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Bexomer (Eszopiclone)
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Bexomer

EsBexomer, marketed by Sunovion under the brand-name Lunesta, is a nonbenzodiazepine hypnotic agent used in the treatment of insomnia. It is slightly effective for this use. Bexomer is the active dextrorotatory stereoisomer of Bexomer, and belongs to the class of drugs known as cyclopyrrolones. It is also classified as a therapeutic sedative hypnotic and pharmacological cyclopyrrolone.

Other names for this medication:
Bexomer, Eszopiclone, Fulnite, Zolnite, Zopimin, Zopipure

Similar Products:
Epivir, Sumycin, Indocin, Rogaine, Intagra, Arava, Glyburide, Mestinon, Remeron

Also known as: Eszopiclone

Description

Bexomer is a nonbenzodiazepine hypnotic agent that is a pyrrolopyrazine derivative of the cyclopyrrolone class.

Bexomer is a white to light-yellow crystalline solid. Bexomer is very slightly soluble in water, slightly soluble in ethanol, and soluble in phosphate buffer.

Eszopiclone is formulated as film-coated tablets for oral administration. Bexomer tablets contain 1 mg, 2 mg, or 3 mg eszopiclone and the following inactive ingredients: calcium phosphate, colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide, and triacetin. In addition, both the 1 mg and 3 mg tablets contain FD&C Blue #2.

Dosage

Do not take a dose of this drug unless you have time for a full night's sleep of at least 7 to 8 hours. If you have to wake up before that, you may have some memory loss and may have trouble safely doing any activity that requires alertness, such as driving or operating machinery.

This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as nausea, vomiting, flushing, stomach cramps, nervousness, shakiness) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

As you get older, your sleep pattern may naturally change and your sleep may be interrupted several times during the night. Consult your doctor or pharmacist for ways to improve your sleep without medication, such as avoiding caffeine and alcohol close to bedtime, avoiding daytime naps, and going to bed at the same time each night.

Overdose

In clinical trials with Bexomer, one case of overdose with up to 36 mg of Bexomer was reported in which the subject fully recovered. Since commercial marketing began, spontaneous cases of Bexomer overdoses up to 270 mg (90 times the maximum recommended dose of Bexomer) have been reported, in which patients have recovered. Fatalities related to Bexomer overdoses were reported only in combination with other CNS drugs or alcohol.

exaggerations of the pharmacological effects noted in preclinical testing. Impairment of consciousness ranging from somnolence to coma has been described. Rare individual instances of fatal outcomes following overdose with racemic zopiclone have been reported in European postmarketing reports, most often associated with overdose with other CNS-depressant agents.

General symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. Flumazenil may be useful. As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention. The value of dialysis in the treatment of overdosage has not been determined.

As with the management of all overdosage, the possibility of multiple drug ingestion should be considered. The physician may wish to consider contacting a poison control center for up-to-date information on the management of hypnotic drug product overdosage.

Storage

Store Bexomer at room temperature away from moisture and heat.

Keep track of how many capsules have been used from each new bottle of this medicine. Bexomer is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

Side effects

The most common side effects associated with Bexomer are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Bexomer can cause side effects that may impair your thinking or reactions. You may still feel sleepy the morning after taking the medication. Until you know how this medication will affect you during waking hours, be careful if you drive, operate machinery, pilot an airplane, or do anything that requires you to be awake and alert.

Do not drink alcohol while you are taking Bexomer. It can increase some of the side effects of Bexomer, including drowsiness.

Do not take other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxants, and medicine for depression or anxiety).

Avoid taking Bexomer during travel, such as to sleep on an airplane. You may be awakened before the effects of the medication have worn off. Amnesia (forgetfulness) is more common if you do not get at least 8 hours of sleep after taking Bexomer.

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DNA samples from 22 unrelated patients(21 male and 1 female) with G6PD deficiency from Tianjin area in North China were studied for the three common mutations by using both mismatched primers mediated polymerase chain reaction/ restriction enzyme analysis and dideoxy fingerprinting methods. Clinical evaluation of serum transforming growth factor beta 1 assay in the diagnosis of primary hepatic carcinoma. Because these bacteria do not respond very well to drugs but most of the gastrointestinal infections are caused by them, the use of S. IL-6 determination in AF may be a useful indicator to identify neonates with higher risk of in utero bacterial infection. The number of stem cells is predicted to be not less than 4 and not more than 16 per crypt with cell cycle times of between 12 and 32 h respectively. Characterization of the Hydra lamin and its gene: A molecular phylogeny of metazoan lamins. Clinical reports from our laboratory and several other independent sources indicate that static change in eye gaze, from a neutral head-referenced position, is one such behavior that can evoke, modulate and/or suppress these phantom auditory events. But due to sequence divergence and activity specificity linked to substrates, activity prediction is not evident and biochemical characterisation remains necessary. Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves. The distribution of the CDW52 molecule on blood cells and characterization of its involvement in T cell activation.

