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Actos (Pioglitazone)
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Actos

Actos is a moderately priced drug used to treat type 2 diabetes. It is more popular than comparable drugs. It is available in generic and brand versions. Actos is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

Other names for this medication:
Adride, Asoformin, Cetapin, Dibiglim, Euroglip, Geoglit, Glime, Glimkap, Glimsite, Matce, Nodiab, Pianorm, Pichromet, Piodart, Piokind, Piosafe, Piozed, Piozone, Radizone, Triblend, Triexer, Triglaz, Triglimiprex, Triopil, Vogipax, Zipio

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Ticlid, Keflex, Inderal, Claritin, Xenical, Trandate, Glyburide, Neoral, Trileptal, Abhigra

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Also known as: Pioglitazone

Description

You should take Actos according to your doctor’s or healthcare provider’s instructions.

Actos comes as a tablet that you swallow.

When to take

You’ll take Actos once a day. Try to take this medication at about the same time each day.

Don’t take more than one dose in a day.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Taking Actos with food

You can take Actos tablets with or without food.

Can Actos be crushed, split, or chewed?

No, you shouldn’t break, crush, split, or chew Actos tablets. Broken tablets haven’t been studied, so it’s not known if it’s safe to take a tablet that’s broken.

If you’re having trouble swallowing your Actos tablets, talk with your doctor. They may be able to suggest ways to help you take your medication or recommend other drugs that may be easier for you to take.

Dosage

Take Actos by mouth with a full glass of water with or without food. The initial dose of Actos is 15 mg once a day. In case of inadequate glycemic control, the dose can be increased up to 45 mg once daily. If hypoglycemia occurs in a patient co-administering Actos and insulin, the dose of insulin should be decreased by 10% to 25%. Further adjustments to the insulin dose should be individualized based on glycemic response. Take the drug at the same time each day. If you want to achieve the most effective results, do not stop taking Actos suddenly.

Overdose

If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your health care provider immediately. You can experience the following symptoms of Actos overdose: signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Actos are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Actos if you are allergic to pioglitazone, or if you have:

severe or uncontrolled heart failure; or diabetic ketoacidosis (call your doctor for treatment).

This medication may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk.

To make sure Actos is safe for you, tell your doctor if you have ever had:

congestive heart failure or heart disease; a heart attack or stroke; eye problems caused by diabetes; bladder cancer; or liver disease.

Actos may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Follow your doctor's instructions about using Actos if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

Pioglitazone may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

Women may be more likely to have a broken bone while using Actos. Talk with your doctor about ways to keep your bones healthy.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Actos is not approved for use by anyone younger than 18 years old.

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The Cardiovascular Institute at Hoag Hospital in Newport Beach, Calif., has found that partnering with the local visiting nurses has helped congestive heart failure patients more readily use a new telemonitoring system. Teenage pregnancies that end in abortion: what can they tell us about contraceptive risk-taking?. The main criticisms regarding the ACF are then examined, followed by an introduction of the conceptual framework that is adapted to the reality of healthy public policies. Alternative response training, differential reinforcement of other behavior, and extinction in squirrel monkeys (Saimiri sciureus). A reduction in the resting pulse rate by propranolol of more than 7.5 beats per minute resulted in a greater therapeutic response to this drug, alone and in combination. There are still insufficient clinical reports concerning quality-switched Nd:YAG laser (QSNYL) in the treatment of superficial pigmented lesions in Asians. Efficient generation of stable antibody forming hybridoma cells by electrofusion. We report a case of fish hook injury to the eyelid and discuss the various techniques available for removal of fish hooks.

