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Biproate (Divalproex)

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Biproate is used to treat seizure disorders, certain psychiatric conditions (manic phase of bipolar disorder), and to prevent migraine headaches. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

Other names for this medication:
Biproate, Desval, Discern, Divaa, Divalex, Divanet, Dixval, Encorate, Epival, Epsoval, Genval, Jydival, Kayval, Spikalon, Torvate, Trival, Valance, Valate, Valcontin, Valimep, Valowin, Valparin, Valpex, Valporate, Valporil, Valporiv, Valporl, Valpret, Valprid, Valrate, Valric, Valtec, Valvo, Velze, Vinchorate, Zorat, Zoret

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Also known as: Divalproex


Biproate is a perfect remedy in struggle against seizure disorders. Biproate acts by increasing the amount of a certain natural substance in the brain. Biproate is also known as Valproate semisodium, Divalproex sodium, Valproic acid, Divaa. It is anticonvulsant. Generic name of Biproate is Divalproex Sodium. Brand names of Biproate are Biproate, Biproate ER, Biproate Sprinkles.


This section provides information on the proper use of a number of products that contain valproic acid. It may not be specific to Depakote DR. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide or patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the delayed-release capsules or oral capsules whole with a full glass of water. Do not split, crush, or chew it. You may take this medicine with food to decrease stomach upset.

If you cannot swallow the capsule whole, you may open it and sprinkle the contents onto a small amount of soft food (including applesauce or pudding).

Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules, delayed-release capsules, and solution): For seizures: Adults and children 10 years of age or older—Dose is based on body weight and must be determined by your doctor. At first, the usual dose is 10 to 15 milligrams (mg) per kilogram (kg) of body weight per day. Your doctor may gradually increase your dose every week by 5 to 10 mg per kg of body weight as needed. However, the dose is usually not more than 60 mg per kg of body weight per day. If the total dose a day is greater than 250 mg, it is usually divided into smaller doses and taken 2 or more times during the day. Children younger than 10 years of age—Use and dose must be determined by your doctor. For oral dosage form (delayed-release capsules): For mania: Adults—At first, 750 milligrams (mg) once a day, usually divided in smaller doses. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For migraine: Adults—At first, 250 milligrams (mg) 2 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 1000 mg a day. Children—Use and dose must be determined by your doctor.


If you overdose Biproate and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Biproate overdosage: shallow, breathing, weak pulse, sleepiness, feeling drowsy, loss of consciousness.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Biproate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Depakote Sprinkles if you are allergic to it, or if you have:

liver disease; a urea cycle disorder; or a genetic mitochondrial (MYE-toe-KON-dree-al) disorder such as Alpers' disease or Alpers-Huttenlocher syndrome, especially in a child younger than 2 years old.

Depakote Sprinkles can cause liver failure that may be fatal, especially in children under age 2 and in people with liver problems caused by a genetic mitochondrial disorder.

Tell your doctor if you have ever had:

liver problems caused by a genetic mitochondrial disorder; depression, mental illness, or suicidal thoughts or actions; or a family history of a urea cycle disorder or infant deaths with unknown cause.

Some people have thoughts about suicide while taking Depakote Sprinkles. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Using Depakote Sprinkles during pregnancy may increase the risk of serious birth defects that can develop early in pregnancy, even before you know you are pregnant. Using this medicine during pregnancy can also affect cognitive ability (reasoning, intelligence, problem-solving) later in your child's life. However, having a seizure during pregnancy could harm both the mother and the baby.

If you take Depakote Sprinkles for seizures or manic episodes: The benefit of preventing seizures or manic episodes may outweigh any risks posed by this medicine. There may be other medications that are safer to use during pregnancy. Do not start or stop taking this medicine without your doctor's advice.

Do not use Depakote Sprinkles to prevent migraine headaches if you are pregnant or you could become pregnant.

