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Klonopin (Clonazepam)

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Klonopin is used to prevent and control seizures. This medication is known as an anticonvulsant or antiepileptic drug. It is also used to treat panic attacks. Klonopin works by calming your brain and nerves. It belongs to a class of drugs called benzodiazepines.

Other names for this medication:
Adnil, Alrest, Anxiset, Anxrea, Calmnir, Cloam, Clonapik, Clonasig, Clonazepam, Cloneepam, Clonoasig, Clonotril, Closis, Clotas, Clotweet, Clozep, Convaclon, Cozil, Easyfeel, Epicloz, Escitrac, Esitor, Jasoclam, Jbcloz, Klopam, Lonazep, Lonipax, Melzap, Nexclo, Prasilex, Revozip, Sezolan, Sezolep, Somnolex, Zepam, Zeptril, Zolpidox, Zozep

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Also known as: Clonazepam


Klonopin, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects.

Klonopin has been found effective in treating epilepsy in children, and the inhibition of seizure activity seemed to be achieved at low plasma levels of Klonopin. As a result, Klonopin is sometimes used for certain rare childhood epilepsies; however, it has been found to be ineffective in the control of infantile spasms. Klonopin is mainly prescribed for the acute management of epilepsies. Klonopin has been found to be effective in the acute control of non-convulsive status epilepticus; however, the benefits tended to be transient in many of the people, and the addition of phenytoin for lasting control was required in these patients.

It is also approved for treatment of typical and atypical absences, infantile myoclonic, myoclonic and akinetic seizures. A subgroup of people with treatment resistant epilepsy may benefit from long-term use of Klonopin; the benzodiazepine clorazepate may be an alternative due to its slow onset of tolerance.


Klonopin is indicated for the treatment of panic disorder, with or without agoraphobia, as defined in DSM-V. Panic disorder is characterized by the occurrence of unexpected panic attacks and associated concern about having additional attacks, worry about the implications or consequences of the attacks, and/or a significant change in behavior related to the attacks.

The efficacy of Klonopin was established in two 6-to 9-week trials in panic disorder patients whose diagnoses corresponded to the DSM-IIIR category of panic disorder.

Panic disorder (DSM-V) is characterized by recurrent unexpected panic attacks, ie, a discrete period of intense fear or discomfort in which four (or more) of the following symptoms develop abruptly and reach a peak within 10 minutes: palpitations, pounding heart or accelerated heart rate; sweating; trembling or shaking; sensations of shortness of breath or smothering; feeling of choking; chest pain or discomfort; nausea or abdominal distress; feeling dizzy, unsteady, lightheaded or faint; derealization (feelings of unreality) or depersonalization (being detached from oneself); fear of losing control; fear of dying; paresthesias (numbness or tingling sensations); chills or hot flushes.

The effectiveness of Klonopin in long-term use, that is, for more than 9 weeks, has not been systematically studied in controlled clinical trials. The physician who elects to use Klonopin for extended periods should periodically reevaluate the long-term usefulness of the drug for the individual patient.


Benzodiazepines like Klonopin became popular prescription medications, as alternatives to another class of anti-anxiety medications called barbiturates. Barbiturates were once very popular in the treatment of anxiety; however, they were highly addictive, carried a high risk for overdose, and were frequently abused. Benzodiazepines also carry a significant risk for the development of physical dependence and abuse (see below); however, they do not appear to carry the same risk of overdose that is associated with barbiturates (although overdose on benzodiazepines can occur).

Many of the cases of overdose that include benzodiazepines also include the co-occurring use of other drugs, such as alcohol, narcotic pain medications, or antidepressants. Using these drugs and benzodiazepines like Klonopin together enhances the effects of all drugs as well as increases the risk for overdose and potential fatalities due to drug interactions and drug overdose.


Tablets should be kept at room temperature, between 15 C and 30 C (59 F and 86 F).

Side effects

The most common side effects associated with Klonopin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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A new method to control the averaging process and to check the stability of evoked potential (EP) components is described. Seven male patients (age range 19-55) presented over a 36 h period following ingestion of varying quantities of DEG. The purpose of this study was to examine the association between eating a regular breakfast and B-Pb among children using data from the China Jintan Child Cohort Study. The response of the granulocytic progenitor cells (CFU-C) of blood and bone marrow in dogs exposed to low doses of X irradiation. The recombinogenic potential of chlorhexidine digluconate was evaluated on Aspergillus nidulans by the production of cells homozygous for the following nutritional markers: riboA1, pabaA124, biA1, methA17 and pyroA4. From the very beginning of proteomics as an analytical science there has been a growing interest in developing standardized methods and experimental procedures in order to ensure the highest quality and reproducibility of the results. Telomerase activity is present in most malignant tumours and might provide a mechanism for unlimited replication of neoplastic cells.

