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Diovan (Valsartan)

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Diovan is an angiotensin II receptor blocker (sometimes called an ARB). Diovan is used to treat high blood pressure (hypertension) in adults and children who are at least 1 year old. Lowering blood pressure may lower your risk of a stroke or heart attack. Diovan is also used in adults to treat heart failure and lower your risk of needing to be hospitalized, and to lower your risk of death after a heart attack.

Other names for this medication:
Alpertan, Alsart, Alsartan, Arovan, Cardival, Codiovan, Corixil, Diovane, Disys, Dosara, Kalpress, Miten, Nisis, Nisisco, Provas, Rixil, Sarteg, Sarval, Simultan, Tareg, Teval, Valaplex, Valcap, Valitazin, Valpression, Valsabela, Valsan, Valsaprex, Valsartanum, Valtan, Valturna, Valzaar, Valzek, Valzide, Varexan, Vartalan

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Also known as: Valsartan


Diovan (valsartan) is an angiotensin II receptor blocker (sometimes called an ARB). Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Diovan is used to treat high blood pressure (hypertension) in adults and children who are at least 1 year old. Lowering blood pressure may lower your risk of a stroke or heart attack.

Diovan is also used in adults to treat heart failure and lower your risk of needing to be hospitalized, and to lower your risk of death after a heart attack.


Usual Adult Dose for Congestive Heart Failure:

Initial dose: 40 mg orally twice a day Maintenance dose: 80 to 160 mg twice a day. The dose should be increased to the highest dose tolerated by the patient.

Usual Adult Dose for Hypertension:

Initial dose: 80 to 160 mg orally once a day. Maintenance dose: 80 to 320 mg orally once a day

Usual Adult Dose for Myocardial Infarction:

Initial dose: 20 mg orally twice a day Maintenance dose: The initial dosage may be titrated upward within 7 days to 40 mg twice daily, with subsequent titrations to a target maintenance dose of 160 mg twice a day as tolerated by the patient. If symptomatic hypotension or renal dysfunction occurs, consideration should be given to a dosage reduction. Comment: Valsartan may be initiated as early as 12 hours after a myocardial infarction, and may be given with other standard postmyocardial infarction treatment, including thrombolytics, aspirin, beta blockers, and statins.

Usual Pediatric Dose for Hypertension:

6 to 16 years: Initial dose: 1.3 mg/kg once a day (up to 40 mg) Maintenance dose: up to 2.7 mg/kg (up to 160 mg) once a day titrated according to patient response Comments: If the calculated dosage does not correspond to the available tablet strengths, or if children are unable to swallow tablets, the use of a suspension (which can be prepared from the tablets) is recommended. The valsartan dose may need to be increased if the suspension is replaced by a tablet. No data are available in pediatric patients either undergoing dialysis or with a glomerular filtration rate less than 30 mL/min.

Detailed Diovan dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include fast heartbeats or fainting.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep your medicine container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Diovan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Diovan if you are allergic to valsartan.

To make sure Diovan is safe for you, tell your doctor if you have:

a heart condition other than one being treated with Diovan; kidney disease (or if you are on dialysis); or if you are on a low-salt diet.

Do not use Diovan if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Valsartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

If you plan to get pregnant, ask your doctor for a safer medicine to use before and during pregnancy. Having high blood pressure during pregnancy may cause complications in the mother and the baby.

You should not breastfeed while using this medicine.

Diovan is not approved for use by anyone younger than 1 year old.

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The antiphlogistic effect of 6-MP probably is due to a considerable proportion by the direct influence on the inflammatory cells. This is the first study investigating the clinicopathologic role of estrogen receptor beta variants in gastric cancer. Nasal continuous positive airway pressure and gram-negative sepsis in low-birthweight infants. The mechanism underlying these effects remains unknown, although the benefits of exercise are often attributed to an increase in the neurotrophin brain-derived neurotrophic factor (BDNF). Tumors use various strategies to prevent efficient presentation of their antigens in lymphoid organs. Dynamic radiologic examinations have been used to investigate the relationships between disc degeneration and lumbar kinematics or disc height changes under different loading conditions in vivo.

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Utility of histopathologic analysis in the evaluation of onychomycosis. By assaying the enzymatic activity of six active-site mutants and by comparing the crystal structure-derived active site conformations of YiiL, RbsD, and a galactose mutarotase, we were able to define the amino acid residues required for catalysis and suggest a possible catalytic mechanism for YiiL. This study investigated the role of perceptual similarity in SSM errors. Rather than biasing estimates of effect size, the major consequence of non-conformity to the assumptions is to introduce bias into estimates of the variance, thus affecting test statistics, power, and false positive rates. Phagocytosis of seemingly intact tumor cells was common and appeared to account for much of the loss in tumor cell numbers. IGF-I and A-myb were up-regulated in estrogen-treated cells while MKP-1 was down-regulated. The association of human connexin 40 genetic polymorphisms with atrial fibrillation. Identifying Cytosine-Specific Isomers via High-Accuracy Single Photon Ionization. Safety net clinics face multiple barriers in providing and coordinating breast cancer screening services for low income or uninsured patients.

