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Bemetrazole (Metronidazole)
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Bemetrazole

Bemetrazole is an antibiotic and antiprotozoal medication. It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis.

Other names for this medication:
Amevan, Anamet, Arilin, Aristogyl, Camezol, Collazole, Deprocid, Diazole, Entizol, Flagicure, Flagystatin, Flazol, Gynoplix, Mebadiol, Mecozol, Medazol, Menilet, Metazole, Metrazol, Metrocreme, Metronex, Metrozol, Metryl, Metsina, Molazol, Mtrocol, Negazole, Nidagel, Nidagyl, Nidazea, Onida, Orogyl, Orvagil, Pharmaflex, Promuba, Protogyl, Rhodogil, Rodogyl, Rozagel, Servizol, Taremis, Trichodazol, Tricozyl, Trikozol, Vagilen, Venogyl, Wingyl

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Sinequan, Flagyl, Amaryl, Myambutol, Lozol, Levitra, Imitrex, Cycrin, Parlodel, Tenormin

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Also known as: Metronidazole

Description

Metronidazole is used to treat bacterial infections in different areas of the body. The extended-release tablets are used to treat women with vaginal infections (bacterial vaginosis).

Metronidazole belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain metronidazole. It may not be specific to Flagyl. Please read with care.

Use this medicine exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

This medicine is to be used only in the vagina. Use it at bedtime, unless your doctor tells you otherwise.

Do not get it into your eyes, nose, mouth, or skin. If this medicine does get into your eyes, wash them out right away with large amounts of cool tap water. If your eyes still burn or are painful, check with your doctor.

This medicine comes with a patient information leaflet and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Wash your hands with soap and water before and after using this medicine.

Nuvessa™ is available inside a prefilled applicator. The applicator is open at one end where you will insert the plunger and has a pink cap on the other end where the medicine will come out.

Vandazole® is in a tube. You will use an applicator to put the gel into your vagina. The applicator has a plastic tube called a barrel that is open at one end and has a plunger (another piece of plastic that can move inside the barrel) at the other end.

To use the medicine:

To fill the applicator: For cream or gel dosage forms: Nuvessa™: With the pink cap still on, push the tip of the plunger into the open end of the prefilled applicator. Pull the cap off before you insert the applicator into your vagina. Vandazole®: Break the metal seal at the opening of the tube by using the point on the top of the cap. Screw the applicator onto the tube. Squeeze the medicine into the applicator slowly until it is full. Remove the applicator from the tube. Replace the cap on the tube. For vaginal tablet dosage form: Place the vaginal tablet into the applicator. Wet the vaginal tablet with water for a few seconds. To insert vaginal metronidazole using the applicator: For all dosage forms: Relax while lying on your back with your knees bent (or in any position that you feel comfortable). Hold the full applicator in one hand. Insert it slowly into the vagina. Stop before it becomes uncomfortable. Slowly press the plunger until it stops. Withdraw the applicator. The medicine will be left behind in the vagina. Remove the applicator from your vagina. Use each applicator only once, and then throw it away.

To help clear up your infection completely, it is very important that you keep using this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days. If you stop using this medicine too soon, your symptoms may return. Do not miss any doses. Also, continue using this medicine even if your menstrual period starts during the time of treatment.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For bacterial vaginal infections: For vaginal dosage form (cream): Adults—One applicatorful (500 milligrams [mg]), inserted into the vagina. Use the medicine 1 or 2 times a day for 10 or 20 days. Children—Use and dose must be determined by your doctor. For vaginal dosage form (gel): Nuvessa™: Adults and children 12 years of age and older—One applicatorful (5 grams [g]) inserted into the vagina once (at bedtime). Each applicatorful of Nuvessa™ contains 65 mg of metronidazole. Children younger than 12 years of age—Use and dose must be determined by your doctor. Vandazole®: Adults—One applicatorful (5 grams [g]) inserted into the vagina once a day (at bedtime) for 5 days. Each applicatorful of Vandazole® contains 37.5 mg of metronidazole. Children—Use and dose must be determined by your doctor. For vaginal dosage form (tablets): Adults—One 500 milligram (mg) tablet, inserted high into the vagina. Use the medicine once a day in the evening for 10 or 20 days. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Bemetrazole and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Bemetrazole overdosage: dizziness, seizures, torpor, retching, nausea, lack of balance, problems with coordination, tingling.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Metronidazole topical dosage information

