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Capres (Capecitabine)
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Capres

Capres is used together with docetaxel to treat metastatic breast cancer (breast cancer that has spread to other parts of the body) in patients who have received other medicines (eg, paclitaxel) but did not worked well, or in patients who cannot receive cancer medicines anymore.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Zyrtec, Paxil, Risperdal, Cleocin, Rulide, Coreg, Lasix, Lamictal, Prograf

Also known as: Capecitabine

Description

Xeloda (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

Xeloda is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

Xeloda is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Xeloda for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Xeloda for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Xeloda dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Capres are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Xeloda if you are allergic to capecitabine or fluorouracil, or if you have:

severe kidney disease.

To make sure Xeloda is safe for you, tell your doctor if you have ever had:

a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests.

Capecitabine can harm an unborn baby if the mother or the father is using Xeloda .

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using Xeloda and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using Xeloda, and for at least 2 weeks after your last dose.

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Iodine-Catalyzed Cross Dehydrogenative Coupling Reaction: A Regioselective Sulfenylation of Imidazoheterocycles Using Dimethyl Sulfoxide as an Oxidant. Dating the origin of the Orchidaceae from a fossil orchid with its pollinator. Very many sequence features show highly significant differences between essential and viable mouse genes. It is likely that synaptogenesis including BDNF-TrkB signaling in the prefrontal cortex (PFC) and hippocampus may be required for the mechanisms promoting this sustained antidepressant effect. Maximum plasma concentration, time of maximum concentration, and apparent volume of distribution after single doses in patients with renal impairment were in the same range as those observed in healthy volunteers. Bacteriocins are bacterially produced antimicrobial peptides with narrow or broad host ranges. A clinically relevant approach to patient care grounded in neurobiological constructs and evidence based practice which emphasizes a relevant psychopharmacology is needed to optimally train psychiatry residents. Perioperative antibiotic prophylaxis in maxillofacial surgery: penetration of clindamycin into various tissues. A Non-Intrusive Cyber Physical Social Sensing Solution to People Behavior Tracking: Mechanism, Prototype, and Field Experiments. We accurately measured the conductance responsible for the afterhyperpolarization (medium AHP) that follows a single spike in spinal motoneurons of anesthetized cats.

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ANALYSIS OF HEAD SHAPE DIFFERENCES BETWEEN TWO INTERFERTILE SPECIES OF HAWAIIAN DROSOPHILA. We found that the estimated survival time of a cryptic frog was reduced when associating with an aposematic partner. The similarity of species composition of both benthic diatoms and ciliates decreased with increasing geographic distance. SKIN IMPEDANCE AND PHASE ANGLE AS A FUNCTION OF FREQUENCY AND CURRENT. We tested the hypothesis that inflammation disrupts developmental cortical plasticity in vivo using the mouse ocular dominance model of experience-dependent plasticity in primary visual cortex. Ultrastructural and immunoelectron microscopic study of three unusual plurihormonal pituitary adenomas. Among 57 909 children aged 5-17 years who participated in the 2000-2002 National Health Interview Survey, we identified 312 children with vision/hearing disabilities, 711 with mental retardation, 603 with attention-deficit/hyperactivity disorder (ADD/HD), and 403 with chronic asthma.

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Since WM has been associated with Theta activity (6-12 Hz) in EEGs, and since EEG abnormalities have been observed in these mice before, we studied the effect of mGluR7 gene ablation on EEG activity in the hippocampus, in particular in the Theta zithromax antibiotic dose range, during performance of a WM task. Robotic training is commonly used to assist walking training in patients affected by multiple sclerosis (MS) with non-conclusive results. Detecting those structures is very important for understanding the organization and function of networks. The renal tissue was immunolabeled with anti-IgG, and the thyroid tissue was immunolabeled with anti-thyroglobulin. While we found no association between cognitive impairment and depression or any measure of distress, behavioral impairment was strongly associated with depressive symptoms and diagnoses although seldom addressed by clinicians. The hierarchical organization of the shell layers (secondary and/or tertiary elements) is highlighted for species non-yet observed from this point of view, and is compared to a few already mentioned in the literature. Aerobic exercise has the potential to positively impact these detriments, but is under-researched in this patient population. Arousing dopamine caused transient hyperpolarization of dFB neurons within tens of milliseconds and lasting excitability suppression within minutes.

