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Atipam (Lorazepam)
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Atipam

Atipam, an antianxiety agent, has the chemical formula, 7-chloro-5-(o-chlorophenyl)-1,3- dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one. It is a nearly white powder almost insoluble in water. Each Atipam tablet, to be taken orally, contains 0.5 mg, 1 mg, or 2 mg of lorazepam. The inactive ingredients present are lactose monohydrate, magnesium stearate, microcrystalline cellulose, and polacrilin potassium.

Other names for this medication:
Almazine, Anxilor, Anxionil, Anxipose, Atipam, Biokalm, Biolar, Calmese, Dulozep, Larosh, Larpose, Lopam, Lopez, Loracalm, Lorakar, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Loripam, Lorivan, Lorpam, Lorvin, Lotweet, Nexlor, Norpose, Olraz, Trapex, Urpam, Zelor, Zepatrac, Zepnap

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Cipro, Elavil, Rebetol, Combivent, Adalat

Also known as: Lorazepam

Description

Atipam, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or intravenous routes of administration.

Atipam is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Atipam affects chemicals in the brain that may become unbalanced and cause anxiety. Atipam is used to treat anxiety disorders.

Atipam may be habit-forming and should be used only by the person it was prescribed for. Atipam should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

Dosage

The Atipam dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Atipam to treat
  • your age
  • the form of Atipam you take
  • other medical conditions you may have
Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

Drug forms and strengths

  • Tablet: 0.5 mg, 1 mg, 2 mg
  • Solution for injection (IV): 2 mg per mL, 4 mg per mL

General dosage information

The usual oral dosage for Atipam tablets is 2 to 6 mg daily. This dosage amount is usually divided and taken two or three times daily.

Dosage for anxiety

Typical dosage: 1 to 3 mg taken two or three times daily.

Dosage for insomnia due to anxiety or stress

Typical dosage: 2 to 4 mg at bedtime.

Dosage for IV Atipam

  • Intravenous (IV) Atipam will be given by your doctor or nurse. Your doctor will determine the best dosage for your condition.

Special dosage considerations

Older adults and people with certain physical conditions may need to start with a lower dosage. This might be 1 to 2 mg, taken two or three times daily for anxiety or once at bedtime for insomnia.

What if I miss a dose?

If you miss a dose, take it as soon as you can. However, if it’s just a few hours until your next dose, skip the missed dose and take the next one on schedule.

Never try to catch up by taking two doses at a time. This can cause dangerous side effects.

Overdose

In cases of a suspected Atipam overdose, it is important to establish whether the patient is a regular user of Atipam or other benzodiazepines, since regular use causes tolerance to develop. Also, one must ascertain whether other substances were also ingested.

Signs of overdose range through mental confusion, dysarthria, paradoxical reactions, drowsiness, hypotonia, ataxia, hypotension, hypnotic state, coma, cardiovascular depression, respiratory depression, and death.

Early management of alert patients includes emetics, gastric lavage, and activated charcoal. Otherwise, management is by observation, including of vital signs, support and, only if necessary, considering the hazards of doing so, giving intravenous flumazenil.

Patients are ideally nursed in a kind, nonfrustrating environment, since, when given or taken in high doses, benzodiazepines are more likely to cause paradoxical reactions. If shown sympathy, even quite crudely feigned, patients may respond solicitously, but they may respond with disproportionate aggression to frustrating cues. Opportunistic counseling has limited value here, as the patient is unlikely to recall this later, owing to drug-induced anterograde amnesia.

Storage

Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Atipam is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Atipam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The additive central-nervous-system effects of other drugs, such as phenothiazines, narcotic analgesics, barbiturates, antidepressants, scopolamine, and monoamine-oxidase inhibitors, should be borne in mind when these other drugs are used concomitantly with or during the period of recovery from Atipam Injection.

Extreme caution must be used when administering Atipam Injection to elderly patients, very ill patients, or to patients with limited pulmonary reserve because of the possibility that hypoventilation and/or hypoxic cardiac arrest may occur. Resuscitative equipment for ventilatory support should be readily available.

When Atipam injection is used IV as the premedicant prior to regional or local anesthesia, the possibility of excessive sleepiness or drowsiness may interfere with patient cooperation in determining levels of anesthesia. This is most likely to occur when greater than 0.05 mg/kg is given and when narcotic analgesics are used concomitantly with the recommended dose.

As with all benzodiazepines, paradoxical reactions may occur in rare instances and in an unpredictable fashion. In these instances, further use of the drug in these patients should be considered with caution.

