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Duphaston (Dydrogesterone)

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Duphaston contains progestin (female hormone) that plays a major role in regulating the menstrual cycles in females. It initiates the normal, regular growth as well as shedding of the womb lining. Duphaston is a man-made version of progesterone, the natural female sex hormone.

Other names for this medication:
Climaston, Dabroston, Didrogesterona, Didrogesterone, Dirogest, Dufaston, Dydrogesteron, Dydrogesterone, Dydrogesteronum, Femaston, Femoston, Femphascyl, Gestatron, Isopregnenone

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Also known as: Dydrogesterone


Generic Duphaston is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, Generic Duphaston has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, Generic Duphaston is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol. Generic name of Generic Duphaston is Dydrogesterone. Duphaston is also known as Dydrogesterone. Brand name of Generic Duphaston is Duphaston.


The dosage schemes below are meant as general recommendations. For optimal therapeutic effect, the dosages are to be adapted to the nature and severity of the disorder. In irregular cycles due to endogenous progesterone deficiency Generic Duphaston 5 to 10 mg is recommended especially in irregular cycles due to shortened luteal phase (ie pre-menopause). Treatment should be repeated for several cycles. In secondary amenorrhoea Administration of Generic Duphaston in combination with an estrogen is usually recommended as in these conditions endogenous progesterone deficiency is nearly always accompanied by estrogen deficiency. 0,05 mg ethinylestradiol is administered each day from the 1st to the 25th day of the cycle, and 5 mg Generic Duphaston is added twice daily from the 11th to the 25th day. Five days after the subsequent withdrawal bleeding, the same is repeated to imitate a natural cycle. In dysfunctional uterine bleeding The symptomatic treatment is aimed at stopping the bleeding and including a subsequent withdrawal bleeding. To stop bleeding: Generic Duphaston 10 mg together with 0,10 mg ethinylestradiol twice daily for 5 to 7 days. To prevent heavy bleedings: Generic Duphaston 5 mg twice daily from day 11 to day 25 of the cycle, if necessary, combined with an estrogen during the first half of the cycle. In post-menopausal complaints If for the symptomatic treatment of post-menopausal complaints estrogens are used (hormone replacement therapy A?A?A? HRT), Generic Duphaston 10 mg is used to counteract the effects of unopposed estrogens on the endometrium. A subsequent withdrawal bleeding is induced. On continuous estrogen therapy: Generic Duphaston 10 mg twice daily during the first 12 to 14 days of each calendar month. On cyclic estrogen therapy: Generic Duphaston 10 mg twice daily during the last 12 to 14 days of the treatment. If you want to achieve most effective results do not stop taking Generic Duphaston suddenly.


If you overdose Generic Duphaston and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Duphaston overdosage: diarrhea, stomach pain, hot and dry skin, confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, and muscle weakness or limp feeling.


Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Generic Duphaston if you are allergic to Generic Duphaston components. It is unknown how Generic Duphaston affects pregnant women or nursing mother. Do not take Generic Duphaston if you have undiagnosed vaginal bleeding or a history of thromboembolic disorders. Be careful with Generic Duphaston if you have cardiovascular, renal or hepatic impairment, diabetes mellitus, asthma, epilepsy and migraine, history of mental depression. Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Some medicines or medical conditions may interact with this medicine. Inform your doctor or pharmacist of all prescription and over-the-counter medicine that you are taking. Do not stop taking Generic Duphaston suddenly.

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Nevertheless, epidemiological, clinical, and some experimental evidence points to the possible role of a bacterium (or bacteria) in the initiation of the autoimmune process that leads to the development of this unique clinical phenotype. Evidences presented here suggest that under Cd stress, GSH accumulation occurred at least partially by enhanced LcMKK gene expression and the ethylene signal transduction pathways might be involved in this accumulation. Individual differences in working memory within a nomological network of cognitive and perceptual speed abilities. Evaluation of family planning activities in the health centers of Latin American Social Security Institutes. In a sensitivity analysis, increased UFC/Cr level and increased UFC/Cr variability predicted increased AD risk an average of 6 years before AD onset. The biosynthesis of aminocoumarin antibiotics requires two acyladenylate-forming enzymes: one for the activation of L-tyrosine as a precursor of the aminocoumarin moiety and another for the linkage of an acyl moiety to the aminocoumarin moiety. A new approach for determining their cellular activity is described, whereby LOOH reduction kinetics are tracked by high performance thin layer chromatography with peroxide-sensitive tetramethyl-p-phenylenediamine detection (HPTLC-TPD).

