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Paxil (Paroxetine)

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Paxil is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of panic disorder, anxiety, and obsessive-compulsive disorder.

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Also known as: Paroxetine


Paxil (paroxetine) is an antidepressant that belongs to group of drugs called selective serotonin reuptake inhibitors (SSRIs). Paroxetine affects chemicals in the brain that may be unbalanced in people with depression, anxiety, or other disorders.

Paxil is used to treat depression, including major depressive disorder.

Paxil is also used to treat panic disorder, obsessive-compulsive disorder (OCD), anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).


Generic Paxil is available in tablets (10 mg, 20 mg, 30 mg, 40 mg) and oral suspension. You should take it by mouth with meals of without it. It is better to take Generic Paxil every day at the same time for nearly 4 weeks. Generic Paxil cannot be given to patients under 18 years. Take Generic Paxil and remember that its dosage depends on health state of patients. For depression Normal starting dose is 25 mg once a day. For panic and social anxiety disorders Normal starting dose is 12.5 mg once a day. For aged people or patients with kidney or liver problems Normal dose is 12.5 mg once a day. If you want to achieve most effective results do not stop taking Generic Paxil suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Paxil CR can be fatal.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Paxil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Paxil CR if you are allergic to Paxil CR, or if you are also taking pimozide or thioridazine.

Do not use an MAO inhibitor within 14 days before or 14 days after you take Paxil CR. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. After you stop taking this medicine you must wait at least 14 days before you start taking an MAO inhibitor.

Tell your doctor if you have ever had:

heart disease, high blood pressure, or a stroke; liver or kidney disease; a bleeding or blood clotting disorder; seizures or epilepsy; bipolar disorder (manic depression), drug addiction, or suicidal thoughts; narrow-angle glaucoma; or low levels of sodium in your blood.

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with Paxil CR and cause a serious condition called serotonin syndrome.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking an SSRI antidepressant during pregnancy may cause serious lung problems or other complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor's advice.

Do not use Brisdelle if you are pregnant.

You should not breastfeed while using this medicine.

Paxil CR is not approved for use by anyone younger than 18 years old.

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MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications. Primary hormonal therapy for prostate cancer: experience with 135 consecutive PSA-ERA patients from a tertiary care military medical center. A direct role for C1 inhibitor in regulation of leukocyte adhesion. When grouped by primary care site, respiratory symptoms were the most common at OoHs centres, the WIC and general practitioner (GP) surgeries. The multiple evanescent white-dot syndrome with acute blind spot enlargement.

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Glenoid measurements included SI length, AP length, SI radius, and AP radius. The activity of CuZn superoxide dismutase (CuZnSOD) and Mn superoxide dismutase (MnSOD) and the concentration of CuZnSOD were higher, but the activity and concentration of catalase were lower after differentiation. Such a liberation of beta-catenin would abrogate the negative transcriptional control of E-cadherin on the Lef/TCF/beta-catenin responsive genes. Silver nanoparticles inhibit the function of hypoxia-inducible factor-1 and target genes: insight into the cytotoxicity and antiangiogenesis. Nonequilibrium temperatures in steady-state systems with conserved energy. Cold-induced soluble sugar accumulation enhances the degree of freezing tolerance in various cold-hardy plants including Arabidopsis (Arabidopsis thaliana), where soluble sugars accumulate in only a few hours at 2 degrees C. Effect of ethanol on psychomotor performance and on risk taking behaviour. This indicated that the transfer frequency of plasmid pMG229 was reduced during broth mating and was not altered during filter mating.

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This study of university students (64 men and 99 women) examined both dispositional and situational influences of self-critical (SC) perfectionism on stress and coping, which explain its association with high negative affect and low positive affect. The results indicate that frequently experiencing LGBQ microaggressions is a risk factor for LGBQ college students smoking cigarettes. Three members of a family previously reported by Sheldon, Luder and Web in 1961 as having a benign tubular renal disease have since developed renal failure. Sequences encompassing Box1 and Box2 regions of the receptor cytosolic domain and an intact JAK2 or Tyk2 FERM domain are required for these effects. Our results demonstrate that direct injection of autologous expanded MSCs into the spinal cord of ALS patients is safe, with no significant acute or late toxicity, and well tolerated. This difference between viral loads measured by the two assays was found to be due to coating of virions with the Palivizumab that blocked infection of target cells in vitro and shows importance of live imaging in evaluation of RSV therapeutics. This technique benefits the underlying lung by improving the thoracic volume and the respiratory function. ACE inhibitor captopril reduces ecdysteroids and oviposition in moths. Future studies should use prolonged follow-up and should measure costs and possible harms. Synchronous facial vascular vasodilation and salivatory response to atropine in the parasympathetically denervated human salivary parotid gland.