Side effects

The most common side effects associated with Bemetrazole are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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Of the 23 articles identified, only 14 were selected for review. Insulin treatment significantly increased the reduced expression of PECAM-1 in both untreated diabetic groups and VEGF-A expression in untreated STZ-diabetic mice. In the third F(2 )population derived from Swarna/Taipei309, the SSR markers in the vicinity of S5, RM225, RM253, RM50, RM276 and RM136 were identified to co-segregate with HS at a map distance of 3.2, 2.6, 3.4, 2.6 and 6.6 cM, respectively. Effects of malnutrition, immunization and nutritional restoration. The objective of this study was to further elucidate the clinical course and prognostic determinants of patients with this disease. The occurrence and control of nitric oxide generation by the plant mitochondrial electron transport chain.

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The more limited bandwidth of this low-cost accelerometer does not restrict its ability to monitor nasalization because the vibratory energy of interest is below 2,000 Hz. We conclude, among other things, that the network reachability depends much on a core where the path lengths are short and communication frequent, that clustering of the contacts of an edge in time tends to decrease the reachability, and that the order of the contacts really does make sense for dynamical spreading processes. The article also discusses the therapeutic aspects of these conjugates and that these may serve as fascinating tools for drug delivery. In vitro stimulation of human lymphocytes with mycobacterial antigens. The financial costs for the family and community include medical and hospital direct costs of treatments and indirect costs from loss of employment. Each test condition was preceded by a training-baseline condition, and schedule values were arranged in an ascending (four subjects) or descending (four subjects) order. Radionuclide imaging in heart failure: assessing etiology and outcomes and implications for management. Weight gains and feed efficiency were similar for 10 and 50 ppm Cu but were reduced at 200 and 500 ppm Cu.

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After transfer to tomato, cucumber and wild hop, sequence changes were detected in a natural AFCVd isolate from hop, and major variants in tomato, cucumber and wild hop differed in 10, 8 or 2 nucleotides, respectively, from the predominant one in the inoculum. This study examines the association between family structure and adolescent substance use, specifically focusing on the potential conditioning effects of the level of exposure to substance-using peers. Incorporation of nucleic acid precursors during oogenesis in Hemiptera and the effects of some inhibitors. Our results suggest that the implantation of MSC-derived cells elicits de novo neurogenesis and functional recovery in a non-human primate SCI model and should harness the clinical application of BM MSC in SCI patients. New treatment options have been proposed in addition to the standard approach of resection of liver metastases and chemotherapy. An efficient and general method for the synthesis of difluoroalkylated uracils, pyridinones, and coumarins through visible-light-induced reaction with commercial materials is developed. This result illustrates that intranasal administration may act as a promising alternative to conventional routes of administration. For example, some investigators are attempting to develop a vaccine which provides protection from pregnancy and from hepatitis B. Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis. The lens plays a key role in changing the biometrics of the anterior segment.

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Lentiviral-mediated RNAi effectively reduced p38MAPK and p-p38MAPK expressions in osteoblastic cell line (MC3T3-E1) following high glucose (22 mM) induction. Thus, their precise detection is necessary for the diagnosis of such diseases. We address difficulties we encountered and modifications to caCORE that will address these problems. Ku70 protein, cooperating with Ku80 and DNA-dependent protein kinase (DNA-PK) catalytic subunit (DNA-PKcs), is involved in DNA double-strand break (DNA DSB) repair and V(D)J recombination. Unfortunately, as insecticide and drug resistance spread, these burdens will increase unless new control measures are developed.

