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Alpam

Alprazolam, available under the trade name Xanax, is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder, but also in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alpam, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alpam is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Actirax, Alamflu, Alflux, Alpradol, Alpram, Alprasert, Alprax, Alprotame, Alsert, Alzep, Alzolam, Alzonex, Alzoset, Anxigo, Anxitab, Anxorel, Aryalam, Cqlam, Depoxit, Depwell, Destres, Fluwel, Luzarn, Maxorest, Mebasap, Mebaspa, Meloprax, Niravam, Pacyl, Prazil, Procalm, Propnix, Rozin, Sinaday, Somnia, Tenan, Tensfree, Trazopin, Zallpam, Zoloid

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Also known as: Alprazolam

Description

Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Xanax XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Alpam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Xanax XR if you have:

narrow-angle glaucoma; if you are also taking itraconazole (Sporanox) or ketoconazole (Nizoral); or if you are allergic to alprazolam or to other benzodiazepines, such as chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

Before taking Xanax XR, tell your doctor if you are allergic to any drugs, or if you have:

asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems; glaucoma; kidney or liver disease (especially alcoholic liver disease); a history of depression or suicidal thoughts or behavior; or a history of drug or alcohol addiction.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

It is dangerous to try and purchase Xanax XR on the Internet or from vendors outside of the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of alprazolam purchased on the Internet have been found to contain haloperidol (Haldol), a potent antipsychotic drug with dangerous side effects. For more information, contact the U.S. Food and Drug Administration (FDA) or visit www.fda.gov/buyonlineguide

FDA pregnancy category D. Xanax XR can cause birth defects in an unborn baby. Do not use Xanax XR without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Alprazolam can pass into breast milk and may harm a nursing baby. Do not use Xanax XR without telling your doctor if you are breast-feeding a baby.

The sedative effects of Xanax XR may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking Xanax XR. Do not give this medication to anyone under 18 years old.

Xanax XR pregnancy and breastfeeding warnings (more detail)

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An Exploratory Study Investigating How Adults with Intellectual Disabilities Perform on the Visual Association Test (VAT). Cross reaction of the specific primers with DNA template from any of the 6 other bivalve species was not observed. GENETIC CONSTRAINTS TO LIFE-HISTORY EVOLUTION IN THE PITCHER-PLANT MOSQUITO, WYEOMYIA SMITHII. Interestingly, photoinduced polymer aggregation in the confocal volume was observed. Gastrointestinal zygomycotic infection caused by Basidiobolus ranarum: case report and review. Survey of Exposure Dose during Percutaneous Coronary Intervention for Chronic Total Occlusion. We note the recent paradigm shift to sub-divide anxiety into endogenous and exogenous forms, with the former (panic disorder) being viewed as a genetically-determined metabolic disorder. The instruments included the Chinese Beck Self-Concept Inventory, the Chinese Beck Anger Inventory, and the Chinese Resilience Scale. Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes. Gut Microbiota and the Gut-Brain Axis: New Insights in the Pathophysiology of Metabolic Syndrome.

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In summary, our study established a model that STAT4 promotes ovarian cancer metastasis via tumor-derived Wnt7a-induced activation of CAFs. Exposure to cigarette smoke, a major risk factor for sudden infant death syndrome: effects of cigarette smoke on inflammatory responses to viral infection and bacterial toxins. Differential diagnosis of HTLV-I-associated myelopathy and multiple sclerosis in Iranian patients. MicroRNAs in the prognosis of triple-negative breast cancer: A systematic review and meta-analysis. Oral administration of loperamide (0.1 mg/kg) induced, after a delay of 20-30 min, a long-lasting (8-12 hr) stimulation of gastrointestinal motility associated with a disorganization of the cyclic activity at the three levels investigated. We report a case of an amebic liver abscess rupturing into the duodenum, forming a wide fistulous tract. Mitochondrial DNA (mtDNA) found in the basidiomycete Schizophyllum commune (strain 4-40) is a circular molecule 49.75 kbp in length.

