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Angizem (Diltiazem)

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Angizem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it primarily works by inhibiting the calcium influx into cardiac and vascular smooth muscle during depolarization.

Other names for this medication:
Altiazem, Angizem, Cardem, Cardiorex, Cartia, Dicard, Dilacor, Dilcardia, Dilcontin, Dilcor, Dilgard, Dilocor, Dilter, Diltia, Diltiaz, Diltiazem, Dilticard, Diltime, Diltp, Dilzem, Heartil, Icidil, Ionozem, Kaizem, Masdil, Onzem, Taztia, Tiamate, Tiazac

Similar Products:
Addyi, Pamelor, Dulcolax, Ventolin, Avodart, Lipitor, Dramamine, Myambutol, Microzide, Crestor

Also known as: Diltiazem


Diltiazem is used to control rapid heartbeats or abnormal heart rhythms. It belongs to a group of drugs called calcium channel blocking agents. Diltiazem affects the movement of calcium into the cells of the heart and blood vessels. As a result, the heart beats slower and the blood vessels relax, thus, increasing the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain diltiazem. It may not be specific to Cardizem CD. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended-release tablet, extended-release capsule, or tablet whole. Do not open, crush, or chew it. It is best to take the extended-release capsule on an empty stomach.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For chest pain: For oral dosage form (extended-release capsules): Adults—At first, 120 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 180 milligrams (mg) once a day, either in the morning or evening. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 30 milligrams (mg) four times a day before meals and at bedtime. Your doctor may increase your dose if needed. Children—Use and dose must be determined by your doctor.

For high blood pressure: For oral dosage form (extended-release capsules): Adults—At first, 180 to 240 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 180 to 240 milligrams (mg) once a day, either in the morning or at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of diltiazem can be fatal.

Overdose symptoms may include slow heartbeat, weakness, chest pain, shortness of breath, or fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Cardizem LA dosage information

Side effects

The most common side effects associated with Angizem are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

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In addition, postal surveys were received from 21 older people, 36 informal caregivers, 11 NASC workers, and 3 allied health professionals. Estrus, ovulation and conception in hormone treated prepuberal Hereford heifers. To evaluate double-balloon enteroscopy in patients with obscure GI bleeding. The group distinguished by a short pectoralis minor demonstrated scapular kinematics similar to the kinematics exhibited in earlier studies by subjects with shoulder impingement. PFC have been detected in normal human PBL cultures, immunized with sheep red blood cells (SRBC) and supplemented with Concanavalin-A (Con-A) on day 0 (suppressive effect), and on day 2 (helper effect). IGFBP-3, which reportedly promotes apoptosis and modulates the bioavailability of the pro-survival insulin-like growth factor 1, may serve to regulate apoptosis in monocytic cells in an IGF-independent manner. Substrate preferences and glucose uptake in glibenclamide-resistant Leishmania parasites. The distribution of physiological responses was in close agreement with known patterns of ascending inputs.

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The potential consequence of early recognition and treatment of retained fetal bony fragments. Antibody titres achieved by actively immunised young pups were as high as titres transferred transplacentally by mothers immunised on day 40 and 47 of pregnancy. The observation of a unique and ancestral form of methanogenesis suggests that it was preserved in two independent lineages, with some instances of specialization or added metabolic flexibility. A soluble enzyme from Vinca rosea methylating myo-inositol to L-bornesitol. In Mycoplasma hominis, HinT is concomitantly expressed with the proteins P60 and P80, two domains of a surface exposed membrane complex, and in addition interacts with the P80 moiety. In this article we describe the development of a novel GPS instrument suitable for tracking the movements of young children. In addition to conventional coronary risk factors, BPV may be a therapeutic target for coronary atherosclerosis. Various mechanical irritation methods (ultrasonics, shaking, pressing bugs with plunger of syringe) were tested for secretion sampling with a special focus on non-lethal irritation.

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Enteropathogenic, enterotoxigenic and enteroinvasive Escherichia coli isolated from acute gastroenteritis patients in Lagos, Nigeria. Finally, the dynamic problem has been solved numerically by taking into account of all the relevant parameters (in the absence of flow and irregularities in the cell plane) and the obtained results are in excellent correspondence with the experiment. Porosity effects on electron transport in TiO2 films and its application to dye-sensitized solar cells. An automated image analysis system can be beneficial in preclassification of leucocytes in children with hematological disease. An isomerization-induced cage-breaking process in a molecular glass former below T(g). Likewise, phosphorylation of Thr309 in vitro by recombinant PDK1 or mutation of Thr309 and Ser474 to acidic residues rendered the kinase constitutively active. Occlusion of the retinal artery in two cases of orbital granuloma. The impact of Saffold cardiovirus in patients with acute respiratory infections in Yamagata, Japan.

