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Calmese (Lorazepam)

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This medication is used to treat anxiety. Lorazepam belongs to a class of drugs known as benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. This drug works by enhancing the effects of a certain natural chemical in the body (GABA). Calmese may also be used to treat: Symptoms from Alcohol Withdrawal, Mania associated with Bipolar Disorder, Adjunct Treatment, Muscle Spasm, Chronic Trouble Sleeping, A Feeling of Restlessness with Inability to Sit Still, Nausea and Vomiting caused by Cancer Drugs, Prevent Nausea and Vomiting from Cancer Chemotherapy, Psychosis caused by Sudden Alcohol Withdrawal.

Other names for this medication:
Almazine, Anxilor, Anxionil, Atipam, Biokalm, Biolar, Calmese, Dulozep, Larpose, Lopam, Lopez, Loracalm, Lorakar, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Loripam, Lorivan, Lorpam, Lotweet, Nexlor, Olraz, Trapex, Urpam, Zelor, Zepatrac, Zepnap

Similar Products:
Lodine, Desyrel, Prandin, Luvox, Anafranil, Buspar, Motrin, Lunesta, Lopressor

Also known as: Lorazepam


Calmese, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or intravenous routes of administration.

Calmese is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Calmese affects chemicals in the brain that may become unbalanced and cause anxiety. Calmese is used to treat anxiety disorders.

Calmese may be habit-forming and should be used only by the person it was prescribed for. Calmese should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.


The Calmese dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Calmese to treat
  • your age
  • the form of Calmese you take
  • other medical conditions you may have
Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

Drug forms and strengths

  • Tablet: 0.5 mg, 1 mg, 2 mg
  • Solution for injection (IV): 2 mg per mL, 4 mg per mL

General dosage information

The usual oral dosage for Calmese tablets is 2 to 6 mg daily. This dosage amount is usually divided and taken two or three times daily.

Dosage for anxiety

Typical dosage: 1 to 3 mg taken two or three times daily.

Dosage for insomnia due to anxiety or stress

Typical dosage: 2 to 4 mg at bedtime.

Dosage for IV Calmese

  • Intravenous (IV) Calmese will be given by your doctor or nurse. Your doctor will determine the best dosage for your condition.

Special dosage considerations

Older adults and people with certain physical conditions may need to start with a lower dosage. This might be 1 to 2 mg, taken two or three times daily for anxiety or once at bedtime for insomnia.

What if I miss a dose?

If you miss a dose, take it as soon as you can. However, if it’s just a few hours until your next dose, skip the missed dose and take the next one on schedule.

Never try to catch up by taking two doses at a time. This can cause dangerous side effects.


In cases of a suspected Calmese overdose, it is important to establish whether the patient is a regular user of Calmese or other benzodiazepines, since regular use causes tolerance to develop. Also, one must ascertain whether other substances were also ingested.

Signs of overdose range through mental confusion, dysarthria, paradoxical reactions, drowsiness, hypotonia, ataxia, hypotension, hypnotic state, coma, cardiovascular depression, respiratory depression, and death.

Early management of alert patients includes emetics, gastric lavage, and activated charcoal. Otherwise, management is by observation, including of vital signs, support and, only if necessary, considering the hazards of doing so, giving intravenous flumazenil.

Patients are ideally nursed in a kind, nonfrustrating environment, since, when given or taken in high doses, benzodiazepines are more likely to cause paradoxical reactions. If shown sympathy, even quite crudely feigned, patients may respond solicitously, but they may respond with disproportionate aggression to frustrating cues. Opportunistic counseling has limited value here, as the patient is unlikely to recall this later, owing to drug-induced anterograde amnesia.


Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Calmese is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Calmese are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Ativan if you have:

narrow-angle glaucoma; or a history of allergic reaction to any benzodiazepine (lorazepam, alprazolam, diazepam, Ativan, Klonopin, Restoril, Tranxene, Valium, Versed, Xanax, and others).

To make sure Ativan is safe for you, tell your doctor if you have::

breathing problems such as COPD (chronic obstructive pulmonary disease) or sleep apnea (breathing that stops during sleep); drug or alcohol addiction; depression, mood problems, or suicidal thoughts or behavior; kidney or liver disease; seizures; or glaucoma.

Tell your doctor if you are pregnant or plan to become pregnant. Lorazepam may harm an unborn baby. Avoid taking this medicine during the first trimester of pregnancy.

If you use Ativan while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

If you are breastfeeding, tell your doctor if you notice drowsiness or fussiness in the nursing baby.

Ativan is not approved for use by anyone younger than 12 years old.

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