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The membrane of these viruses contains a fusion protein, DAFF2A, that is composed of the catalytic domain of the human complement regulatory protein (CRP) decay-accelerating factor (DAF) and the envelope protein of the amphotropic murine leukemia virus (MuLV) 4070A (EnvA). This system is required for identifying the division site as well as positioning the Z-ring at mid-cell. Production and characterization of a generic antibody against group A trichothecenes. Single-dose (20-Gy) radiation therapy (RT, cesium-137 whole-head irradiation) did prolong survival. Internet addition affects facial expression recognition of individuals. However, literature on work-family conflict has not specifically addressed the health of postpartum women. On 2 consecutive days, the sociability of each test mouse toward an unfamiliar 4-week-old DBA/2J stimulus mouse was assessed with a social choice paradigm conducted in a three-chambered apparatus. Metal oxide silicon field effect transistors are suitable for in vivo dosimetry during intraoperative radiotherapy because their overall uncertainty is comparable to the accuracy required in target dose delivery. We conducted a feasibility study to gather preliminary data to optimize BP-lowering strategies for a public health intervention in rural communities in Bangladesh, Pakistan, and Sri Lanka. Beneficial effect of copper supplementation on deposition of fluoride in bone in fluoride- and molybdenum-fed rabbits.

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Apolipoprotein levels in normolipidemic non-insulin-dependent diabetes mellitus. Growth and product inhibition kinetics of T-cell hybridomas producing lymphokines in batch and continuous culture. To investigate the stimulatory effects of DA, perifused rat anterior pituitary cells were exposed to the highly-specific DA D2 receptor agonist, quinpirole hydrochloride (LY). TNRC4 contains two consecutive N-terminal RNA recognition motifs (RRMs) separated from the C-terminal RRM. The co-incidental finding of endometrial carcinoma in patients with EMH was also studied. Severe hemorrhage intestinal in a child with ileal duplication and brief entity review. The presence of a high activity rate of aspartate aminopeptidase in adenohypophysis implies an active participation of angiotensin peptides at this level.

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The effect of 1-methyl-delta1-androstene-17beta-ol-3-ongamma-17-acetate and 17alpha-ethyl-delta4-estrene-17beta-ol on the male endocrine system. In addition to being utilized in the field of inflammation, cancer, angiogenesis and differentiation, these co-culture systems are of prime importance in the study of the intricate relationships that exist between the different cellular subtypes present in the central nervous system, particularly in the context of neuroinflammation. This evidence shows that primary care helps prevent illness and death, regardless of whether the care is characterized by supply of primary care physicians, a relationship with a source of primary care, or the receipt of important features of primary care. Advances in cancer therapy have improved the long-term survival of cancer patients. MiRNAs were isolated and quantified by polymerase chain reaction (PCR) array. PREVENTIVE WORK OF THE GENERAL PRACTITIONER IN COOPERATIVE VILLAGES. The developed GQSAR models were found to be useful for scaffold hopping and lead optimization of multitarget inhibitors. In this paper we illustrate how co-elution of low quantities of very large analytes in AF4 may cause disturbances in the MALS data which, in turn, causes an overestimation of the size.

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SEROTINY, GEOGRAPHY, AND FIRE IN THE PINE BARRENS OF NEW JERSEY. KWI-56 were cloned in Escherichia coli using pUC19 as a vector plasmid. Moreover, our data indicate that almost all Japanese cases of XP-A are caused by one or more of the 3 mutations, i.e., the splicing mutation of intron 3 and the 2 nonsense mutations of codons 116 and 228. Effects of Shen-Mai injection on sternohyoid contractile properties in chronic intermittent hypoxia rat. Circular dichroism analysis of the calicheamicin-DNA interaction revisited. The values obtained, which depend on the shear rate used, were strongly influenced by the total suspended solids (TSS) content of granular sludge and an exponential relation was found between the TSS and the rheological parameter limit amiloride hcl 5mg tab viscosity. Relative positions of widely separated antennas and celestial coordinates of radio sources have been determined from such measurements with 1 standard deviation uncertainties of about 5 centimeters and 3 milliseconds of arc, respectively. Nutrition information and front-of-pack labelling: issues in effectiveness. In previous RFLP studies we have reported linkage disequilibria between an RsaI and two PstI (a and b) polymorphic restriction sites and electrophoretic types of PLAP. The global responses (clinical and microbiological) at the end of the empirical therapy were also assessed.

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A polysaccharide purified from Radix Adenophorae promotes cell activation and pro-inflammatory cytokine production in murine RAW264.7 macrophages. No excess of neural tube defects was seen, but hydrocephaly was diagnosed more often in twins than in singletons. The split dose recovery observed in strain LY-S could be accounted for by its recovery during postirradiation incubation. We developed a modern numerical approach to the multivariate linear discrimination of Fisher from 1936 based upon singular value decomposition that is sufficiently stable to permit widespread application to spatiotemporal neuronal patterns. Adenoviral vectors encoding the genes for human IL-4 (AxCAIL-4) and bacterial beta-galactosidase (AxCAlacZ) were generated and examined for appropriate production and biological activity. Our results highlight the influence of trait rumination on reward anticipation in a non-depressed sample. Further, at least several of them were also generated under the conditions where only the primary transcription was allowed by inhibiting de novo protein synthesis.

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