There have been reports of possible propylene glycol toxicity (e.g., lactic acidosis, hyperosmolality, hypotension) and possible polyethylene glycol toxicity (e.g., acute tubular necrosis) during administration of Atipam Injection at higher than recommended doses. Symptoms may be more likely to develop in patients with renal impairment.

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Further study established that vagotomy before septic peritonitis resulted in an enhanced influx of neutrophils and a marked increase in proinflammatory cytokine levels and liver damage. These characteristics are interpreted as arising from a statistical mixture distribution. Introduction of this insertion mutation into a strain bearing a fusion between the nitrate reductase operon (chl C, chl I) and the lac structural genes resulted in the constitutive expression of the lac genes of this last fusion. The presence of glutathione S-transferases A1-1 and P1-1 in seminal fluid suggests a role in the protection against (oxidative) damage of spermatozoa, whereas glutathione may play a role in male fertility. Analysis of X ba I polymorphism of FVIII gene and its application on prenatal diagnosis for hemophilia A. Haptophyte Diversity and Vertical Distribution Explored by 18S and 28S Ribosomal RNA Gene Metabarcoding and Scanning Electron Microscopy. (i) To compare the ratio of right ventricular systolic to diastolic duration (SD/DD) in infants with congenital diaphragmatic hernia (CDH) and normal controls and (ii) to examine its association, if any, with outcomes in CDH.

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We conclude that there is changing trend in the aetiologies of gross haematuria among adult Nigerian patients with urological malignancies being now more prevalent than previously reported in our environment. Changes in family life patterns in Poland in the period 1945-1985 are analyzed, including changes in educational levels, occupations, and living conditions. Furthermore, we show that here the first revival time turns out to be larger than for quantum carpets. A case is reported in which a young man undergoing exploratory thoracotomy following a gunshot wound had a cardiac arrest during reinflation of the collapsed lung. These cases were chosen to highlight the complexities that investigators and journals must face when dealing with ethical issues.

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Prevention of AF by pacing is based on prolongation of the premature interval at BB, thus preventing conduction block and reentry. Monte Carlo (MC) simulations have been used to study the structure of an intermediate thermal phase of poly(alpha-octadecyl gamma,D-glutamate). The main advantages or disadvantages of each procedure are discussed after each technical description. In this way, concentrations of chemical species are directly linked to accumulation by biota. TDPC and beta-sitosterol did not affect cholesteryl oleate formation from oleoyl CoA by microsomal acyl CoA:cholesterol acyltransferase (ACAT), whereas melinamide significantly inhibited cholesteryl oleate formation. Effect of thyroid hormone on somatomedin-C release from perfused rat liver. There is a tension between providing enough time between withdrawal of treatment and declaration of death for reasonable confidence to be maintained in the process of DCD and the desirability of keeping warm ischemic time to a minimum in the interest of organ survival.

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PGSB/MIPS PlantsDB Database Framework for the Integration and Analysis of Plant Genome Data. Using immunohistochemistry, we also demonstrated the colocalization of GH secretagogue receptor (GHS-R), the cellular receptor for ghrelin, with CCK-AR in vagal afferent neurons. A comparative analysis of impedance measurements using four-electrode versus two-electrode configurations for impedance measurements also highlighted the advantages of using four electrodes for portable sensor applications. Three additional randomized controlled trials included a structured assessment of sexual dysfunction within an efficacy trial. THE FEATURES OF PHARMACOKINETICS ANTIBIOTIC CEFTRIAXONE WITH INTRAVENOUS WAY THAT ARE DEPOSITED IN AUTOLOGOUS ERYTHROCYTES AND LEUKOCYTES OF RABBIT. Helicobacter pylori is known to be an important pathogen involved in gastric and duodenal inflammation. An ultrastructural study of enkephalin-immunoreactive perikarya forming a hypothalamic nucleus, the magnocellular dorsal nucleus (MDN), was carried out in colchicine-treated guinea pigs. The insertion of microtubules at different levels of the kinetochore may reflect the existence of functionally distinct microtubule classes.