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General findings will be discussed in comparison with positioning and movement of other organelle types in cells. The principles of short course chemotherapy and the rationale behind the currently recommended regimens are outlined in this article. Adaptive makeshift machinery has been replaced with dedicated volumetric and/or gravimetric devices that afford accurate blood flow and ultrafiltrate production rates. Thailand has trained about 20,000 village health volunteers and 200,000 village health communicators. A 9-year-old mixed-breed dog was evaluated for dental malocclusion secondary to mandibular fractures that had been repaired after the dog had been hit by a car. Removal of metal ions from aqueous solutions using carboxymethyl cellulose/sodium styrene sulfonate gels prepared by radiation grafting. Detection of antibody-producing cells in experimental Trypanosoma gambiense infection by immunocytoadherence.

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The ontogenesis of the Mm-system is suggested consisting of 3 stages: formation, existence, and death. Monitoring E-selectin-mediated adhesion using green and red fluorescent proteins. Recently ZIKV invaded the Americas, where it poses a threat to human health, especially to pregnant women and their infants. Single dose intratympanic mesna application inhibits propylene glycol induced cholesteatoma formation. It has been hypothesized that the immediate reduction of collateral flow after PCI of CTO could expose the patients to a higher risk of future ischemic events in the case of vessel reocclusion. Hyperuricemia has been shown to be related to cardiovascular morbidity and mortality.

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We hypothesise that, glutamate acts as a regulator of motoneuron maturation and spinal cord development. The physiologic status of the anorectum after pull-through operations. Access to Genetic Diagnostics for Genodermatoses: Who Should Get Tested?. Non-linear curve fitting techniques were used to predict exposure rate profiles from cylindrical sources using closed form equations for lines and disks. Experimental support for this hypothesis is presented, as well as some predictions about the function of different types of neocortical pathways and plasticity. To test this hypothesis, the expression of LcMKK, LchERF and LcGSH1 genes, endogenous ethylene accumulation, GSH content and Cd concentration in Lycium chinense with or without Cd stress treatment were studied. With the breast compressed by dual grid plates, two oblique exposures are taken.

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The effects of the co-agonist of the N-methyl-D-aspartate receptor (NMDAr) D-serine on glutamatergic neurotransmission and synaptic potentiation were studied in the CA1 hippocampal field of young (3-5 months old) and aged (25-27 months old) Sprague-Dawley rats using ex vivo extracellular electrophysiological recording techniques. The early effect on subclinical discharges turns out to play a major role in the dramatic improvement of sleep quality, behavior, and developmental learning acceleration at school. Evaluation of ionic liquid stationary phases for one dimensional gas chromatography-mass spectrometry and comprehensive two dimensional gas chromatographic analyses of fatty acids in marine biota. Review of the occupational exposure to isocyanates: Mechanisms of action. Fatty acid metabolism pathway play an important role in carcinogenesis of human colorectal cancers by Microarray-Bioinformatics analysis. The BafA1 effect on endocytosis of high concentrations of EGF was similar to that on HRP endocytosis. The present study supports the hypothesis that schizophrenia and bipolar disorder may be associated with abnormalities in dopamine receptor-interacting proteins.

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Summary of WFP / UNHCR guidelines for estimating food and nutritional requirements. These results show the importance of SLP-76 and PLCgamma1 for NF-kappaB activation and raft translocation of PKCtheta and IKKgamma. Remission of intractable asthma in a child during psychotherapy of the mother. Statins have accumulated a plethora of data in the area of general cancer cell line inhibition, and the potential to have a synergistic impact in patients receiving a variety of conventional treatments for a diversity of cancers is endorsed at least by laboratory and some preliminary small clinical studies. Adult mesenchymal stem cells (MSCs) represent promising tools for therapeutic applications such as tissue engineering and cellular therapy. This immobilization stress-induced increase was inhibited by the i.c.v. At 24, 48 and 72 hours post transfection, the green fluorescence was observed through a fluorescence microscope. This is the first study to illustrate that in vivo administration of polyI:C affects drug metabolism independent of type I interferon production or in the absence of TLR3 through crosstalk between nuclear receptors and antiviral responses. The current literature about single cell detection in carcinoma of the breast and urothelial cancer is reviewed and the potential clinical implications of CTC-detection in bladder cancer are discussed. Translocation of PKC-betaII is mediated via RACK-1 in the neuronal cells following dioxin exposure.