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In the oral cavity, most gp340 is found soluble in saliva and can function as a specific inhibitor of infectivity of HIV-1 and influenza A. A preliminary examination of data on continuation of employment in midwifery. Repletion with zinc reversed upregulation of the iNOS gene within 1 d, whereas UG upregulation required 3-4 d to return to normal. In order to estimate the fluxes of Ra isotopes, we measured 224Ra, 226Ra, and 228Ra activities in the Ulsan Bay mixing zone. Frustrated Lewis pairs are playing an increasingly important role in organometallic chemistry. This study focused on the systematic evaluation of counseling interventions aimed to alleviate the distress in wartime. Further research on factors that promote feedback seeking, receptivity to constructive feedback, and bidirectional feedback would provide valuable insights. Letter to the editor: New metrics to monitor progress towards global HIV targets: using the estimated number of undiagnosed HIV-infected individuals as denominator. However, some breast lesions are mammography occult, and magnetic resonance imaging (MRI) is recommended, but it has lower specificity. The CR7 domain point mutation decreases stability and alters a conserved secondary structure thought to be involved in human telomerase RNA accumulation in vivo.

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The spherical diffusion model performed better than the first-order model. Recently, clonal chromosome abnormalities have been identified in the mural spindle cells in aneurysmal bone cysts (ABCs), but the nature of the cystic spaces is unclear. Allergic Contact Dermatitis to 3-o-Ethyl-L-Ascorbic Acid in Skin-lightening Cosmetics. Post surgery he remained symptom free and showed no sign of jaundice. Obstructive sleep apnoea syndrome (OSAS) is a highly prevalent disease and associated with cardiovascular morbidity and mortality. The photoactive yellow protein (PYP) is the photoreceptor protein responsible for initiating the blue-light repellent response of the Halorhodospira halophila bacterium. In contrast, a pharmacological study indicated that inhibition of PAR-4 was cardioprotective. Immunohistochemical study was performed using the standard EnVision method. The norepinephrine transporter (NET) mediates reuptake of released catecholamines, thus playing a role in the limitation of signaling strength in the central and peripheral nervous systems.

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Significant differences in estradiol secretion were not detected following reproductive experience. Germinal centres are areas of B lymphocytes proliferation that appear in primary lymphoid follicles after immunization. We have completed a comprehensive review of studies that have investigated prognostic biomarkers in either the blood or cerebrospinal fluid (CSF) of animals and humans following SCI. Total scalp avulsion is a rare but severe injury frequently ending in hair loss, and one that can even be life-threatening. Distribution and structure of the population in the Spanish Empire, 1750-1810: the joint Syracuse-Oxford project. The analysis shows that the exponential hindered settling forms, which are most commonly used in traditional SST models, not only account for hindered settling but partly lump other phenomena (compression) as well. Vision and change in biology undergraduate education: Vision and change from the funding front. Electrical and structural characterizations of the GZO thin films were carried out by 4-point probe, Hall measurement, and scanning electron microscopy, and the effects of the pretreatment on the improved properties of GZO thin films were discussed. Risk factor data, including cholesterol and blood pressure measures, were used to create a summary effectiveness outcome, the 10-year probability of developing coronary heart disease (CHD).

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Effects of nifedipine on left ventricular distensibility, relaxation and filling dynamics during pacing-induced myocardial ischemia. Also, the reactivity of anti-Nfasc155 antibodies from these patients was abolished in neurofascin-deficient mice, confirming that the antibodies specifically target paranodal proteins. We compare model predictions to the body-size distribution of piscivorous and herbivorous fishes found on tropical reefs worldwide. In most cases, the significance of binding of the 14-3-3 protein is not known. This study is concerned with social problems related to urbanization in Hungary over the past 20 years. In vascular tissues, angiotensin II is potentially cleaved from angiotensin I by chymase and angiotensin-converting enzyme (ACE). We also studied the gene regulation of HD by analyzing the real whole-genome transcription data of 647 individuals. The studies revealed no significant effect of all visual works in patients with normal tear secretion. Herein, a wheat ADF gene, TaADF4, was identified and characterized.