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These morphological characters suggest that its affinities are with the Ranunculaceae, a basal eudicot family. In all the processes studied, the epithelial part of the cell infiltration area was found to differ from the connective tissue area by cell composition. Consumer reactions to risk information on bovine spongiform encephalopathy in Japan. The animal received 3H-proline (1 mCi/kg body weight) 24 h and 3H-thymidine (0.5 mCi/kg body weight) 3 h prior to killing. We report isolation of two novel rice (Oryza sativa L.) mitogen-activated protein kinases (MAPKs), OsMSRMK3 (multiple stress responsive) and OsWJUMK1 (wound- and JA-uninducible) that most likely exist as single copy genes in its genome. The effect of vesico-ureteral reflux, residual urine and primary disease on the incidence of urinary tract infection after kidney transplantation. Arsenic compounds have been used extensively in agriculture in the US for applications ranging from cotton herbicides to animal feed supplements. It is concluded that several types of cutaneous mechanoreceptors can operate as sensitive proprioceptors of importance for facial kinaesthesia and motor control.

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Our data suggest that a structural difference at codon 72 of the p53 gene may not be a sufficient risk factor for cervical carcinogenesis. Novel substituted EDOTs and the first chiral derivatives were generated in high yields. Illustrative results are presented for a thermal plasma in different mixtures of argon and hydrogen at 1 bar, for temperatures up to 25 000 K and different ratios of electron to heavy species temperature. Constant probabilities of events and constant duration of gestation and postpartum sterility are assumed. We show that gp130-dependent pathways control Stat3 activation after PH. In this article I extend previous work for estimating ancestral population sizes to analyze sequence data from three species under a finite-site nucleotide substitution model. In contrast, Slob57 and Slob51, initiated at the second translational start site, shift the conductance-voltage relationship of dSlo substantially to more depolarized voltages, cause an apparent dSlo channel inactivation, and increase the deactivation rate of the channel.

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Stress-induced salivary cortisol secretion during hypobaric hypoxia challenge and in vivo urinary thromboxane production in healthy male subjects. Thus, dietary compounds that influence microbial flora may thereby impact on inflammatory pathways. In 0.4 M KCl cytosol, only slightly smaller values were determined (approximately 6.5 S, approximately 6.8 nm, and approximately 187,000). AGRP was inversely correlated with indicators of undernutrition such as body mass index and plasma leptin. Contradictory results were found regarding a possible statistically significant correlation between the extent of gingival recession and the amount of incisor proclination during treatment, width of attached gingiva, hygiene, periodontal condition or thickness of the symphysis. What else does the JUPITER trial add regarding C-reactive protein and cardiovascular disease?. Chronic ICD-10 codes were subsequently grouped into broader categories according to clinical criteria. A rare case of a double phytobezoar causing gastric and jejunum obstruction in an adult man: a case report. Data demonstrated that TNCV provided adequate oxygenation and ventilation with flow rates of 3 and 5 L/min with the 14- and 16-g catheters.

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To document the domains and properties of the self-reported needs of ambulatory patients with cancer. Bovine strains, isolated from the milk of cows of private raisers and human strains, isolated from the raisers of the cows, deviated in their characteristical biochemical properties. Beneficial effects of the Src inhibitor, dasatinib, on breakdown of the blood-retinal barrier. Both genomes contain integrin alpha subunits that have the inserted alphaI domain. The facial proportions of HFM patients are maintained, when not treated, throughout growth.

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This effect does not seem to be due to direct cellular toxicity or to a shift in the kinetic pattern of the responses. Impact of Mineral Precipitation on Flow and Mixing in Porous Media Determined by Microcomputed Tomography and MRI. Heart rate response to exercise and cardiorespiratory fitness of young women at high familial risk for hypertension: effects of interval vs continuous training. It is recommended that this technique become the standard method of magnification on all imagers. Cell-free culture supernatants of a lipopolysaccharide (LPS) O-polysaccharide-deficient, single-insertion transposon mutant of the tetragonal surface protein array (S layer)-containing fish pathogen Aeromonas salmonicida were examined by electron microscopy. The poor prognosis of NK/T cell lymphoma might be associated with massive tissue damage with hypercytokinemia. Our FT-IR absorption, NMR, and X-ray diffraction investigations support the view that the beta-turn and 3(10)-helical conformations preferred by the original peptides are not dramatically perturbed in the derivatives monomethylated at position 1. Migrant employment, recessions, and return migration: some consequences for migration policy and development. The most successful BuXN linked protein (Bu30N-r) was inserted into and expressed in yeast and its catalytic properties were tested.

