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Amaryl (Glimepiride)
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Amaryl

Amaryl is a sulfonylurea drug used to treat type 2 diabetes mellitus. First introduced in 1995, Amaryl is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control.

Other names for this medication:
Abepride, Azulix, Bepride, Dezacor, Diaglim, Diapride, Euglim, Euroglip, Glenavon, Glimcip, Glimday, Glimepiride, Glimetis, Glimetop, Glimicon, Glimid, Glimifix, Glimiprime, Glimizide, Glimli, Glimpinor, Glimser, Glimulin, Glinidd, Glinorm, Gliri, Gluformin, Glyfix, Glymaran, Glyree, Glyrim, Gride, Idapride, Iglim, Karmelitus, Mepride, Mepusulin, Metforise, Nilconorm, Pionorm, Roglimet, Secretag, Sigli, Tgmet, Voglibite, Zoryl

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Also known as: Glimepiride

Description

Amaryl (glimepiride) is an oral diabetes medicine that helps control blood sugar levels.

Amaryl is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes.

Insulin or other diabetes medicines are sometimes used in combination with Amaryl if needed.

Dosage

Usual Adult Dose for Diabetes Type 2:

Initial dose: 1 to 2 mg orally once a day Maintenance dose: Increase in 1 or 2 mg increments no more frequently than every 1 to 2 weeks based on glycemic response Maximum dose: 8 mg per day Comments: -Administer with breakfast or first main meal of the day. -In patients who are at increased risk for hypoglycemia, start with 1 mg orally once a day and titrate slowly. -When patients are being transferred to this drug from a longer half-life sulfonylurea, monitor 1 to 2 weeks for overlapping drug effect. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Usual Geriatric Dose for Diabetes Type 2:

Initial dose: 1 mg orally once a day; titrate slowly and monitor closely

Usual Pediatric Dose for Diabetes Type 2:

Not recommended because of adverse effects on body weight and hypoglycemia.

Detailed Amaryl dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An Amaryl overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).

Storage

Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amaryl are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Amaryl if you are allergic to glimepiride, sulphonamides, or if you have:

an allergy to sulfa drugs; or diabetic ketoacidosis (call your doctor for treatment).

To make sure Amaryl is safe for you, tell your doctor if you have ever had:

heart disease; liver or kidney disease; or an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD).

Amaryl may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Follow your doctor's instructions about using Amaryl if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. However, you may need to stop taking Amaryl for a short time just before your due date.

Medications similar to glimepiride have caused severe hypoglycemia in newborn babies whose mothers used the medicine near the time of delivery. If you take glimepiride during pregnancy, stop taking this medicine at least 2 weeks before your due date.

If you breastfeed while taking glimepiride, call your doctor if your baby shows signs of hypoglycemia (extreme drowsiness, feeding problems, mottled skin, blue lips, feeling cold or jittery, or having a seizure).

Amaryl is not approved for use by anyone younger than 18 years old.

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