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Promising, early randomized-controlled trials were followed by a mixed field of positive and negative studies that may serve as a whole to prove that NADA, despite its apparent simplicity, is neither a reductive nor an independent treatment, and the need to refine the research approaches. The afternoon surge of leutinizing hormone (LH) in the plasma of ovariectomized, estradiol-treated rats was advanced by 2 hr after 7 days of treatment with CrMP (4 micro M/kg), and this effect was reversed when hemin (30 micro M/kg) was co-administered with CrMP. Who should have a routine early invasive approach after fibrinolytic therapy?. Why do divalent metal ions either promote or inhibit enzymatic reactions?. End-product control of acetohydroxyacid synthetase by valine in Penicillium chrysogenum Q 176 and a high penicillin-yielding mutant. Evidence of a serologic relationship between Ehrlichia canis and Rickettsia sennetsu. Menstrual blood loss in IUD users: comparative study of eleven different IUDs in Mexican women. In each, the SCAD caused a fresh myocardial infarct, and balloon angioplasty with stenting successfully restored the true lumen of the dissected artery. After guide pin placement, the lateral aspect of the knee was dissected, and the proximity of each guide pin to the important lateral anatomic structures was measured. The unique opportunity this data set affords is an overview of the relationship between intelligence and fertility for a nationally representative sample of Americans whose major reproductive years fell between 1912 and 1982.

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This review summarizes the construction of diverse hybrid nanogels and multicompartment nanogels. Clinical symptoms were evaluated with the Beck Depression Inventory-II, the State-Trait Anxiety Inventory-Form JYZ (STAI-JYZ), and the Maudsley Obsessive Compulsive Inventory. 2nd, one must infer how labor loss effects current rural production. Effects of Temporal Framing on Response to Antismoking Messages: The Mediating Role of Perceived Relevance. Especially during the past decade, clinicians and researchers have paid much attention to peri-implant health and more specifically to the incidence of bone loss. Clinical and biochemical factors associated with preeclampsia in women with obesity. Previous work showed the existence of ecotoxicity of water samples from the Alqueva reservoir due to the presence of the herbicides atrazine, simazine, terbuthylazine and metolachlor. Extra-renal expression of Slc12a2 was examined in 13.5, 15.5, and 16.5 d.p.c. The protocol which was audited required a bolus of 50 U kg(-1) of FVIII followed by CI at an initial rate of 4 U kg(-1) hr(-1).

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Slight improvements in PEM performance in association with medication correlated positively with dose of medication and with medication-related improvements in behavior. Redox control of growth factor signaling: recent advances in cardiovascular medicine. No obvious changes by 8 weeks in these parameters were found in eyes in which the lacrimal glands had been injected with nonstimulated PBLs or in the lacrimal gland-excised eyes contralateral to normal eyes. A new method is proposed to utilise a priori information when the type of flow is known beforehand. The meeting participants examined 4 case studies on the issue of RTI and STDs in the context of family welfare programs. The mechanism of catabolite repression in KKS102 is explained in terms of inhibition of activation by BphQ. If any sterilization acceptor dies within 10 days of the operation Rs 5000 will be paid regardless of the actual cause of death. The phantom consisted of a water-filled balloon (cyst) suspended in varying concentrations of iodine solution, meant to simulate varying levels of renal enhancement. Peptide mimics isolated from phage display peptide libraries by panning with self-tumor-associated Ag (TAA)-specific mAbs are being evaluated as immunogens to implement active specific immunotherapy.

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A comparison of the mono- and diphosphonucleotides of a group C Streptococcus and its rough variant. Higher 1-week survival rates in the heparin, LY294002, and glucagon groups confirmed the dysregulation of the pathway. After excluding 133 patients with metastatic disease or under palliative radiation treatment, 108 patients were discovered appropriate for OT. The rates of the disappearance of FXIIIA chain and the appearance of its activated form (FXIIIAa) in sequential 30-second blood samples collected at the site of microvascular injury were what not to mix with differin gel compared in 14 healthy carriers of the Leu34 allele and 23 Val34 homozygotes both before and after a 7-day aspirin ingestion (75 mg/d), with the use of quantitative Western blotting. Accuracy of cone beam computed tomography for periodontal defect measurements. A small number of Fourier components, corresponding to the time scale of the respective occlusion-release cycle, was sufficient to study the long wavelength behavior. Calvarium is a frequent target site of involvement for common neoplasms. While fertility has been declining, so also has mortality, though there is a great variation in levels and trends among regions and individual countries. Sorption of albumin was studied in model experiments in order to determine the optimal pore structure of carbon haemosorbents. The specific interactions (hydrogen bonds) between DNA origami and the translocating DNA strand yield different residence times and ionic currents.

