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Nuvigil (Armodafinil)

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Nuvigil is a medication that promotes wakefulness. Nuvigil is used to treat excessive sleepiness caused by sleep apnea, narcolepsy, or shift work sleep disorder. Nuvigil may also be used for purposes not listed in this medication guide.

Other names for this medication:
Armod, Armodafinil, Biryth, Waklert

Similar Products:
Wellbutrin, Requip, Elavil, Flomax, Ceftin, Acticin, Addyi, Zetia, Propecia, Imuran

Also known as: Armodafinil


Nuvigil reduces extreme sleepiness due to narcolepsy and other sleep disorders, such as periods of stopped breathing during sleep (obstructive sleep apnea). It is also used to help you stay awake during work hours if you have a work schedule that keeps you from having a normal sleep routine (shift work sleep disorder).

This medication does not cure these sleep disorders and may not get rid of all your sleepiness. Nuvigil does not take the place of getting enough sleep. It should not be used to treat tiredness or hold off sleep in people who do not have a sleep disorder.

It is not known how Nuvigil works to keep you awake. It is thought to work by affecting certain substances in the brain that control the sleep/wake cycle.


Take Nuvigil exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Nuvigil may be habit-forming. Never share Nuvigil with another person, especially someone with a history of drug abuse or addiction. Selling or giving away this medicine is against the law.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Nuvigil is usually taken each morning to prevent daytime sleepiness, or 1 hour before the start of a work shift to treat work-time sleep disorders.

You may take this medicine with or without food.

Nuvigil is usually given for up to 12 weeks. Follow your doctor's instructions.

If you are taking this medicine to treat sleepiness caused by obstructive sleep apnea, you may also be treated with a continuous positive airway pressure (CPAP) machine. This machine is an air pump connected to mask that gently blows pressurized air into your nose while you sleep. The pump does not breathe for you, but the gentle force of air helps keep your airway open to prevent obstruction.

Do not stop using your CPAP machine during sleep unless your doctor tells you to. The combination of treatment with CPAP and Nuvigil may be necessary to best treat your condition.

Taking this medication does not take the place of getting enough sleep. Talk with your doctor if you continue to have excessive sleepiness even while taking this medicine. Nuvigil will not cure obstructive sleep apnea or treat its underlying causes. Follow your doctor's instructions about all your other treatments for this disorder.

Store at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Nuvigil is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Detailed Nuvigil dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, diarrhea, confusion, feeling restless or excited, fast or slow heart rate, chest pain, trouble sleeping, or hallucinations (seeing or hearing things that are not real).


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Do not share this medication with others. It is against the law.

Side effects

The most common side effects associated with Nuvigil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use this medication if you are allergic to Nuvigil or modafinil (Provigil).

Before using Nuvigil, tell your doctor if you have liver or kidney disease, heart disease or high blood pressure, a heart valve disorder, a history of mental illness, a history of drug or alcohol addiction, or if you have recently had a heart attack.

Nuvigil may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid other dangerous activity until you know how this medication will affect your level of wakefulness.

Stop taking Nuvigil and call your doctor if you have a skin rash, no matter how mild. A medicine similar to Nuvigil has caused severe skin reactions serious enough to require hospitalization. Other signs of a severe reaction include fever, sore throat, headache, and vomiting with a severe blistering, peeling, and red skin rash.

There may be other drugs that can interact with Nuvigil. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

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Adults showed greater activations in parietal and frontal regions (part of them belonging to the social brain) than adolescents.An increased number of regions that are part of the mirror system network or the social brain, as well as the caudate nucleus, were recruited with age. More patients of young age and with better liver function tended to undergo surgical treatment. Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption. The aim of the present study was to investigate whether our optimal culture condition (OC) can maintain the phenotype of primary hepatocytes in long-term culture. From a HFP- and a LFP-line five birds with a HFP- and five birds with a LFP-phenotype were selected.

