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Calmnir (Clonazepam)
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Calmnir

Clonazepam, sold under the brand name Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between six and 12 hours. Calmnir was initially patented in 1964 and went on sale in the United States in 1975. It is available as a generic medication.

Other names for this medication:
Alrest, Catier, Cloam, Clodep, Clonapax, Clonark, Clonax, Clonazepam, Cloneepam, Clonix, Clonoasig, Clonzy, Closis, Clozep, Clozipam, Cozil, Deptune, Dipwell, Epcon, Escimax, Escitacalm, Escitrac, Ezinite, Jasoclam, Lonazep, Lonipax, Melzap, Nupam, Prasilex, Repam, Revozip, Sezolan, Sezolep, Xenotril, Xitzen, Zolpidox, Zozep

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Propecia, Anafranil, Avana, Silagra, Atarax

Also known as: Clonazepam

Description

Calmnir is an anti-anxiety medication in the benzodiazepine family, the same family that includes diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan), flurazepam (Dalmane), and others. Calmnir and other benzodiazepines act by enhancing the effects of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter (a chemical that nerve cells use to communicate with each other) that inhibits brain activity. It is believed that excessive activity in the brain may lead to anxiety or other psychiatric disorders. Calmnir is primarily used for treating panic disorder and preventing certain types of seizures.

Calmnir is useful alone or as an adjunct in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. In patients with absence seizures (petit mal) who have failed to respond to succinimides, Calmnir may be useful.

Dosage

Calmnir is also used to treat symptoms of akathisia (restlessness and a need for constant movement) that may occur as a side effect of treatment with antipsychotic medications (medications for mental illness) and to treat acute catatonic reactions (state in which a person does not move or speak at all or moves or speaks abnormally). Talk to your doctor about the possible risks of using this medication for your condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Calmnir.

Do not let anyone else take your medication. Calmnir is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Overdose

Symptoms of clonazepam overdosage, like those produced by other CNS depressants, include somnolence, confusion, coma and diminished reflexes.

Treatment includes monitoring of respiration, pulse and blood pressure, general supportive measures and immediate gastric lavage. Intravenous fluids should be administered and an adequate airway maintained. Hypotension may be combated by the use of levarterenol or metaraminol. Dialysis is of no known value.

Flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. Prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation and intravenous access. Flumazenil is intended as an adjunct to, not as a substitute for, proper management of benzodiazepine overdose. Patients treated with flumazenil should be monitored for resedation, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment. The prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose. The complete flumazenil package insert, including CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, should be consulted prior to use.

Flumazenil is not indicated in patients with epilepsy who have been treated with benzodiazepines. Antagonism of the benzodiazepine effect in such patients may provoke seizures.

Serious sequelae are rare unless other drugs or alcohol have been taken concomitantly.

Storage

Tablets should be kept at room temperature, between 15 C and 30 C (59 F and 86 F).

Side effects

The most common side effects associated with Calmnir are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of clonazepam in the elderly. However, elderly patients are more likely to have confusion and severe drowsiness, or age-related heart, liver, or kidney problems, which may require caution and an adjustment in the dose for patients receiving clonazepam.

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Long-term variations of water quality in the Inner Murchison Bay, Lake Victoria. This finding has implications for evaluating vaccine efficacy and immune status. Neither may an action for relief be brought if there are other judicial or administrative means to obtain the same results. Thermostable xylanase from Thermoascus aurantiacus at ultrahigh resolution (0.89 A) at 100 K and atomic resolution (1.11 A) at 293 K refined anisotropically to small-molecule accuracy. Ursolic acid liposomes with chitosan modification: Promising antitumor drug delivery and efficacy. 5 alpha-dihydrocortisol has been reported to amplify the mineralocorticoid activity of aldosterone.

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Indomethacin was less effective than nifedipine for the fast treatment of preterm labor. Mice rotating at 1G or at 2G acceleration gravity and non-rotating controls were tested for reactivity to a spatial change after either a single 1 h or five repeated 1 h daily rotations in the centrifuge. Research carried out using different in vitro and in vivo techniques of biological evaluation support most of these claims. Thus there was a negative correlation between the amount of fibronectin and cellular cohesiveness. Significant earlier recovery of weakness was observed with Livwin as compared to placebo at 2, 4 and 8 weeks. The same dose of 5-TG protected mice from foot skin damage between days 0 and 40 post-irradiation by a DMF of 1.3, and from late foot deformity during days 60 to 90 post-irradiation by a DMF of 1.2. The retinoids had no effect on prothrombin times of animals fed the supplemented diet. Studies on the natural history of asymptomatic diabetes in young people. We found significant variability in STEMI mortality among Gulf Arab countries and identified areas requiring further efforts to reduce excess mortality in the region.

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