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Astepro (Azelastine)
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Astepro

Astepro nasal spray is a fast-acting, efficacious and well-tolerated H1-receptor antagonist for the treatment of rhinitis. In addition it also has mast-cell stabilizing and anti-inflammatory properties, reducing the concentration of leukotrienes, kinins and platelet activating factor in vitro and in vivo, as well as inflammatory cell migration in rhinitis patients.

Other names for this medication:
Astepro, Azelast, Azelastine, Azenate, Duonase, Nazomac, Oculast, Optihist, Optivar

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Also known as: Azelastine

Description

Astelin (azelastine) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Astelin nasal spray is used to treat sneezing, runny or stuffy nose, itching, and other nasal symptoms of allergies, in adults and children who are at least 5 years old.

Astelin is also used to treat ongoing nasal symptoms (runny or stuffy nose, sneezing, itching) that are not caused by allergies, in adults and children who are at least 12 years old.

Dosage

This section provides information on the proper use of a number of products that contain azelastine. It may not be specific to Astelin Ready-Spray. Please read with care.

Use this medicine only as directed by your doctor. Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of side effects.

This medicine usually comes with patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Follow the instructions on the medicine label if you are using this medicine without a prescription.

This medicine is for use only in the nose. Do not get any of it in your eyes or on your mouth. If it does get on these areas, rinse it off with water and call your doctor right away.

Do not use this medicine for any other nose problem (eg, ulcers or surgery, or injury that has not healed) without checking with your doctor first.

To use the spray:

When you use the azelastine nasal spray for the first time, you must prime the spray. Press down fully 6 times or until a fine spray comes out. Prime the spray after each time you clean the pump, or if you have not used the medicine for 3 days or longer, by spraying the medicine 2 times or until a fine spray comes out. Blow your nose to clear your nostrils. Tilt your head down, looking at your toes, and insert the tip of the nose piece into your nostril. Hold bottle upright and aim the spray tip toward the back of your nose. Tilt your head downward while spraying to avoid a bitter taste in the mouth. Close your other nostril with a finger. Press the pump 1 time and sniff gently at the same time, keeping your head tilted forward and down. Repeat in your other nostril using the same steps. If your healthcare provider tells you to use 2 sprays in each nostril, repeat the steps above for the second spray in each nostril. Do not blow your nose or tip your head back after using the spray. Wipe the tip of the outside of the nose piece with a clean, dry tissue or cloth and put the cap back on.

Do not drink alcohol while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For nasal dosage form (Astelin® spray): For treatment of seasonal allergic rhinitis: Adults and children 12 years of age and older—1 or 2 sprays in each nostril 2 times a day, or 2 sprays in each nostril once a day. Each spray contains 137 or 205.5 micrograms (mcg) of azelastine. Children 6 to 11 years of age—1 spray in each nostril 2 times a day. Each spray contains 137 or 205.5 mcg of azelastine. Children 2 to 5 years of age—1 spray in each nostril 2 times a day. Each spray contains 137 mcg of azelastine. Children younger than 2 years of age—Use and dose must be determined by your doctor. For nasal dosage form (Astepro® spray): For treatment of perennial allergic rhinitis: Children 6 months to 11 years of age—1 spray in each nostril 2 times a day. Each spray contains 137 micrograms (mcg) of azelastine. Children younger than 6 months of age—Use and dose must be determined by your doctor. For treatment of seasonal allergic rhinitis: Adults and children 12 years of age and older—1 or 2 sprays in each nostril 2 times a day. Each spray contains 137 micrograms (mcg) of azelastine. Children 2 to 11 years of age—1 spray in each nostril 2 times a day. Each spray contains 137 mcg of azelastine. Children younger than 2 years of age—Use and dose must be determined by your doctor. For nasal dosage form (Astepro® allergy spray): For treatment of allergic rhinitis or other upper respiratory allergies: Adults and children 12 years of age and older—2 sprays in each nostril once a day or 1 or 2 sprays in each nostril 2 times a day (every 12 hours). Do not use more than 4 sprays in each nostril per day (24 hour period). Each spray contains 205.5 micrograms (mcg) of azelastine. Children 6 to 11 years of age—1 spray in each nostril 2 times a day (every 12 hours). Do not use more than 2 sprays in each nostril per day (24 hour period). Each spray contains 205.5 micrograms (mcg) of azelastine. Children younger than 6 years of age—Use is not recommended.

Overdose

If you overdose Astepro and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the bottle upright with the pump tightly closed.

Detailed Astelin dosage information

Side effects

The most common side effects associated with Astepro are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Astepro if you are allergic to Astepro components. It is not known whether Astepro will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant or breast-feeding. The medicine has a antihistamine in it. Before you start any new medicine, check the label to see if it has an antihistamine (e.g., diphenhydramine) in it too. If it does or if you are not sure, check with your doctor or pharmacist. Astepro may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away. Astepro should be used with extreme caution in children younger than 5 years old; safety and effectiveness in these children have not been confirmed. Do not drink alcohol or use medicines that may cause drowsiness (e.g., sleep aids, muscle relaxers) while you are using Astepro; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. Astepro may cause drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Astepro with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Do not stop taking Astepro suddenly.

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Following IL1beta and IL6 stimulation, expression of TFF genes was analyzed in gastrointestinal cell lines HT-29 and KATO III by reporter gene assays using TFF promoter constructs and by quantitative real-time PCR. Point mutations in this region block proteolysis but do not alter the kinase activity of MEK. As far as TOP is concerned, the huge discrepancies in responses from the professionals highlight the ongoing ethical debate, especially concerning the concept of informed choice in TOP, which we believe should be entirely revisited. These results suggest that impulsive and aggressive traits might contribute significantly to the risk of suicide attempts in alcoholics. Peak gene expression of macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and MIP-2 and interferon-gamma-inducible protein of 10 kd (IP-10) was detected in I/CB on day 11, whereas peak expression of RANTES and eotaxin was observed at 17 days. Whilst much recreational running happens alone, most commonly these studies have centred on the establishment of shared identities and group subcultures. In a previous paper we introduced a method called augmented sparse reconstruction (ASR) that identifies links among nodes of ordinary differential equation networks, given a small set of observed trajectories with various initial conditions. FOSC genomes harbour non-canonical Helitrons that are characterized by asymmetric terminal inverted repeats, show hallmarks of recent activity and likely transpose via a circular intermediate.

astelin 2017-07-01

The brain wave activity of a professional Salpuri dancer was observed while the subject recalled her performance of the Salpuri dance when sitting in a chair with closed eyes. Insulin specific IgE was determined in the sera of diabetic patients. To assess the impact of patient repositioning and internal organ motion on prostate treatment plans using three-dimensional conformal and intensity-modulated radiotherapy. beta 2-Microglobulin levels do not contribute additional information. This is consistent with what is known about the mechanism of action of glucocorticoids in most tissues.

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