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Capecitabine

Capecitabine is a type of chemotherapy drug you might have it on its own or with other types of chemotherapy drugs. It is also called Xeloda. It is a treatment for several types of cancer. It is a tablet you take twice a day morning and evening.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Avodart, Furadantin, Skelaxin, Wellbutrin, Combivent, Ilosone

Description

Xeloda (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

Xeloda is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

Xeloda is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Xeloda for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Xeloda for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Xeloda dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Capecitabine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Xeloda if you are allergic to capecitabine or fluorouracil, or if you have:

severe kidney disease.

To make sure Xeloda is safe for you, tell your doctor if you have ever had:

a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests.

Capecitabine can harm an unborn baby if the mother or the father is using Xeloda .

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using Xeloda and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using Xeloda, and for at least 2 weeks after your last dose.

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MECHANICAL RESPONSES AND CALCIUM INFLUX IN FROG MUSCLES: EFFECTS OF LOW TEMPERATURE AND COOLING. Despite the advances made in gastric cancer surgery, however, there is a definite limit to the surgical treatment of gastric cancer. It is our goal to bring more focus toward understanding the contribution of neuropeptides to the pathogenesis of heart failure, and to consider them as potential therapeutic targets. In the current study, nicotine was administered to adolescent and adult rats for seven days. Dissociated neural basis of two behavioral hallmarks of holistic face processing: The whole-part effect and composite-face effect. To evaluate the ulnar styloid and to analyze the effect of different radiographic views on measurement outcome, measurements were performed in 7 different radiographic positions of both wrists of 69 patients. Treatment patterns and outcomes with subcutaneous bortezomib in patients with relapsed mantle cell lymphoma: a retrospective, observational study of patient medical records from US community oncology practices. Furthermore, no acute microscopic lesions were identified in the histopathological evaluation after contact between the films and pig ear skin.

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Some variants of this disorder also exhibit cutaneous manifestations. Assessment of titrimetric and photometric methods for the determination of chymotrypsin catalytic activity in stool. Cervical malalignment occurring after conventional laminectomy or laminoplasty is caused by intraoperative injuries to the posterior extensor mechanism, including the deep extensor muscles. Crystal structures and pharmacologic activities of 1,4-dihydropyridine calcium channel antagonists of the isobutyl methyl 2,6-dimethyl-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylate (nisoldipine) series. Indications are essentially the abbreviated laparotomy or damage control (especially with abdominal packing), and the post traumatic abdominal compartment syndrome (in the treatment and prevention). In bivariate and multivariate models, living in a household in which adults treated each other violently increased odds of ever receiving a Pap test. In addition, the effects on oral glucose/sucrose tolerance test in normal rats. Camphor activation of rat TRPV1 was mediated by distinct channel regions from capsaicin, as indicated by camphor activation in the presence of the competitive inhibitor capsazepine and in a capsaicin-insensitive point mutant. In the first method, the correctly folded peptide was produced only in the presence of partially hydrophobic solvent conditions. Looped suture versus stapler device in pediatric laparoscopic appendectomy: a comparative outcomes and intraoperative cost analysis.

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The patients with left hemiparesis, and affected right hemisphere, had higher power peak magnitudes of COP displacements than patients with right hemiparesis both in ML and AP directions at low frequencies. Buspirone, clonidine, baclofen and 8-OH-DPAT act via a system dependent on 5-hydroxytryptamine 1a receptor activation. Several criteria for the tests, although not authorized, are widely used. Evaluation of liquid cathode glow discharge-atomic emission spectrometry for determination of copper and lead in ores samples. Despite significant controversy over damage awards and the civil litigation system, there has been little research focusing on the process by which juries determine damages. This new application of CT could prove to be a valuable complement to conventional methods in the radiological assessment of metal cup arthroplasties. This study confirms that Morocco is an endemic area for classical KS, which remains the most frequent type of KS in this country, and emphasises the value of the LNA-1 marker for the early diagnosis of KS lesions. The high mortality rate previously reported and the absence of proven advantage of urgent carotid endarterectomy over natural history, has discouraged consideration of this operation. While both hydrocortisone aceponate and prednicarbate ointment induced no significant reduction in skin thickness, the onset of epidermal-dermal thinning with betamethasone-17-valerate was early and the extent marked.