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We hypothesize that dimethyl Hg fluxes from the ocean to the atmosphere through polynyas and open leads in ice, and is rapidly photolyzed to MMHgCl. The procedure of phenol/chloroform was too labor-intensive to be accepted in routine clinical testing, sodium octanoate which may suppress the inhibitory effect of denatured albumin on the polymerase chain reaction and thus the sensitivity was higher than the method of NaOH denaturation. Serum TSH and free T4 concentrations were derived from 606 healthy, non-pregnant, 18-91-year-old Finns from the Nordic Reference Interval Project (NORIP) and the possible effects of age, sex and thyroid peroxidase antibody (TPOAb) status were evaluated. Effect of acrylodan conjugation and forced oxidation on the structural integrity, conformational stability, and binding activity of a glucose binding protein SM4 used in a prototype continuous glucose monitor. The hydrogen bond reformation likely improved the dissolution rates of the polymers. A simple calibration of a shadow shield counter for the measurement of total body potassium in critically ill patients. The intensity of alpha-helix, beta-sheet was increased, while the intensity of beta-turn was decreased. Also, a possible cis-element for transcriptional regulation was identified. Influence of supplementation of all-rac-alpha-tocopheryl acetate preweaning and vitamin C postweaning on alpha-tocopherol and immune responses of piglets. The levels of serum HI antibody titres did not correlate with the sex of patients with multiple sclerosis or the activity of the disease.

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These results for uptake of the first year of the national programme using aggregate data corroborate findings from intentions surveys and pilot studies. immunization, the state of nonresponsiveness could still be transferred to syngeneic naive mice by parabiosis, as well as by transfer of thoracic duct lymphocytes. Of this sample, 330 were diagnosed as alcohol dependent, alcohol abusers (both according to DSM-IV) or at-risk drinkers. This paper describes the theory noroxin medication and the results of the experimental investigations into the physics of the ultrasonic impact. Although no absolute statements 1 way or the other can be made about such a situation, the Cycle chart for this issue demonstrates that at least some women can have an extremely irregular sleeping pattern and still have an interpretable temperature patterns. In conclusion, these findings provide further characters of histamine as a sympathetic neurotransmitter. Genetic diversity of HPV-16 E6, E7, and L1 genes in women with cervical lesions in Liaoning Province, China. A short survey of the history of large animal surgery in Norway. Common carotid artery (CCA)-IMT and LV mass indexed to lean body mass (LBM). In vitro, paracetamol inhibits cyclooxygenase (COX)-1 and -2 in high concentrations but stimulates in low doses.

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The sensitivity to activation of platelets is part of the delicate equilibrium differentiating hemostasis from thrombosis. In addition, the present findings indicate that the spatial learning deficit in SHR is not directly related to hypertension. Effect of transabdominal vagotomy on the human gastroesophageal high-pressure zone. Leukotriene B(4) (LTB(4)) has been implicated in the pathophysiology of both COPD and asthma. Valerian appears to be less likely to produce CYP-mediated herb-drug interactions. Scans were taken parallel to the mandibular occlusal plane, and morphologic measurements, including distribution of cancellous bone, were obtained. Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. More than half of all patients reported ten or more symptoms at time of discharge. Atoms and bonds within individual molecules have been clearly resolved, indicating the exciting potential of this technique for studying molecular structures, bonding within and between molecules, molecular conformational changes and chemical reactions at the single-molecule level. Their binding affinities at dopamine D(2) and serotonin 5-HT2A and 5-HT2C receptors were determined, showing in some cases an atypical antipsychotic profile.

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Specific epidemiological data are presented in this review, screening programs critically considered, treatment procedures discussed, and the effectiveness of follow-up protocols is analysed together with cost effectiveness issues. Regulatory on/off minimization of metabolic flux changes after genetic perturbations. Percutaneous vertebroplasty for osteoporotic vertebral compression fractures: experiences and prospective clinical outcome in 26 consecutive patients with 50 vertebral fractures. The two heads of biceps femoris were not affected in any patients with L-5 radiculopathy in whom they were examined. Study of the absorption of iodine-131 by the thyroid gland and level of protein-bound iodine in the blood during the development of liver cirrhosis. This study demonstrates that HDI on skin can be collected with tape-strips and quantified at occupational levels using LC-MS. To develop zoledronic acid (ZA)-loaded collagen membranes, and to study its effect on osteoclast and osteoblast so as to investigate whether ZA-loaded membranes can inhibit local bone resorption and promote bone formation. The clinical results, as rated by a knee score, were better in those knees with osteonecrosis of the medial femoral condyle and a postoperative femorotibial angle (as measured on a standing roentgenogram) ranging from 164 to 173 degrees (7 to 16 degrees of valgus angulation). Retrospective study of temporal trends in early progression of perinatal HIV infection among 205 HIV-infected children in Northern California born between January 1, 1988, and December 31, 2001, and followed up through age 3 years. Autophagy: an adaptive risperdal drug category physiological countermeasure to cellular senescence and ischaemia/reperfusion-associated cardiac arrhythmias.

