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Biaxsig (Roxithromycin)
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Biaxsig

Biaxsig (generic name: roxithromycin; brand names include: Roximycin / Biaxsig / Roxar / Surlid) belongs to a class of drugs known as semi-synthetic macrolide antibiotics. Biaxsig is used for the treatment of bacterial infections including infections of the ear, nose and throat, respiratory tract, skin and skin structure infections, and urinary tract infections.

Other names for this medication:
Acevor, Aristomycin, Asmetic, Assoral, Azuril, Bazuctril, Biaxsig, Biostatik, Cadithro, Crolix, Delos, Dorolid, Erybros, Floxid, Infectoroxit, Ladlid, Macrolid, Macrosil, Makrodex, Monobac, Nirox, Odonticina, Overal, Pedilid, Pedrox, Ramivan, Remora, Renicin, Ritosin, Rokilide, Roksimin, Rolicyn, Rolid, Romac, Romyk, Rossitrol, Rotramin, Roxacine, Roxithromycine, Roxithromycinum, Rulid

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Also known as: Roxithromycin

Description

Biaxsig is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Biaxsig is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Biaxsig is available under several brandnames. Biaxsig is not available in the United States. Biaxsig is available in Australia, Israel and New Zealand. Biaxsig has also been tested to possess antimalarial activity.

Biaxsig prevents bacteria from growing, by interfering with their protein synthesis. Biaxsig binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Biaxsig has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.

Dosage

Take Generic Biaxsig by mouth with food. If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water. Swallow Generic Biaxsig tablets whole with a glass of water. Generic Biaxsig should be taken at least 15 minutes before food or on an empty stomach (i.e. more than 3 hours after a meal). Generic Biaxsig works best if you take it on an empty stomach. For treating bacterial infections, Generic Biaxsig is usually taken for 5 to 10 days. If you want to achieve most effective results do not stop taking Generic Biaxsig suddenly.

Overdose

Immediately telephone your doctor or pharmacist. Do this even if there are no signs of discomfort or poisoning.

Storage

Keep the tablets in the foil until it is time to take them.

Keep the tablets/in a cool dry place where the temperature stays below 30 degrees C.

Do not store Biaxsig or any other medicine in the bathroom or near a sink.

Do not leave it in the car on hot days or on window sills.

Heat and dampness can destroy some medicines.

Keep it where children cannot reach it.

A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Biaxsig are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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A PROPOSED MICROBIOLOGICAL METHOD FOR STUDYING THE STABILITY OF PRESERVATIVES IN PARENTERAL SOLUTIONS. Scientific literatures witnessed several reports on variant origin and branching pattern of ulnar artery. The first place is can depakote overdose cause death occupied by haloperidol, perfenazin and chlorpromazine in hallucinatory paranoid syndromes, amitriptyline and clomipramine in depressions. Carbohydrate chain lengths in the hepatolithiasis group were shorter than those in the control group. Results indicate improved accuracy and precision relative to the standard technique in significantly less time for volumes of fetomaternal hemorrhage requiring more than the standard dose of Rho(D)-immune globulin.

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In addition, exposure of macrophages to HRP or BSAman induced cytotoxicity against NIH 3T12 cells. Australian cases of endovascular aneurysm repair (EVAR) performed between 1999 and 2001 have been evaluated to determine the mid-term (6 months to 5 years) safety and efficacy of the procedure. The role of Gln61 and Glu63 of Ras GTPases in their activation by NF1 and Ras GAP. Proceedings of the 9th International Symposium on Enzymology and Molecular Biology of Carbonyl Metabolism. Selective COX-2 inhibitors increase the risk of myocardial infarction and stroke. Exposure of human fibroblast monolayers to several concentrations of morphine, for different periods of time, with and without an artificially induced inflammatory process. The four methods used to address the best practice aspect of the project were described in detail in Part 1. Two-parameter (p63 levels and N/C ratio) analysis revealed the presence of a distinct population of small cells with higher levels of p63 and a large N/C ratio in the limbal epithelium.

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