If you are not pregnant, use effective birth control to prevent pregnancy while using Depakote Sprinkles. Tell your doctor if you start or stop using hormonal contraception that contains estrogen (birth control pills, injections, implants, skin patches, and vaginal rings). Estrogen can interact with this medicine and make it less effective in preventing seizures.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

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Delayed-onset muscle soreness (DOMS) is a serious problem for people who do not exercise on a regular basis. Despite the occasionally-occurring episodes of altered predilection sites the principal organotropic behaviour of given Leishmania strain was remarkably constant in in vivo passages. (2) Does compliant use of CPAP provide a cognitive advantage over noncompliant use?. We found a much higher rate of positive cultures using the latter method than has previously been reported in the literature. Comparison of the kinetic parameters of Pseudomonas isoamylase and Aerobacter pullulanase.

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International comparisons of injury data may be useful for examining differences in risk and for suggesting potential interventions or hypotheses for future studies. The authors studied the effects of aging on the flexible use of categorization rules based on thematic and taxonomic relations. This work has demonstrated that the proposed synergistic approach is an unbiased, reliable, and very efficient structure verification and de novo structure elucidation method that can be applied to difficult structural problems when other experimental methods would be difficult or impossible to use. Up-Regulation of Follistatin-Like 1 By the Androgen Receptor and Melanoma Antigen-A11 in Prostate Cancer. The review was limited to published and indexed research in peer-reviewed journals in five major databases between 1995 and October 2002. Essential tremor (ET), one of the most prevalent neurological diseases, has been associated with a variety of comorbidities and, in some studies, a modest increase in risk of mortality. This study reports results of discontinuing therapy in four patients with Type I Gaucher disease with different genotypes and varying degrees of clinical involvement. Litomosoides carinii infection in cotton-rats: evolution of microfilaraemia before and after treatment with diethylcarbamazine and suramin. We report the case of a 44-year-old woman with obstructive hypertrophic cardiomyopathy without history of prior arrhythmias who underwent surgical myectomy.

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Different brain activation patterns to pain and pain-related unpleasantness during the menstrual cycle. Acute toxicity resembled that seen with the phase I study of a single dose (5). Differential susceptibility of nonmalignant human breast epithelial cells and breast cancer cells to thiol antioxidant-induced G(1)-delay. In the human xenograft FaDu, the growth delay given by a single dose of paclitaxel was enhanced by combination with a single dose of ZD6126, and the growth delay given by the combination was greater than the sum of the growth delays from the individual treatments. Evaluation of the Antioxidant Activity of Extracts and Active Principles of Commonly Consumed Indian Spices. Crystal structure of a secreted insect ferritin reveals a symmetrical arrangement of heavy and light chains.

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The strengthening of only one link of the chain-of-survival did not improve 1 month survival. To maintain the best performance a frozen serum sample should be thawed once to prevent repeated freeze-thaw cycles. Complications associated with the use of autogenous bone in the repair or replacement of tissue side effects of nifedipine er 60 mg lost through injury or disease have driven the search for alternative sources of graft material. YIPF proteins primarily localise to the Golgi complex and can be grouped into trans-Golgi-localising YIPFs (YIPF1 and YIPF2) and cis-Golgi-localising YIPFs (YIPF3, YIPF4 and YIPF5), with YIPF6 and YIPF7 showing a broader profile being distributed throughout the Golgi stack. Twenty-three patients with CADASIL (five men and 18 women) were assessed by psychiatrists using the Structured Clinical Interview for the DSM-IV, clinician version. Evaluation of prostaglandin D2 (PGD2) as an anticoagulative agent for haemodialysis in comparison with prostaglandin E1 (PGE1). To assess the effects of extreme long-term storage on liquid-fill capsule product quality and integrity, with respect to both the capsules per se and a standard blister-pack type (foil-film blister). On the statistical analysis of the GS-NS0 cell proteome: imputation, clustering and variability testing. Being localized in the nucleus renders Int of HK022 as a potential recombinase for site-specific gene manipulations in mammals. In another 2 cases, the conduit was used for palliative RVOT reconstruction.

