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Epivir (Lamivudine)
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Epivir

Epivir is a nucleoside reverse transcriptase inhibitor (NRTI). It inserts itself into the virus's DNA by pretending to be a DNA building block, but actually stops the DNA-making process. When this happens, the virus can't make copies of itself in your body.

Other names for this medication:
Abamune, Combivir, Duovir, Emduo, Emtri, Haptavir, Hepavud, Hepitec, Hepravir, Hivir, Ladiwin, Lamidac, Lamistar, Lamivir, Lamivox, Lamivudine, Lamostad, Lamuvid, Lavir, Lazid, Lmivir, Nevilast, Odivir, Retrolam, Shanvudin, Stadin, Stavex, Tenola, Tenolam, Tenvir, Trimune, Trioday, Viramid, Virolam, Virolis, Zidolam

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Also known as: Lamivudine

Description

Epivir HBV is an antiviral medicine that prevents human immunodeficiency virus (HIV) or hepatitis B virus from multiplying in your body.

Epivir is for treating HIV in adults and children at least 3 months old. HIV is the virus that can cause acquired immunodeficiency syndrome (AIDS). Epivir is not a cure for HIV or AIDS.

Epivir-HBV is for treating hepatitis B in adults and children at least 2 years old. Epivir-HBV should not be used in people who are infected with both hepatitis B and HIV.

Dosage

This section provides information on the proper use of a number of products that contain lamivudine. It may not be specific to Epivir A/F. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Epivir® and Epivir-HBV® both contain the same medicine, but Epivir® has more medicine in each tablet or dose of liquid. Use only the brand of this medicine that your doctor prescribed. If you have HIV or AIDS, you need to use Epivir®. If you have hepatitis B but you do not have HIV or AIDS, you can use Epivir-HBV®.

Your doctor may want to test you for HIV before you start using Epivir-HBV® and during your treatment. Your medicine may need to be changed based on these test results.

It is important to take Epivir® as part of a combination regimen. Take all of the medicines your doctor prescribed at the right time of day. This will make your medicines work better.

Keep using lamivudine for the full time of treatment, even if you or your child begin to feel better. Do not stop using it without checking first with your doctor. When your supply of the medicine is running low, contact your doctor or pharmacist ahead of time. Do not allow yourself to run out of the medicine.

If you are using the oral liquid, use a specially marked measuring spoon, dosing syringe, or medicine cup to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (solution or tablets): For treatment of hepatitis B infection: Adults—100 milligrams (mg) once a day. Children 2 to 17 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 3 milligrams (mg) per kilogram (kg) of body weight per day. The doctor may increase your dose as needed. However, the dose is usually not more than 100 mg per day. If your child cannot swallow the tablets, he or she may take the oral liquid. Children younger than 2 years of age—Use and dose must be determined by your doctor. For treatment of HIV infection or AIDS: Adults—300 milligrams (mg) once a day or 150 mg 2 times a day. Children 3 months of age and older— Solution: Dose is based on body weight and must be determined by your doctor. The dose is usually 5 milligrams (mg) per kilogram (kg) of body weight taken 2 times a day, or 10 mg per kg once a day. The doctor may increase your dose as needed. However, the dose is usually not more than 300 mg per day, taken with other HIV medicines. Tablets: Dose is based on body weight and must be determined by your doctor. The dose is usually 150 to 300 mg per day. If your child weighs 14 kg or more, it is preferred that he or she take the scored tablet. Children younger than 3 months of age—Use and dose must be determined by your doctor.

Note: Patients that require treatment for both hepatitis B and either AIDS or HIV should follow the dosing schedule for HIV or AIDS.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Epivir are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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Prostacyclin (PGI2) was given intravenously in doses of 1 to 5 ng/kg/min to eight consecutive patients with end stage peripheral arteriosclerosis and ischaemic ulcers. Microchemostat-microbial continuous culture in a polymer-based, instrumented microbioreactor. The observed spatial variation at small spatial scales may not be sufficient for coexistence, indicating the importance of considering multiple sources of spatial heterogeneity when scaling up from experiments that investigate local interactions to regional patterns of coexistence. The Easterlin-Crimmins (1982, 1985) model was the framework chosen for the examination. In a large cohort of men, average CRF has improved during the last 40 yr with a slight decline in the favorable trend notable in the most recent decade. Training cost and the timing of benefits are critical to the outcome of this analysis. Advocacy in the Western Hemisphere Region: some FPA success stories. The author describes the historical demographic data bases developed in Umea, Sweden, and elsewhere in the Scandinavian countries and their use for the purposes of demographic research and social history.

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A Rare Case of Primary Meningococcal Myopericarditis in a 71-Year-Old Male. The anti-inflammatory effect of low-dose radiotherapy is clinically well described. The medical records of infected patients from January 1, 1995 to June 30, 1999 were reviewed retrospectively. This review discusses the molecular analysis of pharmaco- or toxicogenomic gene expression profiles following exposure to cancer chemotherapeutic and chemopreventive agents. Traditional electrodiagnostic testing in lumbar disc herniation. to describe the coping of stoma patients with the news about the ostomy, as well as to analyze the meaning and the experience of their new bodily reality. Four observations showed cross talk between the three molecules SP-C, LPS, and CD14. The authors describe their experience with the management of giant haemangiomas. It is therefore unlikely that the antibodies in human sera which bind to porcine zonae pellucidae could be a causal factor in infertility in women.

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To evaluate the potential of fetal abdominal circumference (AC) measurement as predictor of perinatal complications in term newborns. Cyclic and linear sweep voltammogram are employed to investigate the electrocatalytic activity of the a-MWCNT/FePc for ORR. To register veterinary medicinal products (VMPs) as parasiticides on pastured animals, legislation in the European Union requires an environmental risk assessment to test the potential nontarget effects of fecal residues on dung-dwelling organisms. The study was carried out with identically fixed and embedded tissue using the peroxidase-antiperoxidase (PAP) technique after primary incubation with a C-terminally directed antiserum (R 501). RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins. These models form part of our effort to generate an anatomic framework of Drosophila larval brain structure required for accurate localization of gene expression and gene function in experimental studies of neural development. The antibody titers of sera determined by this way correlated well with those by IF. Structural studies on layered alkylpyridinium iodopalladate networks. The aim was to demonstrate, using the French pharmacovigilance database (FPVD), that CAMTEA allowed for the reporting of a substantial amount of ADRs, comparable in nature to those provided via spontaneous reporting.

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