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Substitution of Usual Perioperative Care by eHealth to Enhance Postoperative Recovery in Patients Undergoing General Surgical or Gynecological Procedures: Study Protocol of a Randomized Controlled Trial. This unique increase could potentially be explained by feedback and interbranch cross-talk signals. High intra-abdominal pressure enhances the penetration and antitumor effect of intraperitoneal cisplatin on experimental peritoneal carcinomatosis. Polymorphism of (Z)-4-bromo-N-(pent-2-enyl)-N-(3-phenylprop-2-ynyl)benzenesulfonamide. PVAc solution in acetone was electrospun under various conditions such as concentration of spinning solution and applied voltage. The double deletion strain is no more sensitive to damaging agents and has no higher spontaneous mutation frequency than the most sensitive single mutant. Hippocampal membranes contain a neurotrophic activity that stimulates cholinergic properties of fetal rat septal neurons cultured under serum-free conditions. In addition, their memory functions were verified by chronoamperometry (CA). To confirm that the transplanted cells were responsible for the correction of hyperglycemia, kidneys containing the transplanted cells were nephrectomized, causing rapid hyperglycemia. Long-term treatment with N-acetylcysteine, but not caloric restriction, protects mesenchymal stem cells of aged rats against tumor necrosis factor-induced death.

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Effective dose of A-bomb radiation in Hiroshima and Nagasaki as assessed by chromosomal effectiveness of spectrum energy photons and neutrons. Comparative study between biochemical and histological methods and image analysis in liver iron overload. These findings suggest that SNAP-29 acts as a negative modulator for neurotransmitter release, probably by slowing recycling of the SNARE-based fusion machinery and synaptic vesicle turnover. We compared the efficacy of an eradication regimen (lansoprazole/amoxicillin/clarithromycin) first or following pretreatment with a PPI. The leucocyte-common antigen (L-CA) from rat thymocytes is a cell surface glycoprotein of 180 000 apparent mol.

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The aim of this study was to examine the extent to which additive genetic, shared environmental and non-shared environmental factors contribute to adolescent and preadolescent sleep problems. Mechanical hypersensitivity, sympathetic sprouting, and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain. The proposed methodology, consisting of dimensionality reduction, predictive modelling, and rule extraction, provides a promising approach to gene expression analysis and disease understanding. To improve the quality of the endometrium following IVF treatment, E2 and progesterone supplementation was added to the usual therapeutic regimen. Health professionals should also be well equipped with all information necessary for appropriate and effective smallpox management in the face of such a bioterrorism attack or the strong potential of one. Marital satisfaction was found to be less important than demographic variables, but more important than socioeconomic variables in explaining fertility variation. PACAP 38 as a modulator of immune and endocrine responses during LPS-induced acute inflammation in rats. Rare clonal karyotypic variants in primary cultures of human breast carcinoma cells.

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Although the micronucleus test did not reveal a genotoxic effect of THQ, in the comet assay the statistically significant increase in DNA damage was observed as compared with the control. Peritoneal lavage may be performed upon these patients but with modifications of technique. TSA and NaB also inhibited osteoclast formation and osteoclast-specific mRNA expression in RAW264 cells stimulated with receptor activator of nuclear factor-kappa B (NF-kappa B) ligand (RANKL). There was no change in cardiac output, proportion of cardiac output delivered to the mammary gland or mammary blood flow 24 hr after the last suckling period. Clinical and molecular remission following reduced intensity conditioning and allogeneic transplantation in a patient with refractory multiple myeloma.

