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Geodon (Ziprasidone)

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Geodon is used in the treatment of schizophrenia (a mental disorder that can result in hallucinations or delusions and also adversely affects a person’s ability to think and behave) and mania.

Other names for this medication:
Azona, Ziprasidone, Zipsydon

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Also known as: Ziprasidone


Ziprasidone injection is used to treat agitation that occurs with schizophrenia. It should not be used to treat behavioral problems in elderly patients who have dementia. Ziprasidone works by changing some of the chemicals in the brain that cause schizophrenia.

This medicine is to be given only by or under the direct supervision of your doctor.


A nurse or other trained health professional will give you this medicine in a clinic or hospital setting. This medicine is given as a shot into one of your muscles.

Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Detailed Geodon dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include cause excessive sleepiness, slurred speech, high blood pressure, shaking, tremors, or anxiety.

While you are taking Geodon, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking this medicine.

Geodon may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or severe drowsiness can cause falls, fractures, or other injuries.

Avoid drinking alcohol. Dangerous side effects could occur.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Geodon are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Geodon if you are allergic to ziprasidone, or if you have:

a heart rhythm disorder; a personal or family history of long QT syndrome; uncontrolled or untreated heart failure; or if you have recently had a heart attack.

Geodon is not approved for use in psychotic conditions related to dementia. Ziprasidone may increase the risk of death in older adults with dementia-related psychosis.

Geodon should never be taken together with any of the following drugs, or a life-threatening heart rhythm disorder could occur:

anagrelide; methadone; tacrolimus; certain anti-nausea medicines including dolasetron, droperidol, or ondansetron; the antibiotics azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, and pentamidine; certain cancer medicines such as arsenic trioxide and vandetanib; the antidepressants citalopram, escitalopram; anti-malaria medications including chloroquine, halofantrine, mefloquine; the following heart rhythm medicines - amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, quinidine, sotalol; or certain anti-psychotics such as chlorpromazine, haloperidol, mesoridazine, pimozide, and thioridazine.

This list is not complete and there may be other drugs that should not be taken at the same time as Geodon. Tell your doctor about all medicines you use.

To make sure Geodon is safe for you, tell your doctor if you have ever had:

any heart problems; a heart attack or stroke; a bone marrow or blood cell disorder; breast cancer; low blood levels of potassium or magnesium; diabetes (ziprasidone may raise your blood sugar); seizures or epilepsy; suicidal thoughts; Alzheimer's disease; trouble swallowing; liver disease; or kidney disease.

Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Geodon, do not stop taking it without your doctor's advice.

It is not known whether ziprasidone passes into breast milk or if it could harm a nursing baby. Talk to your doctor about Geodon if you are planning to breastfeed.

Older adults may be more sensitive to the effects of this medicine.

Geodon is not approved for use by anyone younger than 18 years old.

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