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Azpax (Clonazepam)

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Azpax is used to prevent and control seizures. This medication is known as an anticonvulsant or antiepileptic drug. It is also used to treat panic attacks. Azpax works by calming your brain and nerves. It belongs to a class of drugs called benzodiazepines.

Other names for this medication:
Alrest, Anxiset, Anxrea, Azpax, Calmnir, Catier, Cleps, Clonapax, Clonapik, Clonatrac, Clonaxyl, Clonix, Clonotril, Clopam, Closis, Clotas, Clotweet, Convaclon, Cozil, Epcon, Epizam, Escitapax, Escitrac, Estalonix, Ezinite, Jasoclam, Jbcloz, Lonipax, Lozep, Norep, Nupam, Prasilex, Sezolep, Somnolex, Somnotril, Xitzen, Zepam, Zepamax, Zolpidox

Similar Products:
Duricef, Combivent, Eriacta, Rhinocort, Benemid, Cardizem, Xenical

Also known as: Clonazepam


Azpax is an anti-anxiety medication in the benzodiazepine family, the same family that includes diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan), flurazepam (Dalmane), and others. Azpax and other benzodiazepines act by enhancing the effects of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter (a chemical that nerve cells use to communicate with each other) that inhibits brain activity. It is believed that excessive activity in the brain may lead to anxiety or other psychiatric disorders. Azpax is primarily used for treating panic disorder and preventing certain types of seizures.

Azpax is useful alone or as an adjunct in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. In patients with absence seizures (petit mal) who have failed to respond to succinimides, Azpax may be useful.


This section provides information on the proper use of a number of products that contain clonazepam. It may not be specific to Klonopin Wafers. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence).

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Swallow the tablet whole with water.

If you are using the disintegrating tablet (wafer), make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil. Do not push the tablet through the foil. Do not break or split the tablet. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, you may take a sip of water.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (tablets or disintegrating tablets): For seizures: Adults and children 10 years and older—At first, 0.5 milligram (mg) 3 times per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 20 mg per day. Children up to 10 years or 30 kilograms (kg) of body weight—Dose is based on body weight and must be determined by your doctor. The dose is usually 0.01 to 0.03 mg per kg of body weight per day, given in 2 or 3 divided doses. However, the dose is usually not more than 0.05 mg per kg of body weight. Your doctor may adjust your dose as needed. For panic disorder: Adults—At first, 0.25 milligram (mg) 2 times per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 4 mg per day. Children—Use and dose must be determined by your doctor.


Symptoms of clonazepam overdosage, like those produced by other CNS depressants, include somnolence, confusion, coma and diminished reflexes.

Treatment includes monitoring of respiration, pulse and blood pressure, general supportive measures and immediate gastric lavage. Intravenous fluids should be administered and an adequate airway maintained. Hypotension may be combated by the use of levarterenol or metaraminol. Dialysis is of no known value.

Flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. Prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation and intravenous access. Flumazenil is intended as an adjunct to, not as a substitute for, proper management of benzodiazepine overdose. Patients treated with flumazenil should be monitored for resedation, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment. The prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose. The complete flumazenil package insert, including CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, should be consulted prior to use.

Flumazenil is not indicated in patients with epilepsy who have been treated with benzodiazepines. Antagonism of the benzodiazepine effect in such patients may provoke seizures.

Serious sequelae are rare unless other drugs or alcohol have been taken concomitantly.


Store at 25 degrees C (77 degrees F); excursions permitted to 15 to 30 degrees C (59 to 86 degrees F).

Side effects

The most common side effects associated with Azpax are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Before taking Azpax,

you should know that your mental health may change in unexpected ways, and you may become suicidal (thinking about harming or killing yourself or planning or trying to do so) while you are taking Azpax for the treatment of epilepsy, mental illness, or other conditions. A small number of adults and children 5 years of age and older (about 1 in 500 people) who took anticonvulsants such as Azpax to treat various conditions during clinical studies became suicidal during their treatment. Some of these people developed suicidal thoughts and behavior as early as one week after they started taking the medication. There is a risk that you may experience changes in your mental health if you take an anticonvulsant medication such as Azpax, but there may also be a risk that you will experience changes in your mental health if your condition is not treated. You and your doctor will decide whether the risks of taking an anticonvulsant medication are greater than the risks of not taking the medication. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: panic attacks; agitation or restlessness; new or worsening irritability, anxiety, or depression; acting on dangerous impulses; difficulty falling or staying asleep; aggressive, angry, or violent behavior; mania (frenzied, abnormally excited mood), talking or thinking about wanting to hurt yourself or end your life, withdrawing from friends and family; preoccupation with death and dying, giving away prized possessions, or any other unusual changes in behavior or mood. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

