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Calmnir (Clonazepam)

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Clonazepam, sold under the brand name Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between six and 12 hours. Calmnir was initially patented in 1964 and went on sale in the United States in 1975. It is available as a generic medication.

Other names for this medication:
Alrest, Catier, Cloam, Clodep, Clonapax, Clonark, Clonax, Clonazepam, Cloneepam, Clonix, Clonoasig, Clonzy, Closis, Clozep, Clozipam, Cozil, Deptune, Dipwell, Epcon, Escimax, Escitacalm, Escitrac, Ezinite, Jasoclam, Lonazep, Lonipax, Melzap, Nupam, Prasilex, Repam, Revozip, Sezolan, Sezolep, Xenotril, Xitzen, Zolpidox, Zozep

Similar Products:
Propecia, Anafranil, Avana, Silagra, Atarax

Also known as: Clonazepam


Calmnir is an anti-anxiety medication in the benzodiazepine family, the same family that includes diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan), flurazepam (Dalmane), and others. Calmnir and other benzodiazepines act by enhancing the effects of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter (a chemical that nerve cells use to communicate with each other) that inhibits brain activity. It is believed that excessive activity in the brain may lead to anxiety or other psychiatric disorders. Calmnir is primarily used for treating panic disorder and preventing certain types of seizures.

Calmnir is useful alone or as an adjunct in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. In patients with absence seizures (petit mal) who have failed to respond to succinimides, Calmnir may be useful.


Calmnir is also used to treat symptoms of akathisia (restlessness and a need for constant movement) that may occur as a side effect of treatment with antipsychotic medications (medications for mental illness) and to treat acute catatonic reactions (state in which a person does not move or speak at all or moves or speaks abnormally). Talk to your doctor about the possible risks of using this medication for your condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Calmnir.

Do not let anyone else take your medication. Calmnir is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


Symptoms of clonazepam overdosage, like those produced by other CNS depressants, include somnolence, confusion, coma and diminished reflexes.

Treatment includes monitoring of respiration, pulse and blood pressure, general supportive measures and immediate gastric lavage. Intravenous fluids should be administered and an adequate airway maintained. Hypotension may be combated by the use of levarterenol or metaraminol. Dialysis is of no known value.

Flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. Prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation and intravenous access. Flumazenil is intended as an adjunct to, not as a substitute for, proper management of benzodiazepine overdose. Patients treated with flumazenil should be monitored for resedation, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment. The prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose. The complete flumazenil package insert, including CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, should be consulted prior to use.

Flumazenil is not indicated in patients with epilepsy who have been treated with benzodiazepines. Antagonism of the benzodiazepine effect in such patients may provoke seizures.

Serious sequelae are rare unless other drugs or alcohol have been taken concomitantly.


Tablets should be kept at room temperature, between 15 C and 30 C (59 F and 86 F).

Side effects

The most common side effects associated with Calmnir are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of clonazepam in the elderly. However, elderly patients are more likely to have confusion and severe drowsiness, or age-related heart, liver, or kidney problems, which may require caution and an adjustment in the dose for patients receiving clonazepam.

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Use of cellular telephones and brain tumour risk in urban and rural areas. Although data on HIV/sexually transmitted infection (STI) testing behaviour is increasing, information is still lacking among heterosexual men who receive far lesser attention and are generally invisible in HIV/ STI prevention, particularly in the Asian urban setting. An increase in the fixed-ratio requirement for sample-key responding produced an increase in log d(0) without affecting b, and interpolation of ambient illumination in the delay interval increased b without influencing log d(0). Overall, men were more likely to have hospitalisations for COPD and had a higher proportion of death at hospital than did women. In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives. We determined the localization of each by expression as GFP-fusion proteins or with specific antibodies. We conclude that the colloidal T(4) ring can be used as a sensitive biomarker of perchlorate-induced thyroid disruption in amphibians. Loss of smooth muscle cell disintegrin and metalloproteinase 17 transiently suppresses angiotensin II-induced hypertension and end-organ damage.