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Its mutation is associated with elevated risk for ischaemic heart disease as epidemiological and experimental studies suggest. The results of the study of systemic and local immunity in cases of prolonged and chronic dysentery in children are presented. Metabolic response to provision of mixed protein-carbohydrate supplementation during endurance exercise. In other words, there is a chance that a polypeptide chain misfolds to sequester the preformed elements inside the non-interactive or less-interactive cage, therefore preventing these elements from the unnecessary and unwanted interactions with non-native binding partners. The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1. To assess the long-term safety and efficacy of canakinumab in Japanese patients with cryopyrin-associated periodic syndrome (CAPS). MRCP was followed with a more invasive test a majority of the time. Diagnostic importance of the quantitative determination of the extent of bacteria excretion during the chemotherapy process in chronic destructive pulmonary tuberculosis. These droplets are dispensed into a vessel containing a layer of oil over a layer of water. The large snoRNA family in plants is an ideal model for investigation of mechanisms of evolution of gene families in plants.

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Reactive oxygen species (ROS) are known mediators of intracellular signal cascades. Demonstrated with two multi-domain proteins, we present a method to characterize protein microsecond-millisecond dynamics based on the analysis of the sPRE. SeqVISTA runs on any operating system with a Java 1.4 virtual machine. The interaction between Cig57 and FCHO2 is dependent on one of three endocytic sorting motif encoded by Cig57. The Hindu religion is strongly opposed to extramarital and premarital sex, two behaviors which promote the spread of HIV. In the present study, biliary excretion of taurolithocholate-sulfate and temocaprilat, substrates of Mrp2, was studied in bile duct-ligated rats and in cholestatic rats induced by ethinylestradiol (EE).

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Many future reconstructive surgeries have been planned to achieve an acceptable quality of life for this infant. The results in terms of bone resorption are comparable with those of the original method, but the risk of a lesion of the mandibular nerve is substantially reduced. Quality improvement systems may struggle to keep up with the pace of innovation, yet evaluation of innovation is often too narrowly focused for the system-wide effects of new practices or technologies to be understood. IM at the SCJ can also appear in young individuals in whom it seems to be associated with reflux related isolated inflammation in cardiac mucosa at the SCJ but not with H pylori gastritis. A novel physical anthropomorphic breast phantom for 2D and 3D x-ray imaging.

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The use of volunteers to support family carers of dementia patients: results of a prospective longitudinal study investigating expectations towards and experience with training and professional support. The objective of our review was to compare antibiotic treatment to no antibiotic treatment, or to compare different combinations of antibiotic treatment, for nontuberculous mycobacteria lung infections in people with cystic fibrosis. The results indicate that consideration should be given to the selection of speech tasks during the process leading to automation of revised speech behavior and that self-reports may be a reliable index of cognitive load. Blood pressures were highest at 1.0 MAC during spontaneous ventilation and lowest at 1.5 MAC during controlled ventilation for either anesthetic protocol. Three hundred eighteen patients also received adjunctive therapy with eptifibatide. Multivariate analyses indicate that parental race/ethnicity, education level, employment status, and child age were other significant independent risk factors. This evolution makes essential the general anaesthesia in paediatric dentistry among the therapeutic arsenal of pedodontists. It is concluded that this entity is the most common cause of peripheral occlusive vascular disease in younger Iranian males. This technique may provide both an attractive way to reduce injury to the anterior neck tissue and a method for ideal cosmetic effect. Pediatric gastroenterologists and parents reported baseline practice variation, and improvement in care processes and outcomes measured during NASPGHAN-sponsored Web-based MOC QI activities.

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Direct comparison of the chloro, bromo, and iodopyrazoles in the Suzuki-Miyaura reaction revealed that Br and Cl derivatives were superior to iodopyrazoles, as a result of reduced propensity to dehalogenation. Does metabolic syndrome mitigate weight loss in overweight Mexican American women treated for 1-year with orlistat and lifestyle modification?. Factors influencing the outcome of Escherichia coli mastitis in the dairy cow. The aim of this paper was to review the current literature on the indications and use of antibiotics and to make recommendations for their prescription in endodontic patients. This indicates that the decrease in consumption is not occurring in those most likely to experience harms. Bleeding occurred three times with cimetidine and twice with the placebo. Lobular carcinoma and scirrhous carcinoma are the most common malignant diseases, but radial scar, inflammatory disease, and surgical scar need to be considered in the differential diagnosis. Nor does the antibody cross-react with heterologously expressed human CYP3A4, CYP2S1, or any of the cytochrome P450 enzymes present in the human liver microsomes. Most Trichobilharzia (visceral species) migrate through the viscera of the host, but nasal species display a neurotropic mode of migration.

