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Azelastine

Azelastine nasal spray is used to help relieve symptoms (eg, stuffy or runny nose, itching, sneezing) of seasonal (short-term) or perennial (year-round) allergic rhinitis (hay fever), vasomotor rhinitis, or other upper respiratory allergies.

Other names for this medication:
Astepro, Azelast, Azelastine, Azenate, Duonase, Nazomac, Oculast, Optihist, Optivar

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Description

Azelastine nasal spray is used to help relieve symptoms (eg, stuffy or runny nose, itching, sneezing) of seasonal (short-term) or perennial (year-round) allergic rhinitis (hay fever), vasomotor rhinitis, or other upper respiratory allergies.

Azelastine is an antihistamine. It works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain azelastine. It may not be specific to Astelin Ready-Spray. Please read with care.

Use this medicine only as directed by your doctor. Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of side effects.

This medicine usually comes with patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Follow the instructions on the medicine label if you are using this medicine without a prescription.

This medicine is for use only in the nose. Do not get any of it in your eyes or on your mouth. If it does get on these areas, rinse it off with water and call your doctor right away.

Do not use this medicine for any other nose problem (eg, ulcers or surgery, or injury that has not healed) without checking with your doctor first.

To use the spray:

When you use the azelastine nasal spray for the first time, you must prime the spray. Press down fully 6 times or until a fine spray comes out. Prime the spray after each time you clean the pump, or if you have not used the medicine for 3 days or longer, by spraying the medicine 2 times or until a fine spray comes out. Blow your nose to clear your nostrils. Tilt your head down, looking at your toes, and insert the tip of the nose piece into your nostril. Hold bottle upright and aim the spray tip toward the back of your nose. Tilt your head downward while spraying to avoid a bitter taste in the mouth. Close your other nostril with a finger. Press the pump 1 time and sniff gently at the same time, keeping your head tilted forward and down. Repeat in your other nostril using the same steps. If your healthcare provider tells you to use 2 sprays in each nostril, repeat the steps above for the second spray in each nostril. Do not blow your nose or tip your head back after using the spray. Wipe the tip of the outside of the nose piece with a clean, dry tissue or cloth and put the cap back on.

Do not drink alcohol while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For nasal dosage form (Astelin® spray): For treatment of seasonal allergic rhinitis: Adults and children 12 years of age and older—1 or 2 sprays in each nostril 2 times a day, or 2 sprays in each nostril once a day. Each spray contains 137 or 205.5 micrograms (mcg) of azelastine. Children 6 to 11 years of age—1 spray in each nostril 2 times a day. Each spray contains 137 or 205.5 mcg of azelastine. Children 2 to 5 years of age—1 spray in each nostril 2 times a day. Each spray contains 137 mcg of azelastine. Children younger than 2 years of age—Use and dose must be determined by your doctor. For nasal dosage form (Astepro® spray): For treatment of perennial allergic rhinitis: Children 6 months to 11 years of age—1 spray in each nostril 2 times a day. Each spray contains 137 micrograms (mcg) of azelastine. Children younger than 6 months of age—Use and dose must be determined by your doctor. For treatment of seasonal allergic rhinitis: Adults and children 12 years of age and older—1 or 2 sprays in each nostril 2 times a day. Each spray contains 137 micrograms (mcg) of azelastine. Children 2 to 11 years of age—1 spray in each nostril 2 times a day. Each spray contains 137 mcg of azelastine. Children younger than 2 years of age—Use and dose must be determined by your doctor. For nasal dosage form (Astepro® allergy spray): For treatment of allergic rhinitis or other upper respiratory allergies: Adults and children 12 years of age and older—2 sprays in each nostril once a day or 1 or 2 sprays in each nostril 2 times a day (every 12 hours). Do not use more than 4 sprays in each nostril per day (24 hour period). Each spray contains 205.5 micrograms (mcg) of azelastine. Children 6 to 11 years of age—1 spray in each nostril 2 times a day (every 12 hours). Do not use more than 2 sprays in each nostril per day (24 hour period). Each spray contains 205.5 micrograms (mcg) of azelastine. Children younger than 6 years of age—Use is not recommended.

Overdose

If you overdose Azelastine and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at a room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and sunlight. Keep in a tightly closed container. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Azelastine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Astepro® nasal spray in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

No information is available on the relationship of age to the effects of Astepro® allergy nasal spray in geriatric patients.

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The method used in this study would provide a valuable tool for studying auditory neuropathy. LP1 belonged to 6 PFGE genotypes, of which 21 belonged to 3 predominant genotypes. Ciprofloxacin concentrations in the sinus tissue and plasmas were assessed using high-performance liquid chromatography. Ovarian cryopreservation is a research way for fertility restoration on patients who will have gonadotoxic treatment. The results indicate that PCR-RFLP can be used as a simple and speedy taxonomical tool for the ecological studies of Armillaria species. The effect of prostacyclin on some hemodynamic parameters in dogs. The method may further contribute to reducing the dosage of x-ray bombardment in gastric fluoroscopy. The tissue specificity of peroxisomal beta-oxidation gene regulation by xenobiotics supports the contention that the development of liver tumors following exposure to peroxisome proliferators correlates well with the inducibility of peroxisome proliferation and the beta-oxidation genes. GNP-IPCR may provide a highly sensitive method for the detection of FMDV.

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Biosynthesis of cadaverine-containing peptidoglycan in Selenomonas ruminantium. Course of life satisfaction in patients with depressive and addictive disorders after therapeutic intervention. In a study biased against diclofenac, patient preference was 9/19 for indomethacin, 4/19 for diclofenac and 7/19 expressing no choice. WSIB patients are seen more frequently for postoperative follow-up, which we would attribute to the persistence of subjective complaints after TKA. The anaphase promoting complex/cyclosome and its activator Cdh1 (APC/C(Cdh1)) restrains axonal growth but the targets of APC/C(Cdh1) in neurons are unknown. Serotonin-related enhancement of recovery of hind limb motor functions in spinal rats after grafting of embryonic raphe nuclei. Mainly longitudinal mechanics respond to unloading of the left ventricle after TAVI for severe aortic stenosis while radial and circumferential deformation is substantially unchanged.

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Emerging implications of nanotechnology on cancer diagnostics and therapeutics. MR spectroscopy of breast cancer for assessing early treatment response: Results from the ACRIN 6657 MRS trial. Delivery of an adapted BFST intervention was acceptable to families and may be a promising treatment approach. This pressor effect was noncompetitively inhibited by the 5-hydroxytryptamine (5-HT) receptor antagonists pizotifen and cyproheptadine (0.1 mg/kg each). Heterotrimeric guanine nucleotide binding G-proteins (G-proteins) relay signals from GPCRs to intracellular effectors. Client politics that dominated over 3 or 4 decades no longer prevail. The DJBL, when used for a period of 6 months, is effective in the control of diabetes, weight loss, improvement of insulin resistance, and decrease of cardiovascular risk among morbidly obese patients with type 2 diabetes mellitus. Here we discuss recent progress in translating the in vivo cardiac microenvironment into PSC models of the human heart. It has long been known that iontophoresis can administer therapeutic amounts of biologically active peptides into the body.

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