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During this extended induction period, the C-terminal residue of shLkn-1 was truncated and this was confirmed by both reverse-phase HPLC and mass spectrometry. Cabbage and vitamin E: their effect on colon tumor formation in mice. Elderly-onset systemic lupus erythematosus: prevalence, clinical course and treatment. Structure and expression of a plastid-encoded groEL homologous heat-shock gene in a thermophilic unicellular red alga. TWO ATTEMPTS TO DEMONSTRATE TONAL SUPRESSION OF NON-NUTRITIVE SUCKING IN NEONATES. Hemobilia after major liver trauma is a difficult problem to manage. Coagulation factor activity was evaluated in female rats treated with danazol. It is currently a condition of the NHS orthodontic contract for providers to monitor a proportion of their cases using the PAR index. Recently, the struggle against the HIV/AIDS epidemic has taught us that protecting the human rights of those most at risk is, in fact, a most effective means of preventing the spread of HIV. The largest number of complications occurred in class III and IIBs patients, and the main complication was postoperative pain.

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Cells with mutations in the calcium dependence region of the 47 Mdal plasmid had greatly reduced virulence in iron compromised mice and were unable to proliferate in the peritoneal macrophages of these mice. Other patient characteristics may be responsible to explain the observed difference between patients with optimal and poor SRH. In addition, the prevalence, course, opening position, and distance of the retromolar canal from the second molar were measured on CBCT images. Lyophilized lenti-BMP-2 with trehalose can maintain high activity for a long time as an effective and reliable storage method. Coronary dissection diagnosis after chest trauma requires clinical suspicion and systematic evaluation. Being born small for gestational age has been associated with neurodevelopmental disabilities and smaller gray matter volumes in childhood. In patients (93) with either essential or renal hypertension the concentration of lactic acid in both venous and arterial blood was significantly (p .001) elevated, whereas there was no significant increase (p .127) in the concentration of blood pyruvate. We hypothesized that patients not on dialysis therapy complete the evaluation process more quickly than patients receiving dialysis. Hypersensitivity reaction following chloramphenicol administration in a patient with typhoid fever.

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Lack of association between MTHFR A1298C polymorphism and outcome of methotrexate treatment in rheumatoid arthritis patients: evidence from a systematic review and meta-analysis. All patients (C1 to C5) had risk factors for ESBLE acquisition, including past history of hospitalization (2.5 to 23 months before). These results are relevant to sudden infant death syndrome (SIDS). A phylogenetic tree drawn with the concatenated amino acid sequences of the 6 conserved PCGs (atp6, cox1-3, and nad2) showed that A. We have cloned the group C1 rfb (O antigen) gene cluster from serovar montevideo strain M40, using a low-copy-number cosmid vector. Consolation in the aftermath of robberies resembles post-aggression consolation in chimpanzees. Serum levels of thyroid-stimulating hormone, free thyroxine and the anti-thyroperoxidase and anti-thyroglobulin antibodies were evaluated. A RE-EXAMINATION OF GENETIC VARIABILITY IN DIALICTUS ZEPHYRUS (HYMENOPTERA: HALICTIDAE).

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Feedforward inhibitory networks are a common type of local circuitry and occur when principal neurons and their afferent inhibitory interneurons receive the same input. In addition, alpha 2-adrenoceptor antagonist, idazoxan, increased the 5-HTP accumulation in both the hippocampus and the dorsal raphe nucleus. The ultrastructural features of the newly formed squamous epithelium, with its basal lamina, are similar to that reported for human adult esophageal epithelium. A growing body of evidence indicates that Foxo proteins furthermore play critical roles in immune cell homeostasis, modulating inflammation in some disease states such as inflammatory arthritis and systemic lupus erythematosus (SLE), via fundamental roles in T cells, B cells, neurophils and other myeloid lineages. The onset of this disorder occurs in infancy, usually characterized by unexplained fever, recurrent dehydration and failure to thrive. Ginsenoside-Rs4, a new type of ginseng saponin concurrently induces apoptosis and selectively elevates protein levels of p53 and p21WAF1 in human hepatoma SK-HEP-1 cells.