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Primary cultures of ovine articular chondrocytes were transfected with the Photinus pyralis luc or the Escherichia coli lacZ genes in monolayer culture in vitro using eight different nonviral compounds. Following this, the flap was sutured into place, reconstructing the defect in the floor of the mouth. It is contraindicated for various medical conditions and infections. Subgroup effect can be defined as the difference in treatment effect across patient subgroups. Due to its general character, our model is also applicable to similar systems in other areas of physics--for example, to chaotically coupled quantum dots.

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Nitrogen compounds are transformed by a complicated network of competing geochemical processes or microbial pathways, each performed by a different ecological guild of microorganisms. With the alarming rise of antibiotic resistance, clinical professionals are called upon to manage antibiotic therapies using the most relevant and recent clinical and laboratory data. The author concludes that the total population as at January 1, 1988, would have been 14.1 million without immigration, instead of an actual 14.7 million. Compression of the pulmonary artery during transesophageal echocardiography in a pediatric cardiac patient. The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models. intimal hyperplasia (IH) is a major cause of re-stenosis post-vascular intervention. Joint-specific power production during submaximal and maximal cycling.

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Hypersensitivity pneumonitis treated with an electrostatic dust filter. Presence and duration of voice disorders were reported over the past 12 months. Low dose acetylsalicylic acid in prevention of pregnancy-induced hypertension and intrauterine growth retardation in women with bilateral uterine artery notches. Antigenic structure and related aspects of the biology of plasmodia: the present situation: Scientific Working Group on the Immunology of Malaria. Introgression started from a selected RIL, which was crossed three times to one of the original parents and then self-fertilized, leading to BC(3)S(1) progenies. Young children had positive blood cultures and lower or negative antibody titers statistically significantly more often than did older children. Quality control systems implementation in the Spanish Dialysis Units. Panellists were also encouraged to provide additional comments on why they felt a particular item was important. The authors then consider differences and similarities in processing and producing census data. Long head of biceps brachii tenotomy is well accepted by patients and the procedure cleocin 1% gel has comparable outcomes in younger manually active and older sedentary populations.

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Molecular weight and subunit composition of adenovirus type 2 fiber. This has stemmed from research in the early 1970s showing that the formation of new blood vessels by pre-existing endothelial cells is essential in tumour growth and progression. A new hypothesis, single spike suppression, supposes that psychotic symptoms are mediated by the single spikes of neurons at the D2 receptor. A reduction of serum IGFBP-3 levels and the associated increased availability of IGFs may represent a strategy whereby melanoma increases its metastatic potential. The influence of the intervertebral disc on stress distribution of the thoracolumbar vertebrae under destructive load. Linear basement membrane zone band with IgG and/or C(3) was seen in 14 cases of patients BP. Internal migration in contemporary Nepal: models which internalize development policies. Ten male New Zealand white rabbits received spherical tantalum bone markers in the nasal, frontal, parietal, and temporal bones: a minimum of two in each bone segment. Cellular DNA synthesis was evaluated by bromodeoxyuridine incorporation. The large Vietnamese pigs had genetic links to Ryukyu wild boars in southern Japan.

