3 receptors induced by transplantable melanomas. Given the role of chemokines in EAE, these sequence polymorphisms are promising candidates for eae7, a locus associated with severity of clinical signs and susceptibility to the shorter, less severe monophasic remitting/nonrelapsing form of disease. To create a prognostic model to estimate survival of patients with refractory coeliac disease. Plucking a liquid chord: mechanical response of a liquid crystal filament. Hemangioma of the urinary bladder is rare and the long term outcome of patients is unknown. An additive response occurred following joint exposure to the structurally related compounds Cipro and Clof, whereas a possible synergistic response occurred at low dose combinations of the structurally dissimilar Cipro and DEHP. In this chapter the physicochemical basis of protein retention in adsorption chromatography has been examined.

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Vascular Stem/Progenitor Cell Migration and Differentiation in Atherosclerosis. Expanders were placed in surgically nimotop cost dissected pockets and filling was performed on an outpatient basis. It has superior contrast resolution without the use of iodinated contrast material and uses no ionizing radiation. The aim of this study was to investigate the influence of artifacts produced by different restorative materials on the detection of approximal caries in cone-beam computed tomography (CBCT) scans with and without the application of an artifact-reduction (AR) option. Not only brain infarctions and haemorrhages (and cysts and angiomas) could be located, but also functional sources associated with TIAs even one week after the symptoms.

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However, among younger patients with BAV, some may have a haemodynamically significant stenosis with minimal AVCd. In this study, we demonstrate that BEN, initially expressed exclusively in the notochord during the early development of rat, is implicated in pancreatic development. Competition of activated protein C and urokinase for a heparin-dependent inhibitor. We find that paternal education is similarly important for reducing childhood undernutrition as maternal education and should therefore receive increased attention in the literature. Selective bond breaking of CO2 in phase-locked two-color intense laser fields: laser field intensity dependence. In this context, we have designed, synthesized and evaluated 1,4-dimethyl-carbazole derivatives, targeting the STAT3 protein. Fast permutation preconditioning for fractional diffusion equations. A three-dimensional treatment planning system for the calculation of dose distributions implemented in conjunction with CT, MRI and DSA stereotactic image analysis systems is presented.

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Overexpression of ER alpha1,2-mannosidase I and EDEMs target misfolded glycoproteins for ERAD, most likely due to trimming of N-glycans. The aim of the study was to evaluate our clinical experience with the CarboMedics Heart Valve Prosthesis. After conventional hematoma removal surgery and X-ray supervision within 24 h and at 7 days, neurological disability and function tests were completed 3, 6, 12, 36 and 60 months later. Multiple endocrine neoplasia type 2A (MEN2A) is a condition with inherited autosomal dominant mutations in RET (rearranged during transfection) gene that predisposes the carrier to extremely high risk of medullary thyroid cancer (MTC) and other MEN2A-associated tumors such as parathyroid cancer and/or pheochromocytoma. Validation was performed with real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Stacks of teleseismic records from regional arrays for 122 intermediate (depths of 100 to 350 kilometers) and deep (depths of 350 to do you have to be 18 to buy allegra 700 kilometers) earthquakes show that the temporal pattern of short-period seismic radiation has a systematic variation with depth. Some aspects of the interrelationship between fertility patterns and health: the case of Mexico. Genetic markers for inherited thrombophilia are associated with fetal growth retardation in the population of Central Russia. RARC had similar short-term postoperative outcomes compared to ORC and did not compromise oncological control in patients with extravesical disease. Scintigraphy with 123I-Tyr-3-octreotide has several major drawbacks as regards its metabolic behavior, its cumbersome preparation and the short physical half-life of the radionuclide.

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THE RELATIONSHIP BETWEEN THE glucotrol 5 mg NUCLEOLUS ORGANIZER AND NUCLEOLAR RNA. We have now generated a companion model, Hu128/21, by intercrossing YAC128 and BAC21 mice on the Hdh-/- background. Besides reduction of intraocular pressure and improvement of vascular condition, those who display psychological disturbances should receive psychological support, such as autogenic training. Central non-opioid physiological and pathophysiological effects of dynorphin A and related peptides. During chromatofocusing of enzyme preparations on a middle pressure chromatograph FPLC (Pharmacia, Sweden) a partial separation of acetyltransferase allelic forms from fast and slow-acetylators took place.

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Effects of an oral glucose tolerance test (37.5, 75, and 150 g) on serum potassium levels were determined in 13 HD patients and 7 healthy controls. Violence Exposure Subtypes Differentially Mediate the Relation between Callous- evista cost canada Unemotional Traits and Adolescent Delinquency. On its own, the model can be integrated into higher-order models of touch receptors because of its accurate simulation of RA currents. Supportive care within the family context can be promoted to address the diverse challenges of survivorship care. In a double-blind, two-period crossover study, 24 healthy volunteers were evaluated to establish the time of onset of action of activity of acrivastine in suppressing the weal and flare response to intradermally injected histamine. The effects of the timing of stressor application on transplanted tumor cells and its possible regulation by an immunomodulator was investigated.

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However, in vivo diffusion tensor (DT) measurements suffer from low signal-to-noise ratio (SNR) that can result in bias when estimating the six parameters of the full DT, thus reducing sensitivity. The lever ratio varied from 1.9 at 0.6 kHz (minimum) to a peak of 6 near 2 kHz. To overcome the limitations, in this work we present a novel algorithm, namely local Bayesian network (LBN), to infer GRNs from gene expression data by using the network decomposition strategy and false-positive edge elimination scheme. The selected models are Nonlinear PLS, Multiway PLS, Hierarchical PLS, Orthogonal PLS, and Bi-modal PLS. However, the absorbed components of the decoction and their related metabolites are little known until now. In particular, the powerful techniques of molecular biology have been brought to bear on tissue culture systems. RNA binding protein MSI2 positively regulates FLT3 expression in myeloid leukemia. Evaluating strategies for reducing the costs of immunosuppression. A 20-gauge Teflon cannula was used in all patients and velocity of flow measured with a Doppler velocimeter probe.

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Carotid angioplasty with cerebral protection can be performed safely in late carotid restenosis with a high technical success rate. Further clinical studies with larger numbers of patients are recommended. We used an augmented version of the Cancer Incidence in Five Continents series to analyze kidney cancer incidence rates 1978-2007 in 16 geographically representative populations worldwide by sex for ages 30-74, using age-period-cohort (APC) analysis. Academics should leave research credentials behind when they move, Stern report says. Acute hemodynamic effects of pimobendan and captopril: a comparative study in the same patients with chronic heart failure. Size-based ecosystem modeling is emerging as a powerful way to assess ecosystem-level impacts of human- and environment-driven changes from individual-level processes. All sets, except for saponin-vaccine, were adjuvated with aluminium hydroxide.

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