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This study addresses these questions by using the 2006 American Community Survey Public Use Microdata Sample (ACS PUMS). Delivery by caesarean section and avoidance of breast feeding further reduce vertical transmission. Development of a cell-selective and intrinsically active multikinase inhibitor bioconjugate. Using a class of explicit-chain C(alpha) protein models with constant elementary enthalpic desolvation barriers between C(alpha) positions, we show that small microscopic pairwise desolvation barriers, which are a direct consequence of the particulate nature of water, can act cooperatively to give rise to a significant overall enthalpic barrier to folding. Participants were wary of dietary advice and sought consistent, reliable, and up-to-date sources of information to guide food choices. A holistic approach to reach the goal of a balanced population growth, reaching the goals of health for all and a net reproduction rate of unity by the year 2000, the role of nongovernmental organizations, community participation, the 1994 International Conference on Population and Development, and using traditional practitioners in family welfare programs are discussed. A quantitative analysis of selected mutants shows that the yKu complex is necessary for anchoring some telomeres at the nuclear envelope (NE), whereas the myosin-like proteins Mlp1 and Mlp2 are not. Recent work has shown that knowledge attributions affect how people think others should behave, more so than belief attributions do. Differences in the composition and the degree of acetylation of the group A soyasaponins were observed among these samples.

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Nonunion of operatively treated capitellum and trochlear fractures. Survival rates were calculated by Kaplan-Meier product-limit method. Does hydroxyurea inhibit chromosome repair in cultured human lymphocytes?. In addition, the HIC method was capable of monitoring the oxidation status of the CDR Trp, as the oxidation rate of the CDR Trp measured by HIC directly correlated with the results of the peptide maps. The purpose of this study was to examine and compare the exposure of the examiner to radiation during myelography versus radiculography and root block. During a cross-sectional study, an unusual case of ectopic tungiasis in the inguinal area was detected. Extensive macrophage/microglia infiltration and demyelination has developed in RAG1-/- mice infected with this recombinant virus. The effect of pore-water velocity on desorption was also studied at pH 6.0. Advanced-stage melanoma here dismal prognosis, and novel therapeutic approaches are urgently required. Fine mapping of the silencing and methylation-spreading functions to the same regions explains the fact that the silencing factors associated with this region primarily repress the neighboring genes and that methylation occurs as a consequence of silencing.

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An early phase II clinical trial was conducted with 109 primary osteoporotic patients. An evaluation of a clerkship in cardiology for general practitioners. Diagnosing benign and malignant lesions in breast tissue sections by using IR-microspectroscopy. Only 1 Doppler ultrasound was ordered during the 15 admissions compared with scans that are routinely ordered. Techniques to measure unemployment are discussed, using data for Hungary for the period 1890-1991. As a result of the all-year-round exposure to house dust mite (HDM), perennial rhinitis patients never have a clear symptom-free period. The genome sequence of Brassica campestris chrysovirus 1, a novel putative plant-infecting tripartite chrysovirus.

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The level of EMB resistance conferred by particular mutations was measured in vitro and in vivo after EMB therapy by daily gavage in a mouse model of aerogenic tuberculosis. The plasma membrane cholesterol content also was altered by various biochemical means, and the effect on the oxygen gradient was studied. Although fully cyclopropanated methoxymycolates are produced in the mmaA2 mutant, cis-cyclopropanation is impaired, leading to accumulation of unsaturated methoxymycolate derivatives. Estimation of the proportion of cell nuclei in tissue sections falling within tritium-autoradiographic range. To compare norcholesterol uptake and magnetic resonance (MR) signal intensity ratios (SIRs) in characterizing adrenal adenomas to differentiate hypersecreting from nonhypersecreting lesions. The analysis was conducted in patients presumed to have suffered the onset of cirrhosis in 2000, observing the disease evolution and, if applicable, death up to the end of the year 2006. There was weak evidence that increased rates of aggressive incidents prompted course attendance, no evidence that course attendance reduced violence, and some evidence that attendance of briefer update courses triggered small short-term rises in rates of physical aggression. Spontaneous lung metastasis of Lewis lung carcinoma cells, which did not significantly express MK, was significantly less extensive in mice deficient in the midkine gene than in wild-type mice, when the tumor was subcutaneously grown above the thigh. In addition, we demonstrate that introduction of plasmids expressing either the WzyE polymerase or the WzzE chain-length regulator proteins drastically reduces the O16 LPS-complementing activity of WzxE.

