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Bestradiol (Estradiol)
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Bestradiol

Bestradiol is a female hormone. It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected

Other names for this medication:
Bestradiol, Conjugase, Divigel, Edval, Espauz, Estogen, Estraderm, Estradiol, Estrofem, Evafem, Evalon, Evaride, Menocare, Mixogen, Oestrogel, Premarin, Progynon, Progynova, Sandrena

Similar Products:
Chloromycetin, Eldepryl, Adalat, Norvasc, Lunesta, Nimotop, Cenforce, Rocaltrol, Altace, Imuran

Also known as: Estradiol

Description

Estrace tablets contains estradiol, a form of estrogen. Estradiol is a female sex hormone that regulates many processes in the body.

Estrace is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women, and to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body.

Estrace is sometimes used as part of cancer treatment in women and men.

Estrace is also available as a vaginal cream.

Dosage

This section provides information on the proper use of a number of products that contain estradiol. It may not be specific to Estrace. Please read with care.

It is very important that you use this medicine exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects.

This medicine is to be used only in the vagina. Use it at bedtime unless your doctor tells you otherwise.

This medicine comes with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

To use the vaginal ring:

This medicine is contained in a ring that you or your caregiver will put into your vagina. The ring will slowly release small amounts of medicine for your body to absorb. Your caregiver will show you how to insert the ring. Do not remove the ring from the sealed pouch until you are ready to use it. Once the ring is in place inside your vagina, you should not be able to feel it. If you feel uncomfortable, the ring may not be inserted far enough. Gently push the ring farther into your vagina. If you feel pain, talk to your doctor. You will leave the ring inside for 90 days (3 months), unless your doctor tells you a different schedule. After that time, remove the ring and insert a new one. If you forget to remove the ring after 90 days, call your doctor for instructions. The ring may move down into the lower part of your vagina accidently. This can happen if you strain to have a bowel movement. Use your finger to gently push the ring back into place. If the ring comes all the way out of your vagina, rinse it off with warm water and put it back in. Call your doctor if the ring comes out several times. If you need to remove the ring, hook your finger through the ring and pull it out.

To use the Imvexxy™ vaginal insert:

The insert should be used only in your vagina. Do not swallow. Keep your hands clean and dry while handling the insert. Push an insert through the foil of the blister package and hold it with the larger end between your fingers. You may choose to put the insert into your vagina using the lying down or standing up position. Put the insert about 2 inches into your vagina, with the smaller end up, using your finger. Most women will start by using a new insert every day for two weeks, then change to using a new insert only 2 days each week. Carefully follow the schedule that your health caregiver tells you to.

To use the Vagifem® vaginal insert:

The tablet should be used only in your vagina. Do not swallow the tablet. Each vaginal tablet comes packaged inside an applicator. Do not take the tablet out of the applicator. If the tablet comes out of the applicator but has not fallen out of the package, carefully put it back into the applicator for insertion. If the tablet falls out of the applicator, throw it away and use a new applicator that still has the tablet inside it. Keep your hands clean and dry while handling the tablet. Take the applicator out of the plastic wrap before using it. Use the applicator only one time and then throw it away. Use a new applicator for each dose. Most women will start by inserting a new tablet every day for two weeks, then change to inserting a new tablet only 2 days each week. Carefully follow the schedule that your health caregiver tells you to.

To use the Divigel®:

Open the packet and use the entire contents of a packet on the skin of either right or left upper thigh once a day. Apply the gel to the right or left upper thigh on alternate days to avoid potential skin irritation. Do not apply the gel on the face, breasts, or irritated skin or in or around the vagina. Allow the gel to dry after application before dressing. Avoid fire, flame, or smoking until the gel has dried. Do not wash the application site within 1 hour after applying the gel. Avoid getting the gel into your eyes. Wash your hands after each application.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine. Grapefruit and grapefruit juice may change the amount of this medicine that is absorbed in the body.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For vaginal dosage form (gel): For atrophic vaginitis, hot flashes, and other symptoms caused by menopause: Adults—At first, 0.25 grams applied on the skin of either right or left upper thigh once a day. Your doctor may adjust your dose as needed up to a maximum of 1.25 grams once a day. Children—Use is not recommended. For vaginal dosage form (ring): For atrophic vaginitis, hot flashes, and other symptoms caused by menopause: Adults—One vaginal ring inserted into the vagina for 3 months. Your doctor may adjust your dose as needed. Children—Use is not recommended. For vaginal dosage form (insert): For treatment of atrophic vaginitis caused by menopause: Adults—10 micrograms (mcg) or one insert into the vagina once a day for 2 weeks, followed by one insert 2 times a week. Children—Use is not recommended. For treatment of painful sexual intercourse caused by menopause: Adults—At first, 4 micrograms (mcg) or one insert into the vagina once a day for 2 weeks, followed by one insert 2 times a week (every 3 to 4 days). Your doctor may adjust your dose as needed. Children—Use is not recommended.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Wrap the used vaginal ring in tissue or toilet paper and throw it in the trash can. Do not flush it down the toilet.

