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Klonopin (Clonazepam)
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Klonopin

Klonopin is used to prevent and control seizures. This medication is known as an anticonvulsant or antiepileptic drug. It is also used to treat panic attacks. Klonopin works by calming your brain and nerves. It belongs to a class of drugs called benzodiazepines.

Other names for this medication:
Adnil, Alrest, Anxiset, Anxrea, Calmnir, Cloam, Clonapik, Clonasig, Clonazepam, Cloneepam, Clonoasig, Clonotril, Closis, Clotas, Clotweet, Clozep, Convaclon, Cozil, Easyfeel, Epicloz, Escitrac, Esitor, Jasoclam, Jbcloz, Klopam, Lonazep, Lonipax, Melzap, Nexclo, Prasilex, Revozip, Sezolan, Sezolep, Somnolex, Zepam, Zeptril, Zolpidox, Zozep

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Silagra, Rulide, Nimotop, Valtrex, Lopid, Moduretic, Actos

Also known as: Clonazepam

Description

Klonopin, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects.

Klonopin has been found effective in treating epilepsy in children, and the inhibition of seizure activity seemed to be achieved at low plasma levels of Klonopin. As a result, Klonopin is sometimes used for certain rare childhood epilepsies; however, it has been found to be ineffective in the control of infantile spasms. Klonopin is mainly prescribed for the acute management of epilepsies. Klonopin has been found to be effective in the acute control of non-convulsive status epilepticus; however, the benefits tended to be transient in many of the people, and the addition of phenytoin for lasting control was required in these patients.

It is also approved for treatment of typical and atypical absences, infantile myoclonic, myoclonic and akinetic seizures. A subgroup of people with treatment resistant epilepsy may benefit from long-term use of Klonopin; the benzodiazepine clorazepate may be an alternative due to its slow onset of tolerance.

Dosage

Klonopin is indicated for the treatment of panic disorder, with or without agoraphobia, as defined in DSM-V. Panic disorder is characterized by the occurrence of unexpected panic attacks and associated concern about having additional attacks, worry about the implications or consequences of the attacks, and/or a significant change in behavior related to the attacks.

The efficacy of Klonopin was established in two 6-to 9-week trials in panic disorder patients whose diagnoses corresponded to the DSM-IIIR category of panic disorder.

Panic disorder (DSM-V) is characterized by recurrent unexpected panic attacks, ie, a discrete period of intense fear or discomfort in which four (or more) of the following symptoms develop abruptly and reach a peak within 10 minutes: palpitations, pounding heart or accelerated heart rate; sweating; trembling or shaking; sensations of shortness of breath or smothering; feeling of choking; chest pain or discomfort; nausea or abdominal distress; feeling dizzy, unsteady, lightheaded or faint; derealization (feelings of unreality) or depersonalization (being detached from oneself); fear of losing control; fear of dying; paresthesias (numbness or tingling sensations); chills or hot flushes.

The effectiveness of Klonopin in long-term use, that is, for more than 9 weeks, has not been systematically studied in controlled clinical trials. The physician who elects to use Klonopin for extended periods should periodically reevaluate the long-term usefulness of the drug for the individual patient.

Overdose

Benzodiazepines like Klonopin became popular prescription medications, as alternatives to another class of anti-anxiety medications called barbiturates. Barbiturates were once very popular in the treatment of anxiety; however, they were highly addictive, carried a high risk for overdose, and were frequently abused. Benzodiazepines also carry a significant risk for the development of physical dependence and abuse (see below); however, they do not appear to carry the same risk of overdose that is associated with barbiturates (although overdose on benzodiazepines can occur).

Many of the cases of overdose that include benzodiazepines also include the co-occurring use of other drugs, such as alcohol, narcotic pain medications, or antidepressants. Using these drugs and benzodiazepines like Klonopin together enhances the effects of all drugs as well as increases the risk for overdose and potential fatalities due to drug interactions and drug overdose.

Storage

Tablets should be kept at room temperature, between 15 C and 30 C (59 F and 86 F).

