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Aviglen (Glibenclamide)
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Aviglen

Aviglen is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Aviglen is in a class of medications called sulfonylureas.

Other names for this medication:
Benformin, Codica, Comdiab, Diabetnil, Diabetrol, Diabnil, Eumet, Glibet, Glifil, Glime, Glimsug, Glucomin, Glucosil, Glucotrac, Glutowin, Glybenclamide, Glybovin, Glybovine, Glymep, Melitus, Metclam, Metica, Monomet, Pionorm, Secrin, Sugatrol, Sugnil, Sugnl, Sugronil, Symet

Similar Products:
Antabuse, Daklinza, Aceon, Biaxin, Arimidex

Also known as: Glibenclamide

Description

Glyburide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels.

Glyburide and metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. glyburide and metformin is not for treating type 1 diabetes.

Dosage

Usual Adult Dose for Diabetes Type 2:

Standard glyburide: -Initial dose: 2.5 mg to 5 mg orally once a day -Dose titration: Increase in increments of no more than 2.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 1.25 to 20 mg orally as a single dose or in divided doses -Maximum dose: 20 mg/day Micronized glyburide: -Initial dose: 1.5 mg to 3 mg orally once a day -Dose titration: Increase in increments of no more than 1.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 0.75 to 12 mg orally as a single dose or in divided doses -Maximum dose: 12 mg/day Comments: -Administer with breakfast or the first main meal of the day -Lower initial doses may be used in patients who are sensitive to hypoglycemic drugs -Once a day therapy is generally satisfactory, however, some patients may have a more satisfactory response with twice-a-day dosing, especially those receiving higher doses. TRANSFER FROM OTHER HYPOGLYCEMIC THERAPY: -Oral Antidiabetic Therapy: No exact dosage relationships exists between standard glyburide, micronized glyburide, or other oral hypoglycemic agents; when transferring patients from other oral hypoglycemic therapy, the maximum starting doses should be observed. -Insulin: --If the insulin dose is less than 20 units per day substitute 2.5 to 5 mg (standard) OR 1.5 to 3 mg (micronized) orally once a day. --If the insulin dose is between 20 and 40 units per day, substitute 5 mg (standard) OR 3 mg (micronized) orally once a day. --If the insulin dose is more than 40 units per day; transition the patient by concomitantly decreasing insulin by 50% and starting glyburide at 5 mg (standard) OR 3 mg (micronized) orally once a day; as insulin is progressively withdrawn, titrate in increments of 1.25 to 2.5 mg (standard) OR 0.75 to 1.5 mg (micronized) orally once a day every 2 to 10 days. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose for Diabetes Type 2:

Initial dose: 1.25 to 2.5 mg (standard) orally or 0.75 to 1.5 mg (micronized) orally once a day.

Detailed Glyburide dosage information

Overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • seizures
  • loss of consciousness

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

Side effects

The most common side effects associated with Aviglen are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to glyburide, micronized or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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The adult pattern of subunit specific mRNA levels is reached at 4-6 weeks postnatally. The ESR signals of 5-DSA changed just as those of Tempol did in control and NO-treated microsomes. Positive surgical margins and early oncological outcomes of robotic vs open radical prostatectomy at a medium case-load institution. Synthesis and Acetylcholinesterase Inhibitory Evaluation of 4-(1,3-Dioxoisoindolin-2-yl)-N-Phenyl Benzamide Derivatives as Potential Anti-Alzheimer Agents. The sequences lying between positions -247 and -25 with respect to the start site of transcription were analyzed for the presence of regulatory elements using an arylsulfatase reporter gene ( Ars) fused to a minimal beta-tubulin promoter.

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We reviewed all cases of genital tract coccidioidomycosis involving testes, epididymis or prostate at our institution between 1990 and 2000, and searched the medical literature for all reports since the first reported case in 1943. We studied changes in rat hemoglobin isoforms during acute adaptation to various hypoxic conditions. However, the geographical coming and going of people in modern society is extremely active. The zebrafish genomic sequence database was analyzed for the presence of genes encoding members of the Rho small GTPases. 5,10,15,20-Tetrakis(4-sulfonatophenyl)prophyrinato iron (III) chloride (FeTPPS), a specific scavenger of ONOO(-), inhibited the effect of clonidine on M. The intensity of immunostaining was weak from 15 gestational weeks to 26 gestational weeks. Different poly(lactide-co-glycolide) (PLGA) polymers with free carboxylic end-group were used to formulate micro- and nanoparticles containing gentamicin, by a water-oil-water solvent-evaporation technique. First, we use spectral biclustering to obtain the best two eigenvectors for class partition. Both of the resulting enzymes exhibited a shift in the pH dependence of the SQR reaction.