Detailed Estrace dosage information

Side effects

The most common side effects associated with Bestradiol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Bestradiol if you are allergic to Bestradiol components. Do not take Bestradiol if you're pregnant or you plan to have a baby, or you are a nursing mother. Do not take Bestradiol if you have a history of stroke or blood clot, circulation problems, hormone-related cancer (breast or uterine cancer), abnormal vaginal bleeding, bleeding or blood-clotting disorder. Be careful with Bestradiol if you have high blood pressure, angina, heart disease, high cholesterol or triglycerides, liver disease, kidney disease, asthma, epilepsy or other seizure disorder, migraines, diabetes, depression, gallbladder disease, hysterectomy, the risk of breast cancer, heart attack or stroke. Do not stop taking Bestradiol suddenly.

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A case of acute severe loss of vision due to perivasculitis typical of frosted retinal branch angiitis due to Herpes simplex virus in an otherwise healthy young Omani lady is presented. Weight change was examined by comparing the baseline weight to the weight two years later to estimate the hazard of death within the following five-year period. This study finds a positive effect of increased prenatal care use on birthweight and evidence of bias in OLS estimates, similar to studies that use US data. Trustworthiness of the data was ensured using an external auditor, member checks, and methods triangulation. At the same time, the deposition of immune complexes (composed of dengue antigen, mouse gamma and beta 1C globulin) could be seen in the renal glomeruli of infected mice.

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The lead uptake by perennial ryegrass and radishes from air, water and soil. However, an alternative route of administration that avoids parenteral injection while inducing mucosal immunity might facilitate vaccine implementation in some settings, and partially overcome the substantial variation in HPV16 antibodies at the cervix seen in ovulating women. CD40 is expressed on basal keratinocytes and Squamous Cell Cancer of the Head and Neck (SCCHN) tumor cells in vivo and in vitro. This study indicates that removal of pets from homes reduces airway responsiveness in patients with pet allergic asthma more than optimal pharmacotherapy alone, thereby enabling a decrease in inhaled corticosteroid doses. Immune responses in monkeys to lenses from patients with contact lens induced giant papillary conjunctivitis. ESWL was done by standard technique using Storz Modulith SLX lithotripter 3rd generation. The use of the Rorschach prognostic rating scale with foster-home children.

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Plant preparations have the potential for scavenging such reactive oxygen species. Short-term results of treatment of humeral and tibial fractures with new inflatable intramedullary nails. Protein denaturation and water-protein interactions as affected by low temperature long time treatment of porcine longissimus dorsi. Impact of family members and health care providers on the use of folic acid in pregnant women. The pattern is different in different amoxil dose calculator countries related to the socio-economic conditions. The present study was designed to evaluate the effect of the polymer (SMA) on the viability and integrity of rat oocytes in vitro.

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The clinical data of 212 operations of orthotopic liver transplantation on 209 patients, 184 males and 25 females, aged 44.5 (18-69), including 3 patients undergoing secondary liver transplantation, between February 1999 and August 2004 were reviewed retrospectively. This 7-year-old boy with Dejerine-Sottas syndrome caused by a mutation in the myelin protein zero gene began to suffer rapid deterioration with increasing leg weakness, loss of the ability to ambulate, and bowel and bladder incontinence. The theory uses a description of the ionization process based on the angular momentum representation for both the initial and final states of the atomic electron. Quality of life studies in unselected gynaecological outpatients and inpatients before and after hysterectomy. In a population-based cohort, caregivers of 1084 young children (mean age 6.7 years) were interviewed with the DSM-based Diagnostic Interview Schedule-Young Child version (DISC-YC), and they scored the Child Behavior Checklist (CBCL). Voluntary sterilization in Eastern and Central Europe: changes are coming.

