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Anxipose (Lorazepam)
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Anxipose

Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. It is used to treat anxiety disorders, trouble sleeping, active seizures including status epilepticus, alcohol withdrawal, and chemotherapy induced nausea and vomiting, as well as for surgery to interfere with memory formation and to sedate those who are being mechanically ventilated. While it can be used for severe agitation, midazolam is usually preferred. It is also used, along with other treatments, for acute coronary syndrome due to cocaine use. It can be given by mouth or as an injection into a muscle or vein. When given by injection onset of effects is between one and thirty minutes and effects last for up to a day.

Other names for this medication:
Almazine, Anxilor, Anxionil, Anxipose, Atipam, Biokalm, Dulozep, Larosh, Larpose, Lopam, Lopez, Loracalm, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Loripam, Lorivan, Lorpam, Lorvin, Nexlor, Norpose, Olraz, Trapex, Urpam, Zelor, Zepatrac, Zepnap

Similar Products:
Asacol, Adalat, Tenormin, Zyrtec, Benemid, Lopid, Zebeta, Revia, Risperdal

Also known as: Lorazepam

Description

Anxipose, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or intravenous routes of administration.

Anxipose is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Anxipose affects chemicals in the brain that may become unbalanced and cause anxiety. Anxipose is used to treat anxiety disorders.

Anxipose may be habit-forming and should be used only by the person it was prescribed for. Anxipose should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

Dosage

When given intramuscularly, Anxipose Injection, undiluted, should be injected deep in the muscle mass.

Injectable Anxipose can be used with atropine sulfate, narcotic analgesics, other parenterally used analgesics, commonly used anesthetics, and muscle relaxants.

Immediately prior to intravenous use, Anxipose Injection must be diluted with an equal volume of compatible solution. Contents should be mixed thoroughly by gently inverting the container repeatedly until a homogenous solution results. Do not shake vigorously, as this will result in air entrapment. When properly diluted, the drug may be injected directly into a vein or into the tubing of an existing intravenous infusion. The rate of injection should not exceed 2.0 mg per minute.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if solution is discolored or contains a precipitate.

Anxipose Injection is compatible for dilution purposes with the following solutions: Sterile Water for Injection, USP; Sodium Chloride Injection, USP; 5% Dextrose Injection, USP.

Overdose

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Anxipose can be fatal. Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, fainting, or coma.

Storage

Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Anxipose is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Anxipose are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Anxipose can interact with several other medications. It can also interact with certain supplements and foods.

Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.

Anxipose and other medications

Below is a list of medications that can interact with Anxipose. This list doesn’t contain all drugs that may interact with Anxipose.

Before taking Anxipose, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Opioids

Taking opioids with Anxipose can cause dangerous side effects. These include excessive drowsiness, breathing problems, respiratory failure, and coma.

Examples of these drugs include:

  • morphine (Astramorph PF, Kadian, MS Contin, and others)
  • oxycodone (Percocet, Roxicet, Oxycontin, and others)
  • hydrocodone (Zohydro ER, Hysingla ER)
  • methadone (Dolophine, Methadose)
  • fentanyl (Abstral, Duragesic, and others)
Opioids should only be used with Anxipose when there are no other treatment alternatives.

Sedative drugs

Taking sedative drugs with Anxipose can cause excessive drowsiness and breathing problems. Examples of sedative drugs include:

  • anticonvulsant medications such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), phenytoin (Dilantin, Phenytek), and topiramate (Qudexy XR, Topamax, Trokendi XR)
  • antihistamines such as diphenhydramine (Benadryl), cetirizine (Zyrtec), chlorpheniramine (Chlor-Trimeton and others), and doxylamine (Unisom and others) — also found in over-the-counter and combination products
  • antipsychotic drugs such as clozapine (Clozaril, Fazaclo ODT), haloperidol (Haldol), quetiapine (Seroquel), and risperidone (Risperdal)
  • anxiety drugs such as buspirone (Buspar)
  • barbiturates such as phenobarbital
  • other benzodiazepines such as alprazolam (Xanax), clonazepam (Klonopin), diazepam (Valium), and midazolam
Probenecid

Taking Anxipose with probenecid, a drug that can be used to treat gout, can increase the levels of Anxipose in your body. This can increase your risk of Anxipose side effects. For people who take probenecid and Anxipose together, the Anxipose dosage needs to be reduced by half.

Valproic acid

Taking Anxipose with valproic acid (Depakene, Depakote), a drug used to treat seizures and other conditions, can increase the levels of Anxipose in your body. This can increase your risk of Anxipose side effects.

For people who take valproic acid and Anxipose together, the Anxipose dosage needs to be reduced by half.

Anxipose and Zoloft

Zoloft (sertraline) can make some people feel tired or drowsy. Anxipose can also cause drowsiness. Taking these medications together may cause you to feel even more tired or drowsy.

Anxipose and Ambien

Anxipose and Ambien (zolpidem) shouldn’t be taken together. Both medications are used to help promote sleep. If taken together, they can cause excessive sleepiness and sedation.

Taking this combination of medications can also increase the risk of odd behaviors such as sleep-driving (trying to drive while asleep).

Anxipose and Tylenol

There are no known interactions between Anxipose and Tylenol (acetaminophen).

Anxipose and herbs and supplements

Taking Anxipose with herbs or supplements that have sedative effects can cause excessive drowsiness and breathing problems. Examples of sedative herbs and supplements that can cause these effects include:

  • chamomile
  • kava
  • lavender
  • melatonin
  • valerian
Anxipose and marijuana

Marijuana shouldn’t be used with Anxipose. Using marijuana with Anxipose can cause excessive drowsiness or sedation.

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Environmental exposures, toxicologic mechanisms, and adverse pregnancy outcomes. Aortic strips from spontaneously hypertensive rats were less responsive than normal animals to the contractile effects of norepinephrine, serotonin, and potassium chloride but more reactive to the relaxant effects of the stimulant of beta receptors, isoproterenol. Localized hypohidrosis is an unrecognized sequela of herpes zoster. Clinical liver I/R did not compromise liver function and displayed a cytokine profile similar to the mild I/R injury model. Massive genome sequencing of thousands of tumors from all major cancer types has enabled cataloging of the so-called driver and passenger mutations, and facilitated molecular classification of cancer, guiding precision medicine approach for the patients. The model incorporates large-scale interactions among US counties and the small-scale dynamics of disease spread within a county. Most of the behavioral effects of cannabis and its active ingredients, the cannabinoids (delta9THC being the most abundant of these), appear to be mediated by cannabinoid receptors. The influenza virus infection may be severe in non-immune people. The ovarian response was elicited under both treatment schedules.

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