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While the relationship between MLDA and DUI events among young adults has been extensively studied, less information is available on other potential consequences of underage drinking. We sought to describe the overall survival (OS) of women with stage I endometrial cancer and examine how the estimated stage-specific OS is altered in the 2009 system. Birth prevalence of congenital talipes equinovarus in low- and middle-income countries: a systematic review and meta-analysis. The distribution of fibronectin in the pannus in rheumatoid arthritis. Influence of type and level of water-soluble additives on drug release and surface and mechanical properties of Surelease films. Metabolism of C19-steroids by foetal cotyledons from the bovine placenta at term. MicroRNAs are a class of small, nonprotein coding RNAs which negatively regulate mRNA translation, thus providing finite control over gene expression in a plethora of biological settings. Our results show that chicken wing meat contamination resulted mainly from farm strain carryover, and that the carcasses were probably contaminated during processing.

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These results may be useful for predicting the stability of U(IV) in aquifers. Areas of focus are demographic characteristics, motivations for serving as BTAPs, their perceptions of the advantages and disadvantages of the BTAP role, and the influence or impact the role had on their own health behaviors or personal lives. Our data suggest that simulation of the local folding of RNA facilitates the discovery of potent antisense sequences. In E(0) mice, oral insulin supplementation attenuates the atherosclerotic process. Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus. Data was collected using a pretested and structured questionnaire. In situ characterization of cell infiltrates in the dermis of human scabies. One should pay attention to anchorage control in using 0.019 x 0.025 inch rectangular wire. Primary resistance of Helicobacter pylori to levofloxacin and moxifloxacine in Iran. Studies on the biosynthesis of mannan in Micrococcus lysodeikticus.

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The second part of the study examines trends in demographic aging in the region since 1900 and changes in the spatial distribution of the population between 1950 and 1981. By using this new method, we estimated whole-genome homozygosity intensities by analyzing real whole-genome sequencing data of 959 related individuals from 20 large pedigrees provided by Genetic Analysis Workshop 19 (GAW19). With both forms of ventilation, arterial oxygen tension progressively improved as mean airway pressure increased. Nevertheless, according to UNAIDS, 2.1 million individuals were infected with HIV-1 in 2015 worldwide. As with any new technology, there will be a learning curve to understanding 3D imaging. However, this type of composite is still a under studied research area due to the difficulties in material handling and processing.

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A total of 272 SOT recipients were HCMV-seropositive pretransplant and were managed using preemptive therapy. In contrast to the studies with Mg, these studies did not show a consistent effect on the absorption of these minerals. This approach is further improved by augmenting snapshot selection with chemical shift predictions by which we can obtain a representative subset of snapshots that gives the smallest predicted error, compared to experiment. Plethysmography: a simple method of studying and following peripheral vascular disorders. The mechanisms by which such recruitment takes place are not well understood. Transfected mouse melanoma lines that express various levels of human melanoma-associated antigen p97. Skin-to-stone distance (cm), angle of the percutaneous tract to the anterior-posterior axis (degrees), and visceral organ-to-tract distance (cm) were measured. This paper presents a method that characterises work time consumption and physical work load of manual work, using video recordings synchronised with physiological measurements of, e.g.

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An integrated technique using zero-valent iron and UV/H2O2 sequential process for complete decolorization and mineralization of C.I. Sexual dysfunction in schizophrenics patients, the role of antipsychotics. Targeting vascular redox biology through antioxidant gene delivery: a historical view and current perspectives. Magnetization transfer imaging techniques in multiple sclerosis patients: state of the ar. Stimulation of bovine milk galactosyltransferase activity by bovine colostrum N-acetylglucosaminyltransferase I. It is unlikely that the reduction in plasma free carnitine in females was a direct causative factor in their reduced exercise tolerance, but probably reflects greater muscle de-conditioning/atrophy with age in female patients. GORD substantially impairs many aspects of HRQL, including sleep, vitality and emotional health. The SCF ubiquitin E3 ligase regulates ubiquitin-dependent proteolysis of many regulatory proteins such as p27(Kip1), IkappaB, and beta-catenin. It is thus concluded that appropriate combination of soil- and plant-specific options can minimise TE transfer to the food chain.

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DESIGN, SETTING, AND ANALYSIS: Thirty waves (1968 to 1997) of the nationally representative Panel Study of Income Dynamics (PSID) data set were merged for analysis. Excision of 8-methylguanine site-specifically incorporated into oligonucleotide substrates by the AlkA protein of Escherichia coli. The statistical rate theory of interfacial transport (SRT) was applied to interpret relaxation time of ion adsorption. The unique Jim Crow effect for US black women for breast cancer ER status underscores why analysis of racial/ethnic inequities must be historically contextualized. To investigate the significance of clinicopathological stage of chronic idiopathic myelofibrosis (CIMF) in WHO classification of 2001. Megakaryocyte (MK) colony formation has been studied in the chronic phase and in the blast crisis of chronic myeloid leukaemia (CML). We report the crystal structure of the estrogen receptor alpha (ERalpha) ligand binding domain (LBD) bound to the structurally similar compound GW5638, which has therapeutic potential and does not stimulate the uterus. Rerupture of cerebral aneurysms during angiography--a retrospective study of 13 patients with subarachnoid hemorrhage. IL-6, IL-10 and CRP were quantified by enzyme-linked immunosorbent assay and T lymphocytes by flow cytometry. Phase and Index of Refraction Imaging by Hyperspectral Reflectance Confocal Microscopy.

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