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Betrol (Glibenclamide)

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Betrol is in a drug class known as sulfonylureas. Sulfonylureas work by telling your pancreas to release insulin, which lowers your blood sugar. The usual starting dose of Betrol as initial therapy is 2.5 to 5 mg by mouth once daily with breakfast or the first main meal.

Other names for this medication:
Afdiex, Benclamet, Benformin, Bionil, Combidos, Comdiab, Daocon, Diabnil, Duotrol, Dutrol, Glibet, Glifil, Glinil, Glucomin, Glucored, Glucosafe, Glucosil, Glucotrac, Glutowin, Glybonil, Glyboral, Glybovin, Glycurub, Glymep, Secrin, Sugnil, Sugnl

Similar Products:
Aurogra, Ovral, Feldene, Aricept, Propecia

Also known as: Glibenclamide


Glyburide is an oral diabetes medicine that helps control blood sugar levels.

Glyburide is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Glyburide is not for treating type 1 diabetes.


Usual Adult Dose for Diabetes Type 2:

Doses provided as glyburide-metformin -As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Glyburide (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: -Give with meals; 5 mg-500 mg dose should not be used as initial therapy due to an increased risk of hypoglycemia; initial doses should be conservative to avoid hypoglycemia largely due to glyburide and gastrointestinal side effects largely due to metformin. -For patients who are switching to combination therapy, initial doses should not exceed the daily dose of glyburide (or equivalent sulfonylurea) and metformin already being taken; the decision to switch to the nearest equivalent dose should be based on clinical judgement. -Addition of thiazolidinedione may be appropriate for patients not adequately controlled on glyburide-metformin; in patients experiencing hypoglycemia, consider reducing the dose of the glyburide component. -Monitor patients closely for signs and symptoms of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Detailed Glyburide/metformin dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glyburide overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

Side effects

The most common side effects associated with Betrol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies have not been performed on the relationship of age to the effects of glyburide in the pediatric population. Safety and efficacy have not been established.

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Irreversible and reversible structural deformation and electromechanical behavior of carbon nanohorns probed by conductive AFM. Generalization of a new procedure for the syntheses of pyrrolo(2,3-d)pyrimidines. Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis. The serine/threonine kinase IL-1R-associated kinase (IRAK)4 is a critical regulator of innate immunity. Food and external parasites of Sorex palustris and food of Sorex cinereus from St. Proteus mirabilis cystitis was induced in 9 ponies by chemically eroding the bladder mucosa before the organism was inoculated. Multiplex PNA-fish to detect cystic fibrosis polymicrobial communities. This situation resulted to a high proportion of babies born to teenage mothers fathered by adult men. Normal presentation was found in 3 cases, with clear images of the abdominal aorta and its branches.

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The response of murine macrophage colony-forming cells to endotoxin in C3Heb/FeJ and C3H/HeJ mice. The use of information on residence of relatives to measure international migration. Previous studies have indicated that suicide rates have significant seasonal variations. Studies into the mechanism of ILK-mediated Rac activation suggest an important role for the ILK-beta-parvin interaction and the activity of the Rac/Cdc42-specific guanine nucleotide exchange factor alpha-PIX downstream of ILK. Furthermore, cell proliferation, migration and invasion assays were examined and inhibitors of CXCR4 were used to determine the effect on cell migration. High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis.

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Inhibition of the p53 Y220C Mutant by 1-Hydroxy-2- Methylanthraquinone Derivatives: A Novel Strategy for Cancer Therapy. A combination of their slow-growing nature and high use-values have resulted in population declines for many species around the world, and to date the vast majority of fisheries-related work on sharks has focused on the commercial sector. Image processing and volume rendering have been applied to magnetic resonance (MR) images to produce three-dimensional views of the surface of the brain. Application outside of this setting is based on attempts to delineate further tumour-specific or, increasingly, tumour-selective targets. the excretion rate of Beta2-microglobulin in diabetic subjects did not differ from that of the healthy subjects. Radiobioassay program of the Institutional Total Diet Sampling Network. The results showed that there was a significant difference between nurses with low and moderate/high burnout in all the three components in almost all the examined organizational variables. Consideration is given to the problems caused by the quality of the available data.

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Search for alpha-glucosidase inhibitors: new N-substituted valienamine and conduramine F-1 derivatives. MiR-150 promotes cellular metastasis in non-small cell lung cancer by targeting FOXO4. Our results, which are based on axisymmetric Newtonian supernova simulations, indicate that the dominant emission process of gravitational waves in core-collapse supernovae may be the oscillations of the protoneutron star core. Furthermore, the effect of increased H(2)O(2) levels on the subcellular localization of a subset of proteins was assessed. Effects of antihypertensive therapy on blood pressure control, cognition, and reactivity. The biochip was fabricated using conventional photolithographic methods on a glass substrate etched using a HF-based solution. Clinically, these structural changes cannot be directly quantified.

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