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Aristomycin (Roxithromycin)
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Aristomycin

Aristomycin is an antibiotic that is used to treat infections such as infections of the chest, tonsils, skin or genitals. It works by killing or stopping the growth of bacteria (bugs). Like all antibiotics, Aristomycin is not effective against infections caused by viruses.

Other names for this medication:
Acevor, Aristomycin, Assoral, Bazuctril, Biostatik, Cadithro, Claramid, Crolix, Floxid, Ladlid, Macrosil, Monobac, Nirox, Overal, Pedilid, Ramivan, Redotrin, Renicin, Ritosin, Roksimin, Rolexit, Romyk, Rossitrol, Rotramin, Roxacine, Roxithromycine, Roxitromicina

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Also known as: Roxithromycin

Description

Aristomycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Aristomycin is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Aristomycin is available under several brandnames. Aristomycin is not available in the United States. Aristomycin is available in Australia, Israel and New Zealand. Aristomycin has also been tested to possess antimalarial activity.

Aristomycin prevents bacteria from growing, by interfering with their protein synthesis. Aristomycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Aristomycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.

Dosage

Take Generic Aristomycin by mouth with food. If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water. Swallow Generic Aristomycin tablets whole with a glass of water. Generic Aristomycin should be taken at least 15 minutes before food or on an empty stomach (i.e. more than 3 hours after a meal). Generic Aristomycin works best if you take it on an empty stomach. For treating bacterial infections, Generic Aristomycin is usually taken for 5 to 10 days. If you want to achieve most effective results do not stop taking Generic Aristomycin suddenly.

Overdose

Symptomatic treatment should be provided as required. There is no specific antidote.

Storage

Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the blister pack they may not keep well.

Keep the medicine in a cool, dry place where the temperature stays below 25 degrees C.

Do not store it or any other medicine in the bathroom, near a sink or on windowsill.

Do not leave it in the car. Heat and damp can destroy some medicines.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Aristomycin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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Antibiotics First Versus Surgery for Appendicitis: A US Pilot Randomized Controlled Trial Allowing Outpatient Antibiotic Management: A Little Step Toward a Patient-Centered Approach and Rethinking the Management of Acute Appendicitis. In this article, we first propose a Bayesian neighborhood selection method to estimate Gaussian Graphical Models (GGMs). Acute pancreatitis is a severe disease with unpredictable course and outcomes. Alternative approaches may produce a substantial reduction in psychosocial risks, at the cost of a small reduction in medical benefits, and thus improve the benefit/risk balance. The energy route to the equation of state of hard-sphere fluids is ill defined since the internal energy is just that of an ideal gas, and thus it is independent of density. For the TC regimen, the obese and normal groups had significantly lower leukocytopenia (grade 3/4) rates than did the underweight group. Then, an improved beta-IFN expression vector was constructed, which contains a dhfr transcription unit. Oxytocin and Other Pharmacologic Preventive Interventions for Posttraumatic Stress Disorder: Not a One-Size-Fits-All Approach. In a second cordocentesis the cordblood specimen was found to be HBsAg positive as well.

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BIOSYNTHESIS OF 3-ACETYLPYRIDINE-ADENINEDINUCLEOTIDEPHOSPHATE (3-APADP) FROM NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (NADP). Major increases in VE were seen only when saline or citric acid was instilled into the lower tr, the citric acid responses exceeding saline ones. Randomized controlled trial evaluating response to metformin versus standard therapy in the treatment of adolescents with polycystic ovary syndrome. Creatinine, total bilirubin, gamma-glutamyltransferase, alanine aminotransferase, and aspartate aminotransferase were elevated in protein-deficient pigs compared with controls after 7 weeks of depletion. Sensitive and specific detection of Salmonid alphavirus using real-time PCR (TaqMan). The use of the microspheres for encapsulation was demonstrated by the inclusion of a solution of Texas Red fluorescent dye. This study addresses the interaction between Gi-proteins and the extracellular regulated kinase (ERK) component of the mitogen activated protein kinase (MAPK) cascade in regulating mitogenesis in an experimental model of HCC.

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