Side effects

The most common side effects associated with Klonopin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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Significant differences in estradiol secretion were not detected following reproductive experience. Germinal centres are areas of B lymphocytes proliferation that appear in primary lymphoid follicles after immunization. We have completed a comprehensive review of studies that have investigated prognostic biomarkers in either the blood or cerebrospinal fluid (CSF) of animals and humans following SCI. Total scalp avulsion is a rare but severe injury frequently ending in hair loss, and one that can even be life-threatening. Distribution and structure of the population in the Spanish Empire, 1750-1810: the joint Syracuse-Oxford project. The analysis shows that the exponential hindered settling forms, which are most commonly used in traditional SST models, not only account for hindered settling but partly lump other phenomena (compression) as well. Vision and change in biology undergraduate education: Vision and change from the funding front. Electrical and structural characterizations of the GZO thin films were carried out by 4-point probe, Hall measurement, and scanning electron microscopy, and the effects of the pretreatment on the improved properties of GZO thin films were discussed. Risk factor data, including cholesterol and blood pressure measures, were used to create a summary effectiveness outcome, the 10-year probability of developing coronary heart disease (CHD).

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Effects of nifedipine on left ventricular distensibility, relaxation and filling dynamics during pacing-induced myocardial ischemia. Also, the reactivity of anti-Nfasc155 antibodies from these patients was abolished in neurofascin-deficient mice, confirming that the antibodies specifically target paranodal proteins. We compare model predictions to the body-size distribution of piscivorous and herbivorous fishes found on tropical reefs worldwide. In most cases, the significance of binding of the 14-3-3 protein is not known. This study is concerned with social problems related to urbanization in Hungary over the past 20 years. In vascular tissues, angiotensin II is potentially cleaved from angiotensin I by chymase and angiotensin-converting enzyme (ACE). We also studied the gene regulation of HD by analyzing the real whole-genome transcription data of 647 individuals. The studies revealed no significant effect of all visual works in patients with normal tear secretion. Herein, a wheat ADF gene, TaADF4, was identified and characterized.

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Promising, early randomized-controlled trials were followed by a mixed field of positive and negative studies that may serve as a whole to prove that NADA, despite its apparent simplicity, is neither a reductive nor an independent treatment, and the need to refine the research approaches. The afternoon surge of leutinizing hormone (LH) in the plasma of ovariectomized, estradiol-treated rats was advanced by 2 hr after 7 days of treatment with CrMP (4 micro M/kg), and this effect was reversed when hemin (30 micro M/kg) was co-administered with CrMP. Who should have a routine early invasive approach after fibrinolytic therapy?. Why do divalent metal ions either promote or inhibit enzymatic reactions?. End-product control of acetohydroxyacid synthetase by valine in Penicillium chrysogenum Q 176 and a high penicillin-yielding mutant. Evidence of a serologic relationship between Ehrlichia canis and Rickettsia sennetsu. Menstrual blood loss in IUD users: comparative study of eleven different IUDs in Mexican women. In each, the SCAD caused a fresh myocardial infarct, and balloon angioplasty with stenting successfully restored the true lumen of the dissected artery. After guide pin placement, the lateral aspect of the knee was dissected, and the proximity of each guide pin to the important lateral anatomic structures was measured. The unique opportunity this data set affords is an overview of the relationship between intelligence and fertility for a nationally representative sample of Americans whose major reproductive years fell between 1912 and 1982.

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This review summarizes the construction of diverse hybrid nanogels and multicompartment nanogels. Clinical symptoms were evaluated with the Beck Depression Inventory-II, the State-Trait Anxiety Inventory-Form JYZ (STAI-JYZ), and the Maudsley Obsessive Compulsive Inventory. 2nd, one must infer how labor loss effects current rural production. Effects of Temporal Framing on Response to Antismoking Messages: The Mediating Role of Perceived Relevance. Especially during the past decade, clinicians and researchers have paid much attention to peri-implant health and more specifically to the incidence of bone loss. Clinical and biochemical factors associated with preeclampsia in women with obesity. Previous work showed the existence of ecotoxicity of water samples from the Alqueva reservoir due to the presence of the herbicides atrazine, simazine, terbuthylazine and metolachlor. Extra-renal expression of Slc12a2 was examined in 13.5, 15.5, and 16.5 d.p.c. The protocol which was audited required a bolus of 50 U kg(-1) of FVIII followed by CI at an initial rate of 4 U kg(-1) hr(-1).

