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Glyburide (Glibenclamide)

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Glyburide belongs to the class of drugs known as sulfonylureas. It lowers blood sugar by causing the release of your body's natural insulin. Glyburide is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. It may also be used with other diabetes medications..

Other names for this medication:
Afdiex, Aviglen, Benclamet, Benformin, Betanase, Betrol, Bionil, Codica, Combidos, Comdiab, Daocon, Daonil, Diabetnil, Diabetrol, Diabnil, Diolin, Duotrol, Dutrol, Euglucon, Glibact, Glibenclamide, Glibet, Glime, Glimsug, Glinil, Gluconil, Glucored, Glucosafe, Glucotrac, Glunil, Glutowin, Glybenclamide, Glybonil, Glyboral, Glybovin, Glybovine, Glymep, Metclam, Metica, Monomet, Pionorm, Secrin, Sugnil, Sugnl, Sugronil, Sycored, Symet, Triglucored, Triglycomet

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Aldara, Imovane, Crestor, Clozaril, Parlodel, Lamisil, Myambutol, Cordarone, Maxalt, Zanaflex

Also known as: Glibenclamide


Glyburide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels.

Glyburide and metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. glyburide and metformin is not for treating type 1 diabetes.


Take glyburide, micronized exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Carefully follow the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.

Do not change to another brand without checking with your doctor. The number of tablets that you take depends on the brand and strength of the medicine. If you refill your medicine and it looks different, check with your pharmacist.

The dose of glyburide, micronized will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of glyburide, micronized. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For type 2 diabetes: For oral dosage form (micronized tablets): Adults—At first, 1.5 to 3 milligrams (mg) once a day taken with breakfast or the first main meal. Some patients may start at 0.75 mg per day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 12 mg per day. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glyburide overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

Side effects

The most common side effects associated with Glyburide are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use glyburide if you are allergic to it, or if:

you are being treated with bosentan (Tracleer); you have type 1 diabetes; or you have diabetic ketoacidosis (call your doctor for treatment).

Tell your doctor if you have ever had:

hemolytic anemia (a lack of red blood cells); an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD); a nerve disorder affecting bodily functions; liver or kidney disease; or an allergy to sulfa drugs.

Before taking glyburide, tell your doctor if you have taken another oral diabetes medicine or used insulin during the past 2 weeks.

Glyburide may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Tell your doctor if you are pregnant or breastfeeding.

Follow your doctor's instructions about using glyburide if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

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Deductions in formal serology, demonstrated on Helix agglutinine. The results, on the other hand, showed that the large increase in the influx of illegal immigrants is macroeconomically beneficial, having significant adverse distribution implications when flexible wage adjustment is assumed in various labor markets. The pH-sensitive precursor (Dex-MA) was synthesized by reacting dextran with maleic anhydride in the presence of triethylamine catalyst. Superinfection of Laodelphax striatellus with Wolbachia from Drosophila simulans. This case report supports the idea that sulcus placement of the anterior IOL helps to prevent interlenticular opacification. We found that in addition to bacillus Calmette-Guerin therapy a prolonged interval free of disease and better performance status had a better prognosis. A comparison of fatigue crack growth in resin composite, dentin and the interface. Toxicity study of maternal transfer of polychlorinated biphenyls and diethyl phthalate to 21-day-old male and female weanling pups of Wistar rats. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. The interpretation of this data to extract actionable information is one of the keys to developing novel therapeutic strategies to treat complex diseases.

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Use of subcutaneous recombinant human erythropoietin in children undergoing continuous cycling peritoneal dialysis. Determination of the appetite suppressant P57 in Hoodia gordonii plant extracts and dietary supplements by liquid chromatography/electrospray ionization mass spectrometry (LC-MSD-TOF) and LC-UV methods. During atrial test stimulation a 2 degree AV block occurred at a rate of only 110/min and dual-chamber provision was thus necessary. When comparing serum PSA levels expressed as a fraction of the baseline PSA, Caucasian and African-American patients demonstrated similar rates of metabolism. The early identification and treatment of vulnerable populations with risk factors for suicide across the lifespan will help in planning and implementing strategies for prevention. Amplitude- and phase-resolved ultrafast transmission experiments directly reveal the coherent coupling between surface plasmon polaritons (SPPs) induced by periodic variations in the dielectric function. Duration and progress through each phase varied slightly for individual nurses. Retinal sensitivity was evaluated by electroretinography at 11.00 h. They provide detailed neuroanatomical evidence to support previous observations showing the contribution of these neurochemical systems in the neural, behavioral and endocrine response to isotonic BVE.

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Ancient host-pathogen associations maintained by specificity of bactrim dosing based on trimethoprim chemotaxis and antibiosis. The turning point of the learning curve of 3D laparoscopic hysterectomy and pelvic lymphadenectomy is earlier than that of robotic sugery in patients with cervical cancer, and there is no obvious benefit from robotic surgery than 3D surgery in the terms of short-term medical index and hospitalization cost. Timing of introduction of gluten into the infant diet is associated with the appearance of CDA in children at increased risk for the disease. In all groups, LH was low from Days 16 to 20 of gestation, and then rose progressively through birth, i.e. An exponent higher than 2 for serial sensitive structures can effectively reduce the maximum dose. Toward a better understanding of ADHD: LPHN3 gene variants and the susceptibility to develop ADHD. COX7A2L/SCAFI and Pre-Complex III Modify Respiratory Chain Supercomplex Formation in Different Mouse Strains with a Bcs1l Mutation. Individuals in the iPGY1 group took a Web-based course on infection control practices. wedges of tunica albuginea to be excised to correct an individual deformity.

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In both men and women, statin remained inadequately used, and low HDL cholesterol level was a major lipid abnormality. Right ventricular dysfunction in septic shock: assessment by measurements of right ventricular ejection fraction using the thermodilution technique. Changes in DNA methylation patterns with age frequently have been observed and implicated in the normal aging process and its associated increasing risk of disease, particularly cancer. Regular arrays of freestanding single carbon nanotubes (CNTs) were prepared on Ni dot arrays by dc plasma-enhanced chemical vapour deposition. This technique involves the purification of endogenously formed RBP-mRNA complexes with specific antibodies from cellular extracts, followed by the identification of associated RNAs using DNA microarrays. Upper gastrointestinal (GI) endoscopy and contrast study confirmed its communication with the stomach. Multiple primary cutaneous plasmacytoma a decade after a nasal solitary extramedullary plasmacytoma: a puzzling case. We used a syngeneic pseudo-orthotropic mouse model of prostate cancer to test the efficacy of combining androgen withdrawal with FDA-approved COX-2 inhibitor celecoxib.

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Review of knowledge on care of patients with cardiovascular problems. Functional and Anatomical Relations of Taste, Olfaction, and Somatic Sensibility. The clinical benefit of Nitillium clips was demonstrated even in patients with several risk factors for SWC. We detected complete loss of HLA class I antigen presentation for 2 tumor cell lines from 1 melanoma patient, the first originated from a regional lymph node lesion diagnosed simultaneously with the primary tumor and the second established 8 months later from a metastatic pleural effusion sample. Effects of antiplatelet therapy and oral anticoagulation on indices of endothelial damage/dysfunction in patients with systolic heart failure in sinus rhythm.

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