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Long-term variations of water quality in the Inner Murchison Bay, Lake Victoria. This finding has implications for evaluating vaccine efficacy and immune status. Neither may an action for relief be brought if there are other judicial or administrative means to obtain the same results. Thermostable xylanase from Thermoascus aurantiacus at ultrahigh resolution (0.89 A) at 100 K and atomic resolution (1.11 A) at 293 K refined anisotropically to small-molecule accuracy. Ursolic acid liposomes with chitosan modification: Promising antitumor drug delivery and efficacy. 5 alpha-dihydrocortisol has been reported to amplify the mineralocorticoid activity of aldosterone.

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A section on the issues and options to implementing reform is followed by consideration of the role of donor agencies. Expression of IFIGs was significantly higher in SLE patients compared with disease controls or healthy donors. Plasma phospholipid transfer protein (PLTP) plays an important role in lipoprotein metabolism. This might be due to an increased use of and microbials in nursing homes of a certain size. While purifying selection is the dominant force driving the evolution of these housekeeping genes, positive selection also appeared to operate on the abcZ and gpdh loci. The child presented with an acute onset of significant visual impairment and headache. The protein was not demonstrably associated either covalently or non-covalently with the peptidoglycan layer of the cell envelope. School-based programmes must be embedded within comprehensive approaches that involve community- and policy-level interventions. In the present study, we investigated the effect of wedge prism adaptation on postural control in normal subjects. Anemia is one of the many complications seen in patients with persistent nephrotic syndrome and may occur as a result of excessive urinary losses of iron, transferrin, erythropoietin, transcobalamin and/or metals.

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Somatotopic organization of forelimb representation in cervical enlargement of raccoon dorsal horn. This PVA film could further interact with the carboxyl-group functionalized CNTs and act to lock the CNTs onto the surfaces of the Cu flakes. Despite the same gamma(c), these cytokines have different effects on diverse cells. In this paper, we investigate the space complexity of the Estimation of Distribution Algorithms (EDAs), a class of sampling-based variants of the genetic algorithm. Risk factors were measured, and two-field fundus photographs were taken annually and graded according to the EURODIAB study group. Heparin was detected in the cytoplasm only after incubation of the cells with heparin and SNAC. We reported 3 cases of laryngeal cartilaginous tumors with the image findings, including CT, FDG PET/CT, and MRI and reviewed literatures. The majority of the population were ignorant about the etiology and mode of spread of the disease.

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Indomethacin was less effective than nifedipine for the fast treatment of preterm labor. Mice rotating at 1G or at 2G acceleration gravity and non-rotating controls were tested for reactivity to a spatial change after either a single 1 h or five repeated 1 h daily rotations in the centrifuge. Research carried out using different in vitro and in vivo techniques of biological evaluation support most of these claims. Thus there was a negative correlation between the amount of fibronectin and cellular cohesiveness. Significant earlier recovery of weakness was observed with Livwin as compared to placebo at 2, 4 and 8 weeks. The same dose of 5-TG protected mice from foot skin damage between days 0 and 40 post-irradiation by a DMF of 1.3, and from late foot deformity during days 60 to 90 post-irradiation by a DMF of 1.2. The retinoids had no effect on prothrombin times of animals fed the supplemented diet. Studies on the natural history of asymptomatic diabetes in young people. We found significant variability in STEMI mortality among Gulf Arab countries and identified areas requiring further efforts to reduce excess mortality in the region.

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Innovation as the core strategy for the future success of academic health centres. Interlayer Exciton Optoelectronics in a 2D Heterostructure p-n Junction. The frequency of asymptomatic disturbances of cardiac rhythm and conduction in middle-aged men. Most colorectal cancer (CRC) screening guidelines recommend average-risk screening up to the age of 75 years. Red blood cell sodium content and permeability changes in hemorrhagic shock. These data seem to support the notion of a potential impact of circulatory function for the prognosis of AD at a prodromal stage. To evaluate the occurrence of professional delay in the diagnosis, referral, and treatment of patients with burning mouth syndrome (BMS). We have also proved that in regions in which the condition is not satisfied, the system is unstable or at least it is not globally stable.