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We studied magnetic resonance images from 50 MTLE patients and 15 healthy subjects. Synthesis of N-Mannich bases of 6-azauracil and its biological activities. RT-PCR results demonstrated that CbVd-1, CbVd-5, and CbVd-6 can be detected accurately in viroid-infected plants but not in viroid-free plants. Biochemical model reactions relevant for the formation of reactive oxygen species in vivo at inflammatory sites were used to determine the antioxidant properties of the two preparations. They were as potent as ICI 182, 780 and more efficient than OH-Tam to prevent estradiol action whereas their inhibition on IGF-I stimulation was less than with ICI 182, 780 and equivalent to that of OH-Tam. There is increasing concern in identifying the mechanisms underlying the intimate control of the intestinal barrier, as deregulation of its function is strongly associated with digestive (organic and functional) and a number of non-digestive (schizophrenia, diabetes, sepsis, among others) disorders.

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We looked to assess the efficacy of low-dose steroids on the postinflammatory response as measured by IL-6 in patients undergoing bilateral total knee replacement (BTKR). The activation of C/EBPbeta and alpha forms and NF-E2-related factor 2 (Nrf2) was assessed by immunochemical assays. These data are strikingly similar to those from our previous study of RH, in which a suboptimal medication regimen was the most common reason for resistance. The mechanisms of chondrosarcoma development are just beginning to be unraveled. Active choice through the EHR was associated with an increase in physician ordering of colonoscopy and mammography. A hyaluronidase supercatalyst for the enzymatic polymerization to synthesize glycosaminoglycans. Evaluation of androgenic activity of Zingiber officinale and Pentadiplandra brazzeana in male rats.

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The combination of epirubicin, cisplatin, and infusional 5-fluorouracil (ECF) currently represents a standard and effective regimen for the treatment of advanced gastroesophageal cancer. Signal qualities satisfy the worldwide interoperability for microwave access (WiMAX) requirement with data signals of 20 Mbps/5.8 GHz and 70 Mbps/10 GHz, respectively. To test the hypothesis that inhibition of Alr by DCS decreases the intracellular pool of D-alanine, we determined the alanine pools in M. Effects of silencing inhibitor of DNA binding-1 gene on the growth and invasiveness of adenoid cystic carcinoma cells. Preoperative diagnosis was based on ultrasound, computed tomography and selective percutaneous cholangiography without tissue diagnosis.

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A pilot study of behavioral activation for veterans with posttraumatic stress disorder. Combining systemic agents with phototherapy is becoming a standard of care for patients with moderate to severe psoriasis. This effect is not lost with repeated exposure to stress, since Nur77-like immunoreactivity and Nur77 mRNA in BNST were increased after the fifteenth stress session. Experience in the construction of medical institutions in rural regions. The obtained phylogenetic trees were also used to produce Robinson-Foulds supertrees. The highest amount of neurotoxin-induced SOD1 activity was generated by NMDA. Before coronary occlusion and 1, 30, 60, and 90 min after reperfusion with the LIMA graft, coronary sinus (CS) blood was sampled to determine intraoperative myocardial ischemia (pH, lactate, pO2) and oxidative stress (malondialdehyde, MDA). Water surface contacting cover system--the basic study for improving the oxygen transfer coefficient and the BOD removal capacity. Some of these mediators show different levels than in patients with chronic pain but no fracture.

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This disorder appears with frequency 1 to 10 cases of ectopic pregnancy. Electrostatic adsorption of heme proteins alternated with polyamidoamine dendrimers for layer-by-layer assembly of electroactive films. Its main activity is the collection of both Hungarian and foreign and international official statistical publications, as well as theoretical and methodological works. Chronic treatment with bromocriptine, a dopamine receptor agonist, had the opposite effect on the NIL, lowering i beta-END levels to approximately one-third of control values, but it did not affect hypothalamic i beta-END concentrations. Autoantibodies to dsDNA cross-react with the arginine-glycine-rich domain of heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2) and promote methylation of hnRNP A2. A case of stent strut fracture-induced restenosis in a bifurcation lesion treated with the crush stenting technique is described.

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Our data, collected from 10 ns molecular-dynamics simulations, show that the E35D mutation results in an increased flexibility of the flaps, thereby affecting the conformational equilibrium between the closed and semi-open conformations of the free protease. Consumption coagulopathy in patients with Klippel-Trenaunay syndrome. To better understand the pathogenesis of type 2 diabetes mellitus, insulin secretion and insulin sensitivity (IS) were evaluated in white Brazilians with impaired glucose tolerance (IGT), using the oral glucose tolerance test (OGTT) and the hyperglycemic clamp technique. In both cases, tadpoles failed to express inducible defences against crayfish, indicating that ca 30 years of contact with the invasive species (roughly 10-15 frog generations) have been insufficient for the evolution of recognition of invasive predator cues. In the upper respiratory tract this protection appeared to be mainly mediated by specific IgA- and IgG2a-producing B cells, whereas ex vivo active effector memory CTL were found in the lower respiratory tract. In contrast, among the 22 infants who weighed 1000 g or less, a major ductus shunt developed in 10 of the 12 given placebo. Smooth muscle cells were freshly isolated by collagenase digest and mechanical trituration with polished pipettes. Monoclonal antibodies against purified fimbriae from this organism blocked its adherence to buccal epithelial cells. Invitees completed a needs assessment, which guided curriculum development. These data suggest that magnolol possesses ability to inhibit tumor growth, and the ability is due to the induction of apoptosis with the activation of caspases.