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Core occupational therapy beliefs and assumptions are strikingly similar to those purported to be important to fostering recovery. Ileus following radiotherapy: importance and therapeutic aspects of surgery for late radiation injuries of the intestine. Thirty-eight appear novel, 26 in COL1A1, and 12 in COL1A2, and these are described here. Reinforcement was then introduced in the presence of darkness (Phase III). The aim of this study was to define the precise influence of the glucose tolerance status on plasma leptin in obese boys and girls separately. The small GTPase Arf6 regulates a recycling branch of short dynamic tubular intermediates used by major histocompatibility class I (MHC-I) molecules to traffic through vesicles between endosomes and the plasma membrane. This article surveys the history of official initiatives to standardize international migration statistics by reviewing the recommendations of the International Statistical Institute, International Labor Organization, and the UN, and reports a recently proposed agenda for moving toward comparability among national statistical systems. By means of intravesical and intrauterine manometry, and electromyography (EMG) of intercostal muscles, we quantified these forces in 21 women during vaginal delivery.

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Total elastase activity was measured by generation of free amino groups from succinylated elastin. Pre-treatment with Efb resulted in a significant prolongation of bleeding time in a mouse model. The purpose of this study was to investigate whether inhibition of ROCK can suppress apoptosis of the corneal endothelium and to determine the role of ROCK signaling in regulating apoptosis. Preference for the larger reward changed systematically as delays increased in all conditions, decreasing for the 6:1, 3:1, and 3:2 ratios, and increasing for the 1:1 ratio. This communication summarizes the procedures that enabled isolation of adult murine thymic stromal cell lines that naturally express Notch ligands Jagged-1 or Delta-1. On examination she did not have classical signs of dengue fever and was found to have bilateral papilledema on fundus examination. Study of radial die-wall pressure changes during pharmaceutical powder compaction.

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The close similarity of lesions of the human and equine diseases suggests that EI may be caused by a laminin-5 defect. New Series of BPL Inhibitors To Probe the Ribose-Binding Pocket of Staphylococcus aureus Biotin Protein Ligase. The failing right heart: implications and evolution in high-risk patients undergoing transcatheter aortic valve implantation. Lipolysis generates platelet dysfunction after in vivo heparin administration. The priorities of the Czech Family Planning Association, therefore, are to identify target groups of women who do not use contraception and to increase the effectiveness of sex education. Trapped positive charges in the molecular junction correlate with high conduction in a feature showing negative differential resistance. Attitudes toward condoms as AIDS prophylaxis in homosexual men: dimensions and measurement. The character of the microflora, its antibiotic sensitivity, the titers of lysozyme and beta-lysines, the phagocytic activity of the leucocytes and the number of the T-cells were studied in 52 patients with chronic osteomyelitis before and 5-8 days after the treatment with antibiotics or their combinations with proteolytic enzymes. Bunyamwera virus (BUN) is the prototype virus of the family Bunyaviridae.

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Acquired resistance was associated with a pattern of pericyte-covered, normalized revascularization, whereas tortuous, uncovered vessels were observed in relative primary resistance. This review describes the daily fluctuations of concentrations or excretions of haematologic, clinical chemical and endocrinological para que es el minocycline 100 mg parameters. Ocular Reconstruction Using Bone-Anchored Implants in Irradiated Facial Deformities After Tumor Extirpation. cDNA microarrays (19,200 human genes) and a clustering algorithm were used to identify patterns of gene expression in the crypt-like proliferative HIEC and tsFHI cells, and villus epithelial cells as well as Caco-2/15 cells at two distinct stages of differentiation. Interventions for treating the posterior interosseus nerve syndrome: a systematic review of observational studies. Moreover, these probes can only be used for 1-2 weeks because of their short isotopic half-life and radiolysis. The elimination of HCV has been reported to be beneficial for asthmatic patients with HCV infection. The kinetic isotope effect (KIE) experiments indicated a typical secondary isotope effect in this process. For the predictions to offer effective decision support they need to be accurate and above all safe. We explain these relations using simple arguments based on polymer dynamics and the equilibrium properties of polymers.

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It has been suggested that nano-HAp may be an ideal biomaterial due to its good biocompatibility and bone integration ability. The author examines trends in the life courses of Japanese women born between 1890 and 1930 according to the occurrence and timing of marriage, childbearing, and death. Patients affected by COPD were studied during acute exacerbation that required hospital admission and 3-4 months after oxygen therapy. The authors trace the history of hospitalists in psychiatry and argue that this model can fit well with the clinical and teaching mission of the modern academic psychiatry inpatient program. Effect of large doses of L-DOPA on the cerebral electrical activity of rabbits (interaction with the metabolism of 5-HT). It is worth noting that the resulting polymeric monolith exhibits great potential as a useful alternative of commercial immobilized artificial membrane (IAM) columns for in vitro predication of drug-membrane interactions.