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Control of hypertension is essential for the secondary prevention of stroke. Effect of low intensity pulsed ultrasound and BMP-2 on rat bone marrow stromal cell gene expression. Phototropin (phot) is a blue-light photoreceptor for phototropic responses, relocation of chloroplasts, and stomata opening in plants. Differences in gene expression between donors are found for two other members of the MACS-family, the fatty acid transport protein 3 (FATP3) and the FATP4. have shown that the VH gene segments closest to the JH cluster, the VH1B 7183 family, are preferentially utilized in transformed fetal pre-B cell lines and in fetal B cell hybridomas. The major source of morbidity and potential mortality after pancreaticoduodenectomy is pancreatic fistula, which is caused by difficulties associated with the pancreatic anastomosis. Suction catheter for enhanced control and accuracy of transseptal access. After oral administration of G-hesperidin or hesperidin to rats, hesperetin was detected in sera hydrolyzed with beta-glucuronidase, but it was not detectable in unhydrolyzed sera. Stressful and traumatic life events have been implicated in the etiology and persistence of symptoms in schizophrenia, but little is known about their impact in later life.

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Our objective was to set up a more objective quantitative laparoscopy-based model in predicting the chances of optimal cytoreductive surgery in advanced ovarian cancer patients. Vowel-related tongue movements in speech: straight or curved paths?. A BASIC program for randomizing and balancing the order of interventions in crossover studies. The geometry of the muscles of the lumbar spine determined by magnetic resonance imaging. Recommendations for the use of the SI international system in clinical biology laboratories. Since steroids play a phenergan dosage in dogs major role in gonadotropin secretion and PCPA has been shown to depress LH release, it is interesting that E2 increased the rate of H-3 serotonin (1 X 10(-7) M) uptake in hypothalamic synaptosomes. The data also indicate that body mass and body mass index were identified as modifiable injury risk factors for both units, which suggests that these injuries are preventable. Enabling heterogeneous data integration and biomedical event prediction through ICT: the test case of cancer reoccurrence. Moreover, Rg1 treatment promoted the translocation and activation of Nrf2.

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Timing of callase activity and cytoplasmic male sterility in Petunia. Relationship between anal manometry and anal electromyography and its clinical relevance. Pharmacokinetics of cisplatin in long-term hemodialysis treatment. It may lead to dehydration and death if appropriate medical management is not rapidly initiated. Despite their segregated origin in different regions of the telencephalon, projection neurons and interneurons born synchronically end up adopting the same cortical layer, suggesting that layer acquisition is highly coordinated for both neuronal types. Targeting heat shock protein 70 (Hsp70) expression and function, together with the induction of lysosomal membrane permeabilization (LMP), could overcome the multiple anti-cell death mechanisms evidenced in NSCLCs that are responsible for the failure of currently used chemotherapeutic drugs. We have recently demonstrated that subchronic phencyclidine (PCP) treatment in rodents induces striatal dopaminergic hyperactivity similar to that observed in schizophrenia.

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A newborn with hemorrhagic meningoencephalitis due to Proteus mirabilis. This study provides insight into the factors related to paediatric sickle cell disease and informs max dose of glucophage xr both clinicians and researchers interested in understanding and improving HRQOL in this population. Axillary meristem development in the branchless Zu-0 ecotype of Arabidopsis thaliana. Oseltamivir carboxylate was present in breast milk but in concentrations significantly lower than considered therapeutic in infants. The correspondence to thermal vesicle fluctuations and molecular dynamics simulations implies that a broad distribution of modes is present, ranging from the membrane size down to the molecular dimensions.

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Monocyte-derived dendritic cells (DCs) remeron medication type are more effective than monocytes/macrophages for detecting and activating NKT cells in fresh blood, with mature alpha-GalCer pulsed DCs being optimal. The implantable cardioverter-defibrillator (ICD) is the standard of care in patients with ischemic and nonischemic cardiomyopathy who are at high risk for arrhythmic events and sudden cardiac death. Both aversive conditioning experiences and pre-existing psychological states appear to be associated with the development of anxiety about dental treatment in this adult population. The histological findings of breast capsules were related to: the nature of the device surface (smooth versus textured), implant duration, and the degree of capsular contracture. Using the sensitive PSI-BLAST search method, sequences representing new purple acid phosphatase-like proteins have been identified in mammals, insects and nematodes.