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The use of modified starch in clinical trials as well as the potential future implications of these systems is also included in this review. Anti-Bordetella antibodies in children with the whooping cough syndrome. A new method for differentiation of olive oil (independently of the quality category) from other vegetable oils (canola, safflower, corn, peanut, seeds, grapeseed, palm, linseed, sesame and soybean) has been developed. Gene expression analysis revealed that BKI1 regulates a subset of ER-responsive genes. Physician practices have a vital bearing on safe management in these patients. Instruction-following behavior of a retarded child and its controlling stimuli. Particle-size effect of CuO and ZnO on biogas and methane production during anaerobic digestion. Along with experiments, computational studies using various approaches have provided key insights into the structure and dynamics of IL systems, as well as aggregate formation and phase behavior of the IL/water mixtures. Non-small cell lung cancer clinical practice guidelines in oncology. Husbands as decision-makers in relation to family size: East-West regional differentials in Turkey.

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The deprived rat lesions could not be explained by pressure, disk rotation, water immersion, infection, necrotizing vasculitis, tyrosinemia, protein deficiency, or reduced rates of mitosis. Plasma protein escape from the intestinal circulation to the lymphatics during fat absorption. Depression of the hemolytic complement titer in the recipients was indicative for complement consumption during the rejection process. Quantification was evaluated using substance P as analyte and 15N3-labeled substance P as an internal standard. Upon DNA damage or DNA replication interference, ATR-ATRIP and two of its key regulators, the Rad17 and the 9-1-1 complexes, are localized to sites of DNA damage and stalled replication forks.

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At the 4th week after the operation, there were no macroscopic or microscopic complications at the anastomotic site. The purpose of this study is to assess the pediatric orthopaedic questions on the 2011 to 2014 OITE, and to compare question categories and cognitive taxonomy with previous data. Furthermore, two animal models of BPD exhibited a specific reduction in 16:0/14:0PC content. Since the MEP of both left and right EHL muscles improved after the L1-2 herniotomy, circulatory insufficiency might have caused the L5 symptoms. The test group was exposed to nicotine tartrate for 8 weeks and the control group was exposed to placebo. Denitrification on poly-beta-hydroxybutyrate in microbial granular sludge sequencing batch reactor. This CR1 element was shown to bring promoter sequences that play a role in the expression of unrelated antibiotic resistance genes. Several molecular genetic alterations have been characterized in gliomas in the past years.

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Neurologic paraneoplastic syndromes occur in patients with all forms of malignancy. Furthermore there is an association between retrolental fibroplasia and the amount of adult blood transfused. Relationship between the internal-external control construct and achievement. Whether or not in combination with oral implants, (semi-)precision attachments often offer patients improved self-confidence and self-image. Expert testimony of tuberculosis transmitted from animals to man. This article will focus only on imaging requiring ionizing radiation. Our aim was to examine the association between various parenting practices and adolescent fruit and vegetable (F/V) intake at different levels of family meal frequency.

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It also suggests that the two forms are pathophysiologically distinct entities. A simple method to measure anti-glycolipid antibody by using complement-mediated immune lysis of fluorescent dye-trapped liposomes. Furthermore, membrane-targeted p110 gamma displayed basal enzymatic activity, but was further stimulated by G beta gamma, even in the absence of p101. This appears to have bearing on the sex-dependent proteinuria in rats, for lysosomal peptidases and proteinases are particularly important in the degradation of filtered proteins that are reabsorbed in the proximal tubule. In predetermined random order, patients were assigned to treatment groups and given either benoxaprofen or one of the comparator drugs (diclofenac, indomethacin, flurbiprofen, or piroxicam) for the first four weeks. New prognostic markers are needed to identify patients with poorer prognosis, and circulating tumor cells (CTCs) seem to be promising to accomplish this. Both green and red fluorescence were linearly related with the total biomass of the biofilms. We sought to determine whether estrogen administration can affect coronary vasomotor tone in patients after angioplasty by reducing 8-iso-prostaglandin (PG) F(2alpha) concentrations, a bioactive product of lipid peroxidation.

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Hence, the suppression of oral biofilm formation is an issue of considerable importance. Compliance and outcome of patients with stage 1 non-seminomatous germ cell tumors (NSGCT) managed with surveillance programs in seven Canadian centres. Alternative retention for an implant-retained auricular prosthesis. Cell proliferation was analyzed using the MTT assay in control and mineralizing conditions at different culture days, up to day 20. The international society of dermatopathology at 25 years of age: a new era has begun. Interindividual differences in homomodal and heteromodal scaling. Men with pre- and postrandomization electrocardiograms (ECGs) from the Testosterone and Pain (TAP) and the Testosterone Effects on Atherosclerosis in Aging Men (TEAAM) Trials.