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Activity of the thyroid and sex hormones in patients with myasthenia after surgical intervention. Furthermore, the concentration of active ingredients in such medicinal preparations is usually very high, so that despite the correct application of the recommended dose, considerable amounts may be absorbed in an unwanted manner through various routes. Health education is the most important prevention and control strategy against AIDS. Depending on the intensity and type of targeted tissues, this apoptosis was accompanied by alterations in the activity of the molecules which act diamox dose iv as activators and effectors (e.g. Recent data have linked various clinical characteristics and biologic markers with outcome to HER-1/EGFR-targeted agents. Extravascular localization of albumin and IgG in normal tonic and phasic muscles of the rat. However, these educators understand that most men who have sex with men in the South Pacific do not self-identify as gay, but rather as men without any specific sexual identity who have sex with both men and women as they see fit. On the mode of action of acetylsalicylic acid (aspirin) on collagen. The pheromonotropic response increased to reach a maximum at 4 days, after which a decreased response was observed. The paucity of clinical trials on ECLS highlights the need for randomized trials to guide the selection of patients.

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Given the difficulty of data gathering, few studies report the intake of sodium in the diet. Exploiting the lethal phenotype associated with the overexpression of Aurora-A in yeast, we performed a dosage suppressor screen in yeast and report here the identification of a novel negative regulator of Aurora-A, named AIP (Aurora-A kinase Interacting Protein). Ising model of polarity formation in molecular crystals: from the growth model to the asymptotic equilibrium state. Changes in object-oriented arm movements that precede the transition to goal-directed reaching in infancy. In this study, the authors wanted to investigate the volume, density, and percentage of three platelet subpopulations present in adult and geriatric males. Prevention of Haemophilus influenzae type b (Hib) meningitis and emergence of serotype replacement with type a strains after introduction of Hib immunization in Brazil. A family planning service may, through its wide range of activities, prevent a useless psychiatrisation of problems. The author makes a case for the inclusion of the study of the family in economic research low dose tramadol withdrawal symptoms elderly .

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Placental mosaicism and intrauterine survival of trisomies 13 and 18. The fractal basin boundary and the riddled basin are observed and they are characterized in terms of the uncertainty exponent. However, further research is needed to evaluate the effect of other interventions on patient anxiety during MRI scanning. Endocrine active agents: implications of adverse and non-adverse changes. Character-complexity effects in Chinese reading and visual search: A comparison and theoretical implications. We analyze the frequencies of the lowest modes as functions of both the number of sites and the discreteness parameter. The related protein Axin2/Conductin, although less extensively studied, is thought to perform similar functions. Hence, because of not only the larger burden of premature deaths, but also the sensitivity, premature mortality is considered to be suitable as a target indicator for cancer prevention strategies. It was found that both clinical condition and quality of life improved in the majority of patients receiving care at this outpatient clinic and that the quality of life questionnaires are equivalent.

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Using a systematic review process, we identified 15 randomised controlled trials comparing either of the two endovenous thermal techniques, radiofrequency or laser ablation, with conventional open surgery for great saphenous varicose veins. The discovery of novel bromodomain inhibitors by fragment screening is complicated by the presence of dimethyl sulfoxide (DMSO), an acetyl-lysine mimetic, that can compromise the detection of low affinity fragments. A total of 24 women having tension-free vaginal tape retropubic sling placement for recurrent stress urinary incontinence after a previous failed Burch urethropexy were enrolled in the present study. These medical students overwhelmingly identified the need for coping strategies when confronting the dying patient. However individuals with the same scores often had very different journeys in system integration. It was reported that the activation of telomerase can turn normal cell into tumor cell. Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3. On each study-test trial, different items were presented, and participants predicted recall performance, received a cued recall test, and postdicted performance. Development of resistance-resistant antibiotics could be achieved via the coordinated networking of clinicians, microbiologists, natural product chemists, and pharmacologists together with pharmaceutical venture capitalist companies.

