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Glyburide (Glibenclamide)
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Glyburide

Glyburide belongs to the class of drugs known as sulfonylureas. It lowers blood sugar by causing the release of your body's natural insulin. Glyburide is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. It may also be used with other diabetes medications..

Other names for this medication:
Afdiex, Aviglen, Benclamet, Benformin, Betanase, Betrol, Bionil, Codica, Combidos, Comdiab, Daocon, Daonil, Diabetnil, Diabetrol, Diabnil, Diolin, Duotrol, Dutrol, Euglucon, Glibact, Glibenclamide, Glibet, Glime, Glimsug, Glinil, Gluconil, Glucored, Glucosafe, Glucotrac, Glunil, Glutowin, Glybenclamide, Glybonil, Glyboral, Glybovin, Glybovine, Glymep, Metclam, Metica, Monomet, Pionorm, Secrin, Sugnil, Sugnl, Sugronil, Sycored, Symet, Triglucored, Triglycomet

Similar Products:
Aldara, Imovane, Crestor, Clozaril, Parlodel, Lamisil, Myambutol, Cordarone, Maxalt, Zanaflex

Also known as: Glibenclamide

Description

Glyburide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels.

Glyburide and metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. glyburide and metformin is not for treating type 1 diabetes.

Dosage

Take glyburide, micronized exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Carefully follow the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.

Do not change to another brand without checking with your doctor. The number of tablets that you take depends on the brand and strength of the medicine. If you refill your medicine and it looks different, check with your pharmacist.

The dose of glyburide, micronized will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of glyburide, micronized. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For type 2 diabetes: For oral dosage form (micronized tablets): Adults—At first, 1.5 to 3 milligrams (mg) once a day taken with breakfast or the first main meal. Some patients may start at 0.75 mg per day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 12 mg per day. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glyburide overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

Side effects

The most common side effects associated with Glyburide are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use glyburide if you are allergic to it, or if:

you are being treated with bosentan (Tracleer); you have type 1 diabetes; or you have diabetic ketoacidosis (call your doctor for treatment).

Tell your doctor if you have ever had:

hemolytic anemia (a lack of red blood cells); an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD); a nerve disorder affecting bodily functions; liver or kidney disease; or an allergy to sulfa drugs.

Before taking glyburide, tell your doctor if you have taken another oral diabetes medicine or used insulin during the past 2 weeks.

Glyburide may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Tell your doctor if you are pregnant or breastfeeding.

Follow your doctor's instructions about using glyburide if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

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Youths from 41 community-based agencies in greater New York City participated in a randomized trial of a skills-based interactive CD-ROM. Oral surgical management of patients with mechanical circulatory support. Considering the six diagnostic levels instead, the reliability was higher for the neurologists participating in the IMS program. Six subjects were taught nine AB-C and three C-D relations and were then tested for nine AB-D (transitive) relations. Altogether, our data facilitate further engineering of the biotechnologically valuable dcAvd scaffold and gives insights into how to guide the quaternary structure assembly of oligomeric proteins. Whilst, for coeliac disease patients with persisting diarrhoea (on a gluten-free diet) in the absence of sinister symptoms, a flexible sigmoidoscopy may be the initial investigation in order to exclude microscopic colitis. A layer of columnar odontoblasts surrounded the outer surface of each denticle. City size distributions and urban density functions: some interrelationships. Many transgenic mouse models have been generated by manipulating growth factors and their receptors, cell cycle regulators, signal transduction pathways, cellular differentiation, oncogenes and tumor suppressor genes. Here, we developed rapid, easy-to use, and cost-effective new rat animal model for invasion and metastasis of cancer using genetically k-ras-induced rat kidney cells (RK3E-ras).

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