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To evaluate the effectiveness of uterine artery embolization in women with uterine myomas in terms of the clinical results for the relief of related symptoms. Primary healing was achieved in 20 of 21 below the knee amputations which were closed with a gastrocnemius myodermal flap. Benedick maintains that investments in measures to slow the rate of population growth--and thereby to reach a stable population earlier, and at lower levels, than under current trends--WO WOMENuld significantly reinforce efforts to address the environmental challenges of the century ahead, and considerably lower the cost of such efforts. At 16 weeks postvasectomy, both PGEs and PGAs were at a significantly higher level than before the operation, but the 190H PGAs were not. Twenty chronic asthmatic subjects were treated with disodium cromoglycate in open trial.

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Epithelial cells obtained from autopsies of full-term fetuses or infants less than 1 year old were isolated, amplified in primary cultures and inoculated in deepithelialized rat tracheas. The algorithm was tested on particulate glass samples for diameters ranging from 1 to 20 microm. Surgical treatment for relief of severe pain with chronic pancreatitis that is resistant to conservative treatment. Collectively, is vantin a strong antibiotic our data document divergent modulation of brainwide neural systems by intranasal administration of OXT and AVP, an effect that involves key substrates of social and emotional behavior. The objective of the study was to study the association of serum BDNF with measures of adiposity in children.

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A Simplified Fe-Based PhotoATRP Using Only Monomers and Solvent. An early event in the pathogenesis of gastroesophageal reflux disease (GERD) is an acid-induced increase in junctional (paracellular) permeability in biaxin xl 500 generic esophageal epithelium (EE). There was no statistically significant difference in infection or overall malfunction rate between the two groups. Duration of air leak, intercostal drainage, and hospital stay comprised primary study end points. Thus, exercise delayed but did not prevent the full development of obesity in the Zucker rat. A novel approach towards quinone methides stabilization has been achieved by anchoring the reactive o-QM intermediate on solid phase (RTHP). Estrogen-receptor-dependent regulation of neural stem cell proliferation and differentiation.

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Medicare Part D provided 3.4 million American seniors with prescription drug insurance. Racial/ethnic disparities in report of physician-provided smoking cessation advice: analysis of the 2000 National Health Interview Survey. Damage recovery pathways in Saccharomyces cerevisiae revealed by genomic phenotyping and interactome mapping. Confirmation of this universal holistic model of scholarship can contribute significantly to a larger nursing identity. The results confirm previous studies on the PAG-VPM connections performed in this laboratory by using HRP technique, and demonstrate, within the PAG, the presence of a good number of double-labeled cells (stained by both E.B. No differences between genotypes were seen when fibre type composition was evaluated with the myosin ATPase method.

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We identified all ASCs operating during the period in the 49 Dartmouth Hospital Referral Regions in the three states. Attractive forces in sterically stabilized colloidal suspensions: from the effective potential to the phase diagram. Recently ultrasound-guided sclerotherapy has appeared, mainly for the treatment of saphenous trunks and incompetent perforating veins. Familial overlap between bipolar disorder and psychotic symptoms in a Canadian cohort. Ischaemic damage to Purkinje cells and loss of interneurons and Purkinje cells were also noted in these groups. Because of the high incidence of foot ulcers, amputations remain a source of morbidity and mortality in persons with diabetes. The subsequent analysis of the backcross progeny resulting from a cross between consomic mice heterozygous for the Mus spretus chromosome 19 and C57BL/6J mice, together with the study of inter-specific recombinant congenic strains (IRCS), suggest that this Tlyr1 locus maps within the D19Mit60-D19Mit40 chromosome interval. A new set of amino acid descriptors and its application in peptide QSARs.

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Anesthetized rats were randomly assigned to sham-operated group, TBI rats treated with saline (1 mL/kg, intraperitoneally), or TBI rats treated with agmatine (50 mg/kg, intraperitoneally). Sociodemographic, medical and functional variables were extracted from data submitted to the UK Rehabilitation Outcomes Collaborative. This Issue Brief summarizes a comparison in another area-inpatient rehabilitation for stroke- and highlights the difficulty and complexity of assessing quality across systems of care. We discuss our results in relation to recent theory of reciprocal pilferage and compare them to behaviours shown by caching birds. An epiretinal prosthesis, consisting of an extraocular microelectronic stimulator and an intraocular electrode array, was implanted in one eye of three blind and three sighted dogs. The advantage of the latter is that gene delivery of these enzymes and receptors does not need to be endothelium specific. Glycation of FN shifts the nature of cellular adhesion from integrin- to RAGE-dependent mechanisms. Structure and function of bistratified intrinsically photosensitive retinal ganglion cells in the mouse.

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