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Historically, their potential to differentiate into cells of the bone and cartilage lineages has led to a variety of experimental strategies to investigate whether MSCs can be used for tissue engineering approaches. We report on electrical transport in the dark and under ultraviolet (UV) illumination through GaN nanowhiskers grown by molecular beam epitaxy (MBE), which is sensitively dependent on the column diameter. This technique could readily be adapted to study other crystal and crystal inhibitor systems, or to study other noncrystal systems that exhibit regularity in the structuring of their component molecules, such as those associated with the new nanotechnologies. Treatment of childhood cancer can result in impaired spermatogenesis. The aggressiveness of this entity and the absence of any standardized treatment protocol make the prognostic unfortunate.

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Studies on the conversion of 60s yeast ribosomes into a 50S component. In the long term, smoking and dyslipidemia were the main predictors of CKD. Reconstruction of an epidemic tree, which shows who infected whom, from the observed dates of onset was performed using the serial interval. No such evolutionary selection was observed in oral pathogens (Porphyromonas and Filifactor) which showed presence of pyruvate as well as amino acid fermenting pathways which might be because the final product butyrate is itself known to be cytotoxic in oral diseases. Phenotypic robustness can increase phenotypic variability after nongenetic perturbations in gene regulatory circuits. However, low or zero rates of greetings occurred in the tenormin 50 mg presence of a second experimenter. Enhancement of the thermal lens signal induced by sample matrix absorption of the probe laser beam.

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This was a multicenter, retrospective, observational case study from seven institutions. Association of episodic physical and sexual activity with triggering of acute cardiac events: systematic review and meta-analysis. Current and future research is directed towards a better understanding of how extrasynaptic GABA receptors may be regulated via manipulation of extrasynaptic GABA levels, possibly involving extrasynaptic GABA transporters, most likely non-GAT1 transporters. However, most of the owners (22/38) preferred a solid dosage form, while few (4/38) chose a liquid formulation. Until these problems are resolved, efforts are needed to improve currently available whole-cell vaccines. Here we review the current status of adenovirus-based vectors as a means to achieve high-level gene transfer into haematopoietic cell types. On CT images, the most common form of malignant lymph node lesions invading the carotid sheath is displacement of ICA and ICV. Nuclear and cytoplasmic DNA synthesis during the mitotic cycle of HeLa cells. Peripheral venous blood was obtained, and genomic DNA was extracted.

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Reliability of upper extremity anaerobic power assessment in persons with tetraplegia. Spinal cord ischemia: an evaluation of pharmacologic agents in minimizing paraplegia after aortic occlusion. All interviews were audio recorded and transcribed for qualitative analysis using open explorative thematic coding. A gas-chromatographic method for the simultaneous determination of phenobarbitone, primidone and phenytoin in serum using a nitrogen detector. The type 2 helper T cell (T(H)2) cytokine interleukin (IL)-4 is thought to play a central role in the early stages of asthma.

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Suppression of glycolysis by DR could contribute to controlling senescence. Morphological characterization yielded at least 24 AM fungi taxa in the field samples, belonging to six genera of AMF: Acaulospora Archaeospora, Entrophospora, Gigaspora, Glomus and Scutellospora. Differentiation of bovine Staphylococcus aureus isolates by use of polymorphic tandem repeat typing. Results of a systematic literature review suggest that the overall incidence of the congenital malformations in children born to women with epilepsy is approximately three times that of healthy women. Ileal resection and small bowel transplantation for large mesenteric desmoid tumor. Haloperidol administration induces a dose-related increase of the orientation component of the motor pattern. Combined use of lamotrigine and electroconvulsive therapy in bipolar depression: a case series. We compared gene expressions of PCs, human mesenchymal stem cells (hMSCs), periodontal ligament cells (PDL-cells) and osteoblasts (MG63) for delimitation of PCs.

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