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Slight improvements in PEM performance in association with medication correlated positively with dose of medication and with medication-related improvements in behavior. Redox control of growth factor signaling: recent advances in cardiovascular medicine. No obvious changes by 8 weeks in these parameters were found in eyes in which the lacrimal glands had been injected with nonstimulated PBLs or in the lacrimal gland-excised eyes contralateral to normal eyes. A new method is proposed to utilise a priori information when the type of flow is known beforehand. The meeting participants examined 4 case studies on the issue of RTI and STDs in the context of family welfare programs. The mechanism of catabolite repression in KKS102 is explained in terms of inhibition of activation by BphQ. If any sterilization acceptor dies within 10 days of the operation Rs 5000 will be paid regardless of the actual cause of death. The phantom consisted of a water-filled balloon (cyst) suspended in varying concentrations of iodine solution, meant to simulate varying levels of renal enhancement. Peptide mimics isolated from phage display peptide libraries by panning with self-tumor-associated Ag (TAA)-specific mAbs are being evaluated as immunogens to implement active specific immunotherapy.

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Total elastase activity was measured by generation of free amino groups from succinylated elastin. Pre-treatment with Efb resulted in a significant prolongation of bleeding time in a mouse model. The purpose of this study was to investigate whether inhibition of ROCK can suppress apoptosis of the corneal endothelium and to determine the role of ROCK signaling in regulating apoptosis. Preference for the larger reward changed systematically as delays increased in all conditions, decreasing for the 6:1, 3:1, and 3:2 ratios, and increasing for the 1:1 ratio. This communication summarizes the procedures that enabled isolation of adult murine thymic stromal cell lines that naturally express Notch ligands Jagged-1 or Delta-1. On examination she did not have classical signs of dengue fever and was found to have bilateral papilledema on fundus examination. Study of radial die-wall pressure changes during pharmaceutical powder compaction.

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Effect of blood transfusion on skin allograft survival in immunosuppressed mice. New agents have been developed that are capable of providing rapid reversal of the anticoagulation effect of NOACs. This paper critically reviews the effectiveness of adolescent family planning programs in the United States. Recently, the pericardial space has been under consideration as an ideal site for prevention and treatment of coronary artery and heart disease. Among other things, this Act amends the US Civil Rights Act of 1968 to extend protections against discrimination based on familial status to include pregnant women and clomipramine medication classification scale adopting parents. We postulate that the production of cartilage within this neoplasm most likely resulted from the metaplastic transformation of preexisting mesenchymal elements within the tumor or from multipotential neural crest-derived ectomesenchymal cells.

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In this study, we analyzed the TCR V beta 1-20 gene repertoire by reverse transcription-polymerase chain reaction (RT-PCR) in peripheral blood lymphocytes (PBLs) from individuals vaccinated with recombinant hepatitis B vaccine and PBLs from healthy donors stimulated by supernatants of the HepG2 2215 cell line transfected by HBV-DNA. We conducted in-depth interviews with 45 purposively sampled participants in the ClaSS project using a checklist of topics relating to their experiences of the screening process. Liver function tests profile in cancer patients on cytotoxic chemotherapy: a preliminary report. beta-Thalassemia trait is not a contributing factor for osteopenia/osteoporosis in children and young adults. Musidunin and musiduol, insect antifeedants from Croton jatrophoides. All these patients had completion thyroidectomy and subsequently presented with elevated serum Tg but negative post-therapy I-131 whole body scans. Frequently the highly technical style of research reports renders them unreadable to the average policy maker or planner. Adaptive variation tends to emerge clinally along environmental gradients or discretely among habitats with limited connectivity.

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