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Cardzaar (Losartan)

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Cardzaar is a medication mainly used to treat high blood pressure. It is also used for diabetic kidney disease, heart failure, and left ventricular enlargement. It is taken by mouth. It may be used alone or in addition to other blood pressure medication.

Other names for this medication:
Acetensa, Angibloc, Angioten, Angizaar, Asart, Biortan, Cardon, Corus, Covance, Cozzar, Czartan, Fortzaar, Lakea, Lepitrin, Lifezar, Logika, Lopernal, Lortaan, Losagen, Losakind, Losalet, Losan, Losapres, Losar, Losarb, Losartan, Losartas, Losartec, Lostan, Lotar, Lozar, Nefrotal, Osartan, Osartil, Ostan, Rasoltan, Sarilen, Sarlo, Sarve, Satoren, Sortiva, Tacicul, Tarnasol, Tiasar, Zartan

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Also known as: Losartan


Cardzaar is indicated for the treatment of hypertension in adults and pediatric patients 6 years of age and older, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and nonfatal cardiovascular (CV) events, primarily strokes and myocardial infarction. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including losartan.

Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than 1 drug to achieve blood pressure goals. For specific advice on goals and management

Cardzaar is indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy, but there is evidence that this benefit does not apply to Black patients

Cardzaar is indicated for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria in patients with type 2 diabetes and a history of hypertension. In this population, Cardzaar reduces the rate of progression of nephropathy as measured by the occurrence of doubling of serum creatinine or end stage renal disease


Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Adult Dose for Hypertension:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Pediatric Dose for Hypertension:

6 Years or Older: Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total) Comments: -May be given as a tablet or suspension. -Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients.

Detailed Cozaar dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Cardzaar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Cardzaar as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Cardzaar. Correct volume or salt depletion prior to administration of Cardzaar.

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Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder. The present findings might contribute to further understanding of the role of CCK in the brain and to the treatment of TD. The use of prostaglandin E1 is introduced as a pharmacologic agent that can produce artificial erections in patients who have failed the initial papaverine test or who were on self-injection programs and later lost rigidity. Thin-layer chromatographic assay of phenethylamine content of the rat brain and its changes after reserpine and imipramine administration. This has shown to be the case not only for kinases that are divergent in primary structure, but also for isoforms with highly conserved structure and ATP binding sites. Two hundred sixteen children who met the clinical criteria for FMF underwent molecular genetic studies to detect the 3 most common mutations in the Israeli FMF patient population (M694V, V726A, E148Q). Potentiation of the chemotherapeutic effect of vinblastine by thymidine. The health detriment is associated with the consequences of bone fractures and the subsequent increases in morbidity and mortality. Further complicating epidemiological studies are the risk factors for both atherosclerosis and periodontitis, with which periodontitis appears to have separate positive feedback relationships.

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