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Irreversible inactivation ensues by transfer of the peptidyl portion, not methyl groups. When recombined tissues are placed in medium supplemented with 12 mM L-glutamate, retinal reattachment is enhanced and there is a four-fold increase in epithelial phagosome content. Fungal levels in the home and allergic rhinitis by 5 years of age. Therefore we determined the association of ACE inhibitor use and ACE genotypes with reduction of pneumonia risk in the Japanese elderly population. Indeed, the effective interfacing of microbial physiology with external parameters that can be used for controlling physiology depends on the acquisition of reliable signals. Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway. Early diagnosis of disease has potential to reduce morbidity and mortality. A LOW-COST PORTABLE ELECTROMAGNETIC BLOOD-FLOW METER SYSTEM UTILIZING COMMERCIALLY AVAILABLE DEVICES. 114 patients, 70 with endobronchial lesions (42 exophytic lesions, 28 submucosal lesions) and 44 with non-endobronchial lesions, suspected to have lung cancers were evaluated at Siriraj Hospital between March and October 2000.

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ON A METHOD OF VITAMIN B-12 ASSAY BY A DIFFUSION METHOD USING ESCHERICHIA COLI 113. The CE values on the rest aspect patches were all not larger than 0.5. Additionally, comparing R2 and background strain animals, as well as reciprocal congenic (R8) and appropriate background strain animals, we assessed Alcw1/Alcdp1 dependent brain gene expression using microarray and quantitative PCR analyses. The orgasm in women does not obviously contribute to the reproductive success, and surprisingly unreliably accompanies heterosexual intercourse. Detection of osteitis and technical advances like whole body magnetic resonance imaging (MRI) exemplify the value of this technology. A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis. These interactions are non-competitive and can occur simultaneously through distinct interaction surfaces. Trajectory of Postoperative Wound Pain Within the First 2 Weeks Following Posterior Spinal Fusion Surgery in Adolescent Idiopathic Scoliosis Patients.

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Activated p38MAPKalpha was predominantly found in synovial macrophages, whereas ERK activation was present in both synovial macrophages and fibroblasts. Patients with advanced pancreatic carcinoma had impaired immune functions. Two patients with definite MS and no significant visual loss are presented, because of the marked bilateral sheathing of retinal veins, and diffuse pigmentary changes in the first patient, and the previously unreported paravenous pigmentation with bone corpuscular configuration in the second patient. In this study, we summarized research advances in the damage and regeneration of mammalian vestibular hair cells. Two bacteriochlorophyll a pigments remain tightly bound to the RC protein at the highest collision energy. The peptide should be useful in studies on modulation of the action of insulin. Early surgical intervention, in fact, makes it possible to free these patients from the prolonged use of orthoses which are often badly tolerated, facilitates easy nursing and often avoids or significantly reduces the pain due to these secondary lesions, so restoring a quality of residual life which is acceptable even in the context of neoplastic disease. Disseminated cryptococcosis in a patient with HIV/AIDS at a teaching hospital in Ghana. These mutations result in two restriction fragment length polymorphisms for the enzymes AvaI and BbvI, a smaller apparent molecular weight of apoE-4Philadelphia on sodium dodecyl polyacrylamide gels, and severe type III hyperlipoproteinemia (HLP) in a 24-year-old homozygous female (Lohse, P., Mann, W.

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This study was undertaken to evaluate whether screening through a uterine artery (UtA) Doppler and biochemical markers of oxidative stress and endothelial dysfunction predict preeclampsia. Our results demonstrate the functional conservation of the type III system of X. Reduced genomic 5-methylcytosine content in human colonic neoplasia. Our morphometric data show that the size of the eyes generally correlates well with that of the optic lobes. The genome of CBPV consists of two segments, RNA 1 and RNA 2, containing respective overlapping fragments.

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In cultured cells, we investigate the mechanisms by which leptin regulates each of these pathways. The structural basis for the functions of A3G-CD1 remains elusive. International congress of geologists.--American committee meeting at Albany. Single-limb landing biomechanics are altered and patellar tendinopathy related pain is reduced with acute infrapatellar strap application. We present three patients who had traumatic amputation of a finger or fingers with subsequent retraction of the flexor digitorum profundus and lumbrical muscle leading to the development of carpal tunnel syndrome. Regulation of protein turnover versus growth state: ascites hepatoma as a model for studies both in the animal and in vitro. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. This protein family includes the classical MDR-associated transporter ABCB1 (MDR1/P-gp).

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