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The study assesses treatment outcomes under current conditions in Switzerland. Alternate stranded triplex formation of chimeric DNA composed of tandem alpha- and beta-anomeric strands. We included studies that reported the prevalence of dementia using standard diagnostic criteria or cognitive impairment as measured on cognitive screening tests. The reabsorption of Pi in the kidney is a major determinant of the plasma Pi level. Due to different and various reasons, insurance medicine in Germany has shown substantial deficits in the past years and decades, mostly in the areas of methodology, scientific basis, guidelines and quality control. Both chlorogenic acids based on trans and cis-cinnamic acid substituents were identified.

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A single or multiple channel system can be used depending on the volume of tissue to be treated. The formation of diethylstilbestrol monoglucuronide in hamster liver homogenates. Implications for clinical neuroprotective strategies are discussed. Measurement was made of total (free plus conjugated) ethinyl estradiol by radioimmunoassay and also by an isotope dilution-mass what are the side effects of celexa 20 mg spectrometry (ID-MS) procedure. In addition, ABCC6 mRNA and protein were present in most neurons of the brain, in alveolar macrophages in the lungs and lymphocytes in the lymph node. F6H8 entered the anterior chamber in 4 cases, but no corneal complications occurred.

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Therefore, it is necessary to have a comprehensive approach to create a primary prevention strategy from even a young age. Purification of rabbit muscle pyruvate kinase by CM-sephadex and evidence for an endogenous inhibitor. The aim of this study was to ascertain the prevalence of meiotic segregation products in embryos from carriers of 13/14 and 14/21 Robertsonian translocations and to estimate the predictive value of testing single cells using the fluorescence in situ hybridization (FISH) technique, to provide more information for decision-making about PGD. We also review the current literature on instructional strategies for introducing AMS into clinical programs, and propose concepts that should be included in didactic coursework in order to provide a foundation for AMS education. A significant decrease in gamma-GTP was detected 24h after significant suppression of intratesticular testosterone and it returned to control levels 2 days after increasing the dose of TP to 500 micrograms/day. We assessed the impact of nocturia on the general and disease-specific health-related quality of life (HRQOL) for men with localized prostate cancer. Here, we describe a different category of mutants that blocks Atg9 sorting from mitochondria. The subjects received 120 mEq sodium and 80 mEq potassium per day. It highlights the emerging concepts in the pathogenesis of MS in the context of known features of pathology, including the characterization of cytokine networks promoting inflammatory damage of the central nervous system, B-cell involvement, and inflammatory damage of axons and neurons.

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Efficacy of chemoimmunotherapy with fludarabine, cyclophosphamide and rituximab for chronic lymphocytic leukemia. The genetics of adaptation to discrete heterogeneous environments: frequent mutation or large-effect alleles can allow range expansion. Autoradiographic studies indicate a greater internalization of hormone during prenatal life and, taking into account the increase of cell size, suggest an unchanged surface density of receptor sites before and after birth. The potential significant therapeutic and prognostic roles for the sex steroid receptors in ovarian cancer are recognized. The presence of cases of subtotal anaesthetic coverage (with necessity to recur to general anaesthesia), and others with good anaesthetic coverage, but difficultly treatable hypotensions show that the best dosage of these local anaesthetics is to be found yet. Population growth under changed fertility schedule in stability conditions. The mechanisms by which PTHrP reduces the coronary resistance of the rat heart have not been worked out but seem to be independent of the classical PTH/PTHrP receptor-mediated, cAMP-dependent effect. Administration of adenosine receptor agonists or antagonists after controlled cortical impact in mice: effects on function and histopathology. Incidence of symptomatic spinal metastasis has increased owing to improvement in treatment of the disease.

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Here we show that BAG-1 itself is a substrate of the CHIP ubiquitin ligase in vitro and in vivo. A model based on the expected utility hypothesis is developed in order to analyze the effects of changing regional economic conditions on migration behavior. After 3 hours, the treated segments were removed and inflammation was assessed by luminal fluid accumulation, myeloperoxidase activity, and histology. Paired mutations abolish and restore the balanced annealing and melting activities of ORF1p that are required is xanax scheduled drug for LINE-1 retrotransposition. Bilateral unicameral bone cysts of the calcaneus are extremely uncommon. Divergent stress coping styles in juvenile brown trout (Salmo trutta). The activity of branched-chain 2-oxo acid dehydrogenase (BCOAD) was increased immediately after exercise but returned to the control value by 10 min postexercise.

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