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Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products. Two cases of pituitary tumour presenting with ptosis are reported. The lectin binding properties of ten cases each of adenomatoid nodule, follicular adenoma, and papillary carcinoma and five cases of microinvasive follicular carcinoma were examined histochemically and compared with adjacent normal thyroid tissue. Percutaneous balloon valvuloplasty in carcinoid pulmonary valve stenosis. The acupuncture experiment consisted of four different groups, one treated at each of three different acupoints (Zusanli (ST36), Yinlingquan (SP9), and a sham-acupoint) and a control group.

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The observation that D-p-Cl-Phe inserted in position 2 of certain LH-RH (luteinizing hormone-releasing hormone) analogs results in large improvements in antagonist activity led us to examine the effect of this and other substituents on position 1 and 2 D-phenylalanyl analog side chains. Calcineurin inhibitor cyclosporine A activates renal Na-K-Cl cotransporters via local and systemic mechanisms. Several potentially hazardous chemicals are required to make modern military aircraft fly. Supra- and infrahyoid IEMG activity during the static recording (clenching) was significantly higher than during the dynamic recordings (grinding). These data provide evidence that introns improve transcriptional and translational yield and are required for competitive growth of yeast.

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A method is presented for repeatedly bleeding rabbits from the central ear artery. Diagnostic difficulties in mastocytosis in the light of an observed case. However, the population changes usually are masked by meteorological effects upon flight activity. The use of automatic exposure for abdominal examinations in childhood. Mid-term outcomes of the modified Cox-maze procedure for elderly patients: a risk analysis for failure. CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo. Therapeutic epigenetics: an emerging clinical approach to hematologic malignancies. Chlamydia infection rates were 20.6 for N-9 and condoms and 22.2 for placebo film ad condoms per 100 woman years. Herein, we report a case of nonarteritic anterior ischemic optic neuropathy (NAION) following uneventful pars plana vitrectomy for macular hole treatment. Before a scheduled dosage increase to 50 mg/week they were examined clinically, serologically, and by ultrasonography using the colour Doppler pixels and the spectral Doppler resistance index (RI) as indicators of inflammation.

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Modifying the set of codons bound by tRNA anticodon molecules or changing the specificity of binding, reduces the replication rate of translational parasites such as viruses. Physiological studies have shown that focal articular surface defects in the human knee may progress to degenerative arthritis. These results suggest that biochemically and histologically torsion/detorsion injury occurs in the contralateral testis following 2-h torsion and 2-h detorsion and that administration of low-dose sildenafil citrate before detorsion prevents ischemia/reperfusion cellular damage in testicular tissue. Handgrip strength is an independent predictor of renal outcomes in patients with chronic kidney diseases. Primary biliary cirrhosis is a rather uncommon, slowly progressive, cholestatic liver disease that predominantly affects middle-aged women. One leakage but no mortality occurred in the patients undergoing semi-elective operation. Efforts to improve data quality in the 1981 census are first discussed.

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Analogous mutations in BRAF and CRAF allowed us to test the generality of the model. The adolescent experience of pregnancy and abortion: a developmental analysis. RNA from two representative xenograft sublines was used for gene-expression profiling. Montmorillonite functionalized with pralidoxime as a material for chemical protection against organophosphorous compounds. Recent research indicates that there is a gap in life expectancy between the rich and the poor. After resecting the stomach, radioisotope uptake in all dissected lymph nodes was measured during and after surgery. Immunohistochemical analysis of type XVIII collagen was performed in mouse ocular tissue, with polyclonal antibodies to the hinge domain. The relations between the dimensional representation of childhood temperament/personality and psychopathology are documented with data from general population and clinical samples of children and adolescents. These abused women scored significantly higher on Emotional Distress, Interpersonal Isolation, and the Self-alienation subscales. Primary health care physicians are interested in continuing education in pharmacological therapeutics as far as it is practical and useful to solve problems of their routine clinical practice.

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The three isozymes showed similar catalytic behavior for prorenin. We present microscope-based dynamic light scattering data on porcine gastric mucin at pH 6 (solution) and pH 2 (gel) with and without the presence of tracer particles. The continuous murmur of persistence of the ductus arteriosus-an historical review. This review focuses on research implicating the cancer cell environment as a particularly important determinant in the emergence of drug resistance. The isolation and partial characterization of chondronectin, an attachment factor for chondrocytes. The most widespread forms of riboswitches are those responsive to TPP (thiamine pyrophosphate) the active form of vitamin B1, thiamine. Baseline patient characteristics, fibroid burden, and impact on life.