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The kidney plays a pivotal role in the physiologic action of PTH, as this peptide hormone increases tubular calcium reabsorption, decreases tubular phosphate reabsorption, and stimulates the renal 25-hydroxy-1-hydroxylase to convert 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D, the hormonal form of the vitamin that stimulates intestinal calcium absorption. Further investigation revealed extensive retroperitoneal abdominal and pelvic lymphadenopathy. DNA synthesis in muscle precursors was initiated 30 h after injury. All patients exhibited a response: 22 patients ovulated, of whom 10 conceived. Rice pads reduce geometric distortion of echo-planar diffusion-weighted images of the cervical spinal cord. Our aim was to study the effect of gemfibrozil on cerivastatin pharmacokinetics. Unrecognized HIV infection, risk behaviors, and perceptions of risk among young black men who have sex with men--six US cities, 1994-1998. In conclusion, thioacetamide-induced immunosuppression was, at least in part, due to the metabolites produced by FMO as well as by P450. In fact, our recent surveys showed that Japanese consumers had become uneasy about the potential health risks of genetically modified foods. The sample for this analysis comes from the AIDS Time-Oriented Health Outcome Study.

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Analytical ultracentrifugation for characterizing nanocrystals and their bioconjugates. Chalcone isomerase gene from rice (Oryza sativa) and barley (Hordeum vulgare): physical, genetic and mutation mapping. Physiologically arbitrary variation of the type observed for /i/ challenges the assumption that phonetic patterns can be determined by independent control of tone (source) and vowel (filter) production units. A master equation approach that provides a is lexapro a strong drug good description of the H2 formation process was proposed. Increased ACR is associated with diminished exercise capacity in the early stages of essential hypertension independently from adverse cardiac adaptations, further elucidating the adverse prognostic role of albuminuria in this setting. RESULTS MiR-206 expression was enriched in both diseased EPCs and plasma of CAD patients.

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Methanol extracts of rat urine, mouse serum, human hepatocytes, rat hepatocytes, and human liver microsomes were analyzed for resveratrol metabolites using reversed-phase high-performance liquid chromatography with on-line ultraviolet-photodiode array detection and mass spectrometric detection (LC-DAD-MS and LC-UV-MS-MS). Halonal is a phenobarbital inductor of the monooxygenase system. Changes in soil carbon and biaxin type of antibiotic nitrogen cycling along a 72-year wildfire chronosequence in Michigan jack pine forests. The effects were more like those occurring when the stimulus was paired with food. Patients had preserved left ventricular ejection fraction at rest and no evidence of coronary artery disease or significant noncardiac illness. Association of estrogen receptors with parenchymal pattern at mammography. Additional searches were made using the reference lists of published papers and chapters.

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The realism of simulated compressions was evaluated by comparing the breast shapes on simulated and real mammograms. Group 2 had increased osmotic excretion in the evening and night, probably due to a high renal osmotic load caused by the diet characteristics of the evening meal. Utilizing diesel exhaust particles (DEPs) as a model air pollutant, we and others have demonstrated that PM contains redox-active chemicals that generate inflammation through an oxidative stress mechanism. By contrast, in procyclic forms, depletion of TbRAB11 blocks both fluid-phase endocytosis and internalization of surface proteins. Child development and quality of parenting in lesbian families: no psychosocial indications for a-priori withholding of infertility treatment. Remarkably, the results obtained for the Bloch function ansatz can be related to results from (discrete) generalized coined quantum walks.

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Geometrical vortex lattice pinning and melting in YBaCuO submicron bridges. Use of plasma-free medium for the in vitro culture of human lymphocytes. Infrared laser photochemistry of metal carbonyls in the presence of cyclopentadiene. Although advanced imaging methods have been developed, routine radiography remains the mainstay in the initial assessment of osseous lesions involving the jawbones. Conditional inference tree modelling was used to determine the discriminatory value of the lactate profile and other pre- and intra-operative risk factors in terms of selecting survivors. The synthesis of a new series of 1beta-methylcarbapenems having pyrrolidine and piperidine moieties is described. Responding of both groups showed summation to tone plus light in testing, with the effect clearly larger for extinction-trained subjects. The patient was asymptomatic until 2004, when he presented again with dysphagia. During this process mutations occur in chromosomal replication forks, provided cells are in the logarithmic phase of growth. Evolving therapeutic indications for N-type calcium channel blockers: from chronic pain to alcohol abuse.

