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Capres (Capecitabine)

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Capres is used together with docetaxel to treat metastatic breast cancer (breast cancer that has spread to other parts of the body) in patients who have received other medicines (eg, paclitaxel) but did not worked well, or in patients who cannot receive cancer medicines anymore.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Zyrtec, Paxil, Risperdal, Cleocin, Rulide, Coreg, Lasix, Lamictal, Prograf

Also known as: Capecitabine


Xeloda (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

Xeloda is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

Xeloda is sometimes used when cancer has spread to other parts of the body (metastatic).


Usual Adult Dose of Xeloda for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Xeloda for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Xeloda dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Capres are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Xeloda if you are allergic to capecitabine or fluorouracil, or if you have:

severe kidney disease.

To make sure Xeloda is safe for you, tell your doctor if you have ever had:

a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests.

Capecitabine can harm an unborn baby if the mother or the father is using Xeloda .

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using Xeloda and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using Xeloda, and for at least 2 weeks after your last dose.

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Seventy-three adult lymphedema patients with 78 affected lower extremities were treated with the Wright Linear Pump. The uncertainties of pedestrian mobility are important factors affecting the accuracy and robustness of an active pedestrian protection system. Genomic variation associated with local adaptation of weedy rice during de-domestication. A genetic basis for atrophy: dominant non-responsiveness and helicobacter induced gastritis in F(1) hybrid mice. In conclusion, the role of adenosine in asthma is clearly complex. The Descending Diencephalic Dopamine System Is Tuned to Sensory Stimuli. In the last 10 years, biodegradable aliphatic polyesters, such as poly(lactic-co-glycolic acid) (PLGA), have attracted increasing attention for their use as scaffold materials in bone tissue engineering because their degradation products can be removed by natural metabolic pathways. At 20 and 80 Hz, Groups 1 and 2 had notably different pressure values than Groups 3 and 4. Together, these data uncover a novel mechanism through which endodermal-myocardial communication can guide the cell movements that initiate cardiac morphogenesis. This was a cross-sectional, hospital-based study involving 86 Malay girls aged 6 to 12 years old in Hospital Universiti Sains Malaysia from 2015-2016.

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The level of expression of class II MHC molecules was related to the length of exposure to IFN-gamma. Generating chimeric spinal cord: a novel model for transplantable oligodendrocyte progenitors derived from embryonic stem cells. Furthermore, the analysis of the main components associated to water indicators highlight the role of water embodied in trade flows as the transmission mechanisms of the main effects. Many of these neurons express the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT), and are designated C1 neurons. The aim was to examine how concepts of compassion are framed, utilised and communicated by intensive care nurses in the context of treatment withdrawal. Incremental Sampling Methodology: Applications for Background Screening Assessments. Twenty-four were allocated to the phobic group, 16 to the control group. MB is a potent reversible inhibitor of MAO A with implications for gut uptake of amines when administered orally.

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In milk-fed animals, changes in plasma and tissue concentrations of almost all digestive regulatory peptides were observed during the 1st month of postnatal life, especially at day 2. The purpose of this study was to evaluate the safety and effectiveness of the laparoscopic total extraperitoneal procedure with the use of staple fixation and polypropylene mesh. Creation of an atrial septal defect for acute postperfusion right ventricular failure. To compare and analyze the clinical information before the operation, the range of lesion and ossicular chain damage in adults group (85 cases) and children group (66 cases). The production of vaccines in transgenic plants was first proposed in 1990 however no product has yet reached commercialization. A green and simple method to prepare metal/semiconductor nanocomposites by selective laser nano-welding metal and semiconductor nanoparticles was presented, in which the sizes, phases, and morphologies of the components can be maintained.

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Further study showed that sumoylation inhibits PLAG1-induced IGF-II expression in reporter assays. This concept is similar to previous biofuel concepts, but more sustainable, as third generation biofuels and other resources can be produced from waste biomass. The characteristics of the ECs cultured with Y27632 by EC marker expression and tube formation assay were also examined. We describe the design and demonstrate the application of a modular integrated fluidized bed bioreactor system. Two cases of cutis marmorata telangiectatica congenita are described in association with nevus flammeus and congenital glaucoma. were found in the volatile oils of Chinese eaglewood for the first time. Intestinal anisakiasis in Italy: a case treated by emergency surgery. Simulation studies suggest that the ratio of the number of events to the number of estimated parameters in a logistic regression model should be not less than 10 or 20 to 1 to achieve reliable effect estimates. Considering this, a previously developed treatment guideline, which the majority of tumors were treated by conventional technique (not micrographic) was tested.