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Collagen types I and III localized to striated collagen fibrils in arterial walls throughout the optic nerve head and to fibrils comprising the core of the lamina cribrosa beams and cost of famvir 500mg optic nerve septa. Characterization of the second conserved domain in the heme uptake protein HtaA from Corynebacterium diphtheriae. Functional outcome and patient satisfaction after Artisan phakic intraocular lens implantation for the correction of myopia. AA caused significant GST inhibition in mussel gills at 12, 18, and 24h. The purpose of this study is to revisit and further characterize the anatomy of this extremely versatile yet underutilized flap. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression in a sequence-specific manner. Effects of various thiol molecules added on morphology of dendrimer-gold nanocomposites. It is best distinguished on the Stratus OCT and gray-scale images of OCT-2000. Genetic heterogeneity for autosomal dominant familial hypertrophic cardiomyopathy in a Pakistani family.

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Fixed number of segments in unidirectional decompositions of fluence matrices for step-and-shoot IMRT. Furthermore, it simplifies the optical and mechanical modules of the super-resolving system by removing the need for mechanical movement of one grating. On warming, biotinyl SP-A was seen in association with coated vesicles and was subsequently located in endosomes and multivesicular bodies. Operative management of acetabular fracture: A 10-year experience in Isfahan, Iran. Our results suggest a novel role for ubiquitin C-terminal hydrolase enzymes in mammals in spatial learning and working memory. While many government-controlled radio stations have used aid funds to develop their facilities and expertise, they now charge for programs which are in the public interest and aimed at improving the lives of Pacific Islanders. Abnormal spirometric findings in older adults without clinical lung disease are associated with increased heart failure risk.

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Measurement of the viscosity-density product using multiple reflections of ultrasonic shear horizontal waves. We conclude that, by interacting with membrane gp130 and possibly by activating Janus kinase/STAT pathways, IL6RIL6 chimera induces OPCs to differentiate into mature oligodendrocytes, promotes their survival, and could deserve investigation as a therapeutic strategy for enhancing remyelination. Understanding processing-induced phase transformations in erythromycin-PEG 6000 solid dispersions. Photochemical experiments are conducted either under matrix isolation conditions or in solution at ambient temperature. Creatine kinase: ATP contaminating creatine phosphate substrate of a commercial kit.

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A novel finding was that among juveniles, which migrate approximately a month later than adults, females preceded males by similar magnitude (1.14 days). The dynamics of adaptation: an illuminating example and a Hamilton-Jacobi approach. Metachronous skeletal osteosarcoma in patients treated with adjuvant and neoadjuvant chemotherapy for nonmetastatic osteosarcoma. Physiological function of the maltose operon regulator, MalR, in Lactococcus lactis. Our studies identified two novel compound heterozygous loss-of-function mutations in POP1, which encodes a core component of the RNase mitochondrial RNA processing (RNase MRP) complex that directly interacts with the RMRP RNA domains that are affected in anauxetic dysplasia. A case report is presented demonstrating the utility of skin-sparing mastectomy and autologous breast reconstruction for locally recurrent PT of the breast, with a literature review of management options in this setting presented. cDNA cloning and characterization of a mannose-binding lectin from Zingiber officinale Roscoe (ginger) rhizomes. In this work we consider the problem of flow turbulence control in a two-dimensional Navier-Stokes equation.

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Fel-O-Vax FIV is a dual-subtype vaccine consisting of inactivated whole viruses of subtype A (Petaluma strain) and subtype D (Shizuoka strain). The second outreach effort was to augment the staff at a local free clinic in Meridian, which needed help to set up their clinic so they could handle the influx of hurricane victims who were arriving daily. Globally, cardiovascular diseases (CVD) remain the leading cause of mortality. Genomics in breast and prostate cancer: assessment of the current state and future perspectives. Histological evaluation of Permacol as a subcutaneous implant over a 20-week period in the rat model. We find that first birth probabilities are elevated during the years immediately following migration. Intestinal can taking too much diflucan cause a bacterial infection perforation during simultaneous lactose tolerance test and motility investigation.

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