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Therapeutic Modulation of Calcium Dynamics using Ultrasound and Other Energy-based Techniques. Wild type and mutant Paramecium tetraurelia were grown in monoxenic cultures by first growing Enterobacter aerogenes on a defined medium and then adding the Paramecium to the stationary phase bacterial culture. The feasibility and accuracy of the sentinel lymph node biopsy for breast carcinoma. However, in gene expression data analysis, each sample is represented by quite a large number of genes, and many of them are redundant or insignificant to clarify the disease problem. Humoral responses of sheep immunised with pDNA formulated with Vaxfectin adjuvant were higher than the responses of the corresponding groups that received pDNA in PBS only. During word recognition, the patients showed overactivation in the left frontal pole and had a less robust right prefrontal response. While it is universally acknowledged that both bottom up and top down factors contribute to allocation of gaze, we currently have limited understanding of how top-down factors determine gaze choices in the context of ongoing natural behavior.

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We demonstrate the nonrenormalization of the chiral separation effect (CSE) in quenched finite-density QCD in both confinement and deconfinement phases using a recently developed numerical method which allows us, for the first time, to address the transport properties of exactly chiral, dense lattice fermions. Cimetidine pharmacokinetics in patients with Zollinger-Ellison syndrome. THE INFLUENCE OF PALEOZOIC OVULE AND CUPULE MORPHOLOGIES ON WIND POLLINATION. Interspecific differences in cuticular hydrocarbon profiles of Myrmica ants are sufficiently consistent to explain host specificity by Maculinea (large blue) butterflies. Guild (1890-1966), published in 1950, on a very large sample of children who previously were reported to have had their hearing loss diminished through radiation, found that irradiation had produced no effect on high-tone loss. A 26-year old man was admitted with blunt trauma to the chest following a high-speed deceleration injury.

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All patients were given antitubercular therapy for 9 months in postoperative period along with adjuvant therapy. THEORETICAL PRINCIPLES AND POSSIBILITIES FOR THE USE OF OUR BALNEOTHERAPY IN MENTAL PATIENTS. To describe the phenomenon of home safety for people with a mental disorder as well as its contributing factors. These models may help to accelerate translational research in cancer biology and tissue engineering. Nodal spacing along regenerated axons following a crush lesion of the developing imipramine 50 mg cost rat sciatic nerve. After washout period, placebos and BC were re-administered to all patients in the same way for 3 months. Our main novelty is the probabilistic nonlinear formulation that enables us to robustly capture nonlinear dependencies between genomic data and phenotype even with small sample sizes. At 6-7.5 days of gestation, high levels of vHNF1 mRNA are present in the visceral extraembryonic endoderm, which co-localize with transcripts of the transthyretin gene. Inflammatory bowel diseases lead to progressive bowel damage and need for surgery.

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Cardiovascular disease represents the most prevalent cause of admissions to the medical service of the University Hospital of the State of Haiti. A random sample of 151 Danish women who had undergone natural menopause reported the age at which this occurred and answered a questionnaire. Lower lid retraction combined with entropion in anophthalmic patients can be corrected effectively using an ear cartilage graft with selective, supplemental procedures. Considering the important role of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) in Treg-mediated immune suppression, the aim of this study was therefore to clarify the involvement of Treg and CTLA-4 in the pathogenesis of INS. The CsWD1 protein is suggested to serve as a platform for interacting partner proteins in the tegumental syncytium of C. SEX RATIO IN THE TROPICAL TREE TRIPLARIS AMERICANA (POLYGONACEAE).

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