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IUD use is contraindicated among young nulliparas because of the possibility of infertility. Remarkably, the arterial system appears to be in general more variable than the venous system. Oxidative C-C Bond Formation Reactivity of Organometallic Ni(II), Ni(III), and Ni(IV) Complexes. Increasing PPC proportion has negative impact on the RBCC production and on the antigen-matched APC donor pool. Six athletes had first degree heart block, four had Mobitz II second degree block, and three had complete heart block. The period during which responses were reinforced was then progressively reduced until it was 1 hr in every 24. Here, an overview is provided of surface plasmon resonance, and its particular value in application to the field of doping analysis. Distributed vector processing of a new local multiscale Fourier transform for medical imaging applications.

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1.6 W continuous-wave Raman laser using low-loss synthetic diamond. Mechanisms of modulation of brain microvascular endothelial cells function by thrombin. Rapid sequential scintiphotography in the radionuclide detection of subdural hematomas. Through the provision of acticin a literature review the authors critique the research into the effectiveness of CBT when delivered within acute mental health-care settings, to clients who are acutely psychotic. To analyze the access to and use of medicines for high blood pressure among the Brazilian population according to social and demographic conditions. Both parameters changed when intertrial-interval duration was varied. This decline begins in the third or fourth decade of life and is progressive throughout the entire adult life span.

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Geographical variation in mortality from leukaemia and other cancers in England and Wales in relation to proximity to nuclear installations, 1969-78. Altered genetic control of NOS2 what is tramadol 50 mg compared to transcription may be a risk factor for SLE among African-American females. Patients demonstrated a significant overall reduction in scores on the Abnormal Involuntary Movements Scale (AIMS) after treatment with alpha-tocopherol, but not after placebo. The availability of many drugs, and the knowledge of HIV related pathogenesis, helped in selecting highly effective antiviral therapies, yet today a major challenge stands, that is the selection of the best regimen(s) in clinical practice. The studies are consistent in finding no long-term effects of vasectomy on the risk of cardiovascular disease, cancer, impotence, prostatic disease, or disease related to immune function and dysfunction. Rodent models of schizophrenia provide powerful experimental tools for elucidating certain manifestations of the brain disease. Care-recipients in the DI group improved significantly from pre- to post-treatment on dyadic adjustment, social adjustment, knowledge, subjective health status and Target Problem 1, whereas the CI and WLC care-recipients failed to improve on any of these measures. lancea are hinesol, a mixture of beta-eudesmol and atractylone, and atractylone. Glycosides 2-4 have carbohydrate chains without precedent in the glycosides from sea cucumbers. Despite implementing PPCI for ST-segment elevation myocardial infarction in older patients, early risk remains high, necessitating continued focus on improving outcomes in this vulnerable population.

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A cross-sectional study was performed, in which cases were divided in to two groups according to the severity of alcohol dependence, ascertained by the Short Form Alcohol Dependence Data scale (SADD). Chronic anal fissure is the most common cause of anal pain associated with internal anal sphincter hypertonia. In vitro evaluation of biodegradable poly(butylene succinate) as a novel biomaterial. By mRNA differential display in mouse hearts, lysyl oxidase (Lox), a key enzyme catalyzing cross-links in elastin and collagens, was found to be up-regulated between embryonic days 11 (E11) and 13 (E13). In hypertension, the processes of endothelial damage and angiogenesis are abnormal, and correlate with overall cardiovascular risk. Human renal transplantation with donor selection by leukocyte typing. A knowledge scale was used to grade the level of knowledge of health care providers.

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Dextran as a Medium for the Demonstration of Incomplete Anti-Rh-Agglutinins: (Preliminary Report). The urologist assisted an experienced laparoscopic surgeon for 20 extraperitoneal radical prostatectomies. Analysis of chloramphenicol, thiamphenicol and florfenicol in chicken by high performance liquid chromatography with electrospray ionization mass spectrometry. Subsequent partial covalent occupancy of surface amine groups with polyethyleneglycol (PEG) was carried out to give them excellent colloidal stability, whilst still leaving reactive anchoring points for further functionalization. Photoelectrochemical investigations verify that the core-shell structured Fe(3)O(4)/WO(3) has a more effective photoconversion capability than pure WO(3) or Fe(3)O(4). One hundred and sixteen HCC lesions were analyzed in 41 patients who received an orthotopic liver transplant (OLT).

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