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Hemisphere and third ventricle volume and the normalized (Talairach) location of three association cortex sulcal landmarks were measured on high-resolution MRI scans in 37 male patients with schizophrenia and 33 male control subjects matched on age, handedness, and parental socioeconomic status. No significant handedness-by-side interaction was obtained in the present study, however. A research was carried out on risk evaluation of workers with different tasks in operating theatre. Flow cytometry was used for monitoring several haemocyte parameters. One hundred nine workers and 254 control subjects were studied to evaluate the effects of formaldehyde on the mucous membranes and lungs. However, there was a huge variation in relation to the applied force, the used force actuator, the number of cycles, and the frequency of cycles per time as well as the number of specimens. As part of a prospective study of 103 stroke patients, we have analyzed the relation between depression and associated variables at 3 months, 6 months, 1 year, and 2 years after stroke. The tractability of entropic measures for categorizing the trajectories of nonlinear dynamics that may be present and chaotic is considered, with a focus on the case where there are two attractors and at least one heteroclinic orbit between them. These approaches may be particularly useful in planning community pharmacy services and so overcome challenges in their implementation into practice. Age and sex-matched control rats that did not receive radiation were used for comparison.

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At 2 weeks, mRNA level of type I collagen was significantly higher than at 1 week. Successful treatment of epilepsy and celiac disease with a gluten-free diet. The genes encoding three SRP proteins (SRP19, SRP72 and SRP68) were identified by bioinformatics analysis. Adjuvant System 03 (AS03) markedly enhances immune responses to H5N1 vaccine antigens, but the underlying molecular mechanisms are incompletely understood. These advantages are ordinarily absent with standard or custom cemented components. Longitudinal assessment of hormonal and physical alterations during normal puberty in boys. Prognostic factors of short-term outcomes of intravitreal ranibizumab in diabetic macular edema. The automated microflow NMR system is controlled and monitored using web-based software. These results demonstrate serum-associated augmentation of PMNL function by clindamycin in vivo which may be of potential clinical benefit in the outcome of infections. Patients treated with topical prednisolone alone had a significantly higher incidence of visually significant pseudophakic macular edema after uneventful cataract surgery than those treated with topical prednisolone and nepafenac.

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The key evidence for their existence came from a series of inelastic electron-nucleon scattering experiments conducted between 1967 and 1973 at the Stanford Linear Accelerator Center. Patient flow analysis in seven primary health care centers in Monastir (Tunisia). A procedure for modifying the occlusal surface of an all cast implant restoration. Sensory Recalibration from Visually Amplified Rotations While Walking. The terminal residues containing SA should be as the basic GM1-like structure in CJ LPS. During evaporation, a water droplet undergoes a wetting transition from a (low-frictional) partial to (adhesive) complete contact with the solid, destroying the superhydrophobicity and the self-cleaning properties of the slippery surface. Histological analysis of the wounds showed that KGF-2 significantly promoted re-epithelialization in both young and old animals.

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A 5-year (1993 to 1997) chart review of neonates with stoma effluent refeeding was undertaken. Characterization of antisera to a synthetic carboxyl-terminal peptide of the glucose transporter protein. When evaluating interictal spikes using dipole source analysis it is important to account for multiple sources and the overlapping background EEG. Advances in technology have been helpful in improving the accuracy of diagnosis but technology is not infallible and an over reliance on it can also result in misdiagnosis. Complex microparticles (MPs) bearing unique characteristics such as well-tailored sizes, various morphologies, and multi-compartments have been attempted to be produced by many researchers in the past decades. A 25-pg amount of this derivative showed a well shaped doublet with a signal-to-noise ratio of more than 300:1. One tetrameric and five octameric oligoamides displaying these side chains were synthesized and shown to be soluble in water. Renal biopsy specimens were evaluated from patients with different autoimmune diseases treated with cyclosporin (CyA). Since completion of genome sequencing of the malarial parasite Plasmodium falciparum, proteomic tools for the identification of parasite proteins have become particularly attractive as they allow a more thorough interpretation of these data. The purpose of this study was to explore the possible principles for remodeling of periodontal tissues under mechanical stretching by investigating the effects of intermittent mechanical stretching delivered by a new invented type of cell stress machine on the proliferation kinetics of the human periodontal fibroblast cells (hPDLFs) in vitro.

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To evaluate the results and cost-effectiveness of prenatal prevention measurement in severe thalassemia diseases at Srinagarind Hospital. Structural studies of the BstVI restriction-modification proteins by fluorescence spectroscopy. Active perinatal care increases the rate of survival of extremely preterm infants, but there are concerns that improved survival might increase the rate of disabled survivors. Cytokine response in crimean-congo hemorrhagic fever virus infection. Cloning and structure of group C1 O antigen (rfb gene cluster) from Salmonella enterica serovar montevideo. In this Review, refractory EoE is defined as persistent eosinophilia in the setting of incomplete resolution of the primary presenting symptoms and incomplete resolution of endoscopic findings following a PPI trial, and after treatment with either topical steroids or dietary elimination.

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A macrocyclic 1,4-bis(4-pyridylethynyl)benzene showing unique aggregation-induced emission properties. Primary structure of DNA complementary to mRNA of murine oncoprotein p53. The nearly neutral theory predicts that bisoprolol hydrochlorothiazide dosing the rate and pattern of molecular evolution will be influenced by effective population size (Ne), because in small populations more slightly deleterious mutations are expected to drift to fixation. cells, but the microsomal GST and cytosolic GR were found to be evenly distributed in the acinus. This systematic review and meta-analysis evaluated the significance of the Tpeak - Tend interval in predicting arrhythmic and/or mortality end points. The amount of ACL graft coverage with preserved remnant tissue improves the control of pivot-shift laxity, as qualitatively determined with an electromagnetic device.

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