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Diagnosed left ventricular hypertrophy by ECG in hypertension patients: the value and strategy. The interaction of the local anesthetic procaine with human erythrocytes, isolated unsealed human erythrocyte membranes (IUM), isolated toad skins, and molecular models is described. Packaging cell lines for generating replication-defective and gutted adenoviral vectors. In the symptomatic patients, R-R variation during deep breathing was abnormal in all nine, the blood pressure response to standing was abnormal in seven, and the response to isometric exercise was abnormal in three. Healthy prenatal and adult ovine aortic valve tissues were evaluated using the developed techniques. Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. Comparison of the effect of midodrine versus octreotide on hemodynamic status in cirrhotic patients with ascites. In PMN and how to use clomid tablet RAuntreated HL-60 cells chloroform did not significantly affect H(2)O(2) levels. Mercuric chloride induces apoptosis via a mitochondrial-dependent pathway in human leukemia cells. With use of the weakly immunogenic MCA 105 tumor of the C57BL/6 mouse, the antitumor reactivity of lymphoid cells derived from the regional draining lymph nodes (RLN) of tumor-immunized and tumor-bearing mice was examined.

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Some are the result of viruses crossing the species barrier from animals to humans. Effects of sex hormones on some T and B cell functions as evidenced by differential immune expression between male and female mice and cyclic pattern of immune responsiveness during the estrous cycle. This paper reviews the importance, benefits, and methods of increasing autopsy percentages. It is thus concluded that pretreatment with dexrazoxane attenuates teniposide-induced oxidative stress and subsequent DNA damage and apoptosis in bone marrow cells. Toxicity in the form of nausea, vomiting, and inanition significantly limited the use of cisplatin in this patient population. A number of long acting hormonal methods based on progestins have been developed, including injectables, some IUDs and vaginal rings, and implants.

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Subsequent, often only slight ICP decreases in this range resulted in a reactive hyperaemisation. On the whole, isolated transients, despite their clear formant structure, provided only partial information for consonant identification, but no less so, it seems, than excerpted natural release bursts. The family of nickel-based sulfides is one of the examples that possesses interesting properties in water-splitting fields. These results provide an insight into reconstructing future post-graduate training and educational urological programs in Japan. Our observational data suggest that higher circulating aldosterone and lower NT-ANP concentrations may be markers of salt sensitivity in the community. This possibility has been opened by an appropriate combination in the arrangement of the reaction of inhibition of the antigenic indirect hemagglutination. We found that these physical values (quantities) correlate with anesthetic potencies estimated according to the thermodynamic equilibrium model.

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The proliferating cell nuclear antigen (PCNA) labeling index and the respiratory control (oxygen consumption in extracted mitochondria) were the tests used to evaluate the liver regeneration after laser irradiation with different wavelengths. Since the duration may be dose related and minimal adverse events can you overdose on latanoprost were observed at 1800 U, further studies are in progress to look at the duration of response resulting from higher doses of BTX-B in the treatment of glabellar wrinkles. While the pharmacological mechanisms of such effects are still elusive, our findings might contribute to shed light on some controversies on the therapeutic action of TPM, and point to this drug as a putative novel adjuvant therapy for some clusters of gating disturbances. The concentration-time data were analyzed using population analysis with NONMEM. After birth, each child is screened for inbornn metabolism defects. Various factors contribute to the complexity of this ecosystem, including community composition, dynamics and interactions, as well as heterogeneous distribution and fluctuation of components of the immune system, antibiotics and nutrients.

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The efficacy and acceptability of zithromax 500 tablet bromocriptine in suppressing postpartum lactation was determined in a double blind study in which bromocriptine 2.5 mg twice daily for 14 days was compared with a placebo. However, neither CK specific activity or CK isoenzyme composition was altered by PTU treatment. Thus, they behave as biological conveyors playing a key role in the tuning of vascular homeostasis. Ten fresh-frozen cadaveric knees underwent a proximal fibula osteotomy to simulate a proximal fibula avulsion fracture. coli polypeptide chain elongation factor Tu (EF-Tu) was determined. Effect of diuretics in late pregnancy toxemia dependent upon position of the body. It is important and necessary to strength the prevention and treatment of glaucoma, since glaucoma is a serious irreversible blinding disease.