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Apoptosis plays a key role in the maintenance of a constant cell number and a low incidence of cancer in the mucosa of the intestine. Uptake of services was similar across all settlement categories, with low levels of use at 6-months post-stroke. An ultrastructural analysis of polyspermy in the surf clam, Spisula solidissima. The processes of dynamic aggregate transformations of micelles at a mica surface were observed using high-speed atomic force microscopy. A hypothesis reconciling the apparent paradox of a similar syndrome appearing under opposite conditions of nutrition is presented in the form of an equation that can account for different patterns of circulating glucose-insulin relationships associated with varying degrees of insulin resistance. At this temperature their PaCO2 was the highest, 42 plus or minus 1.2 mm Hg on the average. Impact of growth hormone resistance on female reproductive function: new insights from growth hormone receptor knockout mice.

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The correction of the deformity was assessed clinically and radiographically. A similar protein has been found only in the closely related species Tuber dryophilum (TDF-1), but not in other truffles. Pain in the TMJ was not related to MR findings of effusion in internal derangement and synovial fluid aspirate findings of total protein concentration. We examined the possibility of hGH stabilization by elimination of its lactogenic activity. The dependence of the diffusion tensor on the parameters of the problem is illustrated in the three-dimensional case. Generation and characterization of monoclonal antibodies against Staphylococcus aureus thermonuclease. The present work studied the antibody profile, interferon gamma (IFN-gamma) serum level and nutritional status among infected school children, aged eleven years in a rural school in Abis 8 village. Poly(D, L-lactide/epsilon-caprolactone)/hydroxyapatite composites as bone filler: an in vivo study in rats. Symmetrical localization of pathological zones of reconstruction in long tubular bones. A cross-sectional survey was distributed among HCPs in six different settings in Saudi Arabia.

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One attack started in stage I/II non-rapid-eye-movement (NREM) sleep, 3 in stage III/IV NREM sleep, and xanax dosage 2 in rapid-eye-movement (REM) sleep. The water system failed, hospitals and equipment collapsed, and doctors and medical personnel left the country. During embryonic development, the primary imprint can lead to generation of secondary epigenetic modifications (secondary imprints) of the chromosomes. The first signal is specific, which T cell receptor could recognize and bind MHC molecule by antigen-presenting cells. Micro-Raman and photoluminescence spectra confirm the properties of the material. Cerebrospinal fluid (CSF) is a clear and colourless fluid that surrounds the brain and spine. Biologic perspectives to support clinical choices in root canal treatment. Multivariable analyses indicated that non-HDL cholesterol is a strong predictor of CVD in men and women with diabetes and is particularly indicative of coronary events.

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Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancer. Pelveo-peritoneal schistosomiasis as a cause of primary infertility. Choroid plexus carcinomas (CPC) are rare tumors predominantly found in children. Moreover, the possible link between mineralocorticoid receptor (MR)-mediated effects on the cardiomyocyte and the coronary arteries is unknown. The exteriors of the pods and the nuts were examined for yeast and molds, including Aspergillus flavus and Aspergillus parasiticus, and for bacteria, including Salmonella and Escherichia coli.

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The resultant monolayer surfaces are useful for silicon-based applications including molecular electron transfer films, monolayer templates, molecular insulators, capsulators, and bioderivatives. These results are consistent with the hypothesis that (1) genes may be turned on following radiation via a mechanism involving hypomethylation of cytosine and (2) radiation-induced hypomethylation results from decreased intranuclear levels of DNA methyltransferase. The primary endpoint is the evaluation of safety and feasibility with acute toxicity scored up to 1 month after the end of RT. The prognostic significance of esophageal carcinoma based on various irradiation methods. Currently, bariatric surgery is more and more widely used to attenuate diabetes-associated diseases. For SP-A, a combination of solid-phase TA08 and horseradish peroxidase (HRP)-conjugated WA28 was found to be more sensitive than other combinations, gave a good dose response and was capable of measuring 0.78 to 100 ng of protein/ml. These methods are described as they are currently used in practice and several key problems in that practice are highlighted including the relevance to public health practice of toxicological evidence. Adherence of Candida albicans to human vaginal epithelial cells: inhibition by amino sugars.

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