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L-Phenylalanine was not an insulin secretagogue and was oxidized by islets at a very low rate, suggesting that 3-phenylpyruvate does not trigger insulin release by enhancing production of reducing equivalents. On the basis of experimental data obtained from the Dahl salt-sensitive rats, we and others have demonstrated that abnormal ENaC activation in response to a dietary NaCl load contributes to the development of high blood pressure in this model. The nuclei of the facial nerve the intracerebral and intracisternal course and its development, the facial canal and its narrow passes are described. Reverse transcription polymerase chain reaction allowed the detection of the specific mRNAs of pAM in the mononuclear hematopoietic cells of the cord blood and immunocytochemistry demonstrated their abundant AM-immunoreactivity. or oral administration of the compound significantly reduced lung metastasis formation and s.c. Twenty-four hours after etoposide addition, a large number of cells of both lines exhibited nuclear and cytoplasmic fragmentation with the formation of numerous blebs typical of apoptosis. The preliminary data obtained in this study suggest that continuous low acoustic power imaging and contrast-enhanced US show similar results to CT in contrast distribution and contrast enhancement patterns. To justify the widespread use of demanded eye contact and to explain its role functionally, one experiment and data from six replications with nine subjects are presented. B-cell-depleting agents, ocrelizumab and ofatumumab and the TNF-inhibitors certolizumab and golimumab). We have documented an overall decline in cardiovascular mortality from 1979 to 1998, together with a small but non-significant decrease in seasonal variation.

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Using SVM analysis and five gene expression profile data confirmation, a 15-gene signature (HES5, ZNF417, GLRA2, OR8D2, HOXA7, FABP6, MUSK, HTR6, GRIP2, KLRK1, VEGFA, AKAP12, RHEB, NCRNA00152 and PMEPA1) were identified as a predictor of recurrence risk and prognosis for colon cancer patients. Social and cultural obstacles to AIDS prevention in developing countries. High plasma MMP-9 concentration in the acute phase of a cerebral infarct is an independent biochemical predictor of HT in all stroke subtypes. Also during August--September 2005, the Massachusetts Department of Public Health reported four cases of human EEEV disease, five times the annual average of 0.8 cases reported from Massachusetts during the preceding 10 years. However, over-expression of miR-34a and knockdown of Bcl-2 could significantly enhance the radio-sensitivity of different cells while inhibition of miR-34a could protect cells from radiation injury. This paper points out the need for a systematic investigation into the effects of this surgery on speech. Such paracrine provisioning of peripheral immune responses improves their efficiency and emancipates activated lymphocytes from competition with other tissues for blood-borne nutrients.

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These choice patterns were not predicted from a literal application of a model that says choice should favor the alternative correlated with the higher (amount/delay) ratio. Marriage dissolution tables by duration of marriage, 1971-1975, 1976-1980, and 1981-1985. Prospective analysis of the relationship between predefined clinical IE features and findings on TOE in 708 IE suspected patients. Sortilin protein expression was elevated upon C2C12 cell differentiation and was further enhanced in the presence of a high concentration of glucose. To evaluate the effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer. The heparin biosynthetic enzymes mainly consist of sulfotransferases and all are integral transmembrane glycoproteins. We have discovered that this process is cotranslational and proceeds in a signal recognition particle-dependent manner.

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Removal of non-ionic organic pollutants from water via liquid-liquid extraction. Laryngeal involvement is rare and usually occurs secondary to the oral, cervical or mandibular disease. Savings for a family will be higher if indirect costs, such as savings in travel times to and from the hospital and labor savings, were taken into account. Angiotensin II infusions did not increase plasma catechol-amines, and lowering of angiotensin II by captopril treatment in patients with severe hypertension or congestive heart failure failed to alter plasma adrenaline or nor-adrenaline levels. Inadequate rates of awareness and control of cardiovascular disease and stroke risk factors are seen in a clinical trial of African American stroke patients and are comparable with those of previously published reports. tularensis, and partially protected against an aerosol challenge with the same strain. In the present paper, we review the physiological and pathophysiological effects of NO and NO-related molecules in the respiratory system and in inflammatory lung diseases. Microarray analyses of gene expression in ARPE-19, confirmed with qPCR, showed upregulation of lipid and cholesterol biosynthesis pathways in SFM. In comparing tails of the different IUDs, the IUDs with relatively smooth tails became less rapidly contaminated during the 1st few months of use. Liver-specific mitochondrial respiratory chain complex I deficiency in fatal influenza encephalopathy.