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In spite of effective hemodialysis procedures pamelor 20 mg cleared patient blood the erythrocyte activities of superoxide dismutase (SOD), glutathione peroxidase (GP) were lower than in healthy controls and hemodialysis procedure insignificantly influenced enzyme activities. Although many other roles have been proposed, the physiological function is still unclear. Modern follow-up studies indicate that, in spite of the efficacy of pharmacotherapy, relapse and recurrence rates in some depressed patients remain high. Prolonged (24h and 48h) exposures to cixutumumab reduced IGF-IR expression. However, it must be borne in mind that any such measure serves only as an indicator of the functioning of a very complex system. The prevalence of MP infection between the two groups was compared. Clopidogrel-associated thrombotic thrombocytopenic purpura presenting with coronary artery thrombosis. A comprehensive reevaluation of the G protein alpha subunit genes specifically expressed in taste buds in the tongue epithelium of rodents revealed that Gq and G14 of the Gq class and Gi2 and Ggust (Gt3, also known as gustducin) of the Gi class are expressed in mammalian taste buds. Purification and characterization of Escherichia coli DNA polymerase V.

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Effect of blood transfusion on skin allograft survival in immunosuppressed mice. New agents have been developed that are capable of providing rapid reversal of the anticoagulation effect of NOACs. This paper critically reviews the effectiveness of adolescent family planning programs in the United States. Recently, the pericardial space has been under consideration as an ideal site for prevention and treatment of coronary artery and heart disease. Among other things, this Act amends the US Civil Rights Act of 1968 to extend protections against discrimination based on familial status to include pregnant women and clomipramine medication classification scale adopting parents. We postulate that the production of cartilage within this neoplasm most likely resulted from the metaplastic transformation of preexisting mesenchymal elements within the tumor or from multipotential neural crest-derived ectomesenchymal cells.

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The task in the smaller pool habituated their flight response to the platform. Characterization of a second-generation focal-plane camera coupled to an inductively coupled plasma Mattauch-Herzog geometry mass spectrograph. Donor remnant liver was significantly reduced after RH compared with LH and LL. A rather simple method for determining the optimum temperature of cell division and growth is based on the analysis of root growth rate. Comprehensive genomic sequencing (CGS) has the potential to revolutionize precision medicine for cancer patients across the globe. The objectives of this study were to evaluate the intra- and inter- what is the maximum daily dose of glyburide observer reliability of lower limb alignment measures manually obtained from hard copy radiographs versus using the Philips Easy Vision system, and to assess the subjective ease of use for the two methods. Statistical methods have been described for the identification of statistically significant differences and associations between an experimental group and a control group or over the course of time after an intervention. The primary outcome of the study was to improve patient satisfaction scores based on physician communication-related questions from Consumer Assessment of Healthcare Providers and Systems (CAHPS) surveys.

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During the 1980s, journals and academic texts in the US debated the so-called black underclass disregarding the effects of Reaganomics: increasing poverty, homelessness, ill health, and unemployment, which affected young African-American women. Recently, another stool antigen test, the Apollo test, was developed, but its accuracy has rarely been validated. Comparison of multiple injections with continuous infusion of tritiated thymidine, and estimation of the cell cycle time. Dialkylaminoalkyl chlorides, valuable chemical manufacturing intermediates, were evaluated for their mutagenicity in several short-term assays: The concentration gradient bacterial mutagen assay, the Ames test, the L5178Y mouse lymphoma cell assay, and the hepatocyte primary culture-DNA repair test. However, imported or import-associated cases of measles have sporadically occurred during this time. Successful revascularization of totally ischemic bronchial autografts with omental pedicle flaps in dogs.

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In this study, we analyzed the TCR V beta 1-20 gene repertoire by reverse transcription-polymerase chain reaction (RT-PCR) in peripheral blood lymphocytes (PBLs) from individuals vaccinated with recombinant hepatitis B vaccine and PBLs from healthy donors stimulated by supernatants of the HepG2 2215 cell line transfected by HBV-DNA. We conducted in-depth interviews with 45 purposively sampled participants in the ClaSS project using a checklist of topics relating to their experiences of the screening process. Liver function tests profile in cancer patients on cytotoxic chemotherapy: a preliminary report. beta-Thalassemia trait is not a contributing factor for osteopenia/osteoporosis in children and young adults. Musidunin and musiduol, insect antifeedants from Croton jatrophoides. All these patients had completion thyroidectomy and subsequently presented with elevated serum Tg but negative post-therapy I-131 whole body scans. Frequently the highly technical style of research reports renders them unreadable to the average policy maker or planner. Adaptive variation tends to emerge clinally along environmental gradients or discretely among habitats with limited connectivity.

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