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Response rate versus time functions for all subjects showed recurring periods of linearly increasing response rates. We are evaluating a dual modality breast scanner developed at the University of Virginia for its ability to distinguish between benign and malignant lesions. We studied 35 nondiabetic adult FPLD subjects (of whom 24 were women) with either the LMNA R482Q or R482W missense mutations and 51 matched normal first-degree relatives (of whom 27 were women). Noninvasive cardiac imaging in the evaluation of suspected acute coronary syndromes. A multiloculated cystic mass was completely resected and histopathological examination confirmed the preoperative diagnosis.

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Mechanical properties of glycerinated fibres from the tymbal muscles of a Brazilian cicada. On echocardiography left ventricular function was impaired as well as on MRI. Forces of modernization, aggressive marketing on the part of infant formula companies, and an equation of bottle-feeding with sophistication all contributed to a decline in the prevalence of breastfeeding in the Pacific Basin. We evaluated whether acute volume shifts within the low pressure system after F induce renin release via neural pathways. The simultaneous absence of Grx3 and Grx4 provokes a serious impairment in cell viability, Slt2 activation and Rlm1 transcription in response to oxidative stress. A new methodology for the preparation of alpha-diimines and beta-aminoenones has been devised and represents an alternative route to these and related nitrogenous ligands bearing highly electronegative substituents. The method assumes the position of the guide wire in the fluoroscopic images is known.

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Model of elastic responses of single DNA molecules in collapsing transition. Electrical and mechanical responses of rat saphenous vein to short-term pressure load. The all-trans isomer of arachidonic acid was found to cause rabbit platelet aggregation at concentrations higher than 0.1 mM and inhibition of PAF-induced platelet aggregation in a concentration dependent manner with an IC(50) in the micromolar range. Studies of the rat and rabbit indicated that MEHP has no teratogenic effects. Age- and sex-specific prevalences of diabetes and impaired glucose regulation in 13 European cohorts. The effect of combined treatment of opioids with methylphenidate on nociception in rats and pain in human. Groupwise registration has become more and more popular due to its attractiveness for unbiased analysis of population data. Changes in blood pressure in mild forms of hypertension after long-term physical training. The evaluation of dermatologic education in the postgraduate period.

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The purpose of this study was to establish the causal relationships between expansion force magnitudes, sutural separation, and sutural bone formation. The success of Internet physical activity and nutrition interventions may depend on the extent to which they lead users to develop self-efficacy for behavior change, but perhaps as important, the extent to which these interventions help them garner social-support for making changes. Fatal small-bowel necrosis and pulmonary hypertension in sickle cell disease. We developed a dynamic prediction model that can make repeated predictions over time for couples with unexplained subfertility that underwent a fertility workup at a fertility clinic. Improvement of gene expressing profil may also be a way to enhance immune function in tumor patients. Shared care between geriatricians and orthopaedic surgeons for older people with hip fractures is associated with a low in-patient mortality, with the majority returning to their pre-morbid place of domicile. Carbon capsules with hierarchical pore structures were fabricated by using core-shell silica nanoparticles as templates and phenolic resin as a carbon precursor. A group of 121 cases treated by arthroscopic lavage and debridement were available for review with a 4 to 6 year follow-up. Sophisticated methods have been developed to distinguish between orthologs and paralogs and to classify paralogs into subtypes depending on the duplication mechanism and timing, relative to speciation.