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Age- and sex-specific rates for 16 countries are examined by cause of death, and possible reasons for differences are considered. A synthetic approach for tropane alkaloids on the basis of tandem (domino) ene-type reactions of acetone silyl enol ethers with iminium ions is shown to be triggered by intermolecular ene-type reactions followed by 6-(2,5) silatropic ene-type cyclizations. It is acknowledged that the C-terminally combined repetitive oligopeptides (CROPs) flomax cr maximum dosage of the toxins function as receptor binding domain. Colitis is associated with increased excitability of afterhyperpolarization neurons (AH neurons) and facilitated synaptic transmission in the myenteric plexus. The clinicopathological parameters, treatment methods and responses, overall survival (OS), and progression-free survival (PFS) were evaluated. Activity of paraoxonase 1 and lipid profile in healthy children.

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An increased oxidative stress may contribute to the development of diabetic nephropathy. Photoinduced single- versus double-bond torsion in donor-acceptor-substituted trans-stilbenes. Review of clinical charts, photographs, and fluorescein angiograms of 115 eyes of 96 patients, accrued over 18 years. Multi-lineage interrogation of the performance characteristics of a split-signal zyrtec 10 mg tablet dosage fluorescence in situ hybridization probe for anaplastic lymphoma kinase gene rearrangements: a study of 101 cases characterized by immunohistomorphology on fixed archival tissue. Since estrogens have been shown to modulate migration and proliferation of cardiac fibroblasts and to modulate the expression of estrogen receptors of cardiomyocytes we examined whether high-dose estrogen treatment can affect post-myocardial infarction left ventricular remodeling. We report our experience with 21 patients and nonunion of long bone fractures. Here, we review the current knowledge on the membrane-embedded MARCH E3 ligases (MARCH-1-6,7,8,11) with a focus on how the transmembrane regions can contribute via GxxxG-motifs to the selection and recognition of other membrane proteins as substrates for ubiquitination. The infection was resistant to both high-dose liposomal amphotericin B and voriconazole. HIV quasispecies dynamics during pro-active treatment switching: impact on multi-drug resistance and resistance archiving in latent reservoirs.

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Different from lipomas found in other locations, those observed in the parotid gland cannot be easily resected by simple dissection. High-dimensional pharmacogenetic prediction of a continuous trait using machine learning techniques with application to warfarin dose prediction in African Americans. In this study, we identified heat shock protein (HSP) 90 as a novel SREBP regulator that binds to and stabilizes SCAP-SREBP. The number of each type of septic postoperative complication and their total did not differ between the group treated by oral antibiotics prior to operation and the group treated peroperatively with systemic antibiotic therapy. Attenuation correction is necessary for the reconstruction of SPECT images. Photodynamic therapy, which involves the action of light-activated dyes on biological tissues, has been attempted to treat tumors.

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A convenient tool for evaluation of the efficiency of target cleavage is the single strand-specific endonuclease, T7EI. A summary of the results of the 1976 census of Cameroon is presented. We previously found that two basic loop-helix-loop transcription factors, PHYTOCHROME-INTERACTING FACTOR4 (PIF4) and potassium dose with lasix PIF5, integrate light and circadian clock signaling to generate rhythmic plant growth in Arabidopsis (Arabidopsis thaliana). In the model, zinc accelerated and sharpened the light response, broadening the frequency response of rod photoreceptors. The most promising candidate has bcc structure and is reminiscent of the blue phase of liquid crystals in that it has line nodes of magnetization protected by symmetry. The mRNAs of Wnt1, beta-catenin, APC, cyclin D1 and c-myc genes were amplified by using of semiquantitative reverse transcription polymerase chain reaction (RT-PCR) from normal rat livers, atypical hyperplasia livers and hepatoma tissues, respectively.

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