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Apalene (Adapalene)

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Apalene is an expensive drug used to treat mild to moderate acne. This drug is slightly more popular than comparable drugs. It is available in generic and brand versions. Over-the-counter Apalene is now available without a prescription.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Keflex, Myambutol, Abhigra, Hytrin, Symmetrel, Exelon, Lunesta, Theolair, Asacol, Parlodel

Also known as: Adapalene


Adapalene is used to treat acne. It works partly by keeping skin pores clear.

Adapalene is available only with your doctor's prescription.


Follow the directions for using this medicine provided by your doctor. Use Apalene exactly as directed. Apalene is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Apalene. Apalene should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Apalene. Continue using Apalene until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Apalene promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


If you overdose Apalene and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Differin dosage information

Side effects

The most common side effects associated with Apalene are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Differin if you are allergic to adapalene.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have other medical conditions.

It is not known whether adapalene passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.

It is not known whether Differin will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.

Differin is not approved for use by anyone younger than 12 years old.

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This study reveals that the Krox-20 null mutation impacts the development of mesencephalic trigeminal (Me5) neurons, a cell group traditionally thought to emerge from the mesencephalon. Mapping the signal sequence-binding site on SRP reveals a significant role for the NG domain. The data presented showed evidence, for the first time, of an interaction between VP2 and a nonstructural rotavirus protein. Pretreatment of the SWNT with Triton-X405 blocks the nonspecific binding of untreated YCC but does not interfere with binding of the oligonucleotide-modified YCC. Mito-inhibitory hepatocyte nuclear p21 expression in humans awaiting liver replacement directly correlated with pathological disease stage and model of end-stage liver disease scoring. Chinensiolide B (2) was transformed to chinensiolide C (3) in a three-step conversion. With the exception of prolactinomas, surgery is the first-line option, but most aggressive pituitary tumors often require repeated surgery. When substrate was bound, there was an upshifted 1528 cm(-1) band of the neutral semiquinoid flavin in CPD photolyase, indicating a weakened hydrogen bond at N5-H of FAD, and band X seemed to be downshifted in (6-4) photolyase, indicating a weakened hydrogen bond at N3-H of FAD.

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Immunofluorescent histological studies of the role of fibronectin in the expression of the associative preferences of embryonic tissues. The objective of our study was to apply the sonographic criteria for the diagnosis of benign thyroid nodules described by Bonavita et al. Comparison of the effects of di(2-ethylhexyl)phthalate, a peroxisome proliferator, on the vitamin metabolism involved in the energy formation in rats fed with a casein or gluten diet. In the first study, 12 volunteers received a single dose of amprenavir, 1200 mg, alone and then again after 7 days of delavirdine, 600 mg twice daily. The mutant-enriched ARMS TaqMan PCR could be useful in the detection of mutation in clinical samples containing only a small number of mutant alleles. Egg hatching response to a range of ultraviolet-B (UV-B) radiation doses for four predatory mites and the herbivorous spider mite Tetranychus urticae. Hyaluronan binding protein 1 (HABP1) is a ubiquitously expressed multifunctional phospho-protein that interacts with a wide range of ligands and is implicated in cell signalling. The gene for the human melanoma-associated antigen p97 has been introduced by cDNA transfection into cells from clone M2 of the K1735 mouse melanoma, which metastasizes to the lung when injected iv into syngeneic C3H/HeN mice.

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Reduction of serum level of IL-6 in multiple myeloma patients and decrease in IL-6R expression on the myeloma cells and IL-6R beta mRNA occur on D14 after oral 400 mg/d thalidomide. The focus group participants supported visiting specialist services, indicating a willingness to use them for consultations, diagnostic and minor procedures. MSSA strains showed lower homology than MRSA strains, in which only two clones were seen. Optic microscopy of the morphology and distribution of blood vessels of the ganglia of the ventral neural network in the earthworm Eisenia foetida L. SIgA:Alb is a useful marker of the severity of stresses encountered during stressful training. Firstly, the neurophysiological background of the P300 is outlined. A growing gap between the required and available funds forces relevant bodies to use more effectively available financial means without decreasing the health care efficiency. In studying the density and temperature dependence of these modes, it is found that, when the value of the Lyapunov exponent lambda((alpha)) is plotted as function of the dominant wave number k(max) of the corresponding LV, all data from simulations with different densities and temperatures collapse onto a single curve. Renal bases for the composition of an extracellular water substitute. Electrophoretic mobility shift assays and immunoprecipitation studies indicated that the mutant O2 proteins form heterodimers with wild-type will bactrim kill staph infection O2 in vitro.

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This article overviews the training of nuclear medicine technologists in chosen European countries, the United States and desyrel cost Canada. Migrant workers in the European Economic Community and the problems of employment in the 1980s. In general, improved understanding of the neurobiological effects of VNS therapy as a function of the different use parameters (frequency, intensity, pulse width, duration, dose) is beginning to guide clinical use and help determine which diseases, in addition to epilepsy, VNS might treat. Effect of insulin and epinephrine on some early oestrogenic responses in the rat uterus. Indispensable is the use of appropriate control groups or control samples and a sufficient case number which permits statistical analysis. Micronuclei formation in somatic cells of mice exposed to 50-Hz electric fields. The agricultural intensity and the urban growth rate were much higher under the historical trend scenario compared to those with more planning interventions. Ivermectin (Mectizan) is an effective and well-tolerated microfilaricidal drug that has emerged as the drug of choice for large-scale treatment of onchocerciasis. It is the possible mechanism of IFN-alpha therapy or combined therapy on CML at chronic phase that the malignant clone expansion is inhibited by promoting apoptotic cell death.

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These immunohistochemical patterns provide an essential data base to evaluate the ongoing clinical trials employing MAbs to GD3 and mel-CSPG for the therapy and immunolocalization of melanomas, and they identify gp57 as a potential marker for subsets of normal and transformed melanocytic cells. A round image indicated that the test object was at the central plane. We show that, at day 12.5 of embryo development, Thg-1 pit expression is restricted to the rhombic lip, subventricular neuroepithelium/mantle zone, and lateral ganglionic eminence, namely the embryonic brain areas where granule cell precursors originate. Therapy with recombinant human growth hormone (rhGH) replacement (0.15 IU/kg/day) was started. The relatively high efficacy of ECS in the therapy for depression may be attributable to the ECS-evoked long-lasting changes in the immune system, which supports the macrophage theory of depression. The pattern of the terminal air spaces in a premature infant of 30-32 weeks that lived nineteen and a quarter hours.

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Private physical therapy practices and outpatient departments of hospitals and rehabilitation centers. Comparative study of the efficacy of eprinomectin versus ivermectin, and field efficacy of eprinomectin only, for the treatment of chorioptic mange in alpacas. Functional Electrical Stimulation assisted cycling (FES-Cycling) is increasingly becoming an alternative option recommended to people with spinal cord injury struggling with paraplegia and interested in practicing sports. By contrast, dental students demonstrated more of a commitment to personal and financial gain. Treatment with mutagenes in moderate doses results in deviation of segregation of marker traits as compared to control towards either increase or decrease of the ratio of recessive allels. Improving the instrumental resolution of sensors based on localized surface plasmon resonance.

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