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The object of this study was to investigate in rats, the sensitivities of the light-enhanced startle (LES) and fear-potentiated startle (FPS) paradigms to sex differences and to determine the effects of maternal separation (MS) on the baseline startle magnitude and potentiated startle response in these paradigms. Selective catheterization and angiography of brachiocephalic vessels in the elderly may be difficult because of tortuosity and unfolding of the thoracic aorta. The proposed method provides various means to discriminate both disease pictures in a clinical environment. The 64-slice CT coronary angiography revealed a large non-obstructing non-calcified plaque in the proximal left anterior descending artery with positive vessel remodeling. Parents Empowering Parents (PEP) Program: understanding its impact on the bleeding disorders community. This review summarizes the general regulatory requirements for establishing bioequivalence between generic and reference oral MR products. sanctum (leaf) possesses some biologically active principles that are antibacterial and immunomodulatory in nature. In hypertension, new patterns can be quantified in these terms and give insights to how structure affects function. UVER efficiently removes both cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6-4) pyrimidone photoproducts (6-4PPs) from genomic DNA. Development terramycin antibiotic powder of the prothoracic glands of permanent larvae of Locusta migratoria obtained by selective irradiation of the hemocytopoietic tissue.

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The use of hemosorption in the treatment of patients with grave patterns of systemic lupus erythematosus, rheumatoid arthritis, psoriasis, systemic vasculitis and similar illnesses in conjunction with conventional therapy (corticosteroids, cytostatics) leads to sequestration of the depositions of immune complexes from the skin. A new technique of culdolaparoscopic oophorectomy during vaginal hysterectomy is described. Heat shock protein therapy fails to prevent diabetes in NOD mice. A theoretical and experimental study of competition between solution and surface receptors for ligand in a Biacore flow cell. This finding is extended, showing that the binding is as a function of concentration and physical form of the antibiotic in solution, i.e., monomers or micellar aggregates. To further our understanding of capsule endoscopy (CE) in children, we systematically compiled data on indications and outcomes and evaluated the effectiveness of CE on patient management using meta-analyses. A comparison of the results obtained with the case of low fillings is conducted. Normally, when the area to be covered is exceptionally large or when skin grafting is not possible because of the location, pedicle or free flaps are used. Hermaphroditism in Rodents, with a Description of a Case in the Mouse. Most studies were of low quality and did not show a statistically significant effect of intervention.

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Insect-resistant biotech crops and their impacts on beneficial arthropods. Moreover, 40 DIV astrocytes showed earlier loss of integrity (at 6 h) than 10 DIV astrocytes (at 24 h) after H(2)O(2) exposure. The academic practice of otolaryngology: philosophical and practical perspectives. We demonstrated previously that human FEN1 endonuclease, an enzyme involved in excising single-stranded DNA flaps that arise during Okazaki fragment processing and base excision repair, cleaves model flap substrates assembled into nucleosomes. Clinicians and researchers can, therefore, use these 12 vasotec medication items, either alone or in combination with other information, to determine if functional ankle instability is present. Three Cry1A-binding proteins, viz., aminopeptidase N (APN), the cadherin-like Bt-R1, and membrane-type alkaline phosphatase (m-ALP), were localized, by immunohistochemistry, in sections from the anterior, middle, and posterior regions of the midgut from second instar M. Technique for using census data to estimate international migration were described and applied to census data from Kuwait for illustrative purposes. The behavior of the two redwinged blackbirds was comparable to that of more conventional organisms working on similar schedules of reinforcement. Circular migration and uncontrolled migration in the New Hebrides: proposals for an effective urban migration policy.

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