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151 women had ancillary chemotherapy with cyclophosphamide, methotrexate, vinblastinsulphate and fluoro-uracil for six cycles. Both patients tolerated the immunosuppressant regime well, and at 31-33 months follow-up they remained free of acute rejection episodes and toxicities associated with CsA. Especially the in vitro manipulation of hematopoietic stem cells remains a challenge which requires more fundamental knowledge on the biology of stem cells including self renewal and homing. Information on suspended sediment source, defined in terms of both source type and spatial origin, is therefore increasingly needed. Survival time and hazard ratio (HR) were estimated by Kaplan-Meier analysis and Cox proportional regression, respectively. These findings suggest that in hypertensive patients, the primary mechanism for short-term alpha1-pressor hypersensitivity in response to hyperlipidemia is via the acute impairment of BRS. 40 such referrals to the John Radcliffe Hospital, Oxford, were reported over a 12-month period.

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According to the National Cholesterol Education Program and International Diabetes Federation criteria metabolic syndrome was observed more frequently in women. We investigated in vitro the use of ultrashort pulsed ultraviolet excimer-laser energy for controlled removal of meniscus cartilage under the aspects of arthroscopic meniscectomy. Monogenic stroke disorders include conditions such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) and hereditary endotheliopathy, retinopathy, nephropathy and stroke (HERNS). Experiments showed that the level of FlgM inside the cell was unchanged after shearing whereas the extracellular FlgM levels increased in the growth medium as time passed. The neuraminidase and the non-structural genes were closely related to the highly pathogenic H7N7 strains from The Netherlands 2003. This index is created by current Expanded Disability Status Scale (EDSS) /disease duration. A variety of conditions of neurodegenerative diseases often lead to post-translational modifications of proteins, including oxidation and nitration, which might be involved in the pathogenesis of neurodegenerative diseases. Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice. Authors describe a rare subject of perineal superficial venous thrombosis in does differin gel clear acne a 51 years old patients.

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Windowed cross-correlation and peak picking for the analysis of variability in the association between behavioral time series. In our previous study we demonstrated that TRC150094, when administered to rats receiving a high-fat diet, stimulated mitochondrial fatty acid oxidation (FAO) and reduced visceral adiposity, opening an interesting perspective for a possible clinical application. Ethics and the ED nurse: rethinking ethics for the incompetent patient. As in conditional gp130 animals, the acute phase response was completely abolished, we considered that other means are essential to define the role of gp130-dependent pathways for liver regeneration. Two transgenic barley line of genotype Oksamitiviy and transgenic callus line of cultivar Getman were obtained after selection on 10 microM of trifluralin. We injected a lentiviral vector carrying an MSCV-EGFP cassette (LvMSCV-EGFP) into tibialis anterior muscles and observed strong EGFP expression in muscle fibers, primary cultured myoblasts, and myotubes isolated from injected muscles. In the present review we summarize recent experimental material suggesting that the cytokines expressed within the myocardium in response to environmental injury, namely tumor necrosis factor (TNF), interleukin-1 (IL-1), and the interleukin-6 (IL-6) family, play an important role in initiating and integrating homeostatic responses. Current treatments such as drug therapy, botulinum toxin injections, kinesitherapy, and physiotherapy are not sufficiently effective in a large number of patients. Classically, however, it has been limited to smaller resections. In the majority of cases USCB is adequate for confident histopathological diagnosis avoiding the need for surgical excision biopsy in cases of suspected head and neck lymphoma.

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Studies involving the administration of a single dose of a NSAID to young healthy volunteers are of limited relevance in establishing the likely effect of an H2-antagonist on the blood concentrations of an NSAID in patients. Generalized correlated states in a ring of coupled nonlinear oscillators with a local injection. Autogenous synovium may be a viable cell source for meniscal tissue engineering. In this study we used broad-specificity amplification of ribosomal DNA (rDNA) genes to survey organisms present in the human outer ear canal. Extensive educational and self-care programs along with long-term follow up such as the program conducted in this study are suggested. However there is inconsistent evidence that lower intensity foot pain is associated with other measures of foot muscle weakness or size. Upregulation of CD23 in huASMC by IL-4 and GM-CSF can contribute to changes in huASMC and may provide an avenue for new therapeutic options in asthma targeting ASMC. Of the 39 cases, 12 were clinically free of cervicitis or cervical erosion, 21 had some sort of cervicitis, and 6 had trichomonal vaginitis. Most female infertility problems can be classified as ovulatory, anatomic, or cervical.

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Successful treatment of a patient with an extraordinarily large deep burn. Knock-down of DapmaDsx1 in male embryos resulted in the production of female traits including ovarian maturation, whereas ectopic expression of DapmaDsx1 in female embryos resulted in the development of male-like phenotypes. Standard statistical tests were conducted to assess value of Doppler US in diagnosis of graft rejection. Polyaniline nanowire array encapsulated in titania nanotubes as a superior electrode for supercapacitors. After more experience with the device, it is thought that nonmedical personnel can be trained to insert it.

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