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Presence and biosynthesis of putrescine and polyamines in amphibians. The shape evolution of two-dimensional islands through periphery diffusion biased by an electromigration force is studied numerically using a continuum approach. Sural-nerve biopsy specimens showed hypertrophic neuropathy with no superimposed inflammation. Our results indicate integrated involvement of (i) TAG/FA cycling and DNL in WAT, and (ii) hepatic very-low-density lipoprotein-TAG synthesis in the control of blood lipid levels and provision of FA fuels for thermogenesis in cold. The IUDs used were the Cu T 220C, Cu 7, Latex Leaf, Dalkon Shield, Multiload (ML) Cu 250, and the ML Cu 375 and were used on 1992 patients over 34,023 woman-months of use. Where appropriate, a summary relative risk (RR) was calculated for dichotomous data and a weighted mean difference (WMD) or standardised mean difference (SMD) for continuous data. No postoperative wound infection occurred and rapid healing of the surgical site ensued. This effect was not diminished after daily inhalation of nicotine for 90 days. To study the effect of pretreatment with heat stress on ischemia-reperfusion injuries of the limbs in rats.

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The unusual properties of these fusion strains, at variance with our original predictions, have provided us the means to initiate a detailed genetic analysis of the protein export process. Deficiency of plasma prostacyclin or PGI2 regenerating ability in sickle zithromax 500 mg tabs cell anaemia. Radioisotope diagnostic methods in the conditions of a country hospital. based on sucrose metabolism in submerged cultures and its comparison with phylogenetic tree. Spatiotemporal Changes of Calcitonin Gene-Related Peptide Innervation in Spinal Fusion. Family planning centers with their large numbers of patients should be a help in solving these problems but other specialists are needed also. Protein C activity and antigen in premature and fullterm newborn infants.

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Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bicyclic arginine surrogates. Subdural hygroma as a complication of endoscopic neurosurgery--two case reports. Viruses must create a suitable cell environment and elude defense mechanisms, which likely involves interactions with host proteins and subsequent interference with or usurpation of cellular machinery. A simple, reproducible, and micro quantity method is described to measure the antibody against glycolipid antigens. The three agents did not show an effect on cholesteryl ester formation by cholesterol esterase (CEase). Increase in life expectancy at birth in Japan: some implications for variable patterns of decrease in mortality. How should best strategy and tight control be translated into clinical practice?.

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Among secondary school children (13-14 year), the prevalence of a negative body image and of weight loss behaviour was high, especially for girls. In some cases culturing of HPLs pretreated with MNU or TRN in the presence of EMFs led to significantly higher frequencies of SCEs when compared to cells cultivated in the absence of EMFs. The present study revealed that from 11 to 15 post-graduate years was the most productive time for Japanese urologists as the first author of urological publications and also that the role in manuscript preparation changed with increases in physician years. Structure, function, and degeneration of bovine hyaline cartilage: assessment with MR imaging in vitro. Maternal and child nutrition benefitted from this program, while children, especially female children, stayed in school for more years than they may have otherwise. Testing testimony: toxicology and the law of evidence in early nineteenth-century England. Demonstration of a cross-reactive idiotype (IdRQ) in rheumatoid factors vasotec dose from patients with rheumatoid arthritis but not in rheumatoid factors from healthy, aged subjects. Likewise, the transmission of antimicrobial resistance genes to bovine-associated human pathogens is a potential public health concern.

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The aim of this paper was to examine the intellectual crisis and the potential sources of reveille in clinical research in psychiatry. The metabolical status was surveilled by 39 different laboratory values. African Americans have a much higher risk of major (above- or below-knee) lower extremity amputation and a lower rate of limb-preserving vascular surgery or angioplasty than white patients. pSilencer4.1-shRNA targeting survivin (pSilencer4.1-s) and pSilencer4.1-NC (negative control) vectors were previously constructed by us. The second antibody, human antismooth muscle antibody (HASMA), was not as sensitive or specific as RAMA by both IF and IP techniques. Clinical and psychological evaluation was also carried out in FM patients and healthy controls.

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