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Nurses can use current knowledge to identify men with prostate cancer who are most at risk for depression. This intervention program may benefit older people with hip fractures in Taiwan by improving their clinical outcomes, self-care abilities, and HRQOL and by decreasing depressive symptoms within 3 months after discharge. Natural killer (NK) cells, of which CD56 is a specific marker, play an important role in host defense against tumors. The Trojan condom joins the Durex Avanti from the London International Group of London, England, as the only nonlatex synthetic male condoms available in the US. Mutagenesis of intact parvovirus H-1 is expressed co-ordinately with enhanced reactivation of ultraviolet irradiated virus in human and rat cells treated with 2-nitronaphthofurans. Likewise, depletion of serum IGF-1 in iLID males at 8 weeks of age, resulted in significantly reduced transverse cortical bone properties (Ct.Ar, Ct.Th) by 32 weeks (late adulthood), but had no effect on trabecular bone architecture. Thus, the I domain and the M domain combine to mediate Gag-lipid raft interactions as defined by these biochemical criteria.

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The objective of this prospective, randomized, patient- and observer-blinded study was to analyze, in vivo, the knee joint kinematics in the sagittal plane in a patient population that had received either a fixed or a mobile TKA. The molecular oscillator that drives circadian rhythmicity in mammals obtains its near 24- flonase 50 mcg generic h periodicity from posttranslational regulation of clock proteins. In this review, the history of the development of techniques based on the interactions of x- and gamma-rays with bone is considered and the ultimate dominance of x-ray based absorptiometry is described. The gazelle digs in the sand to remove most of the bulb of the lily. Formation of blood-group A substance from H substance by an alpha-N-acetylgalactosaminyl transferase. These results show that azaserine causes DNa damage as well as inhibition of purine metabolism. The future shape and organisation of general practice in medicine and dentistry in Northern Ireland. Four hundred twelve brief surveys were sent anonymously to members of the Canadian Lung Association (inserted in their newsletters) to ascertain the experience of Canadian respirologists with LAM.

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Cardiac troponin-I content of skeletal muscle in patients with renal failure. Specifically, the very young need a variety of foods each day including the vitamin and mineral rich vegetables and fruits. The structure of these intermediates has been determined both biochemically and structurally, and their interactions with Holliday junction processing enzymes have been well characterized. The cost effectiveness and risk-benefit ratio of extensive investigation of this group of patients warrants further study. Cost effectiveness and robot-assisted urologic surgery: does it make dollars and sense?. To gain further insight into the role of NRAGE, we investigated the co-expression of NRAGE and p75(NTR) in mature rat brain.

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The features in common with normal menses were mitotic activity in both glands and stroma, secretory vacuoles, edema and extravasation. Although the likelihood that LP will yield a specific bacteriologic diagnosis in critically ill patients is low, the procedure frequently provides important information that can lead to a change in case management, most commonly de-escalation of antibiotic therapy. This critical level of DO(2 levaquin renal dosing uptodate ) (DO(2)crit) produced by CO poisoning was compared to historical values produced by other insults, which decrease global body DO(2). Genetic variation patterns of pines exposed to high radiation in the Chernobyl exclusion zone with or without phenotypic stress symptoms were compared to control trees with a similar origin. This supports the idea that anti-VEGF agents are effective in reducing the amount of VEGF present in the retina. Semi-automated radiotherapy treatment planning with a mathematical model to satisfy treatment goals. US Supreme Court decisions, expert testimony, and implant dentistry. The Diabcare-Asia study was designed for the purpose of describing diabetes control and management, and late complication status in the diabetic population.

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Although it resembles more serious conditions, the condition can be diagnosed clinically and radiographically, making invasive tests and treatment unnecessary. Micronutrients in HIV-infection and the relationship with the inflammatory response. In this report, we describe inhibition of HIV-1 transcription by synthetic dsRNAs constructed with mutated nef genes (nef dsRNAs) derived from long-term non-progressors (LTNPs) using cotransfection of the target gene-expressing plasmid and dsRNA. Using this imaging sequence, we are able to produce human head images with the FID signal immediately following the 90 degrees radiofrequency pulse thus preserving the signal from the very short T2 components. Sixteen months experience with cyclosporin-A in human kidney transplantation. We have measured serum and urine glycosaminoglycan levels by the carbazole method of uronic acid determination in patients with myeloid leukemia or myelodysplasia. Instead, factor concentration affected the overall rate of cell death, the number of degenerating patches, and their distribution across the retina. Treadmill exercise test, CFR and echo Doppler study were performed for all subjects.

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