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Despite a decrease in the fraction of nucleolar Sir2, and in overall Sir2 protein levels, short rDNA strains display normal rDNA silencing and a lifespan indistinguishable from wild type. (3) IQs and social quotients reflected improvement during theophylline treatment. The health care mandate as well as the staff management, the organisational and the constructional-spacial structure of trauma room diagnostics and therapy of the trauma centers of the Universities of Leiden and Munich (Innenstadt) and the Zentralklinikum Augsberg are described. Inactivation and reactivation of antibiotic-resistant bacteria by chlorination in secondary effluents of a municipal wastewater treatment plant. Trees experience low apoplastic water potential frequently in most environments. Familial cylindromatosis is a rare genetic disorder, giving rise to neoplasms of the skin appendages.

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The description of patient travel patterns and variations in health care utilization may guide a sound health care planning process. The suppressing mutation in SPN1 substitutes an asparagine for an invariant lysine at position 192 (spn1(K192N)). Administration of IFN-gamma suppressed expression of pX, the gene critically involved in the onset of HAM rat disease, in an HTLV-1-immortalized rat T-cell line, indicating that IFN-gamma protects against the development of HAM rat disease. Implications of thiazolidinedione singulair cost with insurance use and cardiovascular risk: is it all about the sugar?. C-2 neurectomy during atlantoaxial instrumented fusion in the elderly: patient satisfaction and surgical outcome. In order to investigate the prognostic value of immunologic markers together with the most relevant clinical and hematological disease characteristics in acute myeloblastic leukemia (AML), the reactivity of blast cells from 102 patients with AML was analyzed with a panel of twenty monoclonal antibodies. We have used an in vitro reconstitution system, consisting of cell-free translation products and intact chloroplasts, to investigate the pathway from synthesis to assembly of two polypeptide subunits of the light-harvesting chlorophyll-protein complex.

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Radiologic staging of ovarian carcinoma--necessary or redundant?. Ideally, the growth hormone-secreting adenoma should be completely resected, with preservation or subsequent restoration of pituitary function. Quantification of vertebral bone marrow fat content using 3 Tesla MR spectroscopy: reproducibility, vertebral variation, and applications in osteoporosis. Other functional and immunophenotypic characteristics included a high c-myc expression in the neoplastic lesions, no alteration in p53 expression, and no alteration in the expression of hepatic enzymes except for diffuse expression of succinic dehydrogenase. Only modern contraception can restore longer birth intervals in changing African societies. Peak 1 LHRH was still present and was elevated after EB treatment. Five more patients were dropped from the trial and 78 other cataract operations were performed outside the trial for various reasons. In this chapter, the computational biology of cardiac cavity images is proposed. The amount of detectable antibodies was influenced by the type of antigenic preparation used in the enzyme-linked immunosorbent assay. The diagnosis of growth hormone (GH) deficiency is based on a reduced peak GH response to provocative tests.

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entomophila rapidly succumb despite the induction of both local and systemic immune responses, indicating that this bacterium has developed specific strategies to escape the fly immune response. Feasibility of quality indicators for the management of geriatric syndromes in nursing home residents. Euphorbia Prostrata is a new molecule used for grade I and II hemorrhoids. Inadequate surgical margins were obtained in two cats while six showed evidence of microscopic invasion in other mammary glands. The patient had no signs or symptoms of acquired immune deficiency syndrome (AIDS). Hypoxia was identified by pimonidazole, perfusion by Hoechst 33342, and endothelial cells by CD31.

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The injection of QDs in the right or left pleural space of the pig resulted in migration solely to the ipsilateral highest superior mediastinal lymph node group. It is shown that chloroperoxidase acts as a superoxide scavenger but less effectively than superoxide dismutase. Although many of the injuries at first may seem formidable, most can be repaired using basic reconstructive surgery procedures. Synthesis and anticonvulsant properties of 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea derivatives. Positron emission tomography and measurements of regional tissue function in man. We found the AMBU PEEP valve to be accurate and easy to use with a stable performance meeting all requirements for emergency medical care (EMC). To report our experience on the use of nonpreserved human amniotic membrane transplantation (AMT) in ocular surface reconstruction after excision of extensive ocular surface neoplasia (OSN). An analysis of the radiosensitivity of sarcoma M-1 by the method of varying the regime of irradiation.

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