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Iodine-Catalyzed Cross Dehydrogenative Coupling Reaction: A Regioselective Sulfenylation of Imidazoheterocycles Using Dimethyl Sulfoxide as an Oxidant. Dating the origin of the Orchidaceae from a fossil orchid with its pollinator. Very many sequence features show highly significant differences between essential and viable mouse genes. It is likely that synaptogenesis including BDNF-TrkB signaling in the prefrontal cortex (PFC) and hippocampus may be required for the mechanisms promoting this sustained antidepressant effect. Maximum plasma concentration, time of maximum concentration, and apparent volume of distribution after single doses in patients with renal impairment were in the same range as those observed in healthy volunteers. Bacteriocins are bacterially produced antimicrobial peptides with narrow or broad host ranges. A clinically relevant approach to patient care grounded in neurobiological constructs and evidence based practice which emphasizes a relevant psychopharmacology is needed to optimally train psychiatry residents. Perioperative antibiotic prophylaxis in maxillofacial surgery: penetration of clindamycin into various tissues. A Non-Intrusive Cyber Physical Social Sensing Solution to People Behavior Tracking: Mechanism, Prototype, and Field Experiments. We accurately measured the conductance responsible for the afterhyperpolarization (medium AHP) that follows a single spike in spinal motoneurons of anesthetized cats.

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The sulfoxidation was apparently catalyzed mainly by flavin-containing monooxygenases, as selective thermal inactivation and methymazole significantly reduced the rate of formation of the metabolite. Blood samples from 340 unrelated individuals in Fukui prefecture in the central part of Japan were tested in order to determine the gene frequencies of the C6 common alleles. We employed direct repeat GFP (DR-GFP) and RAD51 foci formation assays to show that EMSY overexpression impairs the repair of damaged DNA, suggesting that EMSY belongs to the family of BRCAness proteins. Pulsed-field gel electrophoresis (PFGE) has been used successfully to discriminate between strains of many different bacterial species. We identified a gene termed hEXT1L/EXTR1/EXTL3 (hEXT1L hereinafter) that was mapped to chromosome bands 8p12-p21 where frequent LOHs of this region was reported in breast cancer. Histological classification of the neoplasms followed the Working Formulation Classification System. Descriptive data analysis: a concept between confirmatory and exploratory data analysis. MSE55 is a nonkinase CRIB (Cdc42/Rac interactive-binding) domain-containing molecule of unknown function. The positive ion chemical ionization mass spectra indicated that these compounds were trichothecene homologs lacking a methyl group on the isovaleroxy substituent at the C-8 position. The differences in distribution patterns between landbridge islands and oceanic islands, and among various taxa (birds, mammals, herptiles, arthropods, fish, and plants) are analyzed.

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ANALYSIS OF HEAD SHAPE DIFFERENCES BETWEEN TWO INTERFERTILE SPECIES OF HAWAIIAN DROSOPHILA. We found that the estimated survival time of a cryptic frog was reduced when associating with an aposematic partner. The similarity of species composition of both benthic diatoms and ciliates decreased with increasing geographic distance. SKIN IMPEDANCE AND PHASE ANGLE AS A FUNCTION OF FREQUENCY AND CURRENT. We tested the hypothesis that inflammation disrupts developmental cortical plasticity in vivo using the mouse ocular dominance model of experience-dependent plasticity in primary visual cortex. Ultrastructural and immunoelectron microscopic study of three unusual plurihormonal pituitary adenomas. Among 57 909 children aged 5-17 years who participated in the 2000-2002 National Health Interview Survey, we identified 312 children with vision/hearing disabilities, 711 with mental retardation, 603 with attention-deficit/hyperactivity disorder (ADD/HD), and 403 with chronic asthma.

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Since WM has been associated with Theta activity (6-12 Hz) in EEGs, and since EEG abnormalities have been observed in these mice before, we studied the effect of mGluR7 gene ablation on EEG activity in the hippocampus, in particular in the Theta zithromax antibiotic dose range, during performance of a WM task. Robotic training is commonly used to assist walking training in patients affected by multiple sclerosis (MS) with non-conclusive results. Detecting those structures is very important for understanding the organization and function of networks. The renal tissue was immunolabeled with anti-IgG, and the thyroid tissue was immunolabeled with anti-thyroglobulin. While we found no association between cognitive impairment and depression or any measure of distress, behavioral impairment was strongly associated with depressive symptoms and diagnoses although seldom addressed by clinicians. The hierarchical organization of the shell layers (secondary and/or tertiary elements) is highlighted for species non-yet observed from this point of view, and is compared to a few already mentioned in the literature. Aerobic exercise has the potential to positively impact these detriments, but is under-researched in this patient population. Arousing dopamine caused transient hyperpolarization of dFB neurons within tens of milliseconds and lasting excitability suppression within minutes.

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We have shown that expression of the activated rat c-erbB2/neu oncogene in mouse embryo fibroblast 3T3 cells is sufficient to induce experimental metastases in nude mice. In healthy individuals, the bacterial translocation is blocked by a single layer of highly specialized intestinal epithelial cells which forms a strong barrier that lines the gut wall. Dose dependent accumulation in the G1-S boundary phase was observed after the combined exposure of IFN-alpha and antitumor agents, especially by sequential exposure, and then accumulation in S and G2-M were observed. Expression of nuclear transcription factor kappaB in hamster buccal pouch carcinogenesis. There was a strong correlation between the presence of IgG aCL and the three other phospholipid-related antibodies: a-beta2-GPI, a-PP, and a-PT. Of the 12 patients with early complications, four underwent relaparotomy due to anastomotic leakage and bleeding.

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The membrane of these viruses contains a fusion protein, DAFF2A, that is composed of the catalytic domain of the human complement regulatory protein (CRP) decay-accelerating factor (DAF) and the envelope protein of the amphotropic murine leukemia virus (MuLV) 4070A (EnvA). This system is required for identifying the division site as well as positioning the Z-ring at mid-cell. Production and characterization of a generic antibody against group A trichothecenes. Single-dose (20-Gy) radiation therapy (RT, cesium-137 whole-head irradiation) did prolong survival. Internet addition affects facial expression recognition of individuals. However, literature on work-family conflict has not specifically addressed the health of postpartum women. On 2 consecutive days, the sociability of each test mouse toward an unfamiliar 4-week-old DBA/2J stimulus mouse was assessed with a social choice paradigm conducted in a three-chambered apparatus. Metal oxide silicon field effect transistors are suitable for in vivo dosimetry during intraoperative radiotherapy because their overall uncertainty is comparable to the accuracy required in target dose delivery. We conducted a feasibility study to gather preliminary data to optimize BP-lowering strategies for a public health intervention in rural communities in Bangladesh, Pakistan, and Sri Lanka. Beneficial effect of copper supplementation on deposition of fluoride in bone in fluoride- and molybdenum-fed rabbits.

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Apolipoprotein levels in normolipidemic non-insulin-dependent diabetes mellitus. Growth and product inhibition kinetics of T-cell hybridomas producing lymphokines in batch and continuous culture. To investigate the stimulatory effects of DA, perifused rat anterior pituitary cells were exposed to the highly-specific DA D2 receptor agonist, quinpirole hydrochloride (LY). TNRC4 contains two consecutive N-terminal RNA recognition motifs (RRMs) separated from the C-terminal RRM. The co-incidental finding of endometrial carcinoma in patients with EMH was also studied. Severe hemorrhage intestinal in a child with ileal duplication and brief entity review. The presence of a high activity rate of aspartate aminopeptidase in adenohypophysis implies an active participation of angiotensin peptides at this level.

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The basic properties of budesonide and data from references have been discussed. Hypertensive episodes and circadian fluctuations of blood pressure in patients with phaeochromocytoma: studies by long-term blood pressure monitoring based on a volume-oscillometric method. We recently identified a new gene, klotho, which is involved in the suppression of multiple aging phenotypes. We report the case of a young woman treated with selective renal embolization for renovascular hypertension caused by intrarenal artery stenosis and show follow-up imaging of the treated kidney. It responds to a decrease in growth temperature by enhancing the expression of the des gene, coding for an acyl-lipid desaturase. Currently normal or pathologic conditions are documental by color slides, photos or videotape. Using our method, it is possible to screen a population and quickly identify a subset of functionally interesting mutants. We chose to examine sucrose, cola drink, honey, human milk, cow milk, and water because some of these have been associated with development of early childhood caries, although direct singulair 10 mg bid experimental evidence is lacking. Suggestions are provided for which services could be delegated by the endodontist to the dental hygienist during each phase of care. Erythema nodosum as a reaction pattern: a broad spectrum of underlying causes.

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The effect of 1-methyl-delta1-androstene-17beta-ol-3-ongamma-17-acetate and 17alpha-ethyl-delta4-estrene-17beta-ol on the male endocrine system. In addition to being utilized in the field of inflammation, cancer, angiogenesis and differentiation, these co-culture systems are of prime importance in the study of the intricate relationships that exist between the different cellular subtypes present in the central nervous system, particularly in the context of neuroinflammation. This evidence shows that primary care helps prevent illness and death, regardless of whether the care is characterized by supply of primary care physicians, a relationship with a source of primary care, or the receipt of important features of primary care. Advances in cancer therapy have improved the long-term survival of cancer patients. MiRNAs were isolated and quantified by polymerase chain reaction (PCR) array. PREVENTIVE WORK OF THE GENERAL PRACTITIONER IN COOPERATIVE VILLAGES. The developed GQSAR models were found to be useful for scaffold hopping and lead optimization of multitarget inhibitors. In this paper we illustrate how co-elution of low quantities of very large analytes in AF4 may cause disturbances in the MALS data which, in turn, causes an overestimation of the size.

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MASSIVE HEMORRHAGE INTO DUODENUM FROM SUTURE LINE RUPTURE OF AORTIC GRAFT. This effect could be enhanced in hypertensives treated with beta-blockers, in whom the vasoconstrictor effect of alpha-adrenergic stimulation is unbalanced. Design of Fuzzy Functional Observer-Controller via Higher Order Derivatives of Lyapunov Function for Nonlinear Systems. We evaluated skin diseases in a cohort of 142 homeless men who were staying overnight in a major Boston homeless shelter for men over a period of 3 months (March-June 1992). Regarding the salience network (SN), increased connectivity was observed in the left superior frontal gyrus and middle frontal gyrus. Indicators of health status derived from an administrative data system and from health interviews are shown to provide roughly similar predictions of nursing-home entry.

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SEROTINY, GEOGRAPHY, AND FIRE IN THE PINE BARRENS OF NEW JERSEY. KWI-56 were cloned in Escherichia coli using pUC19 as a vector plasmid. Moreover, our data indicate that almost all Japanese cases of XP-A are caused by one or more of the 3 mutations, i.e., the splicing mutation of intron 3 and the 2 nonsense mutations of codons 116 and 228. Effects of Shen-Mai injection on sternohyoid contractile properties in chronic intermittent hypoxia rat. Circular dichroism analysis of the calicheamicin-DNA interaction revisited. The values obtained, which depend on the shear rate used, were strongly influenced by the total suspended solids (TSS) content of granular sludge and an exponential relation was found between the TSS and the rheological parameter limit amiloride hcl 5mg tab viscosity. Relative positions of widely separated antennas and celestial coordinates of radio sources have been determined from such measurements with 1 standard deviation uncertainties of about 5 centimeters and 3 milliseconds of arc, respectively. Nutrition information and front-of-pack labelling: issues in effectiveness. In previous RFLP studies we have reported linkage disequilibria between an RsaI and two PstI (a and b) polymorphic restriction sites and electrophoretic types of PLAP. The global responses (clinical and microbiological) at the end of the empirical therapy were also assessed.

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A polysaccharide purified from Radix Adenophorae promotes cell activation and pro-inflammatory cytokine production in murine RAW264.7 macrophages. No excess of neural tube defects was seen, but hydrocephaly was diagnosed more often in twins than in singletons. The split dose recovery observed in strain LY-S could be accounted for by its recovery during postirradiation incubation. We developed a modern numerical approach to the multivariate linear discrimination of Fisher from 1936 based upon singular value decomposition that is sufficiently stable to permit widespread application to spatiotemporal neuronal patterns. Adenoviral vectors encoding the genes for human IL-4 (AxCAIL-4) and bacterial beta-galactosidase (AxCAlacZ) were generated and examined for appropriate production and biological activity. Our results highlight the influence of trait rumination on reward anticipation in a non-depressed sample. Further, at least several of them were also generated under the conditions where only the primary transcription was allowed by inhibiting de novo protein synthesis.

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