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Glucophage

Glucophage is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. It is not associated with weight gain and is taken by mouth.

Other names for this medication:
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Also known as: Metformin

Description

Glucophage XR is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Glucophage XR is sometimes used together with insulin or other medications, but this medicine is not for treating type 1 diabetes.

Dosage

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take MetFORMIN (Eqv-Glucophage XR) with a meal, unless your doctor tells you otherwise. Some forms of MetFORMIN (Eqv-Glucophage XR) are taken only once daily with the evening meal. Follow your doctor's instructions.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Some tablets are made with a shell that is not absorbed or melted in the body. Part of this shell may appear in your stool. This is normal and will not make the medicine less effective.

You may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).

Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

MetFORMIN (Eqv-Glucophage XR) is only part of a complete treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

Store at room temperature away from moisture, heat, and light.

Your doctor may have you take extra vitamin B12 while you are taking MetFORMIN (Eqv-Glucophage XR). Take only the amount of vitamin B12 that your doctor has prescribed.

Detailed Metformin dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Glucophage are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Glucophage XR if you are allergic to it, or if you have:

severe kidney disease; or metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment).

If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Glucophage XR. Be sure your caregivers know ahead of time that you are using this medication.

Tell your doctor if you have ever had:

kidney disease (your kidney function may need to be checked before you take this medicine); high ketone levels in your blood or urine; heart disease, congestive heart failure; liver disease; or if you also use insulin, or other oral diabetes medications.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

Glucophage XR may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while using this medicine.

Glucophage XR should not be given to a child younger than 10 years old. Some forms of metformin are not approved for use by anyone younger than 18 years old.

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Endothelin type A receptor blockade reduces vascular calcification and inflammation in rats with chronic kidney disease. Genome-wide analysis of differentially expressed lncRNAs and mRNAs in primary gonadotrophin adenomas by RNA-seq. This study presents data from three women drawn from a larger study of women who had been diagnosed under the age of 45 and had completed their treatment for breast cancer. Involvement of hypothalamic pituitary adrenal axis on the effects of nifedipine in the development of morphine tolerance in rats. Growth inhibition by connexin26 expression in cultured rodent tumor cells. Electron microscopic study of differentiation of antibody-producing cells in mouse lymph nodes after immunization with horseradish peroxidase. Ninth International Congress of Haematology: NOMENCLATURE OF ABNORMAL HAEMOGLOBINS. An adverse effect on the lipid profile has been identified which appears to be mostly associated with oral methyltestosterone. Preliminary comparison of continuous versus noncontinuous programming and attitude toward and recall of advertisements. In contrast, fibrillar fibronectin was reduced or absent on surfaces of late-passage cells.

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Contraceptive use--efficacy study utilizing medroxyprogesterone acetate administered as an intramuscular injection once every 90 days. The virtual endoscopic images supported prior clinical decision making in 6 of the 11 cases evaluated. When a child is diagnosed with a life-threatening or life-limiting condition, their physical and affective world is immediately changed, regardless of the outcome of treatment. However, when ventolin hfa is brand or generic BDNF was applied 45 min after a brief (2 min) depolarizing KCl (10 mM) pulse or when the adenosine A(2A) receptors were activated with CGS 21680 (10 nM), BDNF (20 ng/ml) increased EPPs amplitude without influencing the resting membrane potential of the muscle fibre. Cost-of-illness study of pneumococcal disease in Italian children.

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All patients had the first CT after 6 months, followed by yearly CT controls. In vitro, demethylating agents given at low doses reactivate tumor suppressor genes, and in mouse models, the development of lung cancer can be retarded. It was found that when rates of reinforcement were equal in the two components, the rate of response in the variable-ratio component was nearly twice that in the variable-interval component. The coupling mechanism between the HF stretching and H(2)O bending vibrations observed in the infrared spectra of HF:H(2)O binary amorphous solids is analyzed using a simple cluster model. Efficacy of Subcutaneous Electrocardiogram Leads for Synchronous Timing During Chronic Counterpulsation Therapy. Preferential induction of autoantibody secretion in polyclonal activation by peptidoglycan and lipopolysaccharide.

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Advancing targeted co-stimulation with antibody-fusion proteins by introducing TNF superfamily members in a single- can bactrim treat a yeast infection chain format. Metabolic clearance and production rates of human growth hormone. Lumbar sympathectomy under CT guidance: therapeutic option in critical limb ischaemia. Even in high concentrations alcohol does not significantly interfere with kidney cell function. Pharmaceutical management in MS is complicated by the numerous secondary impairments in MS and its associated polypharmacy.Head-to-head studies of the various agents are rare. Mass spectrometry analysis of full-length EBP50 and phosphorylation analyses of specific domains, and of mutated or truncated forms of EBP50, indicated that PKC-induced phosphorylation of EBP50 occurred on the Ser337/Ser338 residue within the carboxyl-tail domain of the protein. This cross-sectional survey among GP trainees and young GPs examined 1.

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MicroRNAs are small non-coding RNAs which play significant role in RNA interference. Immunodetection at the light and electron microscopical level shows unequivocally that the heterologous phytase is deposited in the vacuole, albeit that the transformation constructs were designed for secretion to the apoplast. A perturbation-based framework for link prediction via non-negative matrix factorization. Gastric cancer in the Lebanese population is characterized by aggressive features such as advanced stage at diagnosis, high prevalence of diffuse type histology, and HER2 positivity. 3 of the 4 women who developed toxic shock syndrome while using a Today contraceptive sponge had their sponges in place for over 30 hours. Inactivation of rat liver cytochrome P-450 by the suicide substrates parathion and chloramphenicol. The only available drugs that directly target the levaquin family antibiotic underlying vascular features driving nasal obstruction are the sympathomimetic alpha-adrenoceptor agonists due to their vasoconstrictor action. Effluents were collected at 15, 30, 45, and 60 minutes and then at hourly intervals up to seven hours. Future research should be done with existing, generic HRQL instruments and with strict study inclusion criteria.

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