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Bonestat (Calcitriol)

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Bonestat is a hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give Bonestat.

Other names for this medication:
Admax, Alcee, Alfacalcirol, Alfacip, Alphadol, Arcium, Biocitral, Bonetuf, Calasto, Calbec, Calbory, Calbovic, Calcibest, Calcigra, Calcikind, Calcimet, Calcitriol, Calday, Calgel, Calosto, Caltin, Caltop, Calvical, Calzem, Carcal, Coecoral, Devita, Estovon, Fovit, Lctrol, Netxod, Novadee, Ostriol, Primacal, Rical, Riecal, Ritoca, Rockbon, Romical, Solbiocal, Sorvate, Trolec, Vezocal, Vitalpha, Zaxial

Similar Products:
Priligy, Biaxin, Nuvigil, Clozaril, Calan, Benemid, Tofranil, Avodart, Zebeta, Combivent

Also known as: Calcitriol


Generic Bonestat is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Bonestat are intestine and bone. Generic Bonestat receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Bonestat may also act on the kidney and the parathyroid glands. Generic Bonestat is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Bonestat has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Bonestat, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Bonestat in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Bonestat produces other independent beneficial effects. Bonestat is also known as Calcitriol. Generic Bonestat treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Bonestat is Calcitriol. Brand name of Generic Bonestat is Bonestat.


Generic Bonestat is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Bonestat suddenly.


If you overdose Generic Bonestat and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Bonestat are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Generic Bonestat if you are allergic to Generic Bonestat components. Do not take Generic Bonestat if you are pregnant, planning to become pregnant, or are breast-feeding. It is not known if this medication appears in breast milk. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Be careful with Generic Bonestat if you have heart disease, kidney disease or kidney stones, coronary artery disease (hardening of the arteries). Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. It can be dangerous to stop Generic Bonestat taking suddenly.

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Three new anthraquinones, 1-hydroxy-2,3-dimethoxy-7-methyl-9,10-anthraquinone, 1,3-dihydroxy-5,6-dimethoxy-2-methyl-9,10-anthraquinone, and 3-hydroxy-1,5,6-trimethoxy-2-methyl-9,10-anthraquinone, along with five known anthraquinones were isolated from the roots of Prismatomeris tetrandra. Role of the suppressor of cytokine signaling 2 (SOCS2) during meningoencephalitis caused by Bovine herpesvirus 5 (BoHV-5). Somatostatin analog radiopharmacy continues to evolve to include the development of more selective and higher affinity analogs and PET tracers. Multidrug-Resistant Aeromonas veronii Recovered from Channel Catfish (Ictalurus punctatus) in China: Prevalence and Mechanisms of Fluoroquinolone Resistance. Although unprotected anal intercourse is known to be an efficient method for the transmission of HIV and other viral infections, it has rarely been addressed outside cohorts of men who have sex with men. These observations indicate that the reduction of VER latency may be related to neuroexcitation induced by release of excitatory amino acids, the latter constituting a widespread phenomenon, concomitant with brain injuries of various aetiologies. Early diagnosis and aggressive drainage are necessary for achieving a favorable outcome. To better understand the cellular basis for dual tropism, we analyzed the macrophage coreceptors used for Env-mediated cell-cell fusion as well as infection by several dual-tropic HIV-1 isolates. These forms can be globally called mineralocorticoid hypertension and are due to different alterations of the renin-angiotensin-aldosterone system (SRAA).

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A light and electron microscopic study of changes in blood and bone marrow in acute hemorrhagic Trypanosoma vivax infection in calves. Distinguishing those patients who need no treatment from those who need intermediate or extensive treatment can be very difficult. Inconsistencies in the legal status of an unborn child: recognition of a fetus as potential life. In response to learned maternal experience, Mecp2het females exhibited transient changes to cortical inhibitory networks typically associated with limited plasticity. Recovery with a regular dose of antibiotics from bacillary hemoglobinuria in a Holstein cow. The primary objective of the current study was to determine the reliability between methods of supine and prone leg length inequality (LLI) assessment. Single-cell genomics is opening up new ways to tackle these questions by combining the comprehensive nature of genomics with the microscopic resolution that is required to describe complex multicellular systems. Detection of premature atherosclerosis by high-resolution ultrasonography in symptom-free hypopituitary adults. Self-immolative cleavage releases the sulfonate and the two-electron reduction product of a thioquinone methide.

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Detection and Molecular Characterization of Foot and Mouth Disease Viruses from Outbreaks in Some States of Northern Nigeria 2013-2015. Epigenetic mechanisms have the potential to help elucidate biology connecting experiential risk factors with neuropsychiatric disease manifestation. In order to test this we recorded event-related brain potentials (ERPs) of 12 healthy subjects in a visuospatial selective attention task. Rabbit muscle enolase was found to be phosphorylated in vitro by calcium-activated phospholipid-dependent protein kinase. This is compatible with either unequal crossing over of three of the four chromatids in paternal meiosis I or with a double crossing over in meiosis I and II (or an early mitotic division). Aberrant epidermal growth factor (EGF) receptor (EGFR) signaling contributes to neoplastic initiation and progression in lung. Myocardial and serum galectin-3 expression dynamics in response to the early cardiovascular outcomes after acute MI are not fully elucidated. In addition, we independently developed a compact device to facilitate evaluation of SVBA in different gravitational environments. This paper presents biopsy analyses in support of the clinical evidence of muscle recovery induced by a new system of life-long functional-electrical-stimulation (FES) training in permanent spinal-motoneuron-denervated human muscle. Data indicated that intracellular ROS are highly toxic and applying low concentration of Myc not only inhibited cellular ROS production but also was accompanying with the protection of cells against the highly toxic and the lethal effects of peroxide compounds.

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Toxicity and carcinogenicity studies of musk xylol in B6C3F1 mouse. Endovascular reconstruction of the iliac bifurcation with commercial standard stentgrafts is safe and effective. We conducted a retrospective cohort study using the Health Improvement Network database. Health Behaviors and Chronic Conditions Mediate the Protective Effects of Masculinity for Physical Performance in Older Adults. Increased expression of hepatic CD36 protein in response to DIO is sufficient to exacerbate hepatic triglyceride storage and secretion. A comparative study of the elderly in New York and London using the computer diagnosis AGECAT. The fourth contained regenerative mucosa and recanalized submucosal blood vessels.

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Anisakid nematodes are common parasites of fish, mammals, fish-eating birds, and reptiles with a worldwide distribution, causing diseases in human, fish and important economic losses. Comparison trial of clindamycin with aztreonam or gentamicin in the treatment of postpartum endometritis. However, the drug also up-regulates the expression of COX-2, which has been suggested to promote the progression of endometriosis. monocytogenes were a field strength of 8.5 kV/cm, 200 Ohms resistance, 25 microF capacitor with a time constant of 5 ms. STUDIES ON CHANGE IN THE ENERGY STEADY STATE IN PHYSIOLOGICAL ADAPTATION PROCESSES.

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For all cell types, the size of each EPCS had a consistent range in length along the PM from 50 to 300 nm, with microtubules and ribosomes excluded from the EPCS. A greater proportion of individuals who were listed in a national cancer registry reported experiencing fatigue compared with individuals in the general population. Plaque EI and its ratio in plaque and arterial lumen of the ATV group were lower than those in the AS group. Accelerated Loss of TCR Repertoire Diversity in Common Variable Immunodeficiency. An unusual case of a solitary pulmonary nodule associated with an abscess correctly distinguished by Pet/Ct fusion imaging. The extent of total lipid peroxidation of the heart and liver was assessed by 2-thiobarbituric acid reactant substance levels. Vitrectomy with ILM removal and gas tamponade resulted in a marked reduction of the SD in the macular area. Spectral and temporal response patterns of single units in the chinchilla dorsal cochlear nucleus. In patients with pericardial effusion, CT attenuation values seem to be correlated with the characterization parameters of the fluid and may distinguish exudative pericardial effusion from transudative pericardial effusion.

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Risk Factors for In-Hospital Complications of Fall-Related Fractures among Older Chinese: A Retrospective Study. Practice-induced effects of specific balance training on brain structure and activity in elderly people are largely unknown. They had recurrent episodes of pneumothorax during follow-up and placement of chest tubes was the treatment chosen. Postmortem study of renal lesions in 4 recipients of liver transplants treated with cyclosporin A. The necessity of elucidation of the mechanism of generation of actual cases is emphasized since no relation with the usual animal sources could be established. Cancer Registration Manual Understanding by Medical Record Administrators. dulcis fruit extracts were evaluated based on the inhibition of cytochrome P450 (CYP) enzyme activity. Exposure to family members was largely, though not exclusively, determined by the degree of direct contact with the application process. Primitive or residual common bile duct calculi following common bile duct surgery can now be treated with minimum surgery using an endoscopic or X-ray guided approach.

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3-(1-Carboxypropyl) ether derivatives of 15alpha-hydroxyestradiol 15-N-acetylglucosaminide (15alpha-OHE2 15NAG) and 15alpha-hydroxyestriol (E4) 15NAG were synthesized and conjugated with bovine serum albumin. In addition to the orientational and radial melting processes, isomerizations and complex size effects are seen to occur in a very similar way to atomic and molecular clusters. minimum was before associated with neurotoxic symptoms, however, the nature and structure of toxins produced by this dinoflagellate remains unknown. Establishment and characterization of cisplatin-resistant sublines of human lung cancer cell lines. Diabetic toe ulcers are a potentially devastating complication of diabetes. Interestingly, despite bcl-2 expression being a poor prognostic indicator of neuroendocrine tumors, the patient with this tumor has achieved long-term survival (approximately 6 years) at the time of writing this report. In vitro assays showed that TP5 affects the function of T cells and monocytes measured by